| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGF binds and activates two tyrosine kinase receptors called VEGFR 1 and VEGFR 2 and neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| ORFV 2 VEGF was found to bind and induce autophosphorylation of VEGFR 2 and was unable to bind or activate VEGFR 1 and VEGFR 3 , but bound the newly identified VEGF 165 receptor neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| It mediates its activity mainly via two tyrosine kinase receptors , VEGFR 1 ( flt 1 ) and VEGFR 2 ( flk 1 / KDR ) , although other receptors , such as neuropilin 1 and 2 , can also bind VEGF . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| The interaction of neuropilin 1 with vascular endothelial growth factor and its receptor flt 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) , a potent mitogen , is expressed in podocytes in the glomerulus , and VEGF receptors ( flt 1 , KDR , and neuropilin 1 ) are present on endothelial cells and other cell types . ^^^ In conclusion , flt 1 , KDR , and neuropilin 1 are present on cultured HMC , and VEGF ( 165 ) induces HMC proliferation . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Although melanoma cells expressed both , neuropilin 1 and flt 1 , exogenous homodimeric placenta growth factor had no effect on melanoma cell growth . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Expression of vascular endothelial growth factor isoforms and their receptors Flt 1 , KDR , and neuropilin 1 in synovial tissues of rheumatoid arthritis . ^^^ This study examined the expression of vascular endothelial growth factor ( VEGF ) isoforms and VEGF receptors , Flt 1 , KDR and neuropilin 1 , in RA and osteoarthritis ( OA ) synovia , and studied the relationship between their expression and the synovial angiogenesis . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| To investigate the mechanism of neuroprotection by VEGF , the expression of known target receptors for VEGF was measured by Western blotting , which showed that HN 33 cells expressed VEGFR 2 receptors and neuropilin 1 , but not VEGFR 1 receptors . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Using immunohistochemical and in situ hybridization methods we have here demonstrated that VEGF and its receptors Flk 1 , Flt 1 and Neuropilin 1 mRNAs and proteins are induced after incisions in the rat spinal cord . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Both primary and metastatic melanoma cells were found to express the mRNAs encoding for vascular endothelial growth factor and placenta growth factor receptors ( KDR , Flt 1 , neuropilin 1 , and neuropilin 2 ) , and exposure of melanoma cells to these cytokines resulted in a specific proliferative response , supporting the hypothesis of a role of these angiogenic factors in melanoma growth . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| The expression of the signalling VEGF receptors R 1 ( flt 1 ) and R 2 ( flk 1 ) was restricted to the endothelial cells of the cortex whereas neuropilin 1 was expressed by both endothelial and steroidogenic cells . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Although much is known about the biology of VEGF and its cognate receptors , VEGFR 1 and VEGFR 2 , the role of a recently identified co receptor for VEGF , neuropilin 1 , is not well understood . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| TSA inhibited in a dose dependent and reversible fashion the VEGF induced expression of VEGF receptors , VEGFR 1 , VEGFR 2 , and neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Compared with controls , coronary vessels of acute KD had upregulation of VEGF and flt 1 but not KDR or neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analysis revealed the expression of VEGF receptors VEGFR 1 ( Flt 1 ) , VEGFR 2 ( Kdr ) , and VEGFR 3 ( Flt 4 ) , as well as neuropilin 1 and 2 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| We report that vascular endothelial growth factor ( VEGF ) , a major angiogenic factor , is also arequisite autocrine factor for breast carcinoma invasion in vitro and that the VEGF receptor Neuropilin 1 but not Flt 1 is essential for this function . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| However , the mRNA expression of their receptors ( VEGFR 1 = Flt 1 , VEGFR 2 = KDR and neuropilin 1 ) was recognized only in the OA samples . