| Interacting proteins: P08254 and P17936 |
Pubmed |
SVM Score :0.0 |
| Matrix metalloproteinase 3 cleaves insulin like growth factor binding protein 3 ( IGFBP 3 ) into six fragments , four of which bind heparin Sepharose ( Fowlkes , J . ^^^ |
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| Interacting proteins: P08254 and P17936 |
Pubmed |
SVM Score :0.0 |
| For this purpose , human matrix metalloproteinase 3 ( MMP 3 ) , a proteinase that degrades IGFBP 3 in human fibroblast cultures , was first electrophoresed through a polyacrylamide gel containing IGFBP 3 as substrate and then analyzed for its ability to degrade the substrate into immunoreactive fragments that were absorbed onto a polyvinylidene difluoride membrane . ^^^ |
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| Interacting proteins: P08254 and P17936 |
Pubmed |
SVM Score :0.0 |
| Recombinant human matrix metalloproteinase 3 ( MMP 3 ) proteolyzed recombinant human IGFBP 3 or endogenous rat IGFBP 3 in non pregnancy serum pretreated with AEBSF to inactivate endogenous serine proteases . ^^^ |
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| Interacting proteins: P08254 and P17936 |
Pubmed |
SVM Score :0.0 |
| We used real time RT PCR to quantify the mRNA expression of prostate specific antigen , prostate derived Ets transcription factor , tissue inhibitor of matrix metalloproteinase 3 and insulin like growth factor binding protein 3 . ^^^ Pro apoptotic factor caspase 3 , tissue inhibitor of matrix metalloproteinase 3 and insulin like growth factor binding protein 3 were up regulated resulting in apoptosis of tumor cells . ^^^ |
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| Interacting proteins: P08254 and P17936 |
Pubmed |
SVM Score :0.0 |
| Purified human MMPs ( principally MMP 1 and MMP 3 ) degraded IGFBP 3 in solution ; MMP 3 produced a pattern of IGFBP 3 degradation products identical in size to the fragments produced by pregnancy serum . ^^^ Furthermore , the combined addition of antihuman MMP 1 IgG and anti human MMP 3 IgG to rat pregnancy serum blocked almost completely the degradation of 125I rhIGFBP 3 , suggesting that these two MMPs are the principal MMPs involved in IGFBP 3 degradation in rat pregnancy serum . ^^^ |
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| Interacting proteins: P08254 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
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