Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.84871934
Alternative splicing of Cr 2 gene transcripts predicts two distinct gene products that share homologous domains with both human CR 2 and CR 1 . 0.84871934^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.86873713
The striking peptide sequence homology between CR 2 and CR 1 and the cross hybridization of the CR 2 cDNA with the CR 1 specific sequences allow the placement of CR 2 in a recently defined gene family of C 3 and C 4 binding proteins consisting of CR 1 , C 4 binding protein , factor H , and now , CR2 . . 0.86873713^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :1.2329355
A novel protein , termed p 400 , was found by peptide mapping to be related to p 300 , and , like p 300 , to require the E1A amino terminus and a portion of CR 1 for binding . p 130 was shown to be related to p 107 , and like p 107 , to associate with p60cycA . p 107 , p 130 and p105Rb all interacted primarily with CR 2 , however , sequences within CR 1 and the amino terminus were capable of weak interactions and appeared to function cooperatively with CR 2 to bind these proteins . 1.2329355^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.67184398
However , when CR 1 was mixed with CR 2 in the reaction mixture , 6 pyruvoyl tetrahydropterin was reduced to tetrahydrobiopterin in the presence of NADPH . 0.67184398^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Complement receptor type 1 ( C3b / C4b receptor ; CD 35 ) and complement receptor type 2 ( C3d / Epstein Barr virus receptor ; CD 21 ) . ^^^ Complement receptor type 1 ( C3b / C4b receptor ; CD 35 ) and complement receptor type 2 ( C3d / Epstein Barr virus receptor ; CD 21 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Amino acid sequence data derived from tryptic peptides of the decay accelerating factor indicate that this complement regulatory protein contains a sequence with homology to the superfamily of structurally related complement proteins , including the C 4 binding protein , factor H , complement receptor type 1 , complement receptor type 2 , Ba , C1r , and to their non complement relatives , including beta 2 glycoprotein 1 , factor XIIIb , the alpha 1 chain of haptoglobin , and the interleukin 2 receptor . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Neither complement receptor type 1 ( CD 35 ) nor complement receptor type 2 ( CD 21 ) was expressed on any thyroid follicular cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Murine complement receptor type 2 ( MCR 2 ) is homologous to human CR 2 , whereas murine CR 1 ( MCR 1 ) is structurally and evolutionary different from human CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The expression of CR 1 , as well as the complement receptor type 2 ( CR 2 ) and membrane cofactor protein ( MCP ) , were analyzed on cells from the SUP T 1 , CEM SS , HUT 78 , and MOLT 3 cell lines by flow cytometry . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We show here that cross linking of mouse CD 21 ( complement receptor type 2 , CR 2 , C3d receptor ) and CD 35 ( complement receptor type 1 , CR 1 , C3b / C4b receptor ) or co cross linking of CD21 / CD35 and surface IgM rapidly up regulates both B 7 1 and B 7 2 expression on murine resting splenic B cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The influence of complement receptor type 1 ( CD 35 ) and decay accelerating factor ( CD 55 ) on complement receptor type 2 ( CD 21 ) mediated alternative pathway activation by B cells . ^^^ The influence of complement receptor type 1 ( CR 1 ; CD 35 ) and decay accelerating factor ( DAF ; CD 55 ) , both down regulators of complement activation , on the complement receptor type 2 ( CR 2 ) mediated alternative pathway ( AP ) activation of complement on normal B cells , was assessed . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The process is mediated via complement receptor type 2 ( CR 2 , CD 21 ) , with complement receptor type 1 ( CR 1 , CD 35 ) playing a subsidiary role . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A second antigen , Cr 2 , elicits positive skin tests also in approximately 70 % of cockroach sensitive individuals , has a molecular weight of approximately 63 , 000 to 65 , 000 daltons , and has similar heat stability and acid hydrolysis characteristics to Cr 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This stage of maturation approximately corresponded to the myelocyte metamyelocyte stage defined by standard morphologic criteria , and preceded the third stage of surface marker maturation when developing neutrophils began to express CR 1 type C receptors ( immune adherence , C4b C3b receptors ) in addition to CR 2 . ^^^ In the final stage of surface marker defined maturation , CR 2 was lost from high density polymorphonuclear neutrophils and CR 1 was maximally expressed . ^^^ Normal blood polymorphonuclear neutrophils contained only 17 % of CR 2 bearing cells and these were shown to be of lower density than the majority of neutrophils that expressed only CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 ( EAC 1 4b ) showed up later in the differentiation than CR 2 ( EAC 1 3d ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Parallel studies of human and mouse megakaryocytes and platelets for IgG receptor ( FcR ) , complement receptor type one ( CR 1 ) ( C3b receptor ) , complement receptor type two ( CR 2 ) ( C3d receptor ) , and Ia antigen by fluorescence and ( or ) rosette formation methods were performed . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Mouse CR 1 is specific for a non C3d region of C3b , ( possibly analogous to human C3c ) whereas mouse CR 2 is specific for both C3d and the C3d region of C3b . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Normal blood lymphocytes bearing complement receptors ( CRL ) were divided into two populations , one expressing both CR 1 ( C4b C3b receptor ) and CR 2 ( C3d receptor ) and a second expressing only CR 1 . ^^^ Nearly all of the population that expressed both CR 1 and CR 2 also bore membrane surface immunoglobulins ( Ig ) and Ia antigens . ^^^ These Ig CR1+ CR 2 cells could be distinguished from the majority of monocytes and immature granulocytes , in that the latter ingested latex particles and expressed CR 2 as well as CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Although CD21+ ( CR 2 ) and CD35+ ( CR 1 ) cells all expressed DAF , CD11a ( LFA 1 ) levels correlated inversely with those of DAF . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Binding of most of the proteins was affected at least partially by mutations within the amino terminal 25 residues , amino acids 36 69 within conserved region 1 ( CR 1 ) , and residues 121 138 in conserved region 2 ( CR 2 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Three enzyme forms ( CR 1 , CR 2 and CR 3 ) of carbonyl reductase were purified from chicken liver with using 4 benzoylpyridine as a substrate . ^^^ CR 2 and CR 3 cross reacted with anti chicken kidney carbonyl reductase antibody , though CR 1 did not . ^^^ The results suggest that CR 1 is a hydroxysteroid dehydrogenase , and CR 2 and CR 3 are similar to each other and to the kidney enzymes . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Initial addition of CH to the production medium resulted in slightly lower synthesis rates of two of the proteins ( CR 1 and CR 2 ) , while significantly delaying the onset of synthesis of the other two ( CR 3 and CR 4 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 , CR 2 , DAF , MCP , factor H , C4bp , factor B , and C 3 are members of a family of structurally related molecules , the majority of which belong to the complement system . ^^^ These data show that H binds to at least two sites in C3b : the site in the C3c fragment is within the identified CR 1 binding domain while the site in the C3d fragment surrounds the CR 2 binding site . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunofluorescence studies showed C 3 , Factor B , decay accelerating factor , the C3b receptor ( CR 1 ) , and C3d receptor ( CR 2 ) , distributed among cells of the epidermis as well as on cultured keratinocytes . ^^^ In situ hybridization studies suggest the expression of CR 1 and CR 2 mRNA in human epidermis . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Expression , molecular association , and functions of C 3 complement receptors CR 1 ( CD 35 ) and CR 2 ( CD 21 ) on the human T cell line HPB ALL . ^^^ We have investigated the expression , molecular association , ligand binding properties , and ability to transduce intracellular signals of CR 1 and CR 2 C3 receptors on cells of the human HPB ALL T cell line . ^^^ CR 1 and CR 2 on HPB ALL cells bound polymeric C3b and C3dg and several anti CR 1 and anti CR 2 mAb recognizing different epitopes of the receptors on normal peripheral blood cells . ^^^ Immunoprecipitated CR 1 and CR 2 exhibited similar m . w . to those of the receptors on normal peripheral blood T and B lymphocytes . ^^^ CR 1 and CR 2 were partially associated in the form of CR1 / CR2 complexes in the cell membrane as assessed by the ability of the receptors to cocap and cointernalize and to form a detergent sensitive complex upon immunoprecipitation analysis . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The second group was characterized by a diffusely weak to moderate dendritic meshwork pattern of the dark zone to some of the immunostainings of C 9 ( monoclonal ) , S protein , and DF DRC 1 , and all immunostainings of CR 1 ( CD 35 ) , Ber Mac DRC ( CD 35 ) , CR 2 ( CD 21 ) , and R4 / 23 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Using the DWLS fitted acrophase for the melatonin metabolite , the mean absolute phase difference between CR 1 and CR 2 was 40 min ( SD = 26 min ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
To determine whether GVHD can be induced after ABMT with chemopurged marrow in acute myeloid leukemia ( AML ) , we administered intravenous CSP for 28 days ( beginning on the day of ABMT ) to 19 patients with AML ( 12 in first remission [ CR 1 ] , six in CR 2 , and one in CR 3 ) who received busulfan ( 16 mg / kg ) and cyclophosphamide ( 200 mg / kg ) and ABMT with 4 hydroperoxycyclophosphamide ( 4HC ) treated marrow . ^^^ Seven patients ( four CR 1 , three CR 2 ) relapsed with AML at a median of 411 days ( range , 178 to 549 ) after ABMT ; six of seven had positive biopsies for cutaneous GVHD . ^^^ Nine patients ( seven CR 1 , one CR 2 , and one CR 3 ) are alive without relapse at a median of 501+ days ( range , 252+ to 811+ ) after ABMT ; eight of nine had cutaneous GVHD . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
With a median follow up of 4 years the disease free survival ( DFS ) was 44 % for the whole group , with a significant difference between patients in first or second complete remission ( CR 1 and 2 , as one group ) , compared with patients with more advanced disease ( greater than CR 2 ) , 69 . 5 % versus 15 . 4 % ( p less than 0 . 01 ) . ^^^ The main cause of BMT failure was leukemic relapse , with a relapse rate of 15 % for patients in CR 1 and 2 and of 77 % for patients with greater than CR 2 ( p less than 0 . 01 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This feature has also been found in CR 1 , CR 2 , membrane cofactor protein , and murine factor H . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The other two complement receptor specific antibodies had very moderate , if any , effects on the antibody response . 7G6 was able to downregulate CR 1 and CR 2 on the surface of B cells and , in addition , to inhibit rosette formation with C3d coated sheep erythrocytes ( EC3d ) . ^^^ The other downregulated both CR 1 and CR 2 , although not as efficiently as 7G6 , and was unable to inhibit EC3d rosette formation . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Raji cells were found to express CR 2 , DAF and MCP molecules , while MCP was the only known regulatory protein detected on Ramos cells which expressed neither CR 1 , nor CR 2 , H or DAF . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Since four of the five mAbs that were produced by immunization with CR 1 also bound CR 2 , and they bind to different CR 1 epitopes , it seems that murine CR 1 and CR 2 share multiple epitopes . ^^^ Injection of mice with one of the CR 1 CR2 cross reactive mAbs almost eliminated both CR 1 and CR 2 expression , but did not decrease B cell numbers or the expression of B cell IgM , Ia , or B 220 antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In this study , we chose the factors which are constituents of either a classical or an alternative pathway of a complement system and found that mRNAs corresponding to those of C 2 , C 3 , C 4 , C 5 and to those of receptors CR 1 and CR 2 were expressed . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Although our cases are limited and the follow up period is short , our result of ALL [ overall : CCR ( 60 % ) , standard risk ( adult less than or equal to CR 1 , children less than or equal to CR 2 ; 8 / 11 ( 73 % ) and high risk ; 1 / 4 ( 25 % ) ] and CML [ overall : 65 % , CP ; 9 / 10 ( 90 % ) , AP ; 4 / 6 ( 67 % ) , BP ; 0 / 4 ( 0 % ) ] are optimistic . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Phylogeny of the third component of complement , C 3 : analysis of the conservation of human CR 1 , CR 2 , H , and B binding sites , concanavalin A binding sites , and thiolester bond in the C 3 from different species . ^^^ The conservation of binding sites in the different C 3 ' s for human complement receptors type one ( CR 1 ) and two ( CR 2 ) and for factors H and B was investigated due to the structural and functional similarities of these molecules and to the ability of some of them to bind to the same domain ( s ) in human C3 . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The encoded genes and two of the gene like elements share the same orientation and are ordered ( 5 ' to 3 ' ) DAF , CR 2 , CR 1 , MCP like , CR 1 like , and MCP . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Genes encoding for CR 1 , CR 2 and CR 3 have been cloned and they code for integral transmembrane glycoproteins which function as cellular receptors for human C3b , C3dg / C3d and C3bi fragments respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Differential effects of the stimulation of complement receptors CR 1 ( CD 35 ) and CR 2 ( CD 21 ) on cell proliferation and intracellular Ca2+ mobilization of chronic lymphocytic leukemia B cells . ^^^ The regulatory role of CR 1 and CR 2 on B cell activation and proliferation has been investigated by using B cells from patients with chronic lymphocytic leukemia . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Two conserved regions ( CR 1 and CR 2 ) on the adenovirus E1A proteins have previously been shown to be required for cooperation with the ras oncogene in the transformation of primary rodent cells . ^^^ In this paper , we show that CR 1 mutants deficient in p 300 binding and CR 2 mutants with lost or reduced binding of p 105 RB and / or p 107 have a low , but not abolished focus formation activity . ^^^ In contrast , CR1 / CR2 double mutants were deficient in focus formation , suggesting that the transformation activities displayed by the single CR 1 or CR 2 mutants were due to an independent transformation activity by both CR 1 and CR 2 . ^^^ Complex formation between E1A and p 107 , similar to the p 105 RB binding , required sequences within both CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We have shown by immunoprecipitation analysis that the two complement receptors expressed by B lymphocytes , complement receptor 1 ( CR 1 ) and CR 2 , form a detergent sensitive complex on the surface of tonsillar B lymphocytes and on K 562 erythroleukemia cells that were co transfected with cDNAs encoding CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The importance of the complement system for mounting an antibody response in vivo was investigated by down regulating and blocking the complement receptors ( CR ) in mice with three different monoclonal rat antibodies ( mAb ) : mAb 8C12 recognized the C3b binding site of CR 1 , mAb 7G6 recognized another site of CR 1 and the C3d binding site of CR 2 and mAb 7E9 again recognized other epitopes on CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 and CR 2 have served as unusual probes for the analysis of the two major functions of the immune system involving inflammation and the immune response , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
One mouse RCA gene , designated MCR 2 ( or Cr 2 ) , encodes alternatively spliced 21 and 15 short consensus repeat ( SCR ) containing transcripts that crosshybridize with cDNAs of both human CR 2 and CR 1 , or CR 2 alone , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The distribution for autologous bone marrow transplantation ( ABMT ) was 671 in first complete remission ( CR 1 ) and 196 in CR 2 . ^^^ Pretransplantation regimes were : total body irradiation ( TBI ) , 456 ; busulfan plus cyclophosphamide ( BU CY ) 174 ; marrow purging with mafosfamide , 269 ( corresponding to 26 % of all patients in CR 1 and 41 % in CR 2 ) . ^^^ With the restriction of a shorter follow up , the results achieved with the BU CY combinations ( LFS and relapse rate at 3 years , CR 1 47 + / 6 and 45 + / 7 % ; CR 2 , 37 + / 9 and 50 + / 10 % ) did not differ from those with TBI or other chemotherapy combinations . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This finding suggests a differentiation linked expression of CR 2 on human keratinocytes in cytokine mediated skin diseases whereas CR 1 and CR 3 are apparently not expressed . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR1 / CR2 chimeric receptors in which various short consensus repeats ( SCRs ) of CR 1 were attached to CR 2 were transiently expressed on COS cells , and assessed for the binding of polymerized C3b ( pC3b ) and anti CR 2 by immunofluorescence . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The 2 year actuarial event free survival ( EFS ) probabilities are first CR ( CR 1 ) 32 % ( SE 10 % ) , first PR ( PR 1 ) 43 % ( SE 9 % ) , second CR ( CR 2 ) 33 % ( SE 27 % ) , and second PR ( PR 2 ) 5 % ( SE 5 % ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A mAb , 7G6 , that binds to mouse CR 1 and CR 2 and down modulates their expression on splenic B cells in vivo , was used to determine whether a decrease in CR 1 and CR 2 expression affects antibody responses to different T dependent and T independent Ag . ^^^ Taken together , these observations suggest that CR 1 and CR 2 may play an important role in enhancing primary antibody responses to many T dependent and T independent Ag and may contribute to a host ' s response to naturally occurring antigens such as bacteria . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Through the analysis of a series of E1A mutants , we find that sequences in conserved region 1 ( CR 1 ) and conserved region 2 ( CR 2 ) are important for dissociation of the E2F complex , whereas amino terminal sequences are not required . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Full binding activity of CR 2 for p ( iC3b ) was observed with a chimera comprised of SCR 1 and 2 of CR 2 fused to SCR 17 through 30 of CR 1 . ^^^ Finally , the relative abilities of C3b and iC3b to bind to CR 1 and CR 2 were compared . ^^^ The conversion of C3b to iC3b generated a ligand with an approximate 100 fold decrease in affinity for CR 1 and a 10 fold increased affinity for CR 2 , resulting in a 1000 fold greater likelihood for binding to the latter receptor that may then promote B cell activation . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Eight patients were treated in CR 1 , 36 in CR 2 ( first relapse occurring on therapy for 32 ) , seven in further CR , 10 in relapse ( five early first relapse , four second relapse and one fourth relapse ) and one with refractory ALL . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Patients not relapsing at 1 year post ABMT had a probability of being cured at 7 years of 86 and 71 % if autografted in CR 1 and CR 2 for AML and 81 and 59 % for ALL , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Competition for binding sites on C3b by CR 1 , CR 2 , MCP , factor B and Factor H . ^^^ Therefore factor H , factor B , CR 1 , CR 2 and MCP probably comprise a group of mutually competitive proteins with similar or overlapping binding sites on C3b . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
