| Interacting proteins: P17948 and P35222 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescent staining with antibodies to E cadherin and beta catenin showed that VEGFR 1 activation led to translocation of E cadherin and beta catenin from their usual cell membrane bound location to the cytoplasm and nucleus , respectively . ^^^ Western blotting showed that VEGFR 1 activation led to decreased expression of the epithelial markers E cadherin and plakoglobin , increased expression of the mesenchymal markers vimentin and N cadherin , and increased nuclear expression of beta catenin . ^^^ |
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| Interacting proteins: P17948 and P35222 |
Pubmed |
SVM Score :0.0 |
| Such an autocrine loop is supported by constitutive VEGF receptor ( Flk 1 ) tyrosine phosphorylation , Flk 1 and Flt 1 nuclear localization , and mitogen activated protein kinase activation . beta catenin was also found to exhibit significant nuclear localization and constitutively associate with Flk 1 and Flt 1 in EOMA cells but much less so in HUVEC , and immunoprecipitated Flk 1 was able to phosphorylate purified beta catenin in an immune complex kinase assay . ^^^ |
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| Interacting proteins: P17948 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
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