Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.52702394
In contrast to these observations , but in accordance with the Calb studies , we observed interactions between other CR fragments : CR 1 ( 1 60 ) with CR 2 6 ( 61 271 ) , and CR 1 3 ( 1 142 ) with CR 4 6 ( 145 271 ) . 0.52702394^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These data suggest that besides such well known complement regulatory molecules as CD 55 ( DAF ) , CD 46 ( MCP ) , CD 35 ( CR 1 ) and CD 59 ( HRF ) , C1qR too is able to regulate complement activity . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Levels of the membrane complement regulatory proteins , C3b / C4b receptor ( CR 1 , CD 35 ) , membrane cofactor protein ( MCP , CD 46 ) , and decay accelerating factor ( DAF , CD 55 ) , expressed on cells from patients with haematological malignancies and normal subjects were assessed by flowcytometry using the respective monoclonal antibodies ( mAbs ) . ^^^ Levels of complement regulatory proteins , CD 35 ( CR 1 ) , CD 46 ( MCP ) and CD 55 ( DAF ) in human haematological malignancies . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Distribution of C 3 step regulatory proteins of the complement system , CD 35 ( CR 1 ) , CD 46 ( MCP ) , and CD 55 ( DAF ) , in hematological malignancies . ^^^ The distribution and levels of three membrane proteins , CD 35 , CD 46 , and CD 55 , which serve as complement regulators , were examined in normal peripheral blood and hematologically malignant cells . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Immunohistochemical and immunoelectron microscopic localization of complement components , C3d and C5b 9 , and the complement regulatory factors , such as s protein , decay accelerating factor ( CD 55 ) , membrane cofactor protein ( CD 46 ) , complement receptor types 1 ( CD 35 ) and 2 ( CD 21 ) , and protectin ( CD 59 ) , were examined in these tissues . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
METHODS : Unfixed unfertilized oocytes and preimplantation embryos obtained from an in vitro fertilization program were stained by indirect immunofluorescence using monoclonal antibodies raised against membrane cofactor protein , ( MCP or CD 46 ) , decay accelerating factor ( DAF or CD 55 ) , protectin ( CD 59 ) , human C3b / C4b receptor ( CR 1 or CD 35 ) , and major histocompatibility complex class 1 antigen ( MHC class 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Normal blood basophils and KU 812 cells were found to express C5aR ( CD 88 ) , membrane cofactor protein ( CD 46 ) , decay accelerating factor ( CD 55 ) , and membrane attack complex inhibitory factor ( CD 59 ) , as well as the previously recognized CR 1 ( CD 35 ) , CR 3 alpha ( CD11b ) , CR 4 alpha ( CD11c ) , and CR3 / 4 beta ( CD 18 ) . ^^^ Mast cells from all organs as well as HMC 1 cells expressed CD 46 , CD 55 , and CD 59 , but not CD11b , CD 21 , or CD 35 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
DESIGN : Sperm surface C inhibitors were quantitated by indirect immunofluorescence flow cytometry using murine monoclonal antibodies to detect C 3 regulatory proteins , C3b / C4b receptor type ( CR 1 , CD 35 ) , membrane cofactor protein ( CD 46 ) , and decay accelerating factor ( CD 55 ) , and C5b 9 inhibitor , P 18 ( CD 59 ) on acrosome intact human sperm and sperm induced to undergo acrosomal loss . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Third , the membrane regulatory proteins , decay accelerating factor ( CD 55 ) and the C3b / C4b receptor ( CD 35 ) , were normal on sickle and tetrathionate treated erythrocytes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Interestingly , down regulation of CD 46 alone is sufficient to confer susceptibility of cells to complement lysis despite the continued surface expression of other RCA proteins such as CD 35 and CD 55 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
PIF has no significant inhibitory effect on staining of CR 1 ( CD 35 ) , CR 2 , ( CD 21 ) , 20 kDa homologous restriction factor ( CD 59 ) , decay accelerating factor ( CD 55 ) , LFA 1 ( CD11a ) , or p150 . 95 ( CD11c ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We then used flow cytometry to measure expression of the four membrane complement regulatory molecules , decay accelerating factor ( DAF ; CD 55 ) , complement receptor 1 ( CR 1 ; CD 35 ) , membrane cofactor protein ( MCP ; CD 46 ) and CD 59 ; two adhesion molecules of the integrin family LFA 1 ( alpha chain , CD11a ) , complement receptor 3 ( CR 3 ; alpha chain , CD11b ) , and their common beta chain ( CD 18 ) ; the major receptor for immune complexes Fc gamma RIII ( CD 16 ) , and the leucocyte common antigen tyrosine phosphatase ( L CA ; CD 45 ) . ^^^ In RA , SF PMN expressed significantly higher levels of the complement regulators CD 55 and CD 35 , the adhesion molecule CR 3 ( CD11b / CD18 ) and of CD 45 but significantly lower levels of CD 46 and CD11a in comparison with blood PMN from the same patient . ^^^ PMN from RA expressed significantly less of all the complement C 3 convertase regulators ( CD 55 , CD 46 , CD 35 ) , all the adhesion molecules ( CD11a , CD11b , CD 18 ) and the phosphatase CD 45 than did blood PMN from age and sex matched control individuals . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Erythrocytes from elderly donors demonstrate lower levels of detectable CR 1 ( CD 35 ) , decay accelerating factor ( DAF ) ( CD 55 ) and Protectin ( CD 59 ) than do erythrocytes from young donors . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Following our demonstration that normal B cells are capable of activating the AP of complement in a CR 2 dependent fashion , we have chosen to re examine the complement activating ability of B CLL cells in relation to their altered phenotype with respect to CR 2 and the complement regulatory membrane proteins , CR 1 , decay accelerating factor ( DAF ) ( CD 55 ) and membrane cofactor protein ( MCP ) ( CD 46 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
However , the ABC values of leukocyte membrane antigens such as CD 16 , CD 46 , and CD 55 on all leukocytes and CD11b , CD11c , and CD 35 on myeloid cells did not change . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Human preimplantation embryos , gametes and cumulus cells were studied for expression of the complement binding proteins CD 46 ( membrane cofactor protein ) , CD 55 ( decay accelerating factor ) and CD 59 ( membrane attack complex inhibitory factor ) as well as complement receptors type 1 ( CRI ) , type 2 ( CR 2 ) and type 3 ( CR 3 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We investigated the expression of complement regulatory ( CD 46 , CD 55 , CD 59 ) and complement receptor ( CR 1 , CR 2 , CR 3 , CR 4 ) proteins on alveolar cells by flow cytometry . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Different expression and mobilisation of the complement regulatory proteins CD 35 , CD 55 and CD 59 in neonatal and adult neutrophils . ^^^ We investigated the expression and the N formyl methionyl phenylalanine ( fMLP ) and interleukin 8 ( IL 8 ) induced mobilisation of the complement regulatory proteins CR 1 ( CD 35 ) , decay accelerating factor ( CD 55 ) and CD 59 on neutrophils in neonates and adults . ^^^ The addition of the protease inhibitor phenylmethanesulphonyl fluoride during fMLP activation improved the upregulation of CD 35 significantly more in neonates , but not CD 55 or CD 59 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
At least two erythrocyte blood group antigen proteins have complement regulatory functions : the complement receptor type 1 ( CR 1 , CD 35 : Knops antigens ) and decay accelerating factor ( DAF , CD 55 : Cromer antigens ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