An identity matrix analysis suggests that human ancestral CR 2 evolved before divergence of the rodent and primate branches of the evolutionary tree through a series of predictable gene duplications , possibly giving rise to the precursor of human CR 1 and murine CRY . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
C3bi is further degraded by factor 1 and CR 1 ( third cleavage ) to C3dg ( a ligand for complement receptor type two , CR 2 ) and C3c . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Loss of human CR 1 and murine Crry like exons in human CR 2 transcripts due to CR 2 gene mutations . ^^^ Analysis of the coding sequences of the murine Cr 2 gene indicated that it contains two distinct regions of homology to the murine Crry , and human CR 1 and CR 2 genes . ^^^ Amino acid sequence similarity analysis , however , indicated that the sequences encoding the six amino terminal SCR of Cr 2 evolved from a separate lineage of SCR than Crry and CR 1 , suggesting that the human counterparts to these additional Cr 2 SCR had not been identified . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The relationships between functional , biochemical , and genetic homologues of human and mouse C receptors 1 ( CR 1 ) and 2 ( CR 2 ) are incompletely understood . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 ( C3b receptor ) and CR 2 ( C3d / EBV receptor ) are two C 3 receptors expressed on B lymphocytes . ^^^ CR 1 and CR 2 have structural similarities and their cross linking at the B cell surface by antibodies or specific ligands in multimeric forms induce B cell activation . ^^^ However , activation of human B cells through cell surface interactions or by intracellular protein kinase C activators leads to phosphorylation of CR 2 but not CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Deficiencies of human C 3 complement receptors type 1 ( CR 1 , CD 35 ) and type 2 ( CR 2 , CD 21 ) . ^^^ CR 1 ( CD 35 ) and CR 2 ( CD 21 ) are structurally related integral transmembrane glycoproteins that function as cellular receptors for human C3b and C3dg , respectively . ^^^ CR 1 ( CD 35 ) and CR 2 ( CD 21 ) are structurally related integral transmembrane glycoproteins that function as cellular receptors for human C3b and C3dg , respectively . ^^^ The primary sequence of the most common structural allotype of CR 1 and that of CR 2 have been established , and ligand binding on the molecules has been mapped . ^^^ CR 1 and CR 2 genes are located in close vicinity in the RCA locus of chromosome 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
However , since both CR 1 and CR 2 have previously been shown to be absolutely required for immortalization of primary cells by adenovirus E1A , this evidence suggests that the tsa 14 system assays for the maintenance of proliferation and that this requires CR1 . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Thus , oncogenic activation of the Raf kinase can be achieved by removal of CR 1 and CR 2 or by steric distortion and requires retention of an active kinase domain . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Twenty nine children with AML ( five in CR 1 , 24 in CR 2 ) received autografts with chemopurged marrow at a median remission duration of 3 months ( range , 2 15 ) . ^^^ Three patients died from sepsis during aplasia ; 10 children ( one in CR 1 and nine in CR 2 ) relapsed with AML at a median of 7 months ( range , 2 23 ) after ABMT , for an actuarial relapse rate of 47 % . ^^^ Sixteen patients with AML ( four in CR 1 , 12 in CR 2 ) are in unmaintained remission at a median of 16 months ( range , 6 102 ) after ABMT , for an actuarial disease free survival of 49 % . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Sequence analysis showed the presence of all three conserved regions CR 1 , CR 2 and CR 3 previously identified in raf protein kinases . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Eighteen patients in first complete remission ( CR 1 ) , 36 in CR 2 , 16 in CR 3 , and four in CR 4 were transplanted . ^^^ The 5 year event free survival ( EFS ) rates for patients transplanted in CR 1 , CR 2 , and CR 3 are 42 % , 43 % , and 25 % , respectively , at median follow up times of 57 , 54 , and 72 months , respectively . ^^^ The actuarial probability of relapse is 20 % , 26 % , and 48 % for those transplanted in CR 1 , CR 2 , and CR 3 , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Human follicular dendritic cells express CR 1 , CR 2 , and CR 3 complement receptor antigens . ^^^ The expression of complement receptors by human follicular dendritic cells ( FDC ) was investigated by immunohistochemical techniques by using polyclonal and monoclonal antibodies to antigenic determinants of CR 1 , CR 2 , and CR 3 . ^^^ Upon optical immunohistochemical examination of frozen sections from human reactive lymph nodes and tonsils by a three step immunoperoxidase technique , a strong staining of cell bodies and cytoplasmic extensions of FDC was observed in germinal centers with anti CR 1 and anti CR 2 antibodies . ^^^ Immunoelectron microscopy was performed on frozen sections of a lymph node involved with a centroblastic centrocytic B malignant lymphoma and a reactive tonsil with the use of rabbit F ( ab ' ) 2 anti CR 1 antibodies and mouse monoclonal anti CR 2 antibody . ^^^ All the plasma membrane of the cell body and cytoplasmic extensions of FDC in germinal centers and in the mantle zones homogeneously stained for CR 1 and CR 2 antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The functional and immunochemical characteristics of the human glomerular C 3 receptor were investigated by adherence of sheep erythrocytes ( Es ) coated with defined C 3 fragments and by using polyclonal and / or monoclonal antibodies directed against epitopes expressed on complement receptors CR 1 , CR 2 , and CR 3 . ^^^ By indirect immunofluorescence , anti CR 1 antibodies stained all podocytes in glomeruli , whereas no staining of kidney sections was seen with OKM 1 and anti Mol antibodies directed against the alpha chain of CR 3 and with anti CR 2 antibodies anti B 2 and BL 13 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Two patients transplanted in CR 2 and CR 1 remain in CR after 9 . 5 and 12 months respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
By analysis of CR 2 deletion mutants and chimeras formed with CR 1 ( CD 35 ) we determined that of the 15 SCRs in CR 2 , the NH 2 terminal two SCRs are necessary and sufficient to bind both gp350 / 220 and C3dg with affinities equivalent to those of the wild type receptor . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The structural gene for membrane cofactor protein ( MCP ) , a widely distributed C3b / C4b binding regulatory glycoprotein of the complement system , has been mapped to the same locus as the structural genes for CR 1 , CR 2 , DAF , and C4bp . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Enhanced binding of immune complexes processed by erythrocyte CR 1 ( CD 35 ) receptors to purified CR 2 ( CD 21 ) receptors from tonsillar mononuclear cells . ^^^ The binding of immune complexes ( IC ) opsonized by serum complement ( C ) and IC processed by CR 1 ( CD 35 ) receptors on human erythrocytes ( E ) to purified CR 2 ( CD 21 ) receptors was compared . ^^^ Solid phase CR 2 as well as CR 2 subjected to PAGE and blotted onto nitro cellulose membranes bound 125I labelled BSA anti BSA IC which had been opsonized by C and processed by CR 1 up to ten times more efficiently than IC reacted with serum only . ^^^ Preincubation of solid phase CR 2 with purified monomeric C3d did not inhibit the subsequent binding of E CR 1 processed IC . ^^^ The data indicate that E CR 1 have an important role in generating IC which bind effectively to CR 2 receptors on B lymphocytes . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Because the IL 2R has a structural homology with the complement proteins , such as CR 1 and CR 2 , we studied the possible ligand crossreactions on CR 1 and IL 2 receptor , and the direct interaction between C 3 and IL 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Furthermore , immunoelectroblotting analysis showed crossreactivity of CR 2 with 57H anti CR 1 . ^^^ These results indicate that CR 2 has functional and antigenic similarity to CR 1 , thus providing a supporting evidence for placement of CR 2 as a member of the recently defined gene family of C 3 and C 4 regulatory proteins composed of CR 1 , C 4 binding protein , and factor H . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We report the organization of the human genes encoding the complement components C 4 binding protein ( C4BP ) , C3b / C4b receptor ( CR 1 ) , decay accelerating factor ( DAF ) , and C3dg receptor ( CR 2 ) within the regulator of complement activation ( RCA ) gene cluster . ^^^ A physical map of the human regulator of complement activation gene cluster linking the complement genes CR 1 , CR 2 , DAF , and C4BP . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The genes encoding CR 1 , CR 2 , DAF , and C4bp were aligned in that order within a region of 750 kb . ^^^ In addition , the 5 ' to 3 ' orientation of the CR 1 gene ( 5 ' proximal to CR 2 ) was determined using 5 ' and 3 ' specific DNA probes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunoregulatory functions of complement : structural and functional studies of complement receptor type 1 ( CR 1 ; CD 35 ) and type 2 ( CR 2 ; CD 21 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Structure and function of the complement receptors , CR 1 ( CD 35 ) and CR 2 ( CD 21 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The procedure was carried out in the first complete remission ( CR 1 ) in 5 patients , in CR 2 in 11 , in CR 3 in 2 , and in CR 4 in another 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Fifty four patients with acute lymphoblastic leukemia ( ALL : 1 relapse , 21 high risk first complete remission ( CR 1 ) , 29 second CR ( CR 2 ) , and 3 third CR ( CR 3 ) were treated by autologous bone marrow transplantation at three centers . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This mature B cell also bears two related membrane proteins , CR 2 ( the C3d / Epstein Barr virus receptor ) ( CD 35 ) [ 15 ] , which can mediate the binding of ligands to which appropriate cleavage fragments of C 3 have become attached [ 16 ] . ^^^ Proliferation of resting B cells is modulated by CR 2 and CR 1 . ^^^ In light of previous in vivo observations we decided to assess the function of CR 2 and CR 1 in relation to B cell activation through the membrane IgM receptor . ^^^ Antibodies to CR 2 or CR 1 either alone or in crosslinked form did not enhance B cell proliferation . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Only CR 1 , and not CR 2 or CR 3 were found to be essential for the repression of the genes , indicating that CR 1 , one of the regions essential for cell transformation , represents an autonomous gene regulatory function that can operate in the absence of CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The effect of different murine monoclonal antibodies ( Mab ) specific for the glycoprotein complement receptor type 1 ( CR 1 ) , type 2 ( CR 2 ) , and type 3 ( CR 3 ) on the adhesion to and on the phagocytosis of human senescent red blood cells ( S RBC ) by monocytes or by monocyte derived macrophages ( M phi ) was investigated . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Comparison of the CR 2 peptide sequence with those of other members of the gene family has identified many regions highly homologous with human CR 1 , fewer with C4bp and decay accelerating factor , and very few with factor H , and suggested that CR 2 and CR 1 arose by duplication of the same ancestral gene sequence . ^^^ The homology between CR 2 and CR 1 extended to the transmembrane and cytoplasmic regions , suggesting that these sequences were derived from a common membrane bound precursor . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Two other crisp like Neurospora mutants , cr 2 and cr 3 which , in contrast to cr 1 , contain normal levels of cAMP , did not exhibit the thermotolerance phenomenon observed for cr 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Histiocytosis 10 cells express C3b , C3d , and C3bi receptor ( CR 1 , CR 2 , and CR 3 ) antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Decreased expression of the C3b / C4b receptor ( CR 1 ) and the C3d receptor ( CR 2 ) on B lymphocytes and of CR 1 on neutrophils of patients with systemic lupus erythematosus . ^^^ Receptor expression was measured by 2 color fluorescent flow cytometry of peripheral blood B cells , identified by the presence of the B 1 antigen , that had also been stained with anti CR 1 or anti CR 2 . ^^^ The expression of CR 1 correlated with that of CR 2 among patients ( r = 0 . 63 ; P less than 0 . 01 ) but not with the expression of CR 2 among normal individuals ( r = 0 . 36 ; P greater than 0 . 1 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In the majority of 188 non Hodgkin lymphomas ( NHL ) investigated in this study , we found a simultaneous expression of the receptors for c3b and c3d ( CR 1 & CR 2 ; cccorr = 0 . 69 , P less than 0 . 0005 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Receptors for C 3 degradation fragments ( CR 1 , CR 2 , and CR 3 ) are present on many human cells including phagocytes and lymphoid cells and may be critical in the attachment of invading microorganisms . ^^^ Antibodies to human CR 1 , CR 2 , and CR 3 were used to evaluate their potential for blocking adherence of the test erythrocytes to Candida . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Results indicate the presence of two types of C 3 receptors on glomerular epithelial cells CR 1 for C3b and CR 2 for C3d . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Identification in the mouse of two new genes related to the CR 1 and CR 2 gene family . ^^^ DNA sequence analysis of a cDNA specific for the 10 and Y sequences indicates the mature protein ( s ) will contain the 60 amino acid consensus repeat characteristic of a group of other proteins including CR 1 , the C3d receptor ( CR 2 ) , H , C 4 binding protein ( C4bp ) , the interleukin 2 ( Il 2 ) receptor and others . ^^^ The identity of the mouse 10 and Y genes , and the function of the proteins which they encode , is not known ; however , the small size of the mRNA and the tissue specific expression suggests they do not encode mouse CR 1 or CR 2 but instead encode a related protein ( or proteins ) which is expressed in a wide variety of mouse tissues . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Receptors for C 3 and C 4 in human peripheral nerve tissue were studied by examining the adherence of complement ( C ) coated erythrocytes ( E ) and by using monoclonal antibodies against epitopes on the receptors for C3b ( CR 1 ) , C3d ( CR 2 ) and C3bi ( CR 3 ) . ^^^ By immunofluorescence , anti CR 1 antibodies stained the nerve fibres , whereas anti CR 2 and anti CR 3 antibodies did not . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We sought biochemical evidence for a role of C receptors types 1 ( CR 1 ) and 2 ( CR 2 ) in B cell activation . ^^^ A flow cytometer was used to measure the fluorescence of tonsillar cells that had been loaded with the calcium dependent indicator indo 1 , and cells were stimulated by cross linking cell bound DA4 . 4 anti IgM , Yz 1 anti CR 1 or HB 5 anti CR 2 with goat anti mouse IgG . ^^^ To determine whether CR 1 or CR 2 could modify the increase in Cai induced by cross linking membrane IgM , Cai was monitored after addition of second antibody to cells bearing combinations of either Yz 1 or HB 5 with a limited amount of DA4 . 4 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
These molecules were found to be independent , non linked , B cell surface structures , because capping CR 1 , CR 2 , sIgM , or sIgD with a specific antibody did not affect the distribution of the remainder of these molecules . ^^^ Both CR 1 and CR 2 , if bound by antibodies that did not independently cap CR , however , became associated with cross linked sIg because CR that have been bound by intact anti CR antibodies or their Fab fragments co capped with sIgM or sIgD that had been bound by divalent anti IgM or anti IgD antibody . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We have established that the complement receptor is CR 2 which binds C3d on immune complexes but not CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Addition of antibodies against CR 1 and CR 2 or proteolytic removal of these complement receptors with trypsin inhibited by about 60 % the enhancing effect of TT bound C3b and C4b in both binding and functional assays . ^^^ These results indicate that binding of C3b or C4b to antigen enhances antigen specific proliferative and cytotoxic responses of T cells by targeting opsonized antigen onto complement receptors CR 1 and CR 2 of LCL . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The IC showed a two to three fold increased binding to C3d , g receptors ( CR 2 ) on Raji cells , when E CR 1 had been present during the reaction with NHS , compared to IC similarly reacted with NHS only . ^^^ It is concluded that interaction of complement reacted IC with CR 1 on erythrocytes leads to a more efficient generation of CR 2 binding C3d , g containing IC with reduced reactivity to PMN cells . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Certain marrow transplant protocols can now result in a 50 70 % long disease free survival and low relapse rates in acute leukemia ( AL ) in CR 1 , CR 2 , or CML following cytoreduction and HLA identical marrow infusion . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
PFGE has defined the linkage of the CR 1 , C4BP and DAF genes , together with the CR 2 gene in an 800 kb segment of DNA , and it is clear that this technique will eventually be applied to the molecular mapping of other complement genes in relation to their flanking loci . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
