| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Activated Ha Ras but not TPA induces transcription through binding sites for activating transcription factor 3 / Jun and a novel nuclear factor . ^^^ Of many different activating transcription factor / cAMP responsive element binding protein / activating protein 1 factors tested , one part of the sequence selectively binds endogenous proteins immunologically related to activating transcription factor 3 ( ATF 3 ) and Jun isotypes . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Injury specific expression of activating transcription factor 3 in retinal ganglion cells and its colocalized expression with phosphorylated c Jun . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Activating transcription factor 3 ( ATF 3 ) is a basic leucine zipper protein which is highly homologous to c Jun dimerization protein 2 ( JDP 2 ) , especially within the threonine / proline phosphoacceptor site , Thr 148 . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Among the 41 statistically significant named overexpressed genes at the 1 hour time point were early growth response 1 ( EGR 1 ) , jun B proto oncogene ( jun B ) , jun D proto oncogene ( jun D ) , and activating transcription factor 3 ( ATF 3 ) . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Expression of the activating transcription factor 3 prevents c Jun N terminal kinase induced neuronal death by promoting heat shock protein 27 expression and Akt activation . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Peripheral severance of the vagus or the sciatic nerve resulted in a massive and rapid , but transient increase of the activated JNK ( p JNK ) in neuronal nuclei , followed by c Jun phosphorylation and activating transcription factor 3 ( ATF 3 ) induction . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| The NRG targets are FBJ murine osteosarcoma viral oncogene homolog B , Early growth response 1 , 5 jun avian sarcoma virus 17 oncogene homolog , Activating transcription factor 3 , Homo sapiens cDNA FLJ 31636 fis , Jun B proto oncogene , Forkhead box C 1 , Platelet / endothelial cell adhesion molecule 1 , NADPH dependent retinol dehydrogenase / reductase , Dual specificity phosphatase 5 , NGF inducible protein TIS 21 , Connective tissue growth factor , Jun D proto oncogene , Serum response factor , Cullin 1 , 5 myc avian myelocytomatosis viral oncogene , Transient receptor potential channel 1 , Low density lipoprotein receptor , Transforming growth factor beta 1 , Nucleoporin 88 kDa , and Pleckstrin homology like domain A 1 . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Facial axotomy did not induce significant motoneuron loss nor enhance SOD 1 immunoreactivity in these tg rats and non tg littermates at 2 weeks postoperation , although both axotomy and avulsion elicited intense immunolabeling for activating transcription factor 3 , phosphorylated c Jun , and phosphorylated heat shock protein 27 in injured motoneurons of all these animals . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| In addition , binding of activating transcription factor 3 ( ATF 3 ) to the putative activator protein 1 site located adjacent to the NFAT binding site also repressed the promoter activity . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| We showed that overexpression of activating transcription factor 3 ( ATF 3 ) , ATF 4 , ATF 5 , c Jun , JunD and caspase 3 is associated with sensitivity to bortezomib induced apoptosis , whereas overexpression of heat shock protein ( HSP ) 27 , HSP 70 , HSP 90 and T cell factor 4 is associated with bortezomib resistance . . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| The mRNA for the transcription factors ATF 3 , c fos , c jun , junB , and zif / 268 is induced by A 23187 . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Among many different ATF / AP 1 factors tested , two factors , ATF 3 and c Jun , stimulate proenkephalin transcription in an FGF or Ras dependent fashion . ^^^ Finally , we show that ATF 3 and c Jun form heterodimeric complexes in SK N MC cells and that the levels of both proteins are increased in response to FGF but not cAMP . ^^^ Together , these results indicate that growth factor and cAMP dependent signaling pathways converge at CRE 2 to synergistically stimulate gene expression and that ATF 3 and c Jun regulate proenkephalin transcription in response to both growth factor and cAMP dependent intracellular signaling pathways . . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| After 40 min of renal ischemia followed by reperfusion for as little as 5 min , binding of ATF 2 and c Jun , but not ATF 3 or CREB ( cAMP response element binding protein ) , to oligonucleotides containing either an ATF / cAMP response element ( ATF / CRE ) or the jun2TRE from the c jun promoter , was significantly increased . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Significantly , co transfection of DNAs expressing ATF 2 and c Jun activates the ATF 3 promoter . ^^^ A possible mechanism implicating the C Jun NH 2 terminal kinase / stress activated protein kinase ( JNK / SAPK ) stress inducible signaling pathway in the induction of the ATF 3 gene is discussed . . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| The cJun associated proteins represent different forms of the bZIP transcription factor ATF 3 , the human homolog of rat LRF 1 . ^^^ Through induction of ATF 3 expression and the subsequent formation of cJun / ATF3 heterodimers , E1A alters the repertoire of AP 1 / ATF factors and may thereby redirect the corresponding gene expression program . ^^^ Since the induction of ATF 3 is a function of sequences within the transforming 12S ElA protein , cJun / ATF3 complexes might be involved in establishing cellular transformation by AdE1A . . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Upon treatment of cells with JNK 1 inducing doses , ADR caused an elevation of steady state levels of c jun and ATF 3 mRNAs , as measured by RT PCR . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| We also examined the expression pattern of two stress responsive genes , c Jun and ATF 3 . ^^^ However , in the kidney c Jun and ATF 3 expression is induced only by ischemia / reperfusion . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Second , the gadd153 / Chop10 promoter contains two functionally important binding sites for ATF 3 : an AP 1 site and a C / EBP ATF composite site , a previously unidentified binding site for ATF 3 . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| In the present study , we demonstrated that microtubule binding agents ( MBAs ) taxol and colchicine induced immediate early gene ( c jun and ATF 3 ) expression , cell cycle arrest , and apoptosis in the human breast cancer cell line MCF 7 . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Double labeling using immunohistochemistry revealed that the population of DRG neurons expressing ATF 3 included those expressing c jun , and in motoneurons ATF 3 and c jun were concurrently expressed after axotomy . ^^^ In contrast to c jun , ATF 3 was not induced transsynaptically in spinal dorsal horn neurons . ^^^ ATF 3 regulates transcription by binding to DNA sites as a homodimer or heterodimer with Jun proteins . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| ATF 3 is a transcription factor belonging to the Jun / Fos family whose mouse homologue ( TI 241 ) was isolated , using the differential screening method , from B 16 mouse melanoma cells as a blood borne metastasis associated gene . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Homocysteine responsive ATF 3 gene expression in human vascular endothelial cells : activation of c Jun NH ( 2 ) terminal kinase and promoter response element . ^^^ Gel shift , immunoprecipitation , and cotransfection assays demonstrated that a complex ( or complexes ) containing ATF 2 , c Jun , and ATF 3 increased binding to the ATF / CRE site in the homocysteine treated cells and activated the ATF 3 gene expression , while ATF 3 appeared to repress its own promoter . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| We also report the novel finding that a component present in this inducible AP 1 complex is ATF 3 . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Jun and Fos , ATF 3 might play a role in the control of cell proliferation and participate in oncogenic transformation . ^^^ To investigate this putative ATF 3 function directly , the rat ATF 3 protein was compared with 5 Jun for its ability to transform primary cultures of chick embryo fibroblasts ( CEFs ) . ^^^ Like CEFs accumulating 5 Jun , CEFs accumulating the ATF 3 protein displayed a typical , fusiform morphology , associated with an enhanced capacity to grow in medium with reduced amount of serum . ^^^ However , in contrast to 5 Jun transformed CEFs , the ATF 3 overexpressing cells could not promote colony formation from single cells in agar . ^^^ Partial transformation induced by ATF 3 was found to be associated with repression of multiple cellular genes that are also down regulated by 5 Jun , including those coding for the extracellular components fibronectin , decorin , thrombospondin 2 , and the pro apoptotic protein Par 4 . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis and co transfection experiments demonstrate that overexpression of ATF 3 enhances cyclin D 1 mRNA expression and activates the cyclin D 1 promoter 2 . 