From the data of this study and our previous studies , mini CR 1 was more effective than membrane cofactor protein ( MCP , CD 46 ) , and as effective as decay accelerating factor ( DAF , CD 55 ) in this system . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
A functional analysis of recombinant soluble CD 46 in vivo and a comparison with recombinant soluble forms of CD 55 and CD 35 in vitro . ^^^ The human cell surface complement regulatory proteins CD 46 ( MCP ) , CD 55 ( DAF ) and CD 35 ( CR 1 ) protect autologous cells from complement mediated damage by inhibiting C 3 and C 5 convertases . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
However , unequivocal staining with antibodies to two soluble complement regulatory proteins , S protein and clusterin , and to the membrane complement inhibitor CD 59 was found , although three other membrane inhibitors , CR 1 ( CD 35 ) , DAF ( CD 55 ) , and MCP ( CD 46 ) , were not detected . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Reduction in erythrocyte complement receptor 1 ( CR 1 , CD 35 ) and decay accelerating factor ( DAF , CD 55 ) during normal pregnancy . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
X irradiation does not affect the levels of complement regulatory proteins , CD 35 ( CR 1 ) , CD 55 ( DAF ) and CD 59 on concentrated red cells . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The expression of complement regulatory antigens C3b / C4b receptor , ( CD 35 ) membrane cofactor protein ( CD 46 ) , decay accelerating factor ( CD 55 ) , and homologous restriction factor 20 ( CD 59 ) was determined immunohistochemically on ten primary malignant melanomas , 16 metastatic lesions , and ten melanocytic nevi . ^^^ Additionally , CD 55 could be detected in two CD46+ / CD59+ metastases , and CD 35 in one . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The influence of complement receptor type 1 ( CD 35 ) and decay accelerating factor ( CD 55 ) on complement receptor type 2 ( CD 21 ) mediated alternative pathway activation by B cells . ^^^ The influence of complement receptor type 1 ( CR 1 ; CD 35 ) and decay accelerating factor ( DAF ; CD 55 ) , both down regulators of complement activation , on the complement receptor type 2 ( CR 2 ) mediated alternative pathway ( AP ) activation of complement on normal B cells , was assessed . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These include complement receptor 1 ( CR 1 ) , decay accelerating factor ( DAF , CD 55 ) and membrane cofactor protein ( MCP , CD 46 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Of the other complement regulatory proteins expressed by PMN , only CD 59 colocalized with CR 1 , while CD 55 and CD 46 were almost absent . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Expression of complement regulatory proteins CD 35 , CD 46 , CD 55 , and CD 59 in benign and malignant endometrial tissue . ^^^ To investigate whether neoplastic endometrial tissues overexpress these proteins to escape complement damage , we examined the distribution of complement receptor type 1 ( CR 1 , CD 35 ) , membrane cofactor protein ( MCP , CD 46 ) , decay accelerating factor ( DAF , CD 55 ) , and protectin ( MACIF , CD 59 ) on frozen endometrial tissue samples . ^^^ CONCLUSIONS : Overexpression of all the CRPs studied ( CD 35 , CD 46 , CD 55 , CD 59 ) was observed in the malignant as compared with the benign endometrial tissues . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Cytofluorometry was used to quantify in vitro erythrophagocytosis and to measure red cell surface immunoglobulin G ( IgG ) and the complement regulatory proteins CR 1 , CD 55 , and CD 59 . ^^^ Red cells from patients with severe anemia were more susceptible to phagocytosis and also showed increased surface IgG and deficiencies in CR 1 and CD 55 compared with controls . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The surface expressions of complement regulatory proteins , complement receptor 1 ( CR 1 , CD 35 ) , decay accelerating factor ( DAF , CD 55 ) , and homologous restriction factor 20 ( HRF 20 , CD 59 ) , on peripheral blood and bone marrow blasts were evaluated by using flow cytometry in 16 acute myeloblastic leukemia ( AML ) , 16 acute lymphoblastic leukemia ( ALL ) , 4 chronic lymphocytic leukemia ( CLL ) , 3 chronic myelocytic leukemia ( CML ) patients and control granulocytes and lymphocytes obtained from 15 healthy volunteers . mRNA expression was investigated by Northern blot analysis . mRNA abundances were calculated after normalization according to 28s rRNA . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
H 2 cells expressed strongly the membrane attack complex inhibitor protectin ( CD 59 ) , moderately CD 46 ( membrane cofactor protein ) and CD 55 ( decay accelerating factor ) , but no CD 35 ( complement receptor 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Investigation of the role of the complement inhibitors CD 35 , CD 46 , CD 55 , and CD 59 showed that CD 55 , and to a lesser extent CD 59 , are important regulators of complement mediated cytotoxicity ( CDC ) in FL cell lines as well as in fresh cases of FL : Blocking CD 55 and / or CD 59 function with specific antibodies significantly increased CDC in FL cells . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Fetal neurons were stained for CD 59 and CD 46 and were negative for CD 55 and CD 35 . ^^^ In contrast , fetal astrocytes were strongly stained for CD 59 , CD 46 , CD 55 , and were negative for CD 35 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Autologous cells are protected against complement mediated cell injury by the self recognition mechanism using complement regulatory proteins composed of complement receptor type 1 ( CR 1 , CD 35 ) , membrane cofactor protein ( MCP , CD 46 ) , decay accelerating factor ( DAF , CD 55 ) and homologous restriction factor ( protectin , CD 59 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Like `` normal ' ' basophils , basophils in MDS expressed interleukin 3 receptor alpha ( CD 123 ) , E NPP 3 ( CD203c ) , CR 1 ( CD 35 ) , CR 3 ( CD11b ) , CR 4 ( CD11c ) , membrane co factor protein ( CD 46 ) , decay accelerating factor ( CD 55 ) and membrane attack complex inhibitory factor ( CD 59 ) , as well as receptors for C3a , C5a ( CD 88 ) , and IgE . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
AIMS : To investigate the deposition of complement components , C3d and C5b 9 , and the expression of complement regulating factors ( S protein , membrane cofactor protein ( MCP ; CD 46 ) , protectin ( CD 59 ) , decay accelerating factor ( DAF ; CD 55 ) , and type 1 complement receptor ( CR 1 ; CD 35 ) ) in gastric cancers . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CD 35 ( complement receptor 1 ) , CD 55 ( decay accelerating factor ) , CD 59 ( membrane inhibitor of reactive lysis ) and CD 47 ( integrin associated protein ) flow cytometric assays were compared for infected and uninfected RBCs . ^^^ CD 35 , CD 55 , CD 59 and CD 47 levels showed no significant differences . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Membrane associated complement regulatory proteins , such as CD 55 ( DAF , Decay Accelerating Factor ) , CD 46 ( MCP , Membrane Cofactor Protein ) , CD 35 ( CR 1 , Complement Receptor type 1 ) and CD 59 , which serve as an important mechanism of self protection and render autologous cells insensitive to the action of complement . appear to be over expressed on certain tumors . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CR 1 ( EAC 1 4b ) showed up later in the differentiation than CR 2 ( EAC 1 3d ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