These molecules are factor H , CR 1 ( C3b / C4b receptor ) , CR 2 ( C3d / EBV receptor ) , C4BP ( C4b binding protein ) , DAF ( decay accelerating factor ) , MCP ( membrane cofactor protein ; earlier designated p45 / 70 ) , CR 3 ( iC3b receptor or Mac 1 ) and CR 4 ( protein 150 / 95 ) . ^^^ Due to structural , genetic and functional features these factors are members of one or several newly recognized large families of proteins : ( 1 ) molecules with 60 amino acids long repeats ( H , CR 1 , CR 2 , C4BP , DAF ) ; ( 2 ) proteins with 1 , 2 diacylglycerol membrane anchoring ( DAF ) ; ( 3 ) proteins with a heterodimer structure and preference for ligands containing the tripeptide arginine glycine asparagine ( CR 3 , CR 4 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Human complement receptors for C3b ( CR 1 ) and C3d ( CR 2 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The amino acid composition was significantly similar to that of the C3b / C4b receptor , factor H and C 4 binding protein , suggesting that CR 2 may be a member of this newly defined protein family . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The sites mutated were in the three conserved regions ( CR ; amino acids 178 186 [ CR 1 ] , 322 330 [ CR 2 ] , and 464 475 [ CR 3 ] ) identified previously by comparative sequence analysis ( G . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Expression of CR 1 and CR 2 complement receptors following Epstein Barr virus infection of Burkitt ' s lymphoma cell lines . ^^^ Rosette assays using erythrocytes coated with human C3b , C3bi , and C3d , inhibition of rosette formation with anti receptor antibodies , and flow cytometry analysis of stained cells demonstrated that EBV converted lines expressed C3b and C3d receptors , CR 1 and CR 2 . ^^^ Anti receptor antibodies recognized an average of 40 , 700 anti CR 1 and 140 , 000 anti CR 2 binding sites on an EBV converted line ( BL41 / B95 ) , whereas no specific binding occurred on the corresponding EBV negative ( BL 41 ) cells . ^^^ Because CR 1 and CR 2 are involved in B cell proliferation and / or differentiation , enhanced expression of C 3 receptors following the interaction between EBV and B cells and / or subsequent infection of the cells by EBV may provide a basis for positive control of B lymphocyte proliferation by EBV . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Allogeneic bone marrow transplants ( BMT ) in acute lymphoblastic leukemia following cyclophosphamide ( Cy ) and total body irradiation ( TBI ) has resulted in disease free survival ( DFS ) for CR 1 , CR 2 , and CR 3 of 10 / 18 ( 56 % ) , 16 / 30 ( 53 % ) and 4 / 17 ( 24 % ) , respectively . ^^^ One relapse was seen in CR 1 , 1 in CR 2 , and 6 in CR 3 . ^^^ Allogeneic BMT in acute nonlymphoblastic leukemia ( ANLL ) following busulfan ( Bu ) resulted in DFS for CR 1 , CR 2 + CR 3 + early relapse of 21 / 47 ( 45 % ) and 13 / 41 ( 32 % ) , respectively . ^^^ BMT of autologous BMT with 4 hydroperoxy cyclophosphamide ( 4 HC ) purged marrow in ANLL in CR 1 ( 5 ) , CR 2 ( 32 ) and CR 3 ( 9 ) following Bu + Cy resulted in DFS of 19 / 46 ( 41 % ) for 1 67 months ( median 15 months ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The analysis of the results shows that the disease free survival of ALL and ANLL are similar ( 45 and 52 % , respectively ) and no significant difference can be demonstrated between patients transplanted in CR 1 or CR 2 , although there is a trend in favor of ABMT in CR1 . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The regulatory proteins factor H , C4BP , CR 1 , CR 2 and DAF , which are involved in the control of C 3 convertase activity , are encoded by closely linked genes , termed the regulators of complement activation ( RCA ) linkage group , that have been mapped to human chromosome 1 . cDNA clones for all these proteins have been isolated , and this has made it possible to investigate the organization and structure of the MHC class 3 genes and the genes in the RCA linkage group . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Neutrophils express a receptor for iC3b , C3dg , and C3d that is distinct from CR 1 , CR 2 , and CR 3 . ^^^ In the present study we examined human neutrophils for the expression of a receptor capable of binding C3dg and defined the relationship of this receptor to those that have been previously described , namely CR 1 , CR 2 , and CR 3 . ^^^ Thus , a receptor resides on neutrophils that binds the C3d region of iC3b and C3dg and is distinct from CR 1 , CR 2 , and CR3 . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The protein has , beginning at the NH 2 terminus , four approximately 60 amino acid repeat units that match the consensus sequence found in a multigene family of complement regulatory proteins ( C3b receptor or CR 1 , C3d receptor or CR 2 , decay accelerating factor , C 4 binding protein , and factor H ) , as well as several other complement and non complement proteins . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The main finding is the concomitant expression of CD 22 , CD 21 ( CR 2 ) and CD 35 ( CR 1 ) molecules , all involved in B cell activation . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Tissue specific phosphorylation of complement receptors CR 1 and CR 2 . ^^^ Phosphorylation of CR 2 , however , did occur in PMA treated B lymphocytes and SB cells , suggesting that this receptor , rather than CR 1 , may be involved in regulation of B lymphocyte function . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A panel of monoclonal antibodies and ligands that bind to the CR 1 or CR 2 complement receptors of B cells has been used to investigate the role of these membrane molecules in regulating B cell proliferation and differentiation . ^^^ In contrast , modulation of other cell surface molecules , HB 2 , B 1 , and the C3b receptor ( CR 1 ) , or pretreatment of B cells with C3d , g ( a CR 2 ligand ) or HB 5 antibody , alone minimally inhibited these responses . ^^^ Whereas CR 2 appears to be the functionally relevant receptor for Epstein Barr virus on B cells , the effects of ligand interactions with CR 1 and CR 2 on normal B cell proliferation or differentiation remain unidentified . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Fifteen patients had acute lymphoblastic leukaemia : four were autografted in CR 1 and 11 children were grafted in CR 2 ; the conditioning regimen was fractionated total body irradiation followed by cyclophosphamide for all but one patient who was conditioned with BACT ( Burkitt leukaemia ) ; the marrow was purged by a chemical agent in 11 patients and by monoclonal antibodies and C ' in four : four out of 15 patients relapsed ( two grafted in CR 1 and two grafted in CR 2 ) ; 10 patients are still in unmaintained CR : two adults grafted in CR 1 ( 26+ ; 12+ months ) and eight children with a mean follow up of 13 . 4 months post graft ( 2 + 45+ months ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We purified a hepatic aldehyde reductase ( AR 1 ) and two carbonyl reductases ( CR 1 , CR 2 ) from the Mongolian gerbil , an animal recently shown to closely resemble man in its metabolism of a carbonyl containing organochlorine pesticide . ^^^ The apparent molecular weights of AR 1 , CR 1 , and CR 2 were 40 , 700 , 33 , 000 , and 34 , 700 , respectively . ^^^ Typical of similar enzymes in other species , gerbil AR 1 reduced aliphatic and aromatic aldehydes and was inhibited by phenobarbital or valproate , whereas CR 1 and CR 2 catalyzed the reduction of aromatic aldehydes and ketones as well as quinones and were inhibited by p chloromercuribenzoate , mercuric chloride , or pyrazole . ^^^ Antibodies raised against CR 1 reacted with purified CR 1 and CR 2 , but not with AR 1 , as judged by immunoblot analyses . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Most of these CR 1 , CR 2 , CR 3 , `` CR 4 ' ' , DAF , HSV 1 c glycoprotein , Gp 45 70 , p 150 , 95 , cell surface Factor H , and a 90 kD protein interact with C 3 or C 4 and their degradation products . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The involvement of molecules such as CR 1 , CR 2 , factor H , IL 2 receptor and others with a basic structure of repeating units of 61 amino acids in the triggering processes is a surprising finding and certainly suggests their functional importance . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Structure and biological activity of complement receptors , CR 1 , CR 2 CR3 ] . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Four mutant strains , CR 1 , CR 2 , CR 3 , and CR 4 , were unable to methylate the oxygen at C 5 of the macrolide moiety and produced essentially only the avermectin B components . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The isolated molecules were subjected to NaDodSO4 / PAGE , and autoradiographs of these gels indicated that C 3 binding proteins could be divided into three groups based on Mr : ( 1 ) gp 200 , an approximately 200 , 000 Mr molecule previously identified as the C3b / C4b receptor or CR 1 ; ( 2 ) gp 140 , an approximately 140 , 000 Mr molecule previously identified as the C3d receptor or CR 2 ; and ( 3 ) gp 45 70 , a heretofore unrecognized group of 45 , 000 70 , 000 Mr C 3 binding molecules . ^^^ B plus null cells , chronic lymphocytic leukemia cells , and an Epstein Barr virus transformed B cell line possess CR 1 , CR 2 , and gp 45 70 . ^^^ A polyclonal antibody to CR 1 and monoclonal antibodies to CR 1 and CR 2 do not immunoprecipitate gp 45 70 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
However , such neutrophil EC3dg and EC3bi rosettes were not inhibited by rabbit anti gp 140 nor an excess of anti CR 1 , anti CR 2 , and anti CR 3 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Studying the rosette formation between TA EC3b or TA EC3d and cells expressing C3b ( CR 1 ) and C3d ( CR 2 ) receptors and the inhibition thereof with anti CR 1 and anti CR 2 antibodies as well as with C 3 sheep E membrane protein complexes , we found that TA EC3b and TA EC3d bound exclusively to CR 1 and CR 2 , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Marginal zone B cells express CR 1 and CR 2 receptors . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The factor H like cofactor activity of the C3bR promotes the cleavage of bound C3b to iC3b , C3c , and C3d , g , which may enhance the clearance of circulating immune complexes and the generation of ligands for CR 2 and CR 3 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Inhibition of rosetting by antibodies to these proteins indicates that CR 1 is responsible for C3b mediated rosetting and that the 145000 Mr receptor ( CR 2 ) is responsible for C3d mediated rosetting . ^^^ Partial inhibition by both anti CR 1 and anti CR 2 antibodies of iC3b mediated rosetting indicates that both receptors are involved in iC3b mediated rosetting . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Three peptides ( Cr 1 , Cr 2 plus Cr2A , and Cr 3 ) stimulated antigen specific proliferation , indicating that at least three T cell determinants of the native molecule are sequential or continuous in nature . ^^^ Stimulation was also obtained with 27 residue and 13 residue synthetic peptides ( designated R 21 and R 20 , respectively ) that included sequences towards the carboxy terminal end of Cr 1 , but not with synthetic peptides that included sequences of Cr 2 and Cr 3 ( which are both glycosylated in virus derived material ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Acute myelogenous leukaemia cells ( AML ) and cells of chronic myelogenous leukaemia blast crisis ( CGL CB ) were examined for the presence of receptors for Fc IgG fragment ( FcR ) , receptors for the complement components ( CR 1 and CR 2 ) , and the surface immunoglobulins including the light kappa and lambda type chains . ^^^ As a rule , they contained very small amount of detectable FcR , CR 2 , and CR 1 . ^^^ Analysis of AML cell populations separated on the discontinuous density gradient revealed that the appearance of FcR was followed by CR 2 and CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The occurrence of the Fc IgG ( FcR ) and complement component receptors ( CR 1 and CR 2 ) in each fraction was estimated . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Surface receptors specific for either the C4b ( CR 1 ) or C3d ( CR 2 ) component of complement were examined on the neoplastic cells from 30 cases of non Hodgkin ' s lymphoma of B cell origin and on cells derived from 9 normal lymphoid tissues . ^^^ Lymphocyte suspensions from non neoplastic peripheral blood , tonsils , and lymph node contained three categories of complement receptor lymphocytes ( CRL ) : cells with receptors for both C4b and C3d ( CR1+ , CR2+ ) ; cells with receptors for C4b but not C3d ( CR1+ , CR 2 ) , and cells with receptors for C3d but not C4b ( CR 1 , CR2+ ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In these experiments IgM was shown to redistribute independently from both CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The specificity , distribution , and structure of 8 different types of leukocytes membrane complement ( C ) receptors ( CR 1 , CR 2 , CR 3 , and receptors for C1q , beta 1H , C3e , C3a , and C5a ) are discussed . ^^^ Specific assay procedures are recommended for measuring CR 1 ( C4b C3b receptor ) , CR 2 ( C3d receptor ) , CR 3 ( C3bi receptor ) , and the beta 1H receptor . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Assay of membrane complement receptors ( CR 1 and CR 2 ) with C3b and C3d coated fluorescent microspheres . ^^^ A sensitive and specific fluorescence assay for membrane complement ( C ) receptors ( CR 1 and CR 2 ) was developed with purified C3b and C3d fragments coupled to fluorescent microspheres ( 0 . 9 mu diameter ) . ^^^ Inhibition studies with anti CR 1 and anti CR 2 demonstrated that C3b ms and C3d ms bound exclusively to CR 1 and CR 2 , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Very little spontaneous release of C3b inactivator occurred in the absence of beta 1H . beta 1H treated lymphocytes that either lacked complement receptor type one ( CR 1 , the C4b C3b receptor ) or had their CR 1 blocked with Fab ' anti CR 1 formed rosettes with C3b coated sheep erythrocytes ( EC3b ) by adherence to complement receptor type two ( CR 2 , the C3d C3bi receptor ) . ^^^ This lymphocytes generated EC3bi then bound to CR 2 , forming rosettes . beta 1H induced EC3b rosettes were completely inhibited by the presence of either anti C3b inactivator , F ( ab ' ) 2 anti CR 2 , Fab anti C3c , or Fab anti C3d , but were unaffected by the presence of fluid phase concentrations of beta 1H up to 5 . 5 mg / ml or Fab ' anti CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Using complement coated sheep erythrocytes or bacteria , we were unable to detect complement receptors ( CR 1 , CR 2 , or CR 3 ) on resident alveolar macrophages of male Sprague Dawley rats . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Second order ' fear ' conditioning in humans : persistence of CR 2 following extinction of CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Evidence is presented to show that these rosettes resulted from a new type of C 3 receptor which is different from either CR 1 ( C3b receptor ) , CR 2 ( C3d receptor ) or CR 3 ( C3bi receptor ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In six patients with BCR ABL pos ALL who were in CR by conventional criteria ( 5 in CR 1 and 1 in CR 2 ) , we studied a total of nine paired BM and PB samples prior to scheduled ABMT . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
As shown in previous studies , CR 2 was also found to be reduced on B cells from the HIV infected persons and there was extensive overlap between the B cell subsets which lacked expression of CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
There were no significant differences between patients in CR 1 ( 82 . 5 % ) and CR 2 ( 68 % ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
It has previously been reported that the expression of the complement receptors , CR 1 on erythrocytes and blood leucocytes and CR 2 on B cells , is reduced in patients with SLE , and that the reduced expression of CR 1 on erythrocytes is related to disease activity . ^^^ We have confirmed , for a proportion of the patients studied , reduced expression of CR 1 and CR 2 on B cells , and shown a consistency between low CR 2 expression and reduced in vitro AP activation in the presence of homologous , normal serum . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 2 and Crry are conserved , and the C3b receptor of neutrophils and platelets is distinct from CR 1 . ^^^ In the mouse , CR 1 and CR 2 on B lymphocytes are encoded by alternatively spliced Cr 2 gene transcripts . ^^^ In this study , rabbit anti mouse CR1 / CR2 Ab immunoprecipitated a 145 to 150 kDa CR 2 protein from rat platelets , neutrophils , and splenocytes , but not a approximately 200 kDa CR 1 protein . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Murine macrophages lack expression of the Cr 2 145 ( CR 2 ) and Cr 2 190 ( CR 1 ) gene products . ^^^ Because of the similarity in size to human complement receptors , the Cr 2 190 protein has been dubbed murine CR 1 while the murine Cr 2 145 product has been termed murine CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We examined the binding of C3S / HAV4 . 1 and C3F / HAV4 . 1+ to complement receptors CR 1 , CR 2 , and CR 3 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Complement activation by either the classical or alternative pathway results in the covalent binding of C 3 molecules to Ag in forms that ligate complement receptors type 1 ( CR 1 ) and 2 ( CR 2 ) . ^^^ We hypothesized that C 3 bound Ag might cross link CR 2 and / or CR 1 with surface ( s ) IgM and alter the signal that would be transduced through sIgM by Ag binding alone . ^^^ We find that co cross linking of mouse CR 2 and CR 1 with sIgM rescues both resting B cells and WEHI 231 . 7 cells from apoptosis induced by sIgM ligation in a fashion similar to that found using soluble mouse CD 40 ligand ( mCD40L ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Plasmid shuffle assays with mutant forms of E1A show that conserved region 1 ( CR 1 ) is required for rescue of the growth of the web 1 and web 2 E1A dependent yeast mutants , while the N terminal 22 amino acids are only partially required ; conserved region 2 ( CR 2 ) and the C terminus are dispensable . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Cys 165 and Cys 168 are located within the conserved cysteine rich region of the CR 1 domain , and Ser 259 is a conserved site of serine phosphorylation found within the CR 2 domain . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The 2 year overall survival was 31 % in 14 patients with multifocal disease in first complete remission ( CR 1 ) and was 37 % for 15 patients in second CR ( CR 2 ) . ( 6 patients with local disease in CR 1 have been excluded . ) These results are better than observed under conventional dose chemotherapy . 67 patients were grafted with measurable disease showing a response rate of 72 % . ^^^ The overall survival at 5 years was 10 % in refractory patients and 58 % for 113 responding patients not in CR 1 ( i . e . first partial remission , CR 2 and sensitive relapses ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Case control analysis was performed comparing 25 allogeneic transplant patients ( cases ) with 97 patients treated with maintenance chemotherapy ( controls ) , who were matched for site of relapse , duration of CR 1 and leukemia free interval from onset of CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 , which is more divergent from CR 2 and CR 3 , displays the most restricted pattern of DNA sequence recognition . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Comparing the survival between standard ( < or = CR 1 : 21 of 31 ( 68 % ) ) and high risk ( > or = CR 2 : 4 of 17 ( 24 % ) ) AML , our data suggest that the preparative regimen for high risk AML was not potent enough to eradicate the residual disease in advanced AML . ^^^ Although our cases are limited and the follow up period is short , the result of ALL ( overall : 56 % , standard risk ( adult < or = CR 1 , children < or = CR 2 : 10 of 14 ( 71 % ) and high risk ( adult > or = CR 2 , children > CR 2 ) : 5 of 13 ( 38 % ) ) and CML ( overall : 60 % ; CP : 19 of 27 ( 70 % ) , AP or BC : 5 of 13 ( 38 % ) ) are promising . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