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) is utilized to measure the VEGF receptors flt 1 , KDR / flk 1 , flt 4 , neuropilin 1 ( NRP 1 ) , and neuropilin 2 ( NRP 2 ) . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Stimulation by either 50 ng / ml VEGF A 165 or by 24 h of anoxia resulted in an altered pattern of receptor expression for VEGF R 2 ( Flk 1 ) , VEGF R 3 ( Flt 4 ) , neuropilin 1 , and neuropilin 2 , whereas VEGF R 1 ( Flt 1 ) remained unexpressed . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors ( VEGFR 1 , its soluble form sVEGFR 1 , VEGFR 2 and neuropilin 1 ) are expressed predominantly by endothelial cells . ^^^ We used quantitative RT PCR , Western blot , gelatin zymography and immunohistochemistry to study the expression of VEGF , VEGFR 1 , VEGFR 2 , sVEGFR 1 , neuropilin 1 , MT 1 MMP , MMP 2 , MMP 9 and TIMP 2 in 20 human GBMs and 5 normal brains . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization demonstrated presence of mRNA for VEGF receptors Flt 1 , fetal liver kinase 1 , neuropilin 1 and 2 in several important cellular compartments of the spinal cord . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| In addition , the VEGF receptors neuropilin 1 and flt 1 were also upregulated . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| METHODS : Normal and arterialized vein graft segments were evaluated by reverse transcription polymerase chain reaction ( RT PCR ) for expression of VEGF R 1 ( flt ) , VEGF R 2 ( KDR ) , and neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| A receptor binding assay revealed that snake venom VEGFs bound to KDR IgG with high affinity ( Kd = approximately 0 . 1 nm ) as well as to VEGF 165 but did not interact with Flt 1 , Flt 4 , or neuropilin 1 at all . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Presence of GMP was associated with increased expression in tumour endothelium of the VEGF A receptors KDR , FLT 1 and neuropilin 1 , as well as VEGF D protein . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( Nrp 1 ) and Neuropilin 2 ( Nrp 2 ) are nonkinase vascular endothelial growth factor receptors ( VEGFR ) identified in several vertebrates , which function as coreceptors for the receptor tyrosine kinases VEGFR 1 and VEGFR 2 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| These receptors include VEGFR 1 , VEGFR 2 , VEGFR 3 , neuropilin 1 ( NRP 1 ) , and NRP 2 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| To evaluate a possible contribution of the VEGF receptors , we performed immunohistochemical stainings of VEGF R 1 ( flt ) , R 2 ( KDR , flk ) , and Neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| VEGFR 1 mRNA expression increased 2 h after exercise , and neuropilin 1 expression was transiently reduced , while all three receptors increased by 6 h . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| The mRNA levels of 13 genes including CD 147 ( receptor for CypA ) , PDGF BB , endothelin 1 ( ET 1 ) , vascular endothelial growth factor receptor 1 ( VEGFR 1 ) , VEGFR 2 , VEGFR 3 , neuropilin 1 ( NRP 1 ) , NRP 2 , eNOS , iNOS , nNOS , ICAM 1 , and PECAM 1 were semiquantitatively determined by real time RT PCR as standardized with a house keeping gene beta actin . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| A longer unique antisense oligo against a different region of pICln mRNA was found to also enhance EC growth and tube formation and to decrease mRNAs for soluble Flt 1 and neuropilin 1 vascular endothelial growth factor ( VEGF ) receptors , the angiostatic factors that are generated by alternative RNA splicing . ^^^ Conversely , pICln overexpression suppressed EC growth and increased the mRNAs for both soluble Flt 1 and soluble neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| After induction of follicular growth by the eCG treatment , each mRNA expression of VEGF 120 , VEGF 164 , Neuropilin 1 and Flt 1 significantly increased . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| We now report that normal human melanocytes ( Mc ) maintained in serum free , hormone , and growth factor supplemented medium lacking phorbol ester and choleragen constitutively express VEGF receptor 1 ( VEGFR 1 ) , VEGFR 2 , and neuropilin 1 . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| However , transcripts for VEGF 189 , VEGF 165 , and VEGF receptors ( Fms like tyrosine kinase 1 [ Flt 1 ] , kinase insert domain receptor [ KDR ] / fetal liver kinase 1 [ Flk 1 ] , and neuropilin 1 ) were suppressed in the BPD models . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| We used immunohistochemistry to demonstrate expression of Neuropilin 1 in 63 malignant and 35 benign ovarian tumours and compared it to VEGF , Flt , Flk , SST expression and tumour microvessel density ( MVD ) . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Real time RT PCR analysis showed that ( 1 ) the level of mRNA for VEGF was lower in old animals than young animals ; ( 2 ) the mRNA levels of Flt 1 and neuropilin 1 are lower in old animals than young animals , while that of KDR / Flk 1 remained unchanged with advancing age ; and ( 3 ) the levels of mRNA for angiopoietin 1 and 2 remained unchanged , while the mRNA for Tie 2 was lower in old animals than young animals . ^^^ |
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| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Prostate cancer cells expressed the mRNA for VEGF receptor ( VEGFR ) neuropilin 1 but not the VEGFRs Flt 1 or KDR . ^^^ In contrast , mouse pre osteoblastic cells ( MC3T3 E 1 ) expressed Flt 1 and neuropilin 1 mRNA but not KDR . ^^^ |
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| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| For example , levels of proangiogenic VEGF A , VEGF B , neuropilin 1 , VEGFR 1 , and VEGFR 2 were reduced and the levels of antiangiogenic thrombospondin 1 and retinoblastoma like 2 were increased . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of VEGF ( 165 ) and its receptors Flt 1 , KDR , NRP 1 , and NRP 2 was evaluated by real time reverse transcription polymerase chain reaction . ^^^ RESULTS : VEGF ( 165 ) mRNA was upregulated in Stage 3 and 4 and Flt 1 and KDR gene expression was increased in Stage 3 , while NRP 1 and 2 mRNA and protein levels were higher in Stages 1 4 vs . controls ( P < 0 . 05 ) . ^^^ |
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| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| To assess the contribution of NRP 1 to VEGF A mediated EC proliferation , migration , and PAF synthesis , we used porcine aortic EC ( PAEC ) recombinantly expressing Flt 1 , NRP 1 , KDR or KDR and NRP 1 . ^^^ Cells were stimulated with VEGF A , which binds to Flt 1 , KDR and NRP 1 , and VEGF C , which binds to KDR only . ^^^ In contrast , stimulation of PAEC Flt 1 and PAEC NRP 1 with VEGF A or VEGF C did not induce proliferation , migration , or PAF synthesis . ^^^ |
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| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| The mRNA and protein levels of NRP 1 , NRP 2 , VEGFR 1 , VEGFR 2 , and VEGFR 3 were semiquantitatively determined by real time PCR and Western blot , respectively . ^^^ RESULTS : In PBS treated HUVECs , mRNA levels of NRPs and VEGFRs were NRP 1 ( 0 . 013 ) , NRP 2 ( 0 . 007 ) , VEGFR 2 ( 0 . 006 ) , VEGFR 1 ( 0 . 0024 ) , and VEGFR 3 ( 0 . 0009 ) . ^^^ |
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| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| However , it is unknown whether VEGF A ( 165 ) is mediating PGI ( 2 ) synthesis through VEGF receptor 1 ( VEGFR 1 ) and / or VEGF receptor 2 ( VEGFR 2 ) activation and whether the coreceptor NRP 1 potentiates VEGF A ( 165 ) activity . ^^^ Treatment of BAEC with VEGF analogs , VEGF A ( 165 ) ( VEGFR 1 , VEGFR 2 and NRP 1 agonist ) and VEGF A ( 121 ) ( VEGFR 1 and VEGFR 2 agonist ) ( up to 10 ( 9 ) m ) , increased PGI ( 2 ) synthesis by 70 and 40 fold within 15 min . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) , its receptors ( VEGFR 1 , VEGFR 2 ) and neuropillin 1 ( NRP 1 ) are expressed at variable levels in bone marrow . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| Although mRNA for VEGF 121 , VEGF 165 , VEGFR 1 and NRP 2 was widely expressed , mRNA expression for VEGF 189 , VEGFR 2 and NRP 1 was linked to a malignant phenotype such as local invasion . ^^^ |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and P17948 |
Pubmed |
SVM Score :0.0 |
| NA |
|