If a defibrillator containing capacitance C , inductance L , and internal resistance RI , is discharged into increasing 5 to 100 ohm resistive loads R , it is shown for underdamped output waveforms that  = RI / 2L + R / 2L and ? = CRI + CR , where  = pi [ t2tan ( pit1 / t2 ) ] , ? = 2 / [ 2 + ( pi / t2 ) 2 ] , t 1 = time from onset to peak , and t 2 = time from onset to first zero crossing of the output waveform on the oscilloscope trace . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Using the DWLS fitted acrophase for the melatonin metabolite , the mean absolute phase difference between CR 1 and CR 2 was 40 min ( SD = 26 min ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Red blood cells ( RBCs ) from children with severe malarial anemia are deficient in complement regulatory proteins ( CR 1 and CD 55 ) . ^^^ RBC CR 1 and CD 55 deficiencies resolved after treatment , suggesting that these changes were acquired . ^^^ Using conditional logistic regression , a decline in CD 55 ( or CR 1 ) ( odds ratio [ OR ] , 4 . 2 ; 95 % confidence interval [ CI ] , 2 . 1 8 . 1 ; P < . 001 ) and an increase in immune complex level ( OR , 2 . 6 ; 95 % CI , 1 . 5 4 . 8 ; P= . 001 ) were significantly associated with severe malarial anemia . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Of the multiple resistance strategies exploited by cancer cells , the expression of membrane complement regulatory proteins ( mCRPs ) , such as CD 46 ( membrane cofactor protein ( MCP ) ) , CD 55 ( decay accelerating factor ( DAF ) ) , CD 35 ( complement receptor type 1 ( CR 1 ) ) and CD 59 , has received most attention . ^^^ CD 46 , CD 55 and CD 35 block the complement cascade at the C 3 activation stage and CD 59 prevents assembly of the membrane attack complex of complement ( MAC ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Other complement regulators ( CD 35 , CD 46 and CD 55 ) were not expressed on the Purkinje cells , whereas CD 59 , CD 46 and CD 55 were present on the molecular , granulosa and endothelial cells . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Additional studies suggest that the levels of expression of CR 1 and the complement regulator CD 55 on erythrocytes vary with age , being low in young children and increasing with age . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In humans , they include decay accelerating factor ( DAF , CD 55 ) , membrane cofactor protein ( MCP , CD 46 ) , complement receptor 1 ( CR 1 , CD 35 ) and CD 59 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Fourteen cases were transplanted in first complete remission ( CR 1 ) and eight with other chemosensitive status ( four later CR , two partial remissions and two sensitive relapses ) . ^^^ From the 14 cases transplanted in CR 1 , four had previous bone marrow involvement and one meningeal infiltration ; eight cases were Ann Arbor stage 4 and fulfilled accepted high risk criteria for relapse . ^^^ The procedure related mortality was 9 % ( 7 % in CR 1 patients ) . ^^^ The actuarial 2 year overall survival for CR 1 patients was 85 % at a median follow up of 19 months . ^^^ In this study the DFS in CR 1 patients was not influenced by bone marrow involvement or high risk criteria predictive for relapse . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
This treatment revealed a 50 % response rate ( CR 1 , PR 2 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
With a median follow up of 4 years the disease free survival ( DFS ) was 44 % for the whole group , with a significant difference between patients in first or second complete remission ( CR 1 and 2 , as one group ) , compared with patients with more advanced disease ( greater than CR 2 ) , 69 . 5 % versus 15 . 4 % ( p less than 0 . 01 ) . ^^^ The main cause of BMT failure was leukemic relapse , with a relapse rate of 15 % for patients in CR 1 and 2 and of 77 % for patients with greater than CR 2 ( p less than 0 . 01 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Raji cells were found to express CR 2 , DAF and MCP molecules , while MCP was the only known regulatory protein detected on Ramos cells which expressed neither CR 1 , nor CR 2 , H or DAF . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The importance of the complement system for mounting an antibody response in vivo was investigated by down regulating and blocking the complement receptors ( CR ) in mice with three different monoclonal rat antibodies ( mAb ) : mAb 8C12 recognized the C3b binding site of CR 1 , mAb 7G6 recognized another site of CR 1 and the C3d binding site of CR 2 and mAb 7E9 again recognized other epitopes on CR 1 and CR 2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In particular , stimulation with hrGM CSF is followed by an enhanced expression of the complement receptors CD 35 ( CR 1 ) and CD11b ( CR 3 ) while the low affinity Fc gamma receptor CD 16 ( FcRIII ) is downregulated . ^^^ We found a marked increase in CD 35 ( CR 1 ) and CD11b ( CR 3 ) expression and a substantial decrease or even loss of CD 16 ( FcRIII ) on these granulocytes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
A mAb , 7G6 , that binds to mouse CR 1 and CR 2 and down modulates their expression on splenic B cells in vivo , was used to determine whether a decrease in CR 1 and CR 2 expression affects antibody responses to different T dependent and T independent Ag . ^^^ Taken together , these observations suggest that CR 1 and CR 2 may play an important role in enhancing primary antibody responses to many T dependent and T independent Ag and may contribute to a host ' s response to naturally occurring antigens such as bacteria . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Polymorphonuclear leukocytes ( PMN ) constitutively synthesize various plasma membrane proteins including CR 1 ( 3 ) ( CD 35 ) , CR 3 ( or Mac 1 ) alpha chain ( CD11b ) and MHC class 1 . ^^^ Granulocyte macrophage colony stimulating factor increases synthesis and expression of CR 1 and CR 3 by human peripheral blood neutrophils . ^^^ PMN are also able to up regulate rapidly the expression of CR 1 and CR 3 to the plasma membrane in response to agonists such as FMLP . ^^^ CR 1 , CR 3 and class 1 proteins immunoprecipitated from lysates of 35S methionine pulse labeled PMN were resolved by SDS PAGE , fluorographed and quantified by densitometry . ^^^ GM CSF treated PMN synthesized 4 . 5 fold more class 1 protein , 3 . 7 fold more CR 1 , 2 . 4 fold more CD11b and 3 . 4 fold more CR 3 beta chain ( CD 18 ) , compared with untreated control cells . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The distribution for autologous bone marrow transplantation ( ABMT ) was 671 in first complete remission ( CR 1 ) and 196 in CR 2 . ^^^ Pretransplantation regimes were : total body irradiation ( TBI ) , 456 ; busulfan plus cyclophosphamide ( BU CY ) 174 ; marrow purging with mafosfamide , 269 ( corresponding to 26 % of all patients in CR 1 and 41 % in CR 2 ) . ^^^ Patients autografted in CR 1 with no high risk factor ( standard risk ) had a leukemia free survival ( LFS ) and relapse rate at 7 years of 48 + / 2 and 41 + / 3 % , respectively . ^^^ With the restriction of a shorter follow up , the results achieved with the BU CY combinations ( LFS and relapse rate at 3 years , CR 1 47 + / 6 and 45 + / 7 % ; CR 2 , 37 + / 9 and 50 + / 10 % ) did not differ from those with TBI or other chemotherapy combinations . ^^^ LFS and relapse rates were correlated with several pretransplant intervals : in CR 1 , patients reaching CR more rapidly ( less than or equal to 40 days ) had a better LFS ( 53 + / 3 versus 42 + / 3 % ; p = 0 . 