At time of autologous BM transplantation ( ABMT ) ; 64 AMLs were in first complete remission ( CR 1 ) , and 20 were in second CR ( CR 2 ) ; 35 ALL were in CR 1 , and 6 were in CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 ( CD 35 ) and CR 2 ( CD 21 ) complement C 3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus . ^^^ The present study demonstrates that the C3b receptor CR 1 ( CD 35 ) and the C3dg / Epstein Barr virus receptor CR 2 ( CD 21 ) are expressed by 25 % and 70 % of normal human thymocytes , respectively . ^^^ CR 1 ( CD 35 ) and CR 2 ( CD 21 ) complement C 3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus . ^^^ The functionality of CR 1 and CR 2 on thymocytes was evidenced by the ability of the receptors to mediate infection of cells with complement opsonized human immunodeficiency virus ( HIV ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Of these 362 patients , 187 received an autograft , 129 in first remission ( CR 1 ) and 58 in second remission ( CR 2 ) , and 175 an allograft , 142 in CR 1 and 33 in CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Human and murine CR 1 and CR 2 are defined as evolutionary homologues on the basis of their in vitro activities and a shared structural motif known as a short consensus repeat ( SCR ) . ^^^ To identify additional similarities between the two species , we analyzed the functional domains within the mouse receptors by constructing mouse human chimeric cDNAs in which the C 3 binding site of human CR 2 has been replaced by different regions within the first eight SCRs of mouse CR 1 . ^^^ There is no C3d binding area within the first six SCRs , but our data confirms previous studies indicating an additional C3b / C3d binding region within SCRs 7 and 8 of mouse CR 1 ( SCRs 1 2 of mouse CR 2 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The results of these studies indicate that the CR 1 and CR 2 regions in the E 7 protein , and sequences distinct from the p 53 binding region in the E 6 protein , are critical for activation of the c fos promoter . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
PIF has no significant inhibitory effect on staining of CR 1 ( CD 35 ) , CR 2 , ( CD 21 ) , 20 kDa homologous restriction factor ( CD 59 ) , decay accelerating factor ( CD 55 ) , LFA 1 ( CD11a ) , or p150 . 95 ( CD11c ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Adenovirus early region 1A ( E1A ) products induce DNA synthesis , transform primary rodent cells , and activate transcription factor E2F through complex formation with an array of cellular proteins via the E1A amino terminus and conserved regions 1 and 2 ( CR 1 and CR 2 ) . ^^^ Interactions with the retinoblastoma tumor suppressor , pRb , and related proteins p 107 and p 130 rely somewhat on CR 1 but largely on CR 2 , which contains a core binding sequence Leu 122 10 Cys 10 Glu . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
IC generated with fresh serum bore iC3b and bound to CR 1 ( CD 35 ) , CR 2 , and CR 3 ( CD11b / CD18 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Neither normal nor CF BAL macrophages express appreciable amounts of the complement receptors CR 1 , CR 2 , or CR 3 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The mRNAs of several complement components ( C 2 , C 3 , C 4 , C 5 ) and receptors ( CR 1 , CR 2 ) were also detected . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We determined whether the six short consensus repeats ( SCRs ) that are appended to the amino terminus of murine CR 2 to form murine CR 1 contain a binding site for C4b in addition to that for C3b , and whether these sites overlap or are distinct . ^^^ The murine CR1 / human CR 2 chimera containing murine SCRs 1 6 resembled the full length human CR 1 in binding both EC3b and EC4b . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The latest relapses in acute myelogenous leukaemia ( AML ) were observed following BMT at 6 . 6 years in a patient transplanted in first remission ( CR 1 ) and at 3 . 7 years in a patient transplanted in second remission ( CR 2 ) , and following ABMT at 6 years and 5 . 1 years respectively . ^^^ The latest relapses in acute lymphoblastic leukaemia ( ALL ) were observed following BMT at 4 years in a patient transplanted in first remission ( CR 1 ) and at 6 . 8 years in a patient transplanted in second remission ( CR 2 ) , and following ABMT at 5 . 3 years and 4 . 5 years respectively . ^^^ Of the numerous other prognostic factors studied , female sex in AML , the use of total body irradiation ( TBI ) in ALL and status in CR 1 , rather than CR 2 3 , for both ALL and AML allografted were correlated with a lower relapse incidence . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In the regions of high similarity belong the C 3 domains that contain the thiolester site and the properdin binding sites , whereas the regions that correspond to regions of human C 3 where CR 1 and CR 2 bind show low amino acid sequence similarity . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Through the use of a number of glutathione S transferase fusion proteins representing different regions of E1A , as well as in vivo expression of E1A proteins containing deletions of either conserved region 1 ( CR 1 ) or CR 2 , we find that CR 2 of E1A can form stable complexes with E2F . ^^^ E1A proteins containing both CR 1 and CR 2 also associate with E2F , although the presence of these proteins results in the release of free E2F from its complexes . ^^^ Peptide competition experiments demonstrate that the pRB binding domain of the human E2F 1 protein can compete with the CR 1 but not CR 2 domain of E1A for binding to pRB . ^^^ These results indicate that E1A CR 1 and E2F 1 may bind to the same or overlapping sites on pRB and that E1A CR 2 binds to an independent region . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Thirty three patients with AML ( 18 in first remission [ CR 1 ] , 10 in CR 2 , and 5 in CR 3 ) received intravenous CSP , beginning on the day of ABMT , after a preparative regimen of busulfan and cyclophosphamide and ABMT with 4HC treated marrow . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Sixteen AML patients were studied in early first CR prior to intensive consolidation with high dose cytarabine ( HDAC ) and had a median ID 95 of 130 ( range 90 190 ) micrograms mafo / ml ; the median ID 95 in 3 of 7 AML CR 1 and 4 of 7 AML CR 2 patients who previously had HDAC therapy was 75 ( range 55 110 ) micrograms / ml whereas a control group of 7 patients with lymphoid malignancies in CR 1 showed a median ID 95 of 100 ( range 80 160 ) micrograms / ml . ^^^ In AML the difference between patients in CR 1 prior to HDAC and patients in CR 1 after HDAC late consolidation or in CR 2 was highly significant ( p = 0 . 0006 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Five patients were in advanced stage , 2 in drug resistant relapse , 6 in drug sensitive relapse , 6 in first complete remission ( CR 1 ) and 2 in CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
C 3 deposition in human fetal tibia primary spongiosa was localised immunohistochemically and complement receptors CR 1 , CR 2 , CR 3 , and CR 4 were localised cellularly . ^^^ CR 1 and CR 2 , however , could not be shown on either mononuclear or multinuclear osteoclasts . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Evidence for the role of CR 1 ( CD 35 ) , in addition to CR 2 ( CD 21 ) , in facilitating infection of human T cells with opsonized HIV . ^^^ We have studied complement mediated enhancement of infection of the human CD 4 positive T cell line HPB ALL which expresses the CR 1 ( CD 35 ) and CR 2 ( CD 21 ) receptors for C 3 . ^^^ CR 1 and CR 2 are present on 15 % and 40 % of normal peripheral blood CD 4 positive T lymphocytes respectively . ^^^ Experiments using serum deficient in complement factor 1 demonstrated that CR 1 mediates the interaction between opsonized virus and T cells in addition to its ability to serve as a cofactor for the cleavage of C3b into smaller fragments that interact with CR 2 . ^^^ Thus , CR 1 and CR 2 contribute in an independent and complementary fashion to penetration of opsonized virus into complement receptor expressing T cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In this study the structural and functional relationships of gC from HSV type 1 ( HSV 1 ) and known human complement regulatory proteins factor H , properdin , factor B , complement receptor 1 ( CR 1 ) and 2 ( CR 2 ) were investigated . ^^^ All the mAb that inhibited gC / C3b interactions , in a differential manner , also prevented binding of C 3 fragments to factors H , B , CR 1 or CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Previous experiments have shown that the CR 1 and CR 2 domains of E1A are required for this activity . ^^^ In addition , the E1A CR 1 domain , but not the CR 2 domain , is sufficient to prevent the interaction of E2F with Rb or p 107 . ^^^ On the basis of these results , we suggest a model whereby the CR 2 domain brings E1A to the E2F complexes and then , upon a normal equilibrium dissociation of Rb or p 107 from E2F , the E1A CR 1 domain is able to block the site of interaction on Rb or p 107 , thereby preventing the re formation of the complexes . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Thirty four patients were in first complete remission ( CR 1 ) , 12 patients in second complete remission ( CR 2 ) , and 4 patients in relapse . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Disease stage at ABMT was : first complete remission ( CR 1 ) 46 cases , CR 2 33 , other stages 11 . ^^^ The 3 year probability of disease free survival ( DFS ) was influenced by disease stage at ABMT : CR 1 48 % , CR 2 28 % , CR 3 plus CR 4 15 % . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Blocking experiments with monoclonal antibodies ( MoAbs ) against CD 4 , CD 21 ( complement receptor 2 [ CR 2 ] ) , CD 35 ( CR 1 ) , CD 19 , and CD 5 surface molecules indicated that infection of B cells involves CD 4 , CD 21 , and CD 35 antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Adenovirus ( Ad ) E1A proteins carry two conserved domains ( CR 1 and CR 2 ) required for transformation of primary rodent cells and essential for association with cellular proteins , including p105RB , p58cyclin A and p33cdk2 . ^^^ We show that in normal rat kidney 49F ( NRK ) cell lines expressing various mutant Ad 5 E1A genes , CR 2 , but not CR 1 , deletion mutants induce a typical transformed phenotype as characterized by morphology , absence of density arrest and loss of serum requirement . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
It has previously been reported that the expression of the complement receptors CR 1 ( CD 35 ) and CR 2 ( CD 21 ) on malignant B cells in CLL is reduced compared with the expression on normal B cells , while deposition of complement C 3 fragments , as a consequence of alternative pathway ( AP ) activation of complement , is observed on mononuclear cells from patients with B CLL . ^^^ Following our demonstration that normal B cells are capable of activating the AP of complement in a CR 2 dependent fashion , we have chosen to re examine the complement activating ability of B CLL cells in relation to their altered phenotype with respect to CR 2 and the complement regulatory membrane proteins , CR 1 , decay accelerating factor ( DAF ) ( CD 55 ) and membrane cofactor protein ( MCP ) ( CD 46 ) . ^^^ We have confirmed the reduced expression of CR 1 and CR 2 on CLL cells and have shown that AP activation in the presence of homologous , normal serum was reduced on B CLL cells compared with normal B cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Complement receptor 1 ( CR 1 , CD 35 ) and complement receptor 2 ( CR 2 , CD 21 ) have been implicated as regulators of B cell activation . ^^^ We explored the role of these receptors in the development of humoral immunity by generating CR 1 and CR 2 deficient mice using gene targeting techniques . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Required for this activity is conserved region 2 ( CR 2 ) , while both the N terminal part of E1A and CR 1 are dispensable . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Despite normal expression of complement receptor 1 ( CR 1 [ CD 35 ] ) and CR 2 ( CD 21 ) on follicular dendritic cells , these mice have a profound defect in their capacity to mount a T dependent antibody response . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
To ascertain the effects of C activation on these cells , we have evaluated the expression of CR 1 , CR 2 , and CR 3 ( CD 35 , CD 21 , and CD11b / CD18 ) in primary fetal astrocytes and astrocyte cell lines . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Specifically , 1 ) we include age groups of CR ( CR 1 approximately equal to 90 kcal / wk and CR 2 approximately equal to 58 kcal / wk ) and ad libidum fed ( AL ; approximately 120 kcal / wk ) mice including groups at maximum lifespan ; 2 ) CR was the major dietary manipulation ; 3 ) LF was identified using EM ; 4 ) LF was quantified by areal measurement ; and 5 ) the results were analyzed by inferential statistics . ^^^ We have found that 1 ) LF increased with age and 2 ) that animals in the CR 2 group had significantly less overall LF in the perikarya of the granule cells of the dentate gyrus when compared to CR 1 or AL animals at equivalent ages . ^^^ In addition , CR 2 mice at maximum lifespan ( 45 mo . ) had slightly less LF than did CR 1 or AL mice at their maximum lifespans ( 36 mo . ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Groups of patients were analyzed according to age ( adults and children ) and status at transplant ( first remission = CR 1 ; second remission = CR 2 ) . ( 1 ) 1114 adult patients were transplanted in CR 1 ; 516 received an allograft ; 598 received an autograft . ^^^ Favorable prognostic factors for ABMT were a younger age of the patients at time of transplant , the AML 3 FAB type , and a longer interval from CR 1 to ABMT . ( 2 ) 288 adult patients were transplanted in CR 2 : 98 received an allograft ; 190 received an autograft . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 delta and CR 2 delta E1A proteins were less effective at reducing the number of flat , enlarged cells induced by pRb expression than were the CR 3 delta or wild type E1A proteins . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In acute lymphoblastic leukemia the following circumstances were considered a definitive indication for allogeneic bone marrow transplant ( BMT ) from a matched sibling donor ( MSD ) : infancy , `` high risk ' ' ( HR ) patients in 1st complete remission ( CR 1 ) ; CR 2 patients after an early bone marrow relapse ( defined as a relapse occurring up to six months after stopping therapy ) . ^^^ If a MSD is not available , HR patients in CR 1 and CR 2 patients , after an early bone marrow relapse , were considered a definite indication for a matched unrelated donor ( MUD ) . ^^^ In acute myeloblastic leukemia ( AML ) , CR 2 patients were considered a definitive indication and CR 1 patients were considered an acceptable indication for BMT from a MSD . ^^^ CR 2 patients were considered a definitive indication for ABMT and CR 1 patients an acceptable indication in cases lacking a MSD . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Therefore , from the European data the following conclusions can be drawn : neither in CR 1 nor in CR 2 any statistical advantage for a particular transplantation type can be found . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
