| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Localization of the human chromosome 5q genes Gabra 1 , Gabrg 2 , Il 4 , Il 5 , and Irf 1 on mouse chromosome 11 . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| RH mapping eliminated the candidate genes GABRA 1 and GABRG 2 , which encode GABA A receptor components , by showing that they are telomeric to the target region . . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| These results reveal the clustering of GABRA 6 , GABRA 1 , and the GABAA receptor gamma 2 subunit gene ( GABRG 2 ) on distal chromosome 5q . . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Dinucleotide repeat polymorphisms associated with the human GABAA receptor alpha 1 ( GABRA 1 ) and gamma 2 subunit ( GABRG 2 ) gene cluster on chromosome 5q32 q 35 offer the opportunity to test whether these candidate genes confer susceptibility to IGEs . ^^^ Our linkage analyses in 63 families ascertained through IGE patients with either juvenile myoclonic epilepsy , juvenile absence epilepsy or childhood absence epilepsy do not support the hypothesis that variants within the GABRA 1 and GABRG 2 gene cluster contribute a frequent major gene effect to the expression of the common familial IGEs . . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| A gene cluster consisting of the four gamma aminobutyric acidA ( GABAA ) receptor subunit genes GABRA 1 , GABRA 6 , GABRAB 2 , and GABRG 2 was assigned to a yeast artificial chromosome ( YAC ) contig of 5q33 . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined GABA ( A ) receptor alpha 1 ( GABRA 1 ) , alpha 6 ( GABRA 6 ) and gamma 2 ( GABRG 2 ) subunit genes on 5q34 . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Real time PCR demonstrated that levels of Sts mRNA were reduced by half in the brains of 39 , XO mice compared with 40 , 20 , and that expression levels of a number of GABAA subunits previously shown to be important components of fear processing ( Gabra 3 , Gabra 1 and Gabrg 2 ) were also altered . ^^^ However , 40 , XY * X mice , in which the Y * X is a small chromosome comprising of a complete PAR and a small non PAR segment of the 10 chromosome , exhibited the same pattern of fear reactivity behaviour as 39 , XO animals , but equivalent expression levels of Sts , Gabra 1 , Gabra 3 and Gabrg 2 to 40 , 20 females . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Chromosome 5 contains a cluster of GABA ( A ) receptor genes , GABRA 1 , GABRA 6 , GABRB 2 , and GABRG 2 , which have been among the most extensively studied in relation to alcohol use . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Mutation screen of GABRA 1 , GABRB 2 and GABRG 2 genes in Japanese patients with absence seizures . ^^^ We performed mutation analysis of all the coding exons of GABA ( A ) receptor alpha 1 , beta 2 and gamma 2 subunit ( GABRA 1 , GABRB 2 and GABRG 2 ) genes by direct sequencing to clarify whether there was common molecular biological mechanism underlying both typical and atypical absences . ^^^ We detected five polymorphisms ( T156C in GABRA 1 , C1194T in GABRB 2 , and C315T , T588C and C1230T in GABRG 2 ) , and they are silent mutations . ^^^ In conclusion , mutations in GABRA 1 , GABRB 2 and GABRG 2 do not seem to be a major genetic cause of epilepsy with typical and atypical absences in Japanese subjects . . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| A GABA ( A ) receptor gene cluster on 5q31 35 ( beta 2 [ GABRB 2 ] , alpha 6 [ GABRA 6 ] , alpha 1 [ GABRA 1 ] , and gamma 2 [ GABRG 2 ] subunit genes ) is one of the most attractive candidate regions for schizophrenia susceptibility . ^^^ METHODS : We performed 1 ) systematic polymorphism search of GABRB 2 , GABRA 6 , and GABRA 1 , in addition to our colleague ' s study of GABRG 2 ; 2 ) evaluation of linkage disequilibrium ( LD ) within this cluster with 35 single nucleotide polymorphisms ( SNPs ) ; 3 ) `` selection of haplotype tagging ( ht ) SNPs ' ' ; and 4 ) two stage association analysis that comprised first set screening analysis of all htSNPs ( 288 Japanese schizophrenia patients and 288 control subjects ) and second set replication analysis of the positive htSNPs ( 901 schizophrenic patients and 806 control subjects ) . ^^^ RESULTS : In the first set scan , we found a significant association of two htSNPs in GABRA 1 , but no association of GABRB 2 , GABRA 6 , and GABRG 2 . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| The majority of the genes encode ion channels , including voltage gated potassium channels KCNQ 2 and KCNQ 3 , sodium channels SCN1A , SCN2A , and SCN1B , chloride channels CLCN 2 , and ligand gated ion channels CHRNA 4 , CHRNB 2 , GABRG 2 , and GABRA 1 . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Single nucleotide polymorphisms ( SNPs ) were screened in the following genes : GABRG 1 , GABRA 2 , GABRA 4 , and GABRB 1 on chromosome 4p12 ; GABRB 2 , GABRA 6 , GABRA 1 , GABRG 2 , and GABRP on 5q34 q35 . 1 ; GABRR 1 and GABRR 2 on 6q15 ; and GABRA 5 , GABRB 3 , and GABRG 3 on 15q12 . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| In the present report , we took a two stage candidate gene association approach to investigate a group of gamma aminobutyric acid ( GABA ) A receptor subunit genes ( GABRA 1 , GABRA 6 , GABRB 2 , GABRG 2 , and GABRP ) within our linkage peak . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| The results showed that treatment of QYS significantly increased the expressions of Gabra 1 , Gabra 2 and Gabr 4 and decreased the expression of Gabrg 2 in inferior colliculus . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Mutations in GABRA 1 , GABRA 5 , GABRG 2 and GABRD receptor genes are not a major factor in the pathogenesis of familial focal epilepsy preceded by febrile seizures . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| These include benign familial neonatal convulsions due to mutations in KCNQ 2 or KCNQ 3 , generalized epilepsy with febrile seizures plus due to mutations in SCN1A , SCN2A , SCN1B , and GABRG 2 , autosomal dominant juvenile myoclonic epilepsy ( JME ) due to a mutation in GABRA 1 and mutations in CLCN 2 associated with several IGE sub types . ^^^ |
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| Interacting proteins: P18507 and P14867 |
Pubmed |
SVM Score :0.0 |
| Mutations in GABRA 1 , GABRG 2 , and GABRB 3 are associated with absence seizures , while mutations in CLCN 2 and myoclonin / EFHC1 substantiate juvenile myoclonic epilepsy as a clinical entity . ^^^ |
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