03 ) and a lower relapse rate ( 46 + / 3 versus 57 + / 3 % ; p = 0 . 03 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Inhibition of actin microfilament ( MF ) assembly and stability by cytochalasins B and D completely inhibited M phi phagocytosis of sheep E coated with C3b ( EC3b ) , iC3b ( EC3bi ) , and IgG ( EIgG ) via CR 1 , CR 3 , and FcR , respectively . ^^^ These data indicate that for adherently cultured human M phi : 1 ) binding of ligand coated E to CR or FcR does not require an intact cytoskeleton ; 2 ) intact actin microfilament are required for phagocytosis via CR and FcR ; 3 ) phagocytosis via CR 1 and CR 3 but not FcR is dependent on MT assembly ; 4 ) PMA most likely augments CR mediated phagocytosis through promotion of MT assembly ; and 5 ) PKC activity is involved in the phagocytic signal generated by both CR and FcR . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Red cell transfusion therapy with CR 1 rich erythrocyte for AIDS patients is also promising . ^^^ Transfusion therapy with CR 1 ( c3b receptor ) rich erythrocytes given every 2 months to 9 patients of carinii pneumonia resulted in the survival rate of 5 . 9 for more than 15 months , compared with 2 / 20 for 12 months for those who had occasional blood transfusions . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The 2 year actuarial event free survival ( EFS ) probabilities are first CR ( CR 1 ) 32 % ( SE 10 % ) , first PR ( PR 1 ) 43 % ( SE 9 % ) , second CR ( CR 2 ) 33 % ( SE 27 % ) , and second PR ( PR 2 ) 5 % ( SE 5 % ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
MAb directed against any of the three defined complement receptors ( CR ) on MO M phi ( CR 1 , CR 3 , and CR 4 ) profoundly inhibited binding of serum opsonized encapsulated ( and to a lesser extent acapsular ) organisms to MO M phi . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Eight patients were treated in CR 1 , 36 in CR 2 ( first relapse occurring on therapy for 32 ) , seven in further CR , 10 in relapse ( five early first relapse , four second relapse and one fourth relapse ) and one with refractory ALL . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Patients not relapsing at 1 year post ABMT had a probability of being cured at 7 years of 86 and 71 % if autografted in CR 1 and CR 2 for AML and 81 and 59 % for ALL , respectively . ^^^ Multivariate analysis of relapse rates in several subpopulations confirmed the efficacy of marrow purging in AML CR 1 : in patients transplanted prior to January 1988 ( minimum follow up of 2 years ) , the relapse rate with purged marrow was 35 + / 5 % vs . 47 + / 3 % ( p less than 0 . 005 ) . ( b ) In Paris , St Antoine , using TBI and marrow purged with mafosfamide at levels individually adjusted ( Blood 1986 ; 67 : 1367 ) , the probability of remission and DFS were 84 and 62 % in AML CR 1 63 and 59 % in ALL CR 1 , respectively . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
One hundred and seven consecutive patients with acute non lymphocytic leukemia ( ANL ) aged less than 56 years were allocated to receive either allogeneic ( allo BMT ) or autologous bone marrow transplantation ( auto BMT ) when first complete remission ( CR 1 ) was achieved . ^^^ Twenty four patients had an HLA identical sibling donor and 20 of these ( 83 % ) had an allograft in CR 1 . ^^^ Thirty three patients ( 44 % of the CR 1 patients without donor ) had an autograft in CR 1 . ^^^ The reasons for not transplanting patients in CR 1 were early relapse ( nine patients ) , refusal ( 11 patients ) or medical problems ( 23 patients ) . ^^^ The 4 year leukemia free survival ( LFS ) probability for all the CR 1 patients was 25 % . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CR 1 and 2 are in the amino terminal half , CR 1 comprises the presumed ligand binding site , and CR 3 represents the carboxy terminal kinase domain . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
A mAb against the type 1 CR ( CR 1 ) inhibits adherence of M . tuberculosis by 40 + / 5 % , and three different mAb against the type 3 CR ( CR 3 ) each inhibit adherence by 39 + / 5 % to 47 + / 4 % . ^^^ A mAb against CR 1 used in combination with one of the three mAb against CR 3 inhibits adherence by up to 64 + / 7 % . ^^^ This study demonstrates that human monocyte CR 1 and CR 3 mediate phagocytosis of M . tuberculosis and C component C 3 in serum is acting as the major bacterium bound ligand . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Eighteen patients in first complete remission ( CR 1 ) , 36 in CR 2 , 16 in CR 3 , and four in CR 4 were transplanted . ^^^ Patients in CR 1 were transplanted 1 to 8 months ( median , 3 months ) after attaining CR . ^^^ All 18 patients in CR 1 had one or more poor risk factors : age more than 18 ( N = 17 ) , initial leukocyte count greater than or equal to 20 , 000 ( N = 11 ) , Ph 1 chromosome ( N = 2 ) , delay in attaining CR more than 6 weeks ( N = 8 ) , or extramedullary disease ( N = 1 ) . ^^^ The 5 year event free survival ( EFS ) rates for patients transplanted in CR 1 , CR 2 , and CR 3 are 42 % , 43 % , and 25 % , respectively , at median follow up times of 57 , 54 , and 72 months , respectively . ^^^ The actuarial probability of relapse is 20 % , 26 % , and 48 % for those transplanted in CR 1 , CR 2 , and CR 3 , respectively . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Two patients transplanted in CR 2 and CR 1 remain in CR after 9 . 5 and 12 months respectively . ^^^ Nine patients were transplanted for aggressive lymphoma : four patients were in CR 1 , 2 in CR greater than 1 , 1 in first relapse and 2 refractory to best available second line chemotherapy . ^^^ Nine patients are evaluable : 4 relapsed and 5 remain in CR at 5 , 6 . 5 , 21 , 25 and 39 months , this last patient transplanted in a refractory state , the others in CR 1 . ^^^ However , for the whole group of patients , including those transplanted for acute leukemia in CR 1 , the relapse rate was high . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In contrast , the CR , CR 1 and CR 3 , could be rapidly induced by GM CSF indicating that this cytokine causes the mobilization of preformed molecules to the membrane . ^^^ G CSF and IFN gamma did not alter the expression of CR 1 and CR 3 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Expression of CR 1 was required for the induction of TNF alpha sensitivity . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Phagocytosis of agarose beads by receptors for C3b ( CR 1 ) and iC3b ( CR 3 ) on alveolar macrophages from patients with sarcoidosis . ^^^ We found a significantly increased CR 1 and CR 3 receptor mediated phagocytosis of native agarose beads by AM from the seven patients . ^^^ CR 1 and CR 3 were also detected on AM directly recovered from bronchoalveolar lavage fluid using fluorescein conjugated monoclonal anti receptor antibodies . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
For patients with standard risk AML in CR 1 autografted after TBI ( n = 107 ) , the leukemia free survival ( LFS ) was higher , and the probability of relapse was lower in recipients of purged than of unpurged marrow ( 63 % versus 34 % , P = . 05 and 23 % versus 55 % , relative risk 0 . 34 , P = . 005 , respectively ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