5 fold when activating protein 1 ( AP 1 ) and cyclic AMP response element ( CRE ) sites within the promoter are intact . ^^^ ATF 3 mediated promoter activation is reduced to 1 . 3 fold and 1 . 6 fold respectively when the AP 1 or CRE sites are mutated , and mutation of both sites simultaneously leads to the complete abrogation of promoter activation . ^^^ Furthermore , DNA binding studies demonstrate that ATF 3 binds directly to the AP 1 site within the cyclin D 1 promoter . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| In the transient expression assay , ATF 3 suppressed the p 53 gene promoter activity through its specific binding to an atypical AP 1 element , PF 1 site , in the p 53 gene promoter . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| DOX rapidly activated JNK and c Jun and induced ATF 3 at both mRNA and protein level . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Electrophoretic mobility shift assays identified Nrf 2 , MafG , ATF 3 , and Jun and Fos family members as StRE binding proteins ; binding of Nrf 2 , MafG , and ATF 3 was increased in response to heme . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Jun , ATF 3 , TAB 1 , and TANK ) , suggesting that their up regulation may be in response to secondary necrosis . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| IR was found to enhance the expression of c Jun and , in particular , ATF 3 , but , in contrast to various other stress stimuli , did not induce the expression of c Fos . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization and immunohistochemistry , we compared the expression profile of ATF 3 with those of ATF 2 and c Jun after middle cerebral artery ( MCA ) occlusion . ^^^ The expression profiles of ATF 3 and c Jun were virtually similar , but c Jun expression was also observed in other regions of the brain in control rats . ^^^ Double immunohistochemical labeling revealed concurrent expression of ATF 3 and phospho c Jun in neurons . ^^^ We conclude that the transcription factor ATF 3 is a suitable marker of neurons subjected to ischemic insult directly and indirectly , and that cooperative works of ATF 3 and c Jun may be crucial triggers of various transcriptional responses to the ischemic insult . . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Alternate sections of forebrain were immunoreacted for cholera toxin subunit B or processed for mRNA in situ hybridization for ATF 3 , c jun , GAP 43 , CAP 23 , SCG 10 , L 1 , CHL 1 or krox 24 , each of which has been associated with axotomy or axon regeneration in other neurons . ^^^ Seven days after intracortical axotomy , ATF 3 , c jun , GAP 43 , SCG 10 , L 1 and CHL 1 , but not CAP 23 or krox 24 , were up regulated by layer 5 pyramidal neurons , including identified corticospinal neurons . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Microarray analysis and luciferase reporter assays indicate that adipokines specifically induce several transcriptional programs involved in promoting tumorigenesis , including increased cell proliferation ( IGF 2 , FOS , JUN , cyclin D 1 ) , invasive potential ( MMP 1 , ATF 3 ) , survival ( A 20 , NFkappaB ) , and angiogenesis . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| ATF 3 enhances c Jun mediated neurite sprouting . ^^^ More recently there has been interest in the c Jun related bZIP transcription factor , ATF 3 , and its function in neurons . ^^^ ATF 3 is also induced in nerve cells in response to axotomy and there is a correlation between increased ATF 3 expression and upregulation of c Jun in surviving neurons . ^^^ Moreover , c Jun is able to induce expression of ATF 3 . ^^^ We investigated the effect of co expressing c Jun and ATF 3 in two neuronal like cell lines to model transcriptional events occurring in axotomized neurons undergoing regeneration . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Second , induction of ATF 3 is mediated in part by the NF kappaB and Jun N terminal kinase / stress activated protein kinase signaling pathways , two stress induced pathways implicated in both type 1 and type 2 diabetes . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| We attributed this behavior to the significant down regulation of cyclin D 1 , cyclin A , and ATF 3 , known AP 1 targets implicated in cell cycle control and promotion . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| SCG 10 and c Jun were found in neurons in the same regions as retrogradely labeled and ATF 3 positive cells . ^^^ The co expression of ATF 3 with c jun suggests that interactions between these transcription factors may be important for controlling the program of gene expression necessary for regeneration . . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Several genes were selected from p 53 related genes ( CDKN1A , TP53I11 and CDC 14 ) , Akt 2 related genes ( PRKCD , BRCA 1 , TRIB 3 and APPL ) , mitogen activated protein kinase related genes ( RSK and SH3BP5 ) , Ras superfamily genes ( RAP1GA1 , RHOC and ARHGDIA ) and AP 1 family and related genes ( RIP 140 , FOS , ATF 3 , JUN and FRA 2 ) . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Retrograde axonal transport of JNK signaling molecules influence injury induced nuclear changes in p c Jun and ATF 3 in adult rat sensory neurons . ^^^ In the present study , we investigated if the previously observed JNK mediated activation of c Jun and induction of ATF 3 could be ascribed to axonal transport of JNK signaling components , or if axonal transport of the transcription factors themselves contributes to the nuclear changes in injured sensory neurons . ^^^ No or little retrograde transport of c Jun and p c Jun was found , whereas an anterograde transport of Hsp 27 , a protein previously reported in the context of p c Jun and ATF 3 , was observed . ^^^ In separate experiments , we found that in vitro inhibition of axonal transport or axonal inhibition of JNK reduced the number of p c Jun and ATF 3 positive neuronal nuclei . ^^^ The results suggest that retrograde axonal transport of JNK signaling components contributes to the injury induced c Jun phosphorylation and ATF 3 induction . . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Pharmacological studies implicated a combined role for the activities of protein kinase C isozymes , ERK and c Jun N terminal kinase , in modulating ATF 3 expression . ^^^ GnRH induced recruitment of ATF 3 , c Jun , and c Fos to the dual CREs . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Here , we show that low doses of UV trigger delayed activation of the stress induced MAPkinase JNK and its proapoptotic targets c Jun and ATF 3 in TCR deficient primary human fibroblasts from Xeroderma Pigmentosum ( XP ) and Cockayne syndrome ( CS ) patients . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| The role of ATF 3 , a neuronal marker of injury and a c Jun dimerization partner , was also examined . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Increased levels of downstream pathway signaling members , specifically Gadd45beta , c jun , and ATF 3 were observed , as was activation of c jun ( phosphorylation ) . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| ATF 3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis SOD 1 transgenic mice and correlates with c Jun phosphorylation , CHOP expression , somato dendritic ubiquitination and Golgi fragmentation . ^^^ To obtain insight into the morphological and molecular correlates of motoneuron degeneration in amyotrophic lateral sclerosis ( ALS ) mice that express G93A mutant superoxide dismutase ( SOD ) 1 ( G93A mice ) , we have mapped and characterized ' sick ' motoneurons labelled by the ' stress transcription factors ' ATF 3 and phospho c Jun . ^^^ Confocal double labelling immunofluorescence showed that all ATF 3 positive motoneurons were immunoreactive for phosphorylated c Jun . ^^^ Furthermore , the majority of ATF 3 and phospho c Jun positive motoneurons were also immunoreactive for CHOP ( GADD 153 ) and showed Golgi fragmentation . ^^^ A subset of ATF 3 and phosphorylated c Jun immunoreactive motoneurons showed an abnormal appearance characterized by a number of distinctive features , including an eccentric flattened nucleus , perikaryal accumulation of ubiquitin immunoreactivity , juxta nuclear accumulation of the Golgi apparatus and the endoplasmic reticulum , and intense Hsp 70 immunoreactivity . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| Expression of growth associated genes c jun , ATF 3 , SCG 10 and GAP 43 was investigated by immunohistochemistry or in situ hybridisation . ^^^ RESULTS : Application of LPS induced a gradient of inflammation through the full depth of the motor cortex and promoted c Jun and SCG 10 expression for up to 2 weeks , and GAP 43 upregulation for 3 days by many corticospinal neurons , but had very limited effects on neuronal ATF 3 expression . ^^^ |
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| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| In contrast , the phosphorylation of ERK1 / 2 and JNK and the expression of the early response genes c jun , c fos , ATF 3 and egr 1 induced by camostat feeding were not affected by rapamycin . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| ATF 3 overexpression did not increase c Jun expression . ^^^ |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P05412 |
Pubmed |
SVM Score :0.0 |
| NA |
|