| Interacting proteins: P17948 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of phospholipase Cgamma ( PLCgamma ) , tyrosine phosphatase SHP 2 , Crk , and extracellular regulated kinases 1 and 2 ( Erk1 / 2 ) was registered in response to VEGF A treatment of the PAE / VEGFR 1 cells . ^^^ However , these two mutant VEGFR 1 failed to mediate increased mitogenesis and were unable to stimulate increased tyrosine phosphorylation of SHP 2 , Crk , and Erk1 / 2 , indicating that the mutations lead to a perturbation in VEGF A induced signal transduction . . ^^^ |
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| Interacting proteins: P17948 and Q06124 |
Pubmed |
SVM Score :0.0 |
| Tyrosine 1213 of Flt 1 is a major binding site of Nck and SHP 2 . ^^^ We examined the interactions of certain proteins with a SH 2 domain with Flt 1 and KDR using the yeast two hybrid system and found that Nck , SHP 2 , PLC gamma , and PI3K p 85 bind to Flt 1 . ^^^ Nck , SHP 2 , and PI3K bind to Y 1213 of Flt 1 . ^^^ These results suggest that Nck , SHP 2 , PLC gamma , and PI3K play important roles in Flt 1 signal transduction and that Y 1213 of Flt 1 is a major binding site of PI3K , Nck , and SHP 2 . . ^^^ |
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| Interacting proteins: P17948 and Q06124 |
Pubmed |
SVM Score :0.0 |
| SHP 2 , phospholipase C gamma , and Grb 2 could also be shown to bind to the intact Flt 1 intracellular domain . ^^^ |
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| Interacting proteins: P17948 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17948 and Q06124 |
Pubmed |
SVM Score :0.0 |
| NA |
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