E from primates demonstrate type 1 CR ( CR 1 ) with binding specificities for C3b and C4b . ^^^ We showed that three out of four mouse mAb and one polyclonal antiserum , raised against human E CR 1 , cross reacted with baboon E . ^^^ In addition , one anti human CR 1 mAb ( 1B4 ) and a polyclonal anti human CR 1 inhibited the binding of C3b opsonized immune complexes to baboon E . ^^^ Finally , a mAb to human CR 1 ( E 11 ) recognized epitopes on E of a variety of nonhuman primates , including baboons . ^^^ We postulate that the baboon E 65 kDa protein is the equivalent of the human E CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Coagulation increases neutrophil CR 1 and CR 3 expression : primary role for platelet derived growth factor . ^^^ Neutrophil receptors for C3b ( CR 1 ) and C3bi ( CR 3 ) mediate a number of functions important for infection control and tissue repair , such as adherence , aggregation , orientation in chemotactic gradients , and phagocytosis of opsonized particles . ^^^ Neutrophils incubated in serum for 1 hour at 37 degrees C increased the expression of CR 1 3 . 43 fold and CR 3 3 . 06 fold compared with incubation in buffer ( p less than 0 . 001 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Multiple clinical studies have been undertaken to evaluate the role of ABMT in relapse , in second and subsequent remission ( CR greater than or equal to 2 ) , and in first remission ( CR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Fifty four patients with acute lymphoblastic leukemia ( ALL : 1 relapse , 21 high risk first complete remission ( CR 1 ) , 29 second CR ( CR 2 ) , and 3 third CR ( CR 3 ) were treated by autologous bone marrow transplantation at three centers . ^^^ In CR 1 6 or 21 patients have had a relapse , and the actuarial leukemia free survival from CR is 65 % ( median follow up 16 months ) . ^^^ The actuarial leukemia free survival time in the present study for patients with high risk CR 1 and the inversions in CF 2 3 are promising and indicate a potential beneficial effect of ABMT . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Incubation of neutrophils in autologous serum , but not in plasma , increased the mean ( + / SD ) expression of CR 1 ( x3 . 43 + / 0 . 93 ) and CR 3 ( x3 . 07 + / 0 . 86 ) , in comparison with incubation in buffer . ^^^ Similarly , calcium conversion of platelet rich plasma ( but not platelet poor plasma ) to serum also increased both CR 1 and CR 3 expression . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In the majority of 188 non Hodgkin lymphomas ( NHL ) investigated in this study , we found a simultaneous expression of the receptors for c3b and c3d ( CR 1 & CR 2 ; cccorr = 0 . 69 , P less than 0 . 0005 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Receptors for C 3 degradation fragments ( CR 1 , CR 2 , and CR 3 ) are present on many human cells including phagocytes and lymphoid cells and may be critical in the attachment of invading microorganisms . ^^^ Antibodies to human CR 1 , CR 2 , and CR 3 were used to evaluate their potential for blocking adherence of the test erythrocytes to Candida . ^^^ Monoclonal antibodies to human CR 1 and CR 3 ( 3D9 , 1B4 , C 511 , 2B6 , anti B 2 , Mo 1 , and anti Mac 1 ) , in general , did not block adherence of test erythrocytes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
C 3 b receptor ( CR 1 ) on red blood cell and glomerulus in various glomerular diseases ] . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These molecules were found to be independent , non linked , B cell surface structures , because capping CR 1 , CR 2 , sIgM , or sIgD with a specific antibody did not affect the distribution of the remainder of these molecules . ^^^ Both CR 1 and CR 2 , if bound by antibodies that did not independently cap CR , however , became associated with cross linked sIg because CR that have been bound by intact anti CR antibodies or their Fab fragments co capped with sIgM or sIgD that had been bound by divalent anti IgM or anti IgD antibody . ^^^ CR 1 that had bound C3b similarly co capped with sIg when sIg was cross linked . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Pretreatment with zymosan opsonized with human AB serum , however , did not change the expression of other IgG and C binding sites such as FcRII ( examined with mAb IV . 3 and 2E1 ) and CR 1 ( assessed with mAb 57F ) as well as of unrelated cell membrane structures ( beta 2m , MHC class 2 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Complement receptors ( CR ) and cytotoxic responses : monoclonal antibodies directed against CR 1 and CR 3 inhibit the generation of human allospecific and virus specific cytotoxic cells in vitro . ^^^ MAb OKM 1 , which binds to the C3bi CR ( CR 3 ) , and MAb M 710 , which binds to the C3b / 4b CR ( CR 1 ) , inhibited the generation of both allogeneic and virus specific cytotoxic responses in vitro in a dose dependent way ; doses of 1 microgram / ml ( or greater ) completely abrogated the cytotoxic responses . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The sites mutated were in the three conserved regions ( CR ; amino acids 178 186 [ CR 1 ] , 322 330 [ CR 2 ] , and 464 475 [ CR 3 ] ) identified previously by comparative sequence analysis ( G . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
It is noticeable that MPA was effective in all of 4 premenopausal patients ( CR 1 , PR 3 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Thirty three leukaemic patients in CR were treated by high dose therapy followed by ABMT : 18 of them had acute non lymphoblastic leukaemia ( ANLL ) in first remission ( CR 1 ) with a mean age of 23 . 7 years ( 3 44 ) . ^^^ At the time of analysis ( October 1984 ) , four patients had relapsed and eight were still in unmaintained CR 1 ( 44+ , 46+ , 30+ , and five between 2 . 5+ and 8+ months post transplant ) . ^^^ Fifteen patients had acute lymphoblastic leukaemia : four were autografted in CR 1 and 11 children were grafted in CR 2 ; the conditioning regimen was fractionated total body irradiation followed by cyclophosphamide for all but one patient who was conditioned with BACT ( Burkitt leukaemia ) ; the marrow was purged by a chemical agent in 11 patients and by monoclonal antibodies and C ' in four : four out of 15 patients relapsed ( two grafted in CR 1 and two grafted in CR 2 ) ; 10 patients are still in unmaintained CR : two adults grafted in CR 1 ( 26+ ; 12+ months ) and eight children with a mean follow up of 13 . 4 months post graft ( 2 + 45+ months ) . ^^^ The clinical study leads to the following conclusions : in adult patients the marrow should be harvested during CR 1 and at the time of minimal residual disease . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In the gastric cancer group , the response rate for Regimen A was 23 . 2 % ( CR 1 and PR 12 ) out of 56 evaluable cases , and for Regimen B , 40 . 5 % ( CR 1 and PR 14 ) out of 37 evaluable cases . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In the latter cases , it was 40 . 9 to 64 . 3 % for the maxilla , pharynx and oral cavity , and 100 % for the external auditory meatus ( CR 1 , PR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Effectiveness of HLBI therapy was 20 % ( CR 1 case , MR 3 cases , NC 11 cases , PD 5 cases ) . ^^^ With adjuvant OK 432 therapy for patients whose disease proved to be resistant to HLBI , effectiveness was 25 % ( CR 1 case , MR 2 cases , NC 6 cases , PD 3 cases ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We used monoclonal antibodies and flow cytometry to study the expression of the receptors for the complement fragments C3bi ( CR 3 ) and C3b ( CR 1 ) on human polymorphonuclear neutrophil leukocytes ( PMN ) . ^^^ These results demonstrate that both CR 3 and CR 1 expression increase rapidly upon activation of PMN and that isolated cells can be used to study this phenomenon , which may be a critical part of neutrophil function in vivo . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Structural heterogeneity of the C3b / C4b receptor ( Cr 1 ) on human peripheral blood cells . ^^^ In these studies CR 1 polymorphism previously demonstrated on erythrocytes ( E ) was also found on CR 1 bearing peripheral blood leukocytes including polymorphonuclear ( PMN ) , eosinophils , monocytes , and B lymphocytes . ^^^ However several cell specific differences in CR 1 were found : ( a ) an approximately 5 , 000 dalton increase in CR 1 on PMN and eosinophils , ( b ) unequal band intensity among heterozygotes suggests that there is preferential expression of 220 , 000 or 225 , 000 dalton receptors on leukocytes compared to E , and ( c ) `` minor ' ' bands , approximately 15 , 000 daltons larger than the major receptor molecule , were found on E but not on leukocytes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Three of these patients ( 30 % ) had greater than a 50 % improvement in serum Cr 1 week following completion of the irradiation . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Urinary 3MH and Cr after 3 days on a meat free diet were 213 . 9 + / 30 . 8 mumol 10 day 1 and 1 . 60 + / 0 . 3 g 10 day 1 , respectively . 3MH 10 Cr 1 was 135 . 3 + / 16 . 8 mumol 10 g 1 or 15 . 3 + / 1 . 9 molar ratio 10 10 ( 3 ) . ^^^ Nonsignificant correlations were found for 3MH 10 Cr 1 versus VO2max 10 kg 1 10 min 1 versus FFM , 3MH 10 Cr 1 versus VO2max , and FFM versus VO2max 10 kg 1 10 min 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
A spatial association between membrane IgD and the receptor for C3b ( CR 1 ) at the cell surface of murine B lymphocytes . ^^^ Surface immunoglobulin D ( SIgD ) and receptors for C3b ( CR 1 ) were demonstrated to be closely associated at the surface of mouse spleen lymphocytes . ^^^ In addition , co capping of IgD and cR 1 was observed on 65 % of the cells expressing both markers . ^^^ In these experiments IgM was shown to redistribute independently from both CR 1 and CR 2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In six patients with BCR ABL pos ALL who were in CR by conventional criteria ( 5 in CR 1 and 1 in CR 2 ) , we studied a total of nine paired BM and PB samples prior to scheduled ABMT . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We report the safety and efficacy of autologous bone marrow transplantation ( ABMT ) in 30 patients with high grade non Hodgkin ' s lymphoma ( NHL ) in first complete remission ( CR 1 ) following remission induction chemotherapy . ^^^ The remaining 25 patients remain alive , well and in CR 1 with a median follow up of 44 months . ^^^ We conclude that ABMT for high grade NHL in CR 1 with non cryopreserved marrow results in rapid haematological recovery without growth factor support . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
No toxic deaths were registered in 13 patients undergoing BMT in CR 1 ( three allogeneic BMT and ten autologous BMT ) . ^^^ There were no significant differences between patients in CR 1 ( 82 . 5 % ) and CR 2 ( 68 % ) . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
To evaluate the prognostic value of the karyotype in acute myeloblastic leukemia when patients are allocated to have either autologous bone marrow transplantation ( BMT ) or allogeneic BMT at the time of first remission ( CR 1 ) , we have prospectively followed 134 consecutive patients from diagnosis . ^^^ Allogeneic BMT and autologous BMT were performed in 25 and 43 CR 1 patients , respectively . ^^^ In the patients who had autologous BMT in CR 1 , the LFSs were 100 % , 33 % and 10 % with favorable , intermediate and unfavorable karyotype , respectively ( P = 0 . 04 ) . ^^^ The karyotype was of no prognostic value in patients receiving allogeneic BMT who had BMT in CR 1 . ^^^ This study shows that the karyotype retains its prognostic value when the intentions is to treat patients with acute myeloblastic leukemia in CR 1 with BMT . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The median follow up time since megatherapy is 4 years ( range 1 month to 10 years ) , Thirty two patients with metastatic disease at diagnosis ( 22 had metastases to the bone and / or bone marrow ) and consolidated in CR 1 reached an actuarial event free survival ( EFS ) of 21 % at 5 years . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Knops / McCoy / York BGAs have been located on the C3b / C4b receptor ( CR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Participation of CR 1 ( CD 35 ) , CR 3 ( CD11b / CD18 ) and CR 4 ( CD11c / CD18 ) in membranoproliferative glomerulonephritis type 1 . ^^^ Four patterns of CR 1 ( CD 35 ) expression on podocytes were recognized : normal ; generally decreased ; focally / segmentally lost ; and completely lost . ^^^ The intensity of CR 1 expression in group B was less than that in group A at both the 1st and 2nd Bx ( 1st , P < 0 . 05 ; 2nd , P < 0 . 01 ) , and chronological improvement of CR 1 expression was observed only in group A . ^^^ Our results suggest that , in cases with an adverse outcome , a more severe defect of CR 1 initially exists and the expression of CR 1 is not recoverable chronologically . ^^^ This irreversible decrease or loss of CR 1 may partly contribute to the continuous C3c deposition and intraglomerular infiltration of CR3+ and CR4+ cells . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The 2 year overall survival was 31 % in 14 patients with multifocal disease in first complete remission ( CR 1 ) and was 37 % for 15 patients in second CR ( CR 2 ) . ( 6 patients with local disease in CR 1 have been excluded . ) These results are better than observed under conventional dose chemotherapy . 67 patients were grafted with measurable disease showing a response rate of 72 % . ^^^ The overall survival at 5 years was 10 % in refractory patients and 58 % for 113 responding patients not in CR 1 ( i . e . first partial remission , CR 2 and sensitive relapses ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
YT and KEL antigens are located on cell surface enzymes and the CR and KN antigen on molecules involved in complement regulation . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Additionally , CR 1 in gp 120 exhibits a weak similarity to human properdin . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Here we demonstrate the existence of a second transactivating region located within amino acids 28 to 90 ( essentially the CR 1 domain ) of the E1A protein . ^^^ A fusion protein , containing the Gal 4 DNA binding domain linked to CR 1 , was as efficient as the classical CR 3 transactivator in activating transcription from a reporter plasmid containing Gal 4 binding sites . ^^^ Here we show that a Gal 4 fusion protein expressing the CR 1 domain is indeed sufficient for repression of SV 40 enhancer activity . ^^^ Collectively , our results suggest that CR 1 functions as an activator if tethered to a promoter and as a repressor in the absence of promoter association . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Thirty two patients reached CR 1 , seven patients are still alive as of May 1994 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
