| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.51377205 |
| There were significant correlations between serum IGFBP 3 and serum free PSA in three groups ( r = 0 . 46 , p = 0 . 02 for localized PC ; r = 0 . 56 , p = 0 . 01 for metastasized PC , and r = 0 . 31 , p = 0 . 03 for BPH ) . 0.51377205^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen ( PSA ) is an insulin like growth factor binding protein 3 protease found in seminal plasma . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| The prostate specific antigen ( PSA ) decreases the affinity of IGF binding protein 3 . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| After 2 yr , GH , IGF 1 , and IGFBP 3 levels were decreased , whereas prostate specific antigen levels did not change . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Ratios of IGF 1 , IGF binding protein 3 , and prostate specific antigen in prostate cancer detection . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| On comparing the proteolytic activity for IGFBP 4 by purified prostate specific antigen ( PSA ; a known IGFBP 3 protease in SP ) or by SP with measured equivalent concentrations of PSA , the dose response and fragment patterns were identical . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen ( PSA ) is an insulin like growth factor ( IGF ) binding protein 3 ( IGFBP 3 ) protease found in seminal plasma and produced by prostatic epithelial cells ( PC E ) in vivo . ^^^ Biological effects of prostate specific antigen as an insulin like growth factor binding protein 3 protease . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen ( PSA ) has been shown to proteolyze IGFBP 3 . ^^^ Biochemical analysis of prostate specific antigen proteolyzed insulin like growth factor binding protein 3 . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Serum insulin like growth factor binding protein 2 ( IGFBP 2 ) is increased and IGFBP 3 is decreased in patients with prostate cancer : correlation with serum prostate specific antigen . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Finally , prostate specific antigen ( PSA ) , secreted from PC and found in seminal plasma , can function as a potent IGFBP 3 protease . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| The biological impact of some of these IGFBPs on the growth of prostatic cells has been examined , and proteolytic cleavage of IGFBP 3 by prostate specific antigen ( PSA ) has been demonstrated . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| We have previously documented that prostate specific antigen ( PSA ) , a serine protease of the kallikrein family , is an IGFBP 3 protease . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen ( PSA ) , a serine protease , may play a role in the regulation of IGFs ' function through cleavage of IGFBP 3 , resulting in release of active IGFs from IGFBP 3 . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Remarkably , the proteolytic pattern generated by seminal plasma , when incubated with IGFBP 3 at neutral pH , corresponded to that produced by prostate specific antigen ( PSA ) , demonstrating the interpolation of both neutral and acid proteases from prostate cells into seminal plasma . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| METHODS : We analyzed 202 seminal plasmas for prostate specific antigen , glucose , pepsinogen C , insulin like growth factor binding protein 3 , prostaglandin D synthase ( PGDS ) , and BRCA 1 like immunoreactive protein ( BRCA 1 LIP ) using quantitative immunofluorometric procedures . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| The cleavage site specificity of human prostate specific antigen for insulin like growth factor binding protein 3 . ^^^ The cleavage site of human insulin like growth factor binding protein 3 by urinary prostate specific antigen was examined . ^^^ Human insulin like growth factor binding protein 3 was incubated with urinary prostate specific antigen at 37 degrees C and its proteolyzed fragments were separated by a reversed phase HPLC followed by N terminal amino acid sequence analysis , demonstrating that the cleavage mainly occurred at Tyr 159 . ^^^ These results indicate that human insulin like growth factor binding protein 3 is specifically cleaved at Tyr 159 by prostate specific antigen . ^^^ Human insulin like growth factor binding protein 3 was previously reported to be cleaved at five sites including Arg 97 , Arg 132 , Tyr 159 , Phe 173 and Arg 179 by another group , however , prostate specific antigen preparation is possibly contaminated by trypsin like protease . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Prostate specific antigen ( PSA ) is a serine protease that can cleave insulin like growth factor binding protein 3 ( IGFBP 3 ) , thereby decreasing its affinity for insulin like growth factor 1 ( IGF 1 ) . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| To evaluate this , IGF 1 , IGFBP 3 , and prostate specific antigen ( PSA ) were measured in serum from 665 consecutive men ( 179 with prostate cancer ) , aged 55 67 yr , with elevated serum prostate specific antigen ( PSA ; > or = 4 microg / L ) in a screening trial . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Serum levels of insulin like growth factor 1 ( IGF 1 ) , IGF 2 , IGF binding protein 3 , and prostate specific antigen as predictors of clinical prostate cancer . ^^^ In a prospective , cohort , case control study in the Baltimore Longitudinal Study on Aging population , we examined prostate volume by magnetic resonance imaging , and prostate specific antigen ( PSA ) , IGF 1 , IGF 2 , and IGF binding protein 3 ( IGFBP 3 ) in sera obtained approximately 9 yr before diagnosis of prostate cancer in cases ( n = 72 ) or age matched controls ( n = 127 ) and in 76 additional Baltimore Longitudinal Study on Aging men ( normal subjects ) with measured prostate volumes and no prostate cancer . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Further well designed studies are urgently needed to clarify if use of prostate specific antigen ( PSA ) as a diagnostic test for prostate cancer can be improved by incorporating measurements of serum insulin like growth factor 1 ( IGF 1 ) and insulin like growth factor binding protein 3 ( IGFBP 3 ) , and if these measurements might also identify men at higher risk . . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Inverse relation between prostate specific antigen and insulin like growth factor binding protein 3 in bone metastases and serum of patients with prostate cancer . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Plasma levels of lycopene , insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 3 , and prostate specific antigen were measured at baseline and after 3 weeks of supplementation or observation . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen and other prostate derived proteases cleave IGFBP 3 , but prostate cancer is not associated with proteolytically cleaved circulating IGFBP 3 . ^^^ METHODS : We studied proteolysis of IGFBP 3 by three prostate derived proteases , namely prostate specific antigen ( PSA ) , human kallikrein 2 ( hK 2 ) , and trypsin , and also by native seminal plasma . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To assess the relationships among circulating insulin like growth factor 1 ( IGF 1 ) , IGF binding protein 3 ( IGFBP 3 ) , prostate specific antigen ( PSA ) and C reactive protein ( an indicator of inflammatory systemic response ) in patients with prostate disease and cancer of different stages . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Prostate specific antigen ( PSA ) enzymatically cleaves IGFBP 3 into fragments ( BP 3 FR ) . ^^^ Prostate specific antigen and insulin like growth factor binding protein 3 in nipple aspirate fluid are associated with breast cancer . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Plasma levels of lycopene , insulin like growth factor 1 , insulin like growth factor binding protein 3 , and prostate specific antigen were measured at baseline and after 3 weeks of supplementation or observation . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Urologic measures were assessed from the International Prostate Symptom Score , peak urinary flow rates , prostate volume , and serum prostate specific antigen ( PSA ) , and serum IGF 1 and IGFBP 3 levels were measured . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| In this study , we report that IGF binding protein ( IGFBP ) 3 transcripts ( that regulate levels of free IGF ) are down regulated in prostate cancer cells cocultured with PMO , whereas prostate specific antigen ( a protease known to cleave IGFBP 3 ) is detected in the 150 400 ng / ml range . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| We used real time RT PCR to quantify the mRNA expression of prostate specific antigen , prostate derived Ets transcription factor , tissue inhibitor of matrix metalloproteinase 3 and insulin like growth factor binding protein 3 . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To examine whether measurement of insulin like growth factor ( IGF ) 1 , IGF 2 , IGF binding protein ( IGFBP ) 2 or IGFBP 3 , alone or in combination , enhanced the specificity of prostate cancer detection among men with a prostate specific antigen ( PSA ) level of 3 ng / mL or greater beyond that achieved by the free / total PSA index . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| The subjects ' serum samples were analyzed for prostate specific antigen ( PSA ) and the following hormones , which may be related to prostate cancer : testosterone , sex hormone binding globulin , 3alpha androstanediol glucuronide , insulin like growth factor 1 ( IGF 1 ) , and IGF binding protein 3 ( IGFBP 3 ) . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| EXPERIMENTAL DESIGN : We measured the changes in total and free prostate specific antigen ( PSA ) and its association with insulin like growth factor 1 ( IGF 1 ) and IGFBP 3 levels after 1 year of treatment in 24 subjects given 4 HPR and 24 control subjects enrolled in a randomized bladder cancer prevention trial . ^^^ Effect of the synthetic retinoid fenretinide on circulating free prostate specific antigen , insulin like growth factor 1 , and insulin like growth factor binding protein 3 levels in men with superficial bladder cancer . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| However , the combination of IGFBP 3 and VTP 194204 treatments inhibited tumor growth by 50 % and induced a significant reduction in serum prostate specific antigen levels . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Reference intervals for important serum sex steroid hormones , prostate specific antigen , insulin like growth factor 1 and IGF binding protein 3 concentration in a normal Kuwaiti adult male population . ^^^ OBJECTIVES : The purpose of this study was to determine the age specific reference ranges for some important male sex steroid hormones , prostate specific antigen ( PSA ) , insulin like growth factor 1 ( IGF 1 ) , and IGF binding protein 3 ( IGFBP 3 ) , for the Kuwaiti population . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| We conclude that prostate cells express IGFBP 3 and that local proteolysis by PSA could modify this binding protein ' s actions in the prostate . . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| However , it is likely that this does not constitute the only natural substrate of PSA , as PSA has been shown to degrade insulin like growth factor binding protein 3 . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| There was a significant inverse correlation between PSA and IGFBP 3 , measured by IRMA , in PF ( r = 0 . 526 ; P < or = 0 . 004 ) . ^^^ Finally , in the PF of African American men , PSA was significantly lower , and IGFBP 3 determined by IRMA was significantly higher compared to those in Caucasian men . . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Concentrations of IGF 1 and alpha 2 M in human seminal plasma were related to semen quality , basal concentrations of HGH , testosterone , IGFBP 3 , soluble fibronectin receptor ( sFNR ) , PSA and PP 14 in seminal plasma and to serum concentrations of luteinizing hormone ( LH ) and follicle stimulating hormone ( FSH ) . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Serum PSA ( by EIA ) , and IGFBP 2 , IGFBP 3 , IGF 1 and IGF 2 ( by RIA ) were measured in all subjects , and serially in patients with PC . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Serum PSA ( by EIA ) , and IGFBP 2 , IGFBP 3 , IGF 1 and IGF 2 ( by RIA ) were measured in all subjects , and serially in patients with PC . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Based on the known cleavage sites of IGFBP 3 for PSA , MMPs , and the predicted plasmin cleavage sites , we expressed a N terminal IGFBP 3 ( 1 97 ) fragment and a C terminal IGFBP 3 ( 98 264 ) fragment . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| PSA showed a positive correlation with testosterone ( r = 0 . 86 , P < 0 . 001 ) , IGF 1 ( r = 0 . 66 , P < 0 . 001 ) , and IGFBP 3 ( r = 0 . 34 , P = 0 . 004 ) levels . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| PSA , free PSA , IGF 1 and IGF binding protein 3 were measured . ^^^ Adjustment for age and PSA showed significantly lower IGF 1 in cancer cases , while IGF binding protein 3 was not significant . ^^^ ROC values were significantly higher for free to total PSA and PSA than for crude and age adjusted IGF 1 and IGF binding protein 3 . ^^^ CONCLUSIONS : Our data indicate that serum IGF 1 or IGF binding protein 3 does not predict the results of prostate biopsy in men with elevated PSA or abnormal digital rectal examination . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| We studied the prognostic significance of serum IGF 1 and IGFBP 3 levels , and IGF 1 / prostate specific antigen ( PSA ) and IGFBP 3 / PSA ratios in patients with prostate cancer . ^^^ METHODS : Serum levels of IGF 1 , IGFBP 3 , and PSA were determined in 112 patients diagnosed with prostate cancer . ^^^ Univariate analysis showed that serum PSA , IGF 1 / PSA ratio , IGFBP 3 / PSA ratio , T , N and M classifications correlated significantly with relapse free survival of advanced prostate cancer patients treated with hormonal therapy . ^^^ Multivariate analysis identified IGFBP 3 / PSA ratio as the only significant variable for relapse free survival ( odds ratio 5 . 81 , 95 % CI 1 . 57 21 . 51 ) . ^^^ IGFBP 3 / PSA ratio was also an independent predictor of cause specific survival ( stepwise analysis , odds ratio 4 . 86 , P < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| PSA is a serine protease with substrates that include semenogelin 1 and 2 , insulin like growth factor binding protein 3 , fibronectin , and laminin . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Eleven candidate genes were examined , including the androgen receptor , SRD5A2 , CYP 17 , CYP3A4 , vitamin D receptor , PSA , GST T 1 , GST M 1 , GST P 1 , IGF 1 , and IGF binding protein 3 . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| It is thought that PSA cleaves insulin like growth factor binding protein 3 ( IGFBP 3 ) , providing increased local levels of IGF 1 , leading to tumor growth . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| Stepwise forward logistic regression analysis showed that only PSA levels at baseline and PSA at round 2 after 4 yr are good predictors of prostate cancer , whereas total IGF 1 , free IGF 1 , and IGFBP 3 did not predict the development of prostate cancer . ^^^ Our study suggests that the measurement of serum IGF 1 and / or IGFBP 3 concentrations in addition to PSA does not improve the identification of men at high risk to develop early stages of prostate cancer . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| All four hormones increased gene and / or protein expression of PSA , IGF IR , IGF 1 , and IGFBP 2 and decreased that of AR , ERbeta , IGF 2 , and IGFBP 3 . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| We prospectively investigated the associations of plasma IGF 1 and IGFBP 3 concentrations with prostate cancer detected in the PSA era . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| We investigated the binding of IGFBP 3 to additional association proteins in human serum ( IGFBP 3 APs ) . ^^^ Serum ALS migrated separately ( at 88 kDa ) from the novel IGFBP 3 APs ( as evident by Western immunoblot ) , and bound IGFBP 3 weakly ( by reverse ligand blots ) . ^^^ We also demonstrated that large amounts of one of the IGFBP 3 APs and small amounts of ALS were coimmunoprecipitated with IGFBP 3 from human serum . ^^^ Similar to ALS , these IGFBP 3 APs are acid labile and lose their IGFBP 3 binding capacity after exposure to low pH . ^^^ These IGFBP 3 APs may serve as an additional reservoir of IGFBP 3 or modulate its functions . . ^^^ |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07288 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
|