During the subsequent 10 min , this buffering capacity of E was essentially abolished E restricted the initial IC binding to B cells by 73 + / 19 % , but from 3 min of incubation the presence of E promoted , in a CR 1 dependent manner , a progressive uptake via CR 2 by the B cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The cell surface markers included complement receptors [ CR 1 ( CD 35 ) , CR 2 ( CD 21 ) , CR 3 ( CD11b , CD 18 ) ] , immunoglobulin Fc receptors [ FcgammaRII ( CD 32 ) , FcgammaRIII ( CD 16 ) ] , proteins important for lymphocyte function [ CD 3 , CD 4 , CD 8 , CD 19 , CD 25 , CD45RA ] , and the framework antigen HLA ABC . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The effect of initial ( D . p . ) challenge on the early and late airway responses to the subsequent ( CR ) challenge ( CR 2 ) was examined by comparing the responses with those to CR challenge preceded by sham challenge ( CR 1 ) . ^^^ The geometric mean PD 20 of CR allergen in the CR 2 was 2 . 8 BU ( breath unit ) ( range of 1 SD ; 0 . 77 10 . 4 ) , which was 12 . 0 fold less than that ( 33 . 7 BU , 10 . 8 105 . 2 ) in the CR 1 . ^^^ The administration of a 6 . 1 fold less dose ( 8 . 9 BU , 2 . 7 28 . 8 ) in the CR 2 than in the CR 1 ( 54 . 5 BU , 44 . 1 69 . 3 ) provoked a similar degree of late phase reactions ( 18 . 7 + / 7 . 3 % vs 15 . 8 + / 9 . 6 % ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Both conserved region 1 ( CR 1 ) and CR 2 of the human papillomavirus type 16 E 7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice . ^^^ Four lines of animals transgenic for an HPV 16 E 7 harboring a CR 1 deletion and five lines harboring a CR 2 deletion were generated and were observed for overt and histological phenotypes . ^^^ These experiments indicate that binding and inactivation of pRb and pRb like proteins through the CR 2 domain of E 7 are necessary for induction of epidermal hyperplasia and carcinogenesis in mouse skin and also suggest a role for the CR 1 domain in the induction of these phenotypes through as yet uncharacterized mechanisms . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Twenty seven were transplanted for ALL in second remission ( CR 2 ) , and 16 for AML in first remission ( CR 1 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Mouse complement receptors type 1 ( CR 1 ; CD 35 ) and type 2 ( CR 2 ; CD 21 ) : expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL / lpr mice . ^^^ We have studied the expression of mouse CR 2 and CR 1 on normal populations of mouse B lymphocytes in BALB / c mice . ^^^ Mouse CR 2 and CR 1 are also found on peritoneal B1a and B1b cells in addition to IgA+ Peyer ' s patch B cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Human preimplantation embryos , gametes and cumulus cells were studied for expression of the complement binding proteins CD 46 ( membrane cofactor protein ) , CD 55 ( decay accelerating factor ) and CD 59 ( membrane attack complex inhibitory factor ) as well as complement receptors type 1 ( CRI ) , type 2 ( CR 2 ) and type 3 ( CR 3 ) . ^^^ Monoclonal antibodies ( mAbs ) to CRI , CR 2 and CR 3 epitopes gave only occasional reactivity on oocytes and were unreactive with blastocysts , spermatozoa and cumulus cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Repression of p 53 transactivation requires both the extreme amino terminus and CR 1 but not CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We investigated the expression of complement regulatory ( CD 46 , CD 55 , CD 59 ) and complement receptor ( CR 1 , CR 2 , CR 3 , CR 4 ) proteins on alveolar cells by flow cytometry . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 levels on B cells were significantly lower in FI deficient patients than in normal individuals , whereas CR 2 levels were found to be reduced , although not to a significant extent . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The Allo BMT was performed in CR 1 in 7 patients in CR 2 in three patients and with refractory disease in two cases . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We describe 18 patients with a median age of 13 years ( range 4 31 ) who received an ex vivo T cell depleted UD BMT for AML ( 13 in second complete remission ( CR 2 ) and five in first complete remission ( CR 1 ) with high risk features ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Most transplants ( 70 % autologous , 48 % URD ) were in early remission ( first or second complete remission [ CR 1 or CR 2 ] ) ; 376 patients ( 75 % autologous , 64 % URD ) were less than 18 years old . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Introducing a negative charge into the N terminus ( CR 1 ) and a high affinity pRb binding site into CR 2 of HPV 6 E 7 resulted in a transactivator with greater activity than HPV 16 E 7 for both the AdE 2 and B myb promoters . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The MRG 1 mRNA transcript is expressed widely and encodes a nuclear protein that share two highly conserved domains , CR 1 ( 14 aa ) and CR 2 ( approx . 50 aa ) , with MSG 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Elevation of cyclin E levels required both the CR 1 and CR 2 domains of E 7 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A chimeric protein ( E7 / E1A243 ) containing the CR 1 and CR 2 of HPV 16 E7 fused to the CR 3 of Ad E1A 243 was constructed . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This cotransformation ability was abrogated by deletions in CR 1 or CR 2 of E1A , which encode the binding regions for the pRb family and are responsible for E1A mediated cell cycle activation . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The absence of complement receptors 1 and 2 ( CR 1 , CR 2 ) on B cells could affect their activation . ^^^ To compare the roles of CR 1 and CR 2 on B cells vs FDC in this abnormal response , bone marrow ( BM ) chimeric mice were generated and immunized with specific T dependent Ags . ^^^ These experiments are the first to demonstrate an absolute requirement for CR 1 and CR 2 expression on FDC in the generation of a normal humoral immune response . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
RESULTS : Outcome at 5 years for patients transplanted with low grade NHL in first complete remission ( CR 1 ) , in first partial remission ( PR 1 ) , and in second complete remission ( CR 2 ) or beyond showed an event free survival ( EFS ) of 75 % + / 12 % , 46 % + / 18 % , and 57 % + / 24 % , a relapse incidence ( RI ) of 21 % + / 12 % , 49 % + / 19 % , and 43 % + / 25 % , and a transplant related mortality ( TRM ) of 5 % + / 5 % , 10 % + / 7 % , and 0 % , respectively . ^^^ For patients with aggressive NHL transplanted in CR 1 , in PR 1 , in CR 2 or beyond , and in resistant relapse or in primary refractory disease , the EFS was of 73 % + / 9 % , 58 % + / 19 % , 29 % + / 16 % , and 10 % + / 9 % , the RI 22 % + / 9 % , 14 % + / 9 % , 77 % + / 18 % , and 66 % + / 20 % , and the TRM 6 % + / 6 % , 32 % + / 21 % , 11 % + / 10 % , and 71 % + / 22 % , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In fact , due to a markedly increased relapse rate , poor risk children ( ie patients transplanted in more advanced disease ) experienced a significantly worse EFS than those given CBT in a more favorable disease phase ( ie CR 1 or CR 2 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
ABMT was performed in 130 ( 34 % ) out of 377 patients without a donor in CR 1 , in six ( 2 % ) patients during relapse and in 38 ( 10 % ) patients during CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Among the 19 patients with PGR treated by chemotherapy alone , 8 remained in CR 1 and 11 relapsed , of which 4 are in CR 2 or CR 3 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The actuarial 10 year survival is 53 % , 38 % and 20 % , for patients in CR 1 , CR 2 or advanced phase , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Three highly conserved regions were identified at amino acid positions 14 182 ( CR 1 ) , 432 568 ( CR 2 ) and 636 730 ( CR 3 ) of the D . virilis DREF , with 86 . 4 , 86 . 1 and 83 . 3 % identities , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Three patients were grafted with evolutive disease , four were in partial remission after several courses of chemotherapy , two were in CR 2 and four were in CR 1 after initial therapy . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
GST pull down assays also showed that CDP associated with SATB 1 through three of its four DNA binding domains ( CR 1 , CR 2 , and the homeodomain ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
There was no difference in expression of FcepsilonRII , FcgammaRII / III , CR 1 , CR 2 , and CR 3 between low and high responder strains , thus excluding low levels of these FcRs and CRs as a reason for low responsiveness in H 2Ab mice . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
ASCT had been performed in CR 1 for 23 patients and in CR 2 for three . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Co operation between human CR 1 ( CD 35 ) and CR 2 ( CD 21 ) in internalization of their C3b and iC3b ligands by murine transfected fibroblasts . ^^^ CR 1 and CR 2 are expressed as associated proteins on the B lymphocyte surface . ^^^ To investigate their respective contributions to the internalization of C 3 fragments , transfected murine fibroblasts expressing human CR 1 , CR 2 , or both CR 1 and CR 2 were produced . ^^^ CR 1 and CR 1 CR2 expressing cells bound C3b and C3b dimer whereas CR 2 and CR 1 CR2 expressing cells bound iC3b and C3de . ^^^ CR 1 CR2 positive cells internalized two to threefold more C3b and 1 . 5 fold more iC3b than CR 1 and CR 2 single positive cells , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The E1A domains required for induction of apoptosis , analysed by transfection with expression vectors for E1A , Ids and their mutants , followed by flow cytometry , reside in N terminal ( positions 17 38 ) , CR 1 and CR 2 regions . ^^^ The cyclin D 1 promoter activity in S phase was reduced severely by E1A and this reduction is caused through CR 1 and CR 2 regions required for interaction with pRB . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Multi factor analysis demonstrated that AML ( 5 ALL ) , disease status ( second complete remission [ CR 2 ] 5 others ) , age ( < 40 years ) and duration of prior first complete remission ( CR 1 ) ( > 6 months ) were pre transplant variables significantly associated with improved survival . ^^^ Only patients with AML in untreated first relapse or CR 2 , with a duration of CR 1 > 6 months , or patients with T ALL , had a 5 year survival > 20 % . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
These include activities that map to the p 53 binding domain and the amino terminal 176 amino acids which contain the J domain as well as the CR 1 and CR 2 domain required for binding and sequestering the RB family of pocket proteins . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
These highly conserved regions encompass residues 42 94 ( CR 1 ) , 301 329 ( CR 2 ) , and 444 483 ( CR 3 ) on human MDM 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Binding of anti CD 4 monoclonal antibody to D 1 domain ( CR 1 , CR 2 epitopes ) of CD 4 molecule . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Usually expression CD 5 on B CLL cells associated with weak or lack expression of the surface immunoglobulins and CD 79 beta , CD 20 , CD 22 , CD 21 ( CR 2 ) , CD 35 ( CR 1 ) antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The disease status prior to my eloablative therapy was first complete response ( CR 1 ) in three patients , CR 2 in nine , second partial response ( PR 2 ) in one , CR 3 in one , and progressive disease ( PD ) in two . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Sixteen of 18 ( 89 % ) survive at median of 854 . 5 days from bone marrow transplantation , 4 in CR 1 and 10 in CR 2 at a median disease free survival ( for remission 2 ) duration of 341 days . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Patients in complete remission ( CR ) by EP were further subclassified as CR 1 when IF was negative and CR 2 when it remained positive . ^^^ Multivariate analysis confirmed both the absence of differences among CR 2 , PR 1 and PR 2 and the highly discriminatory prognostic capacity of a three category classification : ( 1 ) CR 1 ( 2 ) CR 2 + PR 1 + PR 2 , and ( 3 ) non response ( EFS P < 0 . 00000 ; OS P < 0 . 00000 ; both Cox models P < 0 . 00000 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The CCAAT displacement protein , the homolog of the Drosophila melanogaster CUT protein , contains four DNA binding domains : three CUT repeats ( CR 1 , CR 2 , and CR 3 ) and the CUT homeodomain ( HD ) . ^^^ Thus , the CCAAT displacement activity requires the presence of an additional sequence ( CAAT or CGAT ) and involves CR 1 and CR 2 , but not the CUT homeodomain . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The population comprised 229 consecutive patients ; 165 with AML [ 123 in first remission ( CR 1 ) , 32 in second remission ( CR 2 ) ] ; 61 with ALL ( 46 in CR 1 , 4 in CR 2 ) ; and 3 with undifferentiated acute leukemia . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Status at transplant was : second complete remission ( CR 2 ) : n = 12 ; further CR ( CR > 2 ) : n = 3 , partial remission ( PR ) : n = 2 , relapse : n = 2 and first CR ( CR 1 ) : n = 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The eyeblink CR in all animals showed a similar topography with at least two different components , CR 1 and CR 2 , which were expressed at different rates . ^^^ CR 1 appeared first during acquisition , had a shorter onset latency , and was more phasic and more resistant to extinction than CR 2 . ^^^ CR 1 and CR 2 were present in the rabbit eyeblink CR . ^^^ The cerebellum is implicated in the control of CRs and to study whether separate neural pathways were responsible for CR 1 and CR 2 , direct brachium pontis stimulation was used to replace the forelimb CS . ^^^ CR 1 and CR 2 were present in the CR elicited by the brachium pontis CS . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Forty three of them were ANLL [ CR 1 35 , CR 2 or early relapse ( ER ) 8 ] , 30 were ALL ( CR 1 25 , CR 2 or ER 5 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The interaction of surface blebs with the globular heads of C1q suggests that surface blebs may be capable of directly activating the classical pathway of complement under certain circumstances , generating C 4 and C 3 derived ligands for receptors such as CR 1 , CR 2 , CR 3 , and CR 4 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
However , CR 2 was not necessary for the adipogenic action of C / EBPalpha because a combination of CR 1 and CR 3 can also induce adipogenesis . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Among the 17 autografted patients still in CR 2 , nine patients have already reached a longer CR 2 than first CR ( CR 1 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Fifteen were newly diagnosed cases ( CR 1 ) and one was studied after first relapse ( CR 2 ) . ^^^ By contrast , conversion to a repeatedly PCR negative status was observed in the seven patients who remained in CR 1 after a median follow up of 48 months ( range 31 79 months ) , as well as in the transplanted patient who was monitored in CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In the last decade , genes , protein structure and functions played by murine complement receptors CR 1 and CR 2 ( mCR1 / 2 ) have been deciphered . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Viral yields at 3 days postinfection indicated that wt MAV 1 and pmE 314 , an early region 3 null mutant , were relatively insensitive to both IFN alpha / beta and IFN gamma , whereas early region 1A ( E1A ) mutants pmE 109 ( null ) , dlE 105 ( conserved region 1 deletion , CR 1 Delta ) , dlE 102 ( CR 2 Delta ) , and dlE 106 ( CR 3 Delta ) were sensitive . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Complement C 4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR 1 and CR 2 . ^^^ In contrast , titers and frequencies of ANA in Cr 2 ( ) ( / ) mice , which are deficient in CR 1 and CR 2 , never rose significantly above those in normal controls . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We investigated the structural and functional similarities among short consensus repeats ( SCRs ) of the following human proteins : the alpha chain of the C4b binding protein ( C4bpalpha ) , factor H ( FH ) , factor H related proteins ( FHR 1 through FHR 4 ) , complement receptors type 1 ( CR 1 ) and type 2 ( CR 2 ) , the CR 1 like protein ( CR1L ) , membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , and the sand bass proteins , the cofactor protein ( SBP 1 ) and its homolog , the cofactor related protein ( SBCRP 1 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Twenty five patients were in second complete remission ( CR 2 ) , and 14 had high risk CR 1 disease ( primarily failed remission induction or antecedent myelodysplastic syndrome , often with complex cytogenetic abnormalities ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
DNA was extracted from formalin fixed , paraffin embedded tissue for PCR study with HPV 6 / 11 , 16 , 18 and 7 microsatellite primers : D2S123 ( cr 2 ) , MFD 39 ( cr 8 ) , 635 636 ( cr15q ) , MFD 67 ( cr 1 ) , D11S905 ( cr 11 ) , SCZD 1 ( cr5q ) and DM ( cr 19 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Several retrospective studies have analyzed the outcome of patients undergoing AUTO or ALLO HSCT in first ( CR 1 ) or second ( CR 2 ) complete remission . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Significant binding of fluorescein isothiocyanate conjugated Tg to B cells was observed , and absorption of Tg reactive antibodies from serum markedly reduced this uptake , as did inactivation of serum complement or blockade of complement receptor types 1 ( CR 1 , CD 35 ) and 2 ( CR 2 , CD 21 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We asked if two consecutive endurance runs 1 week apart ( CR 1 , CR 2 ) and additional environmental heat stress affect HSP 72 expression in leukocytes of nonheat acclimated endurance athletes . ^^^ Group HH completed both runs at 28 degrees C ambient temperature , and group NH performed CR 1 at 18 degrees C and CR 2 at 28 degrees C . ^^^ Adaptation of cardiocirculatory / thermoregulatory capacity after CR 2 in HH went along with a more rapid down regulation of HSP 72 compared with CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We approached allogeneic transplantation in four patients with a median age of 62 years ( one chronic myeloid leukaemia in blast crisis , one high risk acute myeloid leukaemia ( AML ) in first complete remission ( CR 1 ) , one AML in 2nd relapse , one AML in CR 2 with pre existing fungal lung infections ( two aspergillus , two mucor ) and additional co morbidity ( diabetes n = 2 , aortic aneurysm n = 1 , arterial sclerosis n = 2 ) by combining non myeloablative conditioning with an intensified supportive care regimen , including amphotericin B and 4 12 ( median 9 ) prophylactic granulocyte transfusions from granulocyte colony stimulating factor ( G CSF ) stimulated volunteer donors . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This rearrangement results in a gene order of cytochrome b / tRNA ( Thr ) / pND6 / pGlu / CR1 / tRNA ( Pro ) / NADH dehydrogenase 6 / tRNA ( Glu ) / CR2 / tRNA ( Phe ) / 12s rRNA , where CR 1 and CR 2 refer to duplicate control regions , and pND 6 and pGlu indicate presumed pseudogenes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Finally , an adenovirus mutant deleted in the CR 1 and CR 2 domains of E1A exhibits preferential replication and cell killing in HPV E6E7 expressing cultures . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We show here that complement is critical for the induction of experimental autoimmune myocarditis and that it acts through complement receptor type 1 ( CR 1 ) and type 2 ( CR 2 ) . ^^^ We also found a subset of CD 44 ( hi ) CD62L ( lo ) T cells that expresses CR 1 and CR 2 and propose that both receptors are involved in the expression of B and T cell activation markers , T cell proliferation and cytokine production . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
As to patients given CHT , a CR 1 duration of more than 12 months was the only parameter significantly related to a better clinical outcome ( survival from relapse : 8 vs . 4 months , p=0 . 002 ; CR 2 duration : 11 vs . 5 months , p=0 . 001 , respectively ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