At time of autologous BM transplantation ( ABMT ) ; 64 AMLs were in first complete remission ( CR 1 ) , and 20 were in second CR ( CR 2 ) ; 35 ALL were in CR 1 , and 6 were in CR 2 . ^^^ At 8 years , patients autografted in CR 1 for AML and ALL had a leukemia free survival ( LFS ) of 58 % and 56 % , respectively , with a relapse incidence ( RI ) of 25 % and 37 % , respectively . ^^^ By multivariate analysis , four factors were found to influence favorably engraftment in addition to a diagnosis of ALL , a younger age , ABMT performed in CR 1 , the adjusted dose technique of purging , and a shorter interval from CR to ABMT . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The CRI concept is demonstrated with longitudinal relaxation data from samples of yeast cells suspended in media containing the contrast agent ( CR ) GdDTPA 2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Maximal inhibition of neutrophil mediated killing was observed by monoclonal antibody blockade of complement receptor ( CR ) 3 alone or in combination with CR 1 or Fc receptor 3 . ^^^ Neutrophil CR 3 and either CR 1 or Fc receptor 3 optimize phagocytosis . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Primary sequence of an alternatively spliced form of CR 1 . ^^^ Chimpanzee erythrocytes express a 75 , 000 M ( r ) complement receptor ( E CR ) that binds C3b bearing immune complexes and is recognized by an anti CR 1 mAb ( E 11 ) . ^^^ Human erythrocytes express the type 1 CR ( CR 1 ) , the most common form being 220 , 000 M ( r ) and consisting of 30 short consensus repeats ( SCRs ) for its entire extracellular region . ^^^ A chimpanzee cell line was identified that expressed a 220 , 000 M ( r ) CR 1 , and a 75 , 000 M ( r ) molecule that was recognized by E 11 and could bind human C3i . ^^^ Utilizing this cell line , chimpanzee CR 1 cDNA was amplified in overlapping segments by the PCR , using primer pairs specific for various regions of human CR 1 cDNA . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Patients who do not achieve CR , who relapse within one year of CR 1 or who have a second relapse will have a survival of less than 20 % at 5 years and these patients are candidates for high dose therapy ( HDT ) and Autologous Bone Marrow Transplantation ( ABMT ) or a second line salvage protocol . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Seven first complete remission ( CR ) ( CR 1 ) , 45 second or third CR ( CR2 / 3 ) , and 11 first relapse ( R 1 ) patients were treated with chemotherapy and TBI or chemotherapy alone followed by ABMT with MoAb purged BM . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
No significant difference in the expression of FcRII , FcRIII , CR 1 and CR 3 was detected in LJP group compared to controls . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Trapping was specifically inhibited with monoclonal antibodies against complement receptor type 1 ( CR 1 ) ( 8C12 ) and CR 1 / 2 ( 7G6 ) , but not with anti CR 3 ( Mac 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Among complement receptors ( CR ) CR 1 , CR 3 , and CR 4 , the major CR mediating uptake of MTB by MN were CR 1 and CR 3 , whereas for AM , CR 4 was the major CR . ^^^ Thus , AM are more efficient in phagocytosis of MTB than MN , and uptake is mediated through CR 4 to a greater extent than CR 1 or CR 3 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Sixteen AML patients were studied in early first CR prior to intensive consolidation with high dose cytarabine ( HDAC ) and had a median ID 95 of 130 ( range 90 190 ) micrograms mafo / ml ; the median ID 95 in 3 of 7 AML CR 1 and 4 of 7 AML CR 2 patients who previously had HDAC therapy was 75 ( range 55 110 ) micrograms / ml whereas a control group of 7 patients with lymphoid malignancies in CR 1 showed a median ID 95 of 100 ( range 80 160 ) micrograms / ml . ^^^ In AML the difference between patients in CR 1 prior to HDAC and patients in CR 1 after HDAC late consolidation or in CR 2 was highly significant ( p = 0 . 0006 ) . ^^^ Hence mafo purging appears to be more efficient when done in early CR 1 compared with later stages of disease . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Concomitantly , the role of complement receptors ( CR ) CR 1 and CR 3 in the attachment and entry of L . ( 5 ) . panamensis into human monocytes was analyzed using mAbs to CR 1 ( CD 35 ) and CR 3 ( CD11b ) to inhibit competitively these early events in the host parasite interaction . ^^^ Opsonization with fresh AB+ serum markedly enhanced uptake by both PBMs and U 937 cells , and the fluid phase blocking of CR 1 and CR 3 resulted in partial inhibition of attachment and / or internalization . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Among 60 patients , 7 showed clinical response ( CR 1 , PR 3 , MR 3 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Recognition and phagocytosis of opsonized yeasts was via PMN complement receptor ( CR ) type 1 ( CR 1 ) , CR 3 , and FcRIII ( CD 16 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Thirty four patients were in first complete remission ( CR 1 ) , 12 patients in second complete remission ( CR 2 ) , and 4 patients in relapse . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
C receptors ( CR ) play an important role in adherence of the three strains to MDM in the presence and absence of serum . mAb against CR 1 , CR 3 , and CR 4 inhibit adherence of Erdman M . tuberculosis in fresh serum by 75 + / 3 % and inhibit the low level of adherence of Erdman ( 71 + / 13 % ) , H37Rv ( 72 + / 1 % ) , and H37Ra ( 64 + / 14 % ) M . tuberculosis in the absence of serum . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The expression of CR 1 , CR 3 , FcRI and FcRII on neutrophils increased significantly after G CSF administration and then decreased after the last G CSF administration . ^^^ On the other hand , the administration of G CSF increased the expression of CR 1 , CR 3 , FcRI and FcRIII on monocytes . ^^^ The expression of CR 1 , CR 3 and FcRI on monocytes then decreased after the last G CSF administration , whereas the expression of FcRIII remained at an increased level . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The inhibition data were analyzed in terms of a simple model that takes into consideration Kg , the normal microtubule growth constant , equal to Cr 1 ( Cr is the critical concentration for microtubule formation ) , and Kb , the binding constant of the drug to tubulin . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
From March 1986 to April 1990 , 23 consecutive patients with poor prognosis stage 4 HD underwent HDT followed by autologous bone marrow transplantation ( ABMT ) after achieving either complete remission ( CR 1 ) or good partial response ( GPR 1 ) ( reduction mass > 75 % ) . ^^^ Ten patients were in GPR 1 and 13 in CR 1 before transplant . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The results of low levels of C3b / C4b receptor ( CR 1 ) and membrane cofactor protein ( MCP ) , and low tendency of decay accelerating factor ( DAF ) and membrane attack complex inhibition factor ( MACIF ) suggested that the function of complement regulatory proteins in patients with Behet ' s disease decreases as a whole . ^^^ Complement regulatory proteins CR 1 , MCP , DAF , and MACIF levels in patients with Behet ' s disease ] . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The CR 1 F phenotypes were significantly smaller at 32 wk than noncarrier full sibs . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Also , the expression of CR 1 , CR 3 , and CR 4 was significantly less upregulated and the L selectin , significantly less downregulated on monocytes and neutrophils . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Moreover , deletion mutant analyses demonstrate that Ad 12 E1A proteins carry three independently acting activation domains : ( 1 ) aa 1 29 , ( 2 ) CR 1 and ( 3 ) CR3 . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Specifically , 1 ) we include age groups of CR ( CR 1 approximately equal to 90 kcal / wk and CR 2 approximately equal to 58 kcal / wk ) and ad libidum fed ( AL ; approximately 120 kcal / wk ) mice including groups at maximum lifespan ; 2 ) CR was the major dietary manipulation ; 3 ) LF was identified using EM ; 4 ) LF was quantified by areal measurement ; and 5 ) the results were analyzed by inferential statistics . ^^^ We have found that 1 ) LF increased with age and 2 ) that animals in the CR 2 group had significantly less overall LF in the perikarya of the granule cells of the dentate gyrus when compared to CR 1 or AL animals at equivalent ages . ^^^ In addition , CR 2 mice at maximum lifespan ( 45 mo . ) had slightly less LF than did CR 1 or AL mice at their maximum lifespans ( 36 mo . ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In this group the mean Cr was 2 . 0 + / 0 . 1 mg / dL at baseline , 3 . 3 + / 0 . 2 mg / dL at the time of biopsy , and 2 . 2 + / 0 . 1 mg / dL 1 month after treatment ( P < 0 . 001 Cr at biopsy 5 Cr 1 month later ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Seven out of 11 patients ( 64 % ) with recurrent cancer of the breast showed a response ( CR 1 , PR 6 , NC 4 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
