| Interacting proteins: O43184 and P17936 |
Pubmed |
SVM Score :0.6196488 |
| ADAM 12 , a disintegrin metalloprotease , interacts with insulin like growth factor binding protein 3 . 0.6196488^^^ |
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| Interacting proteins: O43184 and P17936 |
Pubmed |
SVM Score :0.0 |
| ADAM 12 S cleaves IGFBP 3 and IGFBP 5 and is inhibited by TIMP 3 . ^^^ We now describe the purification of full length recombinant ADAM 12 S and demonstrate that it cleaves insulin like growth factor binding protein 3 ( IGFBP 3 ) . ^^^ This result supports a role for ADAM 12 S in the degradation of IGFBP 3 in the blood of pregnant women . ^^^ Furthermore , we tested for proteolysis of other members of the IGF binding protein family and found that ADAM 12 S cleaves IGFBP 5 in addition to IGFBP 3 , but does not cleave IGFBP 1 , 2 , 4 , or 6 . ^^^ Cleavage of both IGFBP 3 and 5 by ADAM 12 S was inhibited by TIMP 3 , raising the possibility that TIMP 3 is a physiological inhibitor of ADAM 12 S . . ^^^ |
|
| Interacting proteins: O43184 and P17936 |
Pubmed |
SVM Score :0.0 |
| ADAM 12 ( A disintegrin and metalloprotease ) is an IGFBP 3 and IGFBP 5 protease and is present in human pregnancy serum . ^^^ |
|
| Interacting proteins: O43184 and P17936 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : ADAM 12 S is a pregnancy associated insulin like growth factor binding protein 3 ( IGFBP 3 ) and IGFBP 5 protease present in human gestational serum . ^^^ |
|
| Interacting proteins: O43184 and P17936 |
Pubmed |
SVM Score :0.0 |
| NA |
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