To investigate whether K / BxN serum induced RA involves complement activation and / or the complement receptors ( CR ) 1 and 2 , we analyzed the role of complement C 4 and of CR 1 and CR 2 . ^^^ For this purpose we used C 4 ( / ) mice impaired in the classical and the lectin complement pathways ; Cr 2 ( / ) mice lacking CR 1 and CR 2 and , as control strains , BALB / c , C57BL / 6 , KRN and NOD . ^^^ The lack of protection in Cr 2 ( / ) mice suggests that absence of CR 1 had no significant affect , considering its role in immune complex clearance , inhibition of C 3 and C 5 convertase and as receptor for C3b / C4b . ^^^ Hence we conclude that the transmission of K / BxN serum induced RA is independent of the classical and the lectin complement pathways and CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We have used a set of single chain variable fragment antibodies ( sc ) genetically fused with an influenza hemagglutinin derived peptide as a means to investigate the role of CR 1 and CR 2 in antigen presentation by B cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Three moAbs , UZ 5 , UZ 7 , and UZ 6 , specifically inhibit mouse E selectin mediated adhesion by binding to epitopes in domains CR 1 or CR 2 . moAb UZ 4 inhibits leukocyte adhesion to both human and murine endothelium activated with IL 1 or other proinflammatory stimuli . ^^^ The data suggest that E selectin ligand engagement differs between lymphocytes and PMN , and that these differences may be accentuated by the CR 1 and CR 2 domains in the E selectin cell adhesion molecule . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Underlying disease included high risk acute lymphoblastic leukemia ( ALL , CR 1 in 3 children and CR 2 in 5 children ) , acute myeloblastic leukemia ( AML , 9 children ) , non Hodgkin ' s lymphoma stage 4 ( 2 children ) , and neuroblastoma stage 4 ( 2 children ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Deletions within all three CRs in the EBNA LP W1W2 repeat domain completely abrogated function , through inhibition of nuclear localization in the cases of CR 1 and CR 2 but not of CR 3 ; deletions within CR 4 and CR 5 in the Y1Y2 unique domain had relatively little effect , yet loss of the whole Y 2 sequence blocked activity . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Five of them were ALL ( CR 1 4 , CR 2 1 ) , 2 ANLL ( CR 1 ) , 8 CML ( CP 5 , AP 3 ) , and one NHL ( PR ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Analysis of the p 66 homologs from different organisms revealed two highly conserved regions , CR 1 and CR 2 . ^^^ While CR 1 is involved in the association of p 66 with other MeCP 1 components , CR 2 plays an important role in targeting p 66 and MBD 3 to specific loci . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The tests include : ( 1 ) single task : aural Oddball response , the response time ( RT 1 ) and correct rate ( CR 1 ) were recorded ; ( 2 ) dual tasks : manual tracking and aural Oddball response , the response time ( RT 2 ) , tracking error ( ER ) and correct rate ( CR 2 ) were recorded ; ( 3 ) The Stanford sleepiness scale and subjective ratings of task difficulty access . ^^^ Since the subjects changed their response strategy , CR 1 and CR 2 were not influenced by SD at night time . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Sixty four patients underwent transplantation in first remission ( CR 1 ) , 16 in CR 2 or CR 3 , and 47 patients had relapsed ALL or primary induction failure ( PIF ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
From January 1987 to 1999 , 88 consecutively seen patients with ALL who were younger than 18 years received a marrow transplant from an HLA matched ( n = 56 ) or partly matched ( n = 32 ) unrelated donor during first complete remission ( CR 1 ; n = 10 ) , second remission ( CR 2 ; n = 34 ) , third remission ( CR 3 ; n = 10 ) , or relapse ( n = 34 ) . ^^^ Three year rates of leukemia free survival ( LFS ) according to phase of disease were 70 % for CR 1 , 46 % for CR 2 , 20 % for CR 3 , and 9 % for relapse ( P < . 0001 ) . ^^^ Three year cumulative relapse rates were 10 % , 33 % , 20 % , and 50 % , respectively , and 3 year cumulative rates of death not due to relapse were 20 % , 22 % , 60 % , and 41 % , respectively , for patients with CR 1 , CR 2 , CR 3 , and relapse . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
As ligand , aggregated C 3 and aggregated C 3 ( H ( 2 ) O ) , i . e . , multimeric `` C3b like C 3 ' ' , are used , which bind to CR 1 , but not to CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
C 3 / mice showed delayed viral clearance and increased viral titers in lung , whereas mice deficient for complement receptors CR 1 and CR 2 ( Cr 2 / mice ) cleared the infection normally . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Among them , 15 patients suffered from acute leukemia ( ALL ) ( one ph+ ALL in CR 1 , seven in CR 2 or greater , and seven in relapse , including two in relapse after the first all BMT ) , four patients suffered from chronic myelocytic leukemia ( CML ) ( in CP 2 , AP , BC , and relapse after BMT respecively ) , 6 patients suffered from myelodys plastic syndrome ( MDS ) , including one case of refractory anemia with excess of blasts ( REAB ) , one case of refractory anemia with excess of blasts in trransformation ( REAB T ) , and 4 cases of acute leukemia secondary to MDS . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The CR 1 , CR 2 , and CR 3 activating mutations , when combined in cis , cooperated in transforming Rat 2 fibroblasts . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Overexpression of ClaspL promoted accumulation of Clk 4 K189R in the nuclear dots and the exon EB inclusion from CR 1 and CR 2 pre mRNA of Clk 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Remission status prior to allogeneic SCT was CR 1 ( 1 ) , CR 2 ( 1 ) , relapse ( 11 ) , partial remission ( 5 ) or primary refractory induction failure ( 7 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
All were in remission at BMT : eight in CR 1 , 32 in CR 2 and five in greater than CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
All but two patients were in complete remission ( CR ) at the time of transplant ( CR 1 , n = 5 ; CR 2 , n = 4 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The results demonstrate an important role for pentameric IgM in the initiation of Ag trapping , a step independent of C 3 activation and of the interaction of IC with CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The five year disease free survival ( DFS ) was 63 % for 42 patients at CR 1 , 41 % for 41 patients at CR 2 and 33 % for 40 patients at other stages . ^^^ In patients at remission stage for CR 1 and CR 2 , the 5 year DFS by conditioning regimen was 63 % for regimen ( A ) , 54 % for regimen ( B ) and 54 % for regimens with melphalan and TBI . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The five drug chemotherapy ' DIAVE ' ( dexamethazone , idarubicine , cytosine arabinoside , vincristine , etoposide ) , followed by G CSF , previously reported as consolidation , was adopted as a mobilization regimen in 29 children ( median age : 8 years , range : 3 21 ; median weight : 34 kg , range : 15 73 ) with ALL in second remission ( CR 2 : 21 ) , in CR 3 ( 2 ) or ANLL in CR 1 ( 6 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We compared outcomes and toxicities in 712 patients with ALL ( 517 URD , 195 Auto ) in first complete remission ( CR 1 ) or second complete remission ( CR 2 ) who underwent transplantation . ^^^ The proportion of patients in CR 1 versus CR 2 was similar ( 36 % versus 38 % , P = . 57 ) , but more URD recipients than Auto recipients had high risk karyotypes ( 25 % versus 13 % , P = . 003 ) and white blood cell ( WBC ) counts > or =50 10 10 ( 9 ) / L ( 33 % versus 14 % , P < . 001 ) . ^^^ Transplantation related mortality was higher after URD transplantation ( 42 % + / 8 % ) than after Auto transplantation ( 20 % + / 12 % ) in CR 1 ( P = . 004 ) and also in CR 2 . ^^^ Conversely , relapse was more frequent after Auto transplantation in CR 1 ( Auto , 49 % + / 12 % versus URD , 14 % + / 5 % ) and CR 2 ( 64 % + / 8 % versus 25 % + / 5 % ) ( P < . 0001 ) . ^^^ Transplantation in CR 1 yielded similar 3 year survival rates for URD ( 51 % + / 7 % ) and Auto ( 44 % + / 12 % ) , as did transplantation in CR 2 ( 40 % + / 6 % versus 32 % + / 9 % , respectively ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
These findings demonstrate that abnormalities in CR 1 and CR 2 may be linked to the production of autoantibodies by modifying the effect of other systemic lupus erythematosus susceptibility genes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The effect of CR 2 has not been dissected from that of CR 1 in the animal studies performed to date . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Twenty patients were in first complete remission ( CR 1 ) , two in CR 2 , and all were in performance status 0 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Patients with AML were one in CR 1 , one in CR 2 while 4 patients with CML were two in CP and two in AP . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
And auto BMT or auto PBSCT , with conditioning regimen of MAC or MAC + VP 16 , was used to treat 7 cases of hematopathy , including 5 cases of ANLL ( 3 of CR 1 and 2 of CR 2 ) and 2 cases of malignant lymphoma ( 1 of first occurring and 1 of relapse ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The B cell C receptor specific for C3dg ( CR 2 ) shares a number of features with the primate E C receptor ( CR 1 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CDP / Cux ( CCAAT displacement protein / cut homeobox ) contains four DNA binding domains , namely , three Cut repeats ( CR 1 , CR 2 , and CR 3 ) and a Cut homeodomain . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Thirty one trials containing at least 20 patients in first relapse and information on patient age , duration of first complete remission ( CR 1 ) , and rate of second complete remission ( CR 2 ) were analyzed . ^^^ The CR 2 rates were closely associated with age and duration of CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A total of 112 patients with de novo AML in first complete remission ( CR 1 ) , n=90 or second complete remission ( CR 2 , n=22 ) who received un manipulated bone marrow grafts from human leukocyte antigen identical siblings between January 1985 and August 2000 were included . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This review focuses on the role of complement receptors CR 1 ( CD 35 ) and CR 2 ( CD 21 ) expressed on B lymphocytes , which interact with ligands generated upon activation of component C 3 , the major protein of the complement cascade . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Point mutations in UL 15 were designed in four conserved regions : L120N ( CR 1 ) , Q205E ( CR 2 ) , Q251E ( CR 3 ) , G263A ( CR 3 ) , and Y285S ( CR 4 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We analyzed 95 children receiving UCB transplants for AML ( 20 in first complete remission [ CR 1 ] , 47 in CR 2 , and 28 in more advanced stage ) . ^^^ The 2 year leukemia free survival ( LFS ) was 42 % + / 5 % ( 59 % + / 11 % in CR 1 , 50 % + / 8 % in CR 2 , and 21 % + / 9 % for children not in CR ) . ^^^ In CR 2 , LFS was not influenced by the length of CR 1 ( 53 % + / 11 % in CR 1 < 9 . 5 months compared with 50 % + / 12 % in later relapses ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Remission status included 12 patients in CR 1 , 25 in CR 2 , and six in CR 3 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Mutational analyses of HPV 16 E7 indicate that the major activity resides in amino acids 9 to 38 , spanning CR 1 and CR 2 , and does not require casein kinase 2 or Rb binding domain functions . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
OBJECTIVE : The rationale for this retrospective study was to identify the long term overall and event free survival , relapse , and treatment related mortality rates of high risk pediatric and adult first ( CR 1 ) and second remission ( CR 2 ) patients with acute lymphoblastic leukemia ( ALL ) who were treated with a single preparatory regimen consisting of fractionated total body irradiation ( FTBI ) and high dose etoposide ( VP 16 ) prior to allogeneic hematopoietic cell transplantation . ^^^ PATIENTS AND METHODS : Over a 15 year period at Stanford University Medical Center , 85 consecutive high risk pediatric ( up to age 17 years ; n=41 ) and adult ( age 18 55 years ; n=44 ) ; patients with leukemia ( ALL ) in CR 1 ( n=55 ) and CR 2 ( n=30 ) received HLA matched sibling allogeneic bone marrow or peripheral blood progenitor grafts after being treated with FTBI ( 1320 cGy ) and high dose VP 16 ( 60 mg / kg ) as their preparatory regimen . ^^^ Most patients transplanted in CR 1 were adults ( n=39 ) , whereas patients in CR 2 were primarily children or adolescents ( n=25 ) . ^^^ RESULTS : The 10 year Kaplan Meier estimates of relapse were significantly ( p=0 . 05 ) lower in CR 1 patients ( 15 % + / 10 % ) than in CR 2 patients ( 33 % + / 20 % ) . ^^^ There was a significantly ( p=0 . 05 ) higher rate of chronic graft vs host disease in CR 1 ( 32 % + / 14 % ) compared with CR 2 ( 9 % + / 11 % ) patients ; however , overall survival for patients transplanted in CR 1 ( 66 % + / 14 % ) was comparable ( p=0 . 67 ) to that of patients transplanted in CR 2 ( 62 % + / 19 % ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Within this cohort , there was no significant survival difference between patients treated in first ( CR 1 , n = 7 ) or second ( CR 2 , n = 5 ) complete remissions . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Complement receptors type 1 ( CR 1 , CD 35 ) and 2 ( CR 2 , CD 21 ) cooperate in the binding of hydrolyzed complement factor 3 ( C3i ) to human B lymphocytes . ^^^ To evaluate this hypothesis , we examined the uptake kinetics and binding equilibria for C3i dimer interaction with human blood cells in the absence and presence of CR 1 and CR 2 blocking mAb . ^^^ C3i displayed dual uptake kinetics to B lymphocytes , comprising of rapid binding to CR 1 and slower binding to CR 2 . ^^^ The forward rate constants ( k ( 1 ) ) for CR 1 and CR 2 , operating independently , differed ca . 9 fold ( k ( 1 ) =193+ / 9 . 4 and 22 . 2+ / 6 . 0 10 10 ( 3 ) M ( 1 ) s ( 1 ) , respectively ) . ^^^ The maximum association constant ( K ( a , max ) =109+ / 27 . 2 10 10 ( 7 ) l / mole ) was ca . 9 and 6 fold greater , respectively , than those for CR 1 or CR 2 acting alone ( K ( a ) =13 . 2+ / 5 . 3 and 18 . 5+ / 3 . 5 10 10 ( 7 ) l / mole ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
METHODS : 31 patients with APL , 27 in first complete remission ( CR 1 ) , 3 in CR 2 , and 1 in partial remission ( PR ) after the second relapse , were treated with autologous transplantation of ABM . ^^^ Kaplan Meier survival analysis model was used to estimate the disease free survival ( DFS ) rate at 5 years post transplantation and COX regression model was used to analyze the DFS influencing factors , including sex , PML / RARa positive state , pre transplantation state ( CR 1 , CR 2 , or PR ) , white blood cell ( WBC ) count , and platelet ( PBC ) count . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Significant homology between these proteins is confined to three conserved regions of their amino acid sequences which we have designated CR 1 , CR 2 and CR 3 . ^^^ CR 1 and CR 3 contain highly conserved residues which have been shown to be important for the normal function of WNK 1 and WNK 4 , and CR 2 contains a highly conserved 22 amino acid motif specific to chordate species . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In our single center study , we performed RT PCR monitoring in 14 patients with t ( 8 ; 21 ) in CR 1 ( n = 13 ) and / or CR 2 ( n = 4 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CR 1 and CR 2 expression is decreased by approximately 50 % on B cells of patients with systemic lupus erythematosus ( SLE ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Both the absence of CR 2 expression ( along with the alternatively spliced gene product CR 1 ) and the presence of a dysfunctional CR 2 protein are tightly associated with the development of autoreactivity to nuclear antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Two communities ( CR 1 and CR 2 ) showed nearly equal degrees of degradation across a salinity range of 0 % 10 % ( the former degrading about 63 % of the diesel fuel and the latter about 70 % after 53 and 80 d , respectively ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Thereafter , the subjects in the Cr 2 group continued 3 g Cr ingestion a day for 2 weeks while the Cr 1 group ingested the same amount of placebo during the 3 ( rd ) and 4 ( th ) weeks . ^^^ In the Cr groups , the significant decrease was detected from the 3 ( rd ) in the Cr 1 and in the 4 ( th ) measurement in the Cr 2 group . ^^^ In the 1 ( st ) measurement , the mean torque in the Cr 1 group was significantly higher than that in the Cr 2 group ( p < 0 . 05 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We have tested this model in the context of the full length EGFR displayed at the cell surface , by introducing mutations in two regions ( CR 1 and CR 2 ) of the extracellular domain thought to be critical for regulation of receptor activation . ^^^ Mutations in the CR 1 and CR 2 domains have opposing effects on ligand binding affinity , receptor dimerization , tyrosine kinase activation , and signaling competence . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In Al ( 3 ) / SiO2 systems with high Al concentrations of 1 10 10 ( 3 ) , 5 10 10 ( 3 ) and 1 10 10 ( 2 ) M , three charge reversals ( CR ) are observed , separately representing , in order of increasing pH , the point of zero charge ( PZC ) on the SiO 2 substrate ( CR 1 ) , the onset of the surface precipitation of Al hydroxide ( CR 2 ) , and at a high pH , the PZC of the Al ( OH ) 3 coating ( CR 3 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Therefore , a chimeric E1A / E7 gene was constructed that included the N terminus and the CR 1 ( p 300 binding ) domain of E1A fused to CR 2 and the C terminal sequences of E 7 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We performed HLA mismatched stem cell transplantations with megadoses of purified positively selected mobilized peripheral blood CD34+ progenitor cells ( PBPC ) from adult donors in 27 children with acute lymphoblastic leukemia ( ALL ) in first ( CR 1 n = 7 ) , second ( CR 2 n = 10 ) , or third ( CR 3 n = 4 ) complete remission , and in refractory state ( NR n = 6 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CDP / Cux proteins contain four DNA binding domains , three Cut repeat ( CR 1 , CR 2 and CR 3 ) and one Cut homeodomain ( HD ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Sixty seven patients with acute myeloid leukemia ( AML ; 19 complete remission [ CR ] 1 , 14 CR 2 , nine CR > 2 , 25 in relapse ) and 37 with acute lymphoid leukemia ( ALL ; 14 CR 1 , eight CR 2 , two CR > 2 , 13 in relapse ) were conditioned with total body irradiation , thiotepa , fludarabine , and antithymocyte globulin . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Recently , we showed that a subset of CD44high and CD62Llow T cells also expresses CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Of 21 patients with less advanced disease , two were in CR 1 , four were in CR 2 , and 15 were in first responding relapse . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The CCAAT displacement protein / Cut homeobox ( CDP / Cux ) transcription factor is expressed as multiple isoforms that may contain up to four DNA binding domains : Cut repeats 1 , 2 , and 3 ( CR 1 , CR 2 , CR 3 ) and the Cut homeodomain ( HD ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The cerebellar activation was confined to the lateral posterior cerebellar hemisphere ( lobule 6 , 7 B , Cr 1 , Cr 2 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Genomic analysis reveals a duplication of eight rather than seven short consensus repeats in primate CR 1 and CR1L : evidence for an additional set shared between CR 1 and CR 2 . ^^^ Since g like SCRs are found immediately downstream of d SCRs , we suggest that there must have been a functional dg set which has been retained by CR 2 and MCP but which is degenerate in CR 1 or CR1L . ^^^ Interestingly , dg is also present in the CR 2 component of mouse CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Conversely , as these studies have proceeded , a parallel series of analyses have linked defects in expression or function of complement C 4 and other classical pathway activation pathway proteins , as well as CR 2 and the closely related CR 1 , to the loss of self tolerance to nuclear antigens such as double stranded DNA and chromatin in systemic lupus erythematosus . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
