| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Interactions between insulin like growth factor 1 ( IGF 1 ) and the system of plasminogen activators and their inhibitors in the control of IGF binding protein 3 production and proteolysis in human osteosarcoma cells . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| The peritoneal fluid of women with endometriosis contains an increased insulin like growth factor 1 ( IGF 1 ) bioavailability , which is produced by limited hydrolysis of urokinase type plasminogen activator ( uPA ) on IGF binding protein 3 ( IGFBP 3 ) . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Interaction of insulin like growth factor 2 ( IGF 2 ) with multiple plasma proteins : high affinity binding of plasminogen to IGF 2 and IGF binding protein 3 . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| The known genes included alpha 1 ( 1 ) procollagen , alpha 2 ( 1 ) procollagen , fibronectin , ferritin heavy chain , insulinlike growth factor binding protein 3 ( IGFBP 3 ) , osteonectin , human tissue plasminogen activator inhibitor type 1 , thrombospondin , and alpha B crystallin . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Using Western ligand blotting and SDS PAGE analysis of fragmentation patterns of 125I labelled IGFBP 3 and 125 labelled IGFBP 1 , we have examined conditioned media from cultured human cell lines for the presence of proteolytic activity and compared this with the action of circulating proteases and with characterized enzymes including cathepsin D , kallikrein , plasmin and tissue plasminogen activator . 125I Labelled IGFBP 3 was incubated with serum from pregnant women , patients following heart surgery and patients with cancer of the breast , lung or head / neck . ^^^ |
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| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Urokinase activity detected in the conditioned media was depressed by Pefabloc , suggesting that the urokinase type plasminogen activator was involved in the proteolysis of IGFBP 3 . ^^^ In addition , 0 . 01 5 micrograms / ml plasminogen induced a dose dependent increase in both proliferation and the proportions of proteolysed IGFBP 3 in the media . ^^^ We conclude from these results 1 ) that IGF 2 is involved in the autocrine control of PC 3 cell proliferation via the type 1 IGF receptor ; and 2 ) that this proliferation is directly dependent on IGF 2 bioavailability that itself is modulated by the limited IGFBP 3 proteolysis induced , at least in part , by urokinase type plasminogen activator and plasmin . . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| When increasing amounts of plasminogen were added during the final hours of culture , proteolysis of IGFBP 3 and 4 was detected . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| In this paper , the presence of serum IGFBP 3 proteolysis and its potential role in the regulation of IGF bioavailability is discussed partly in view of our recent finding of IGFBP 3 proteolysis by the tissue plasminogen activator ( tPA ) plasminogen plasmin system in human serum . . ^^^ |
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| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| The RNA species encoded by IGFBP 3 ( insulin like growth factor binding protein 3 ) , PAI 1 ( plasminogen activator inhibitor 1 ) and SPARC ( secreted protein acidic and rich in cysteine ; a . k . a . osteonectin ) are overexpressed in senescent human diploid fibroblasts ( HDF ) . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Although these cells did not normally produce an active IGFBP 3 protease , addition of plasminogen resulted in a dose dependent proteolysis of endogenous and exogenous IGFBP 3 , producing fragments similar to those cleaved by skin interstitial fluid , but different from those generated by plasmin . ^^^ Preincubation of cells with IGF 1 or long R 3 IGF 1 divergently changed plasminogen activator inhibitor 1 and 2 secretion , but only IGF 1 blocked IGFBP 3 proteolysis . ^^^ Together , these data indicate that an IGFBP 3 protease similar to that in skin interstitial fluid is generated in plasminogen treated HaCaT cells , and it attenuates the effects of IGFBP 3 on IGF action . ^^^ |
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| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| In contrast , the ability of plasminogen depleted plasma to degrade 125I IGFBP 3 was not affected by the addition of PAs . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| A role for the plasmin system in IGFBP 3 proteolysis in vivo is suggested by data presented here showing that IGFBP 3 binds plasminogen ( Pg ; Glu Pg ) with a dissociation constant ( Kd ) ranging from 1 . 43 to 3 . 12 nM . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| The increased IGFBP 3 proteolysis most probably resulted from amplified expression of tissue type plasminogen activator ( t PA ) and depression of its inhibitor ( PAI 1 ) observed in IGFBP 2 expressing xenografts . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| In the presence of plasminogen , most IGFBP 3 binds directly to fibrinogen , although 35 40 % of the IGFBP 3 binds to fibrinogen bound plasminogen . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Using a series of DNA array membranes , we identified a group of hypoxia induced genes that included plasminogen activator inhibitor 1 ( PAI 1 ) , insulin like growth factor binding protein 3 ( IGFBP 3 ) , endothelin 2 , low density lipoprotein receptor related protein ( LRP ) , BCL 2 interacting killer ( BIK ) , migration inhibitory factor ( MIF ) , matrix metalloproteinase 13 ( MMP 13 ) , fibroblast growth factor 3 ( FGF 3 ) , GADD 45 , and vascular endothelial growth factor ( VEGF ) . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| IGFBP 3 and nuclear localization signal mutant IGFBP 3 stimulated the activation of the plasminogen activator inhibitor 1 promoter but was not additive with TGF beta , suggesting that this end point is not a direct marker of the IGFBP 3 effect on cell proliferation . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Six genes , keratin 1 , plasminogen activator inhibitor type 2 ( PAI 2 ) , ferritin H , peroxiredoxin 5 ( PRDX 5 ) , insulin like growth factor binding protein 3 ( IGFBP 3 ) , and one EST gene , were differentially expressed in HaCaT cells cultured in the presence of a high calcium concentration . ^^^ |
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| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| Genes specifically up regulated by transdifferentiation but not by cellular senescence of PrSCs were metalloproteinase 1 tissue inhibitor ( Timp 1 ) , transgelin ( Tagln ) , gamma 2 actin ( Actg 2 ) , plasminogen activator inhibitor 1 ( Serpinel ) , insulin like growth factor binding protein 3 ( Igfbp 3 ) , parathyroid hormone like hormone ( Pthlp ) , Tgfb 1 , four and a half LIM domains 2 ( Fhl 2 ) , hydrogen peroxide inducible clone 5 ( Hic 5 ) and cartilage oligomeric matrix protein ( Comp ) . ^^^ |
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| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| We review the role that its ligands may have in cognition or AD : apolipoprotein E ( ApoE ) , alpha 2 macroglobulin , Transforming Growth Factor Beta ( TGFbeta , Tissue Plasminogen Activator ( tPA ) , insulin growth factor binding protein 3 ( IGFBP 3 ) , which all bind LRP 1 and apolipoprotein J ( ApoJ ) , which is a ligand for LRP 2 . ^^^ |
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| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| TGF beta 1 inhibited the growth of COLO 357 cells in a time and dose dependent manner and caused a rapid but transient increase in plasminogen activator inhibitor 1 and insulin like growth factor binding protein 3 mRNA levels . ^^^ |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17936 and P00747 |
Pubmed |
SVM Score :0.0 |
| NA |
|