One format ( CR 1 ) used one supervised exercise session per week over 52 weeks , and the second format ( CR 2 ) used weekly supervised sessions for 26 weeks followed by one supervised session per month for the remaining 26 weeks . ^^^ The program costs for both the CR 1 and CR 2 formats were calculated from known expenses . ^^^ RESULTS : Because there were no significant intercohort differences between CR 1 and CR 2 and no significant interaction ( time 10 group ) , data from the two cohorts were pooled for statistical analysis . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Short duration of CR 1 and of CR 2 and extramedullary site at first relapse are particularly adverse . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
More decisively , mice that genetically lack the third component of complement or complement receptor 1 ( CR 1 ) and CR 2 developed increased CNS virus burdens and were vulnerable to lethal infection at a low dose of WNV . ^^^ Both C 3 deficient and CR 1 and CR 2 deficient mice also had significant deficits in their humoral responses after infection with markedly reduced levels of specific anti WNV immunoglobulin M ( IgM ) and IgG . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The human complement RCA proteins analyzed were factor H ( FH ) , C 4 binding protein alpha chain , membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , and complement receptors type 1 ( CR 1 ) and 2 ( CR 2 ) . ^^^ Sequences of key poxvirus regulators of complement activation , vaccinia virus complement control protein ( VCP ) , smallpox inhibitor of complement enzymes ( SPICE ) , and cowpox inflammation modulatory protein ( IMP ) were similar to SCRs 1 through 5 of C 4 binding protein , alpha chain , and they were also clustered with other homologous repeats of MCP , DAF , CR 1 , CR 2 , and FH . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The globular domains correspond to the variable target recognition domains ( TRDs ) , as previously defined for S subunits on sequence analysis , while the two helices correspond to the central ( CR 1 ) and C terminal ( CR 2 ) conserved regions , respectively . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Repeated measures of axial length , anterior chamber depth , and greatest and least corneal radius of curvature ( CR 1 , CR 2 , respectively ) were taken in each eye . ^^^ Mean CR 1 was 7 . 85 + / 0 . 01 mm ( SEM ) and mean CR 2 was 7 . 71 + / 0 . 01 mm ( SEM ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The disease free survival ( DFS ) was 52+ / 4 % for non allografted patients and 57+ / 7 % for allografted patients ( P=NS ) ; a better OS for allografted patients was shown and could be related either to allo BMT early in CR 1 or to a second allo BMT in CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We also newly identified a putative negative cis acting element located between CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Furthermore , gene knockout studies in mice implicate a role for CR 1 ( along with the alternatively spliced gene product CR 2 ) in prevention of autoimmunity . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In this study , we compared the oncolytic potencies of three mutant adenoviruses encompassing deletions within the CR 1 ( Delta 39 ) , CR 2 ( Delta 24 ) regions , or both regions ( Delta 24 / 39 ) of the E1A protein . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
However , the ability of C3d protein conjugates to enhance the antibody response in mice deficient in complement receptor types 1 and 2 ( CR 1 and CR 2 ) has raised questions about the role of C3d CR 2 interactions in the adjuvant effect of C3d . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Forty three patients were transplanted in CR 1 ; 25 in CR 2 or CR 3 ; four were primary refractory ; four in PR ; eight in relapse . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Such a hybrid DNA molecule was constructed by us , encoding a T and B cell epitope containing influenza hemagglutinin peptide and a scFv antibody fragment binding to mouse complement receptors 1 and 2 ( CR 1 and CR 2 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The experimental variables were : ( 1 ) salt based versus a sugar based medium ( Tris versus sucrose ) ; ( 2 ) glycerol concentration ; ( 3 ) detergent ( Equex ) concentration ; ( 4 ) presence of bicarbonate ; ( 5 ) rate of cooling from 22 degrees C to holding temperature ( CR 1 ) ; ( 6 ) holding temperature ( HT ) ; ( 7 ) rate of cooling from holding temperature to 6 degrees C ( CR 2 ) ; ( 8 ) rate of cooling from 10 to 100 degrees C ( CR 3 ) . ^^^ CR 1 and CR 2 had no significant effect on any of the post thaw sperm viability parameters , but a CR1=0 . 2 degrees C / min and CR2=4 degrees C / min appeared to give better results in both media . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Considering that complement receptors CR 1 and CR 2 are involved in the regulation of B cell response , we evaluated the in vitro effect of the F 1 in the activation of B lymphocytes , as well as the participation of complement receptors in this process . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
To compare autologous versus URD transplantation for AML in first ( CR 1 ) or second complete remission ( CR 2 ) , we studied the outcomes of 668 autotransplants were compared with 476 URD transplants reported to the Center for International Blood and Marrow Transplant Research . ^^^ Adjusted 3 year survival probabilities were : in CR 1 57 ( 53 61 ) % with autotransplants and 44 ( 37 51 ) % URD ( P = 0 . 002 ) , in CR 2 46 ( 39 53 ) % and 33 ( 28 38 ) % respectively ( P = 0 . 006 ) . ^^^ Adjusted 3 year leukaemia free survival ( LFS ) probabilities were : CR 1 53 ( 48 57 ) % with autotransplants and 43 ( 36 50 ) % with URD ( P = 0 . 021 ) , CR 2 39 ( 32 46 ) % and 33 ( 27 38 ) % respectively ( P = 0 . 169 ) . ^^^ This retrospective , observational database study showed that autotransplantation , in general , offered higher 3 year survival for AML patients in CR 1 and CR 2 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The alignment of the obtained sequences was the basis for the specific design of species specific primers ( ED 1 , ED 2 , ST 1 , ST 2 , CR 1 , and CR 2 ) located in the nontranscribed spacer regions . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Group Cr 1 received , i . p . , CrEL at 0 . 046ml / kg daily for 7 days , group Cr 2 received CrEL at 0 . 33ml / kg and the controls were injected with CrEL vehicle ( saline solution with 25 % ethanol ) . ^^^ The cytosolic concentration of thiobarbituric acid reactive substances ( TBARS ) increased in both groups of rats receiving CrEL ( Cr 1 : +24 % ; Cr 2 : +33 % ) . ^^^ Reduced glutathione ( GSH ) concentration was not significantly modified at any of the CrEL doses , but both the hepatic concentration of oxidised glutathione ( GSSG ) ( Cr 1 : +37 % ; Cr 2 : +84 % ) and the GSH / GSSG ratio ( Cr 1 : 21 % ; Cr 2 : 45 % ) were significantly modified . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Nine patients received HDC / ASCT in the first ( CR 1 ) or second complete remission ( CR 2 ) , while seven patients received HDC / ASCT as salvage . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Deletion of the amino terminus of pp 150 or disruption of the betaherpesvirus conserved regions , CR 1 and CR 2 , revealed these regions to be critical for replication . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
One hundred forty one patients received transplants in first remission ( CR 1 ) , 47 received transplants in second remission ( CR 2 ) , and 65 patients received transplants in a more advanced phase . ^^^ Higher cell doses exclusively benefited patients who received transplantations in CR 2 or beyond , with LFS of 47 + / 8 versus 20 + / 8 , with no detectable effect for patients who received transplants in CR 1 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Transplants using haploidentical donors are most successful if undertaken in CR 1 and CR 2 and appear to produce EFS rates of about 25 % . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In the GCs of both synovial tissues and lymph nodes in RA , early C components ( C1q , C 4 , C3c , C3d ) , IgM RF , and C3b receptor ( C3bR ) and C3d receptor ( C3dR ) were expressed as a lacy network by light microscopy , and were demonstrated on the surfaces of FDCs and lymphocytes , and in the intercellular spaces by electron microscopy . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In the GCs five complement components ( C1g , C 4 , C3c , C3d , C 5 ) and complement receptors ( C3bR and C3dR ) were positive , displaying a lace like pattern , which were proved , electron microscopically , to coincide with the surface of FDCs and GC cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Receptors for sheep erythrocytes , for the Fc part of IgG ( Fc gamma R ) and IgM ( Fc mu R ) , and for components of activated human complement C 3 ( C3bR and C3dR ) in thymus tissue from fetuses , infants and children were studied using haemadsorption to cryostat sections in a closed chamber . ^^^ Indicator cells demonstrating C3bR adhered focally also to sections from infants and children , while indicator cells demonstrating C3dR did not adhere to sections from individuals older than 38 weeks of gestation . ^^^ Indicator cells demonstrating C3bR and C3dR adhered both to cortex and medulla . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The inflammatory cell infiltrates in human dental periapical granulomas were studied through the demonstration of receptors ( R ) for fragments C3b and C3d of the complement component C 3 , C3bR and C3dR were detected in cryostat sections by the closed chamber hemadsorption technique . ^^^ Of the 62 granulomas studied , 23 showed strong or moderate C3bR activity , and weak C3dR activity was detected in 5 out of 25 specimens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We seldom found cells positive for delta H chain or C3bR ( CD 35 ) ; C3dR ( CD 21 ) positive cells were even more scarce . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Specifically , M phi s from the FHS cases expressed complement receptors , 1 , 2 , and 3 ( CD 35 , CD 21 , and CD11b , respectively ) , the monocyte antigen CD 36 , and the `` activation ' ' antigens CD 25 ( IL 2 R ) and CD 30 ( Ki 1 ) , while those from the IAHS / idiopathic case did not . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CD 3 , CD 5 , CD 19 , CD 20 , CD 21 , CD 22 , CD 24 , CD 35 , CD 38 positive cells were observed . ^^^ These cells were also IgM / D , CD 19 , CD 20 , CD 21 , CD 22 , CD 24 and CD 35 positive . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Monoclonal antibodies against CD 45RB , CD 20 , CD 21 , CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The cell line express CD 20 ( 79 % ) , CD 21 ( 30 % ) , CD 30 ( 63 % ) , CD 35 ( 61 % ) antigens and weakly CD 25 ( 19 % ) . using Southern Blot technique , the existence of specific EBV DNA and polyclonal immunoglobulin genes rearrangement were observed in the cell line . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
DRC 1 , CD14b , CD 21 , CD 23 , CD 35 ) disappeared within a few days of culture . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The distribution and frequency of follicular dendritic cells ( FDC ) and of interdigitating cells ( IDC ) were examined with the monoclonal antibodies J3D3 ( directed against the C3b complement receptor , CD 35 ) and IOB1a ( specific for the C3D , CD 21 ) as well as with the polyclonal anti S 100 protein antiserum in Bouin fixed , paraffin embedded sections using a Streptavidin biotin peroxidase technique . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A larger fraction of B cells in B CLL compared to B MLUS exhibited a higher activation stage as revealed by the expression of the CD 21 , CD 25 and CD 35 structures as well as the FMC 7 antigen . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Cells expressing markers of more mature B cells ( surface IgD , CD 35 , and CD 21 ) were rare . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Like normal FDCs , the leukocyte antigens CD 35 , CD 19 , CD 21 , and CD 23 were expressed strongly and CD 4 antigen weakly . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Binding of CD 35 , CD 21 and CD 11B monoclonal antibodies and EAC complexes to lymphocytes . ^^^ Using cryostat sections of human tonsils after various pretreatments , the adherence of sheep erythrocyte antisheep erythrocyte ( EA ) complexes coated with either fresh mouse complement ( EACm ) or fresh human complement ( EACh ) has been compared with the binding of monoclonal antibodies ( MAbs ) against C3b ( CD 35 ) , C3d ( CD 21 ) and iC3b ( CD 11b ) receptors ( clusters ) . ^^^ After periodic acid oxidation the binding of MAbs to CD 35 , CD 21 was well preserved , whereas EACm and EACh complex adherence and CD 11b binding were abolished . ^^^ These findings seem to prove that the binding sites for EACm and EACh complexes , as well as those for CD 35 , CD 21 clusters ( antigenic structure of the C3b and C3d receptors ) are different . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The majority of B CLL cells expressed Ia , B 4 ( CD 19 ) , B 1 ( CD 20 ) , B 2 ( CD 21 ) , surface immunoglobulin ( sIg ) , and T 1 ( CD 5 ) but lacked C3b ( CD 35 ) receptors . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In the current studies , we incubated purified small resting B cells with 100 nm latex beads bearing various combinations of CD 21 ligands and mAbs to CD 19 , CD 35 , and the Ag receptor . ^^^ CD 21 , CD 19 , and CD 35 have all been implicated in modulating membrane IgM initiated signaling . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Paraffin embedded tissues were stained with current histological methods and immunohistochemically processed with a panel of antibodies against DRC ( CD 21 , CD 35 , IgM ) ; endothelial cells ( factor 8 R . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In all tissues , connexin 43 positivity was detected in follicular dendritic cells positive for CD 21 and CD 35 antigens , around lymphoendothelial cells moderately positive for Factor 8 , CD 31 and cathepsin D antigens ; and somewhat in vascular endothelia including high endothelial venules strongly positive for Factor 8 and CD 31 antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Mast cells from all organs as well as HMC 1 cells expressed CD 46 , CD 55 , and CD 59 , but not CD11b , CD 21 , or CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
By constructing chimeric molecules replacing the extracellular , transmembrane , and cytoplasmic regions of CD 19 and CD 21 with those of HLA A 2 and CD 4 , we have determined that CD 19 and TAPA 1 interact through their extracellular domains , CD 19 and CD 21 through their extracellular and transmembrane domains , and , in a separate complex , CD 21 and CD 35 through their extracellular domains . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Expression of CD 21 and CD 35 , together with ultrastructural demonstration ( in one case ) of long cytoplasmic processes connected by desmosomes , confirmed follicular dendritic cell differentiation . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Hybridization of HeLa messenger RNA with complementary DNA probes for human complement receptors revealed strong expression of CD 21 message but failed to detect message for CD 35 ( complement receptor type 1 ) or CD 18 ( beta chain of complement receptor types 3 and 4 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
On the surface of their dendritic extensions they express transferrin receptors ( CD 71 ) , the B cell epitope CD 20 , class 2 antigens , the myelomonocytic molecule CD 14 , the glycoprotein gp 50 ( CD 40 ) , and several receptors for components of the complement system ( CD11b , CD 21 , CD 35 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The follicular dendritic cell nature of the tumor was confirmed by immunoreactivity with CD 21 and CD 35 antibodies and by ultrastructural demonstration of cell processes connected by desmosomes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The diagnosis in both cases was confirmed by immunoreactivity with CD 21 and CD 35 and by ultrastructural demonstration of interdigitating cell processes with desmosomes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Using parallel cells differentially stimulated with TNF alpha , gamma IFN or thrombin , antibodies within CD 1 through to CD 15 , CDw 17 to CD 19 , CD 21 to CD 23 , CD 26 , CD 27 , CD 29 , CD 30 , CD 33 to CD 35 , CD 37 , CD 38 , CD 40 , CD 43 to CD 46 , CD 48 , CD 51 to CD 53 failed to provide any consistent alteration to reactivity patterns compared to non stimulated cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
This effect is mediated by specific receptors , mCR 1 ( CD 35 ) and mCR 2 ( CD 21 ) , expressed primarily on B cells and follicular dendritic cells in mice . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The tumor cells were positive for CD 21 ( 10 of 11 ) , CD 35 ( 10 of 11 ) , Ki M4p ( seven of eight ) Ki FDRC1p ( six of seven ) , vimentin ( five of nine ) , and S 100 protein ( five of nine ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Three monoclonal antibodies selective for follicular dendritic cells were used : CD 21 , CD 35 and DR 53 , all reactive on paraffin embedded material . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The diagnosis was confirmed by positive immunohistochemical staining with CD 21 , CD 35 , R4 / 23 , and Ki M 4 and by ultrastructural demonstration of convoluted interdigitating cell processes joined by desmosomes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In contrast to B cells , where CD 21 is complexed with CD 19 and CD 81 ( target of anti proliferative Ab 1 ) or , alternatively , with CD 35 ( CR 1 ) , no surface molecules could be coprecipitated with three of four mAbs from these T cell lines . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Paraffin embedded tissues were stained by current histochemical methods and immunohistochemically processed with a panel of antibodies against dendritic reticulum cells ( DRC ) ( CD 21 , CD 35 ) , endothelial cells ( QBEnd / 10 CD 34 , CD 31 , Factor 8 RAg ) , B lymphoid cells ( L 26 , MB 2 ) , T lymphoid cells ( UCHL 1 , DF T 1 , OPD 4 ) , monocytic cells ( PGM 1 , KP 1 ) and interdigitating dendritic cells ( S 100 protein , PGM 1 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The neoplastic cells were immunoreactive for CD 21 ( 17 of 17 cases ) , CD 35 ( 17 of 17 cases ) , desmoplakin ( 10 of 17 cases ) , epithelial membrane antigen ( 14 of 16 cases ) , S 100 protein ( 6 of 17 cases ) , and CD 68 ( 2 of 17 cases ) , but not cytokeratin . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Cx 43 colocalized with CD 21 and CD 35 antigens in the vicinity of desmosomal junctions on FDC embracing lymphocytes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The diagnosis was confirmed using immunoreactivity with CD 21 and CD 35 antibodies and by ultrastructural demonstration of interdigitating cell processes with desmosomes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
For more atypical tumor cells , arranged in a sheet like structure , were present in the inguinal specimen , the tumor cells of which expressed Ki M4p , CD 21 , CD 35 and other antigens known to be expressed on FDC . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The only distinguishing feature in pathology is the expression of CD 21 , CD 30 and CD 35 antigens by histiocytes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In contrast , a higher proportion of B cells in LN stains positive for CD 21 and CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Finally , the presence of CD 21 , CD 32 , CD 35 and CD 64 that may bind immune complexes via Fc or C 3 , suggests their participation in the metabolism of immune complexes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The diagnosis was confirmed by positive immunoreactivity with CD 21 and CD 35 antibodies and by ultrastructural demonstration of convoluted interdigitating cell processes connected by scattered desmosome like junctions . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
For additional definition of the immunophenotype of these unusual B cell lymphomas , we evaluated eight cases of MVL for B cell associated antigens ( CD 21 , CD 35 , CDw 75 , DBA . 44 , bcl 2 ) using paraffin immunoperoxidase . ^^^ DBA . 44 and CD 21 and CD 35 were negative in all of the cases , and four cases ( 50 % ) of eight expressed CD 56 . bcl 2 protein expression was seen in seven of eight cases ; bcl 2 gene rearrangement was present in one case ( 33 % ) of three studied . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
We review results which support an important role for complement in maintenance of B 1 cells , the effect being mediated by B cell expression of complement receptors CD 21 and CD 35 . ^^^ This hypothesis is supported by the finding that mice deficient in CD 21 and CD 35 have a reduced number of CD5+ B 1 cells and are missing specificities for certain antigens commonly found in wild type mice , such as lipopolysaccharide , Escherichia coli surface antigens and neoepitopes expressed on hypoxic intestinal endothelium . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Covalent attachment of activated complement C 3 ( C3d ) to antigen links innate and adaptive immunity by targeting antigen to follicular dendritic cells ( FDC ) and B cells via specific receptors CD 21 and CD 35 . ^^^ Recent characterization of knockout mice deficient in complement components C 3 , C 4 , or the receptors CD 21 and CD 35 as well as biochemical studies of the CD21 / CD19 / Tapa 1 coreceptor on B cells have helped to elucidate the mechanism of complement regulation of both B 1 and B 2 lymphocytes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The tumor cells typically express CD 21 , CD 35 , Ki M4p , Ki FDRC1p , and vimentin , with occasional positivity for S 100 protein , muscle specific actin , and epithelial membrane antigen . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The FDC tumors showed immunoreactivity for CD 21 or CD 35 , vimentin , and CD 68 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The eight cases that showed the largest number of desmin positive cells were immunostained for smooth muscle actin , CD 45 , CD 68 , CD 21 , CD 35 , cytokeratin 8 , and Factor XIIIa . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Light microscopy ( LM ) and transmission electron microscopy ( TEM ) , in situ hybridization ( ISH ) ( HIV specific RNA ) , and immunohistochemistry ( HIV p 24 , OPD 4 , CD 3 , CD 45 UCHL , CD 21 , CD 35 , S 100 , p 55 ( actin bundling protein ) , CD 68 , HAM 56 , alpha 1 antitrypsin , alpha 1 antichymotrypsin , and lysozyme ) studies were performed on hyperplastic tonsil , adenoid , lymph node , and intestinal MALT specimens from HIV+ patients . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A transient increase in the tyrosine phosphorylation of the complement receptors , CD 21 and CD 35 was observed in BCR but not CD 72 stimulated cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemically , the whorl forming spindle cells showed alpha smooth muscle actin reactivity in three of seven cases but were negative for epithelial membrane antigen , CD 21 , and CD 35 indicating lack of relationship with meningioma and dendritic reticulum cell sarcoma , other tumours that may contain whorls . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Paraffin embedded tonsil specimens were stained by current histochemical methods and immunohistochemically processed with a panel of antibodies against follicular dendritic reticulum cells ( CD 21 and CD 35 ) , endothelial cells ( Factor 8 R . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The binding required CD 21 or , to a lesser extent , complement receptor 1 ( CR 1 , CD 35 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The latter were neoplastic growths of oval to spindle cells intermixed with lymphocytes ; the tumor cells grew in long , intersecting bundles , featured various degree of atypia , and expressed the markers of follicular dendritic cells ( CD 21 , CD 35 , KiM4p ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Two proteins known to form complexes with CD 21 on the surface of lymphoid cells , CD 35 and CD 19 , could not be detected at the surface of 293 cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemically , tumor cells were positive for the follicular dendritic cell markers CD 21 , CD 35 , and CD 23 and for S 100 protein , CD 68 , and muscle specific actin . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A review of the entire case with further immunoreactivity for CD 21 and CD 35 confirmed the diagnosis of FDC . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The neoplastic cells were immunoreactive for CD 21 , CD 35 , EMA , and S 100 protein , but not for other lymphoid markers or cytokeratin . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Six CD antigens ( CD 20 , CD 21 , CD 22 , CD 32 , CD 35 and major histocompatibility complex class 2 antigen ) normally found on the surface of B cells , were also found to be expressed within T cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Neoplastic cells were positive for immunohistochemical markers vimentin , CD 68 , CD 21 , CD 35 and R 4 / 23 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The fascicular arrangement of syncytial plump to spindle cells in a background of mixed inflammatory cells was the initial clue to the diagnosis , which was confirmed by the immunoreactivity of the tumour cells to follicular dendritic cell markers ( CD 21 and CD 35 ) , and by the demonstration of focal intercellular desmosome like junctions between the complex cytoplasmic processes of the tumour cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
They were also focally positive for CD 68 and CD 4 , but were uniformly negative for leukocyte common antigen , CD1a , CD 3 , CD 20 , CD 21 , CD 23 , CD 34 , CD 35 , actin , desmin , HMB 45 , cytokeratins , and placental alkaline phosphatase . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
However , CD19+CD5+ cells were negative for kappa light chain , CD 10 , CD11a , CD11b , CD 15 , CD 21 , CD 22 , CD 23 , CD 25 , CD 34 , CD 35 , CD 44 , CD62L , CD 69 , and CD 71 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
All tumors were positive for vimentin and negative for CD 21 , CD 35 , S 100 protein , CD 34 , keratins 8 / 18 , and lysozyme . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunostains for CD 21 and CD 35 , performed on the cell block , were positive in the neoplastic cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The dendritic cell neoplasm exhibited reactivity with CNA 42 , but nonreactivity for CD 21 , CD 35 , smooth muscle actin , desmin , and epithelial membrane antigen ( EMA ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemically , the tumour cells were positive for CD 21 , CD 35 and CD 68 , but negative for cytokeratin , CD 34 , smooth muscle actin , desmin , S 100 protein , epithelial membrane antigen , leukocyte common antigen , HMB 45 and c kit . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Additional immunostainings directed at CD 21 and CD 35 as well as at the HIV associated p 24 antigen were also performed . ^^^ Phenotypically , MGCs were found to be CD68+ , 3A5+ , major histocompatibility complex Class II+ , S 100 protein+ / , CD1a , CD 21 , CD 35 , and CD 83 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
All were negative for epithelial mucin ( D / PAS ) , CEA , BerEP 4 , LeuM 1 ( CD 15 ) , CD 21 , CD 35 , and S 100 protein . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
None of those cases was reactive for CD1a , CD 3 , CD 21 , CD 34 , or CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Follicular dendritic cells in reactive and neoplastic lymphoid tissues : a reevaluation of staining patterns of CD 21 , CD 23 , and CD 35 antibodies in paraffin sections after wet heat induced epitope retrieval . ^^^ Wet heat induced epitope retrieval in Dako Target Retrieval Solution ( TRS ) ( pH 6 . 0 ) enabled the reliable detection of FDCs through CD 21 , CD 23 , and CD 35 antigens in routinely processed tissues from 11 reactive and 69 neoplastic lymphoproliferations , thus allowing the distribution of the FDCs to be reevaluated . ^^^ In four cases of nodular lymphocyte predominance Hodgkin ' s disease ( HD ) , expanded FDC meshwork ' s sharply delineating negative tumor cells and their rosetting T cell , were revealed mainly with the CD 21 and CD 35 antibodies . ^^^ Reproducible demonstration of FDCs in routinely processed paraffin sections with CD 21 , CD 23 , and CD 35 antibodies , as presented here , provides invaluable pieces of information in the diagnosis of lymphoproliferative disorders . . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The tumour cells expressed the FDC markers CD 21 , CD 35 and CNA . 42 and in situ hybridization for Epstein Barr virus encoded RNAs was negative . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemically , the neoplastic spindled cells expressed complement receptors CD 21 and CD 35 and low affinity nerve growth factor receptor but did not express keratin ( AE1 / AE3 and CAM5 . 2 ) , CD 45 ( leukocyte common antigen ) , CD 20 ( L 26 ) , S 100 protein , muscle specific actin , or gp 100 protein ( HMB 45 ) . ^^^ An immunohistochemical panel , including anti CD 21 and CD 35 , can assist in its diagnosis , especially with small bronchial biopsy specimens . 2001 by W . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
However , immunohistochemical stains showed no expression of antigens characteristic of FDCs , including CD 21 , CD 23 and CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The diagnosis can be confirmed by positive immunostaining for CD 21 and CD 35 antigens and negative staining for cytokeratin . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
A panel of antibodies showed positivity only for CD 21 and CD 35 , and a weak response to S 100 . ^^^ The definitive diagnosis of FDT can be concluded only with positive immunostaining for CD 21 and CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemically , tumor cells were strongly and diffusely positive for follicular dendritic cell markers CD 21 and CD 35 . ^^^ Confirmatory immunohistochemical staining with follicular dendritic cell markers such as CD 21 and / or CD 35 is essential for the diagnosis . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
These markers include surface proteases ( CD 10 , CD 13 and CD 26 ) , antigen presenting cell markers ( CD 13 , CD 14 , CD 35 and CD 63 ) , integrins ( CD 18 and CD 61 ) , epithelial / endothelial markers ( CD 21 , CD 31 , CD 47 and CD 59 ) and finally , CD 25 and CD 28 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CD 21 , CD 35 , Ki M4p , Ki FDC1p , and S 100 exhibited variable reactivity . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistological studies for FDC antigens , such as CD 21 and CD 35 , led to final diagnosis . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Seeking to identify antigens detectable in paraffin embedded sections that might allow a more complete , rational immunophenotypic classification of histiocytic / dendritic cell neoplasms , the International Lymphoma Study Group ( ILSG ) stained 61 tumours of suspected histiocytic / dendritic cell type with a panel of 15 antibodies including those reactive with histiocytes ( CD 68 , lysozyme ( LYS ) ) , Langerhans cells ( CD1a ) , follicular dendritic cells ( FDC : CD 21 , CD 35 ) and S 100 protein . ^^^ This analysis revealed that 57 cases ( 93 % ) fit into four major immunophenotypic groups ( one histiocytic and three dendritic cell types ) utilizing six markers : CD 68 , LYS , CD1a , S 100 , CD 21 , and CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The neoplastic cells were intensely immunoreactive for CD 21 , S 100 protein and epithelial membrane antigen , and focally for CD 35 , CD 68 and cytokeratins . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemically , the spindle cells were positive for S 100 protein , CD 45 , CD 68 , and vimentin , but negative for CD 21 and CD 35 ( markers of follicular dendritic cells ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistologically , the cells were positive for CD 21 and CD 35 , consistent with FDC sarcomas . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
No follicle dendritic cell meshwork infrastructure underlying the nodules could be demonstrated by staining for CD 21 or CD 35 antigens . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The neoplastic cells failed to disclose CD 21 , CD 35 , or ALK expression , the latter confirmed by reverse transcription polymerase chain reaction . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The present study compared the expression of FDC markers CD 21 , CD 23 , CD 35 , and chemokine CXCL 13 and the stromal markers low affinity nerve growth factor receptor ( LNGFR ) and CNA . 42 in 35 follicular lymphoma ( FL ) cases with reactive lymphoic tissue . ^^^ CXCL 13 was expressed by follicular stroma in all FLs but most cases showed either partial ( 11 / 35 cases , 31 % ) or complete ( 10 / 35 cases , 29 % ) absence of other FDC antigens , most commonly CD 23 , followed by CD 21 and CD 35 , with variable patterns of LNGFR and CNA . 42 immunostaining . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The diagnosis of FDC sarcoma was confirmed by immunohistochemical staining for dendritic cell markers , that is , CD 21 , CD 23 , and CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Ten cases were further evaluated for the dendritic cell markers fascin , CD 21 , CD 23 , and CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Similarly , pretreatment of GT / mice with a blocking antibody to CD 21 and CD 35 inhibited production of alphaGal reactive antibodies after immunization . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemically , the spindle cells were positive for vimentin , S 100 protein , CD1a , factor XIIIa and focally to smooth muscle actin , but were negative for CD 21 , CD 35 , CD 23 and caldesmon all markers of follicular dendritic cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Identification and characterization of the complement receptors CD 21 and CD 35 and their expression on B lymphocytes provided evidence for a direct role for complement in `` linkage of innate and adaptive immunity ' ' . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
CD 19 , CD 20 , CD 21 , CD 22 , CD 35 receptors were found to be diminished . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Role of complement receptors 1 and 2 ( CD 35 and CD 21 ) , C 3 , C 4 , and C 5 in survival by mice of Staphylococcus aureus bacteremia . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The tumors were negative for ALK 1 , CD 21 , CD 35 , CD 3 , CD 20 , CD 34 , myeloperoxidase , HMB 45 , and keratins . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The tumor bulk demonstrated a diffuse and strong reaction with CD 10 , CD 20 , CD 21 , CD 35 , and stained weakly with CD79a . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The spindle cells were positive for follicular dendritic cell markers CD 21 , CD 35 , and epithelial membrane antigen . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
All cases were positive for CD 21 and CD 35 and ultrastructurally they displayed a morphologic spectrum . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
In addition , complement receptors ( CD 21 and CD 35 ) on B cells cooperate with the B cell antigen receptor ( BCR ) to efficiently recognize and respond to antigens bearing complement C3d ( g ) . ^^^ CD 21 and / or CD 35 engagement is nonmitogenic , and B cell activation via BCR CD 21 coligation is enhanced through the recruitment of CD 19 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
No lesions were positive for anaplastic lymphoma kinase 1 , desmin , S 100 , CD 34 , CD 21 , or CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Tumor cells expressed vimentin , S 100 protein , CD 68 , and MAC 387 , but were negative for LCA , CD1a , CD 3 , CD 15 , CD 20 , CD 21 , CD 23 , CD 30 , CD 35 , carcino embryonic antigen , HMB 45 , cytokeratin AE1 / 3 , EMA , myeloperoxidase , lysozyme , smooth muscle actin , and desmin . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
The diagnosis was based on the typical morphologic appearance of spindle cell proliferation associated with a brisk lymphoplasmacytic infiltrate and strong immunoreactivity to CD 21 and CD 35 . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Tumor cells were immunoreactive for vimentin , CD 21 , CD 35 , fascin , smooth muscle actin and CD 68 , but were negative for all lineage specific lymphoreticular , myeloid , mesenchymal and epithelial markers . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
FDC lines were CD 45 negative and expressed Ags associated to FDC ( CD 21 , CD 23 , CD 35 , CD 40 , CD 73 , BAFF , ICAM 1 , and VCAM 1 ) and Ags specific for FDC ( DRC 1 , CNA . 42 , and HJ 2 ) . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Following immunization , radiation bone marrow chimeric mice lacking complement receptors CD 21 and CD 35 on stromal cells elicited only short lived serum IgG and failed to mount recall responses to subsequent HSV exposure . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
These tumor cells were positive for CD 21 , CD 23 , CD 35 , S 100 protein , fascin and clusterin . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
Immunohistochemical stains for CD 21 , CD 23 , and CD 35 highlighted an extensive dendritic cell network that imparted the nodular appearance and , in addition , was associated intimately with the neoplastic cells . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
FDC tumors are typically diagnosed on histology based on immunoreactivity to at least 1 of the FDC markers ( CD 21 , CD 23 or CD 35 ) or based on the characteristic ultrastructural feature of long , interwoven , cytoplasmic , dendritic processes connected by desmosomes . ^^^
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P20023 and P17927	Pubmed	SVM Score :0.0
NA