G CSF administration increased the expression of FcRI , FcRII , and CR 1 on neutrophils and decreased the expression of FcRIII on neutrophils in both groups . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In first complete remission ( CR 1 ) 145 patients with allografts had a possibility of event free survival ( pEFS ) of 0 . 57 and 140 patients with autografts a pEFS of 0 . 46 . ^^^ Therefore , from the European data the following conclusions can be drawn : neither in CR 1 nor in CR 2 any statistical advantage for a particular transplantation type can be found . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Previously , we demonstrated that monoclonal antibodies ( MAb ) directed against any of the three defined complement receptors ( CR ) for the third component of complement ( CR 1 , CR 3 , and CR 4 ) profoundly inhibited the binding of serum opsonized Cryptococcus neoformans to monocyte derived macrophages . ^^^ Chinese hamster ovary ( CHO ) cells stably transfected with human CR 1 , CR 3 , or CR 4 were challenged with serum opsonized C . neoformans . ^^^ We found that CHO cells transfected with any of the three receptors bound C . neoformans , with the avidity of binding to CR 3 being the greatest followed in decreasing order by CR 1 and CR 4 . ^^^ Both C . neoformans and sheep erythrocytes that were selectively opsonized with the fragments of the third component of complement , C3b and iC3b , were bound preferentially by CHO cells transfected with CR 1 and CR 3 , respectively . ^^^ These data establish CR 1 , CR 3 , and CR 4 as receptors independently capable of binding C . neoformans opsonized with fragments of C 3 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
BACKGROUND : A single center experience using autologous bone marrow transplantation ( ABMT ) as postremission therapy for acute myeloid leukemia ( AML ) in first complete remission ( CR 1 ) in 41 patients is analyzed . ^^^ PATIENTS AND METHODS : From July 1986 to March 1994 , 41 patients with AML in CR 1 underwent an ABMT . ^^^ CONCLUSIONS : ABMT is a feasible treatment for AML in CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The effect of initial ( D . p . ) challenge on the early and late airway responses to the subsequent ( CR ) challenge ( CR 2 ) was examined by comparing the responses with those to CR challenge preceded by sham challenge ( CR 1 ) . ^^^ The geometric mean PD 20 of CR allergen in the CR 2 was 2 . 8 BU ( breath unit ) ( range of 1 SD ; 0 . 77 10 . 4 ) , which was 12 . 0 fold less than that ( 33 . 7 BU , 10 . 8 105 . 2 ) in the CR 1 . ^^^ The administration of a 6 . 1 fold less dose ( 8 . 9 BU , 2 . 7 28 . 8 ) in the CR 2 than in the CR 1 ( 54 . 5 BU , 44 . 1 69 . 3 ) provoked a similar degree of late phase reactions ( 18 . 7 + / 7 . 3 % vs 15 . 8 + / 9 . 6 % ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
To examine the impact of time from diagnosis to transplant on survival and leukemia free survival ( LFS ) , we analyzed 109 patients from the database of the SFGM comprising patients who had all received an HLA identical allogeneic BMT for a diagnosis of AML in first complete remission ( CR 1 ) between January 1987 and December 1992 . ^^^ Practically speaking , this means that when such therapy is chosen for a patient with CR 1 AML , the search for an allogeneic donor should begin immediately and transplant be performed as soon as possible . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Mutations in CR 1 of E1A 12S yield dominant negative suppressors of immortalization and the lytic cycle . ^^^ Thus , loss of the CR 1 seems to be a prerequisite for a mutant to have a dominant negative effect on E1A functions . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In 13 patients , treatment according to this protocol was started in first complete remission ( CR 1 ) . ^^^ The mean remission time in CR 1 patients is 19 ( median 14 ) months , and 9 / 13 remain in CR . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Similar results were also observed in the subset of patients in clinical CR 1 year after treatment . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
BACKGROUND : The aim of this study was to increase disease free survival ( DFS ) in AML in CR 1 using a high dose cytarabine consolidation plus G CSF as in vivo purging and mobilization of CD34+ cells before ablative therapy and peripheral blood autograft . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The shift in the concentration response by CPT was expressed as the concentration ratio ( CR ) and plotted as log ( CR 1 ) against log molar concentration of CPT ( Schild plot ) . pA 2 values were calculated from the intercept on the concentration axis and by application of the equation ; pA 2 = log ( antagonist concentration ) log ( CR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The L MDS neutrophils exhibited lower expressions of CR 1 , L selectin , LFA 1 and CD 18 than those of the controls . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The Allo BMT was performed in CR 1 in 7 patients in CR 2 in three patients and with refractory disease in two cases . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Fusing CR 1 to a heterologous DNA binding domain creates a potent transcriptional activator , suggesting that CR 1 might activate transcription by recruiting p300 / CBP to the promoter . ^^^ We show that both p 300 and CBP enhances CR 1 dependent transactivation . ^^^ However , this enhancement occurs independently of a direct interaction with E1A and does not correlate with the CR 1 activator function . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The roles of complement receptors type 1 ( CR 1 , CD 35 ) and type 3 ( CR 3 , CD11b / CD18 ) in the regulation of the immune complex elicited respiratory burst of polymorphonuclear leukocytes in whole blood . ^^^ Blockade of CR 1 on either erythrocytes ( E ) or leukocytes , before mixing the populations , revealed that the potentiation of the RB by mAb 3D9 was associated with abrogation of E CR 1 function , whereas blockade of leukocyte CR 1 had a diminishing effect . ^^^ In conclusion , CR 3 plays a significant role in the IC mediated generation of an RB and release of specific granules by PMN , while CR 1 on whole blood cells , primarily E CR 1 , restricts the IC elicited RB in PMN . ^^^ We propose that CR 1 in whole blood promotes the degradation of IC bound iC3b to C3dg , thereby rendering the IC inaccessible for binding to CR3 . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
METHODS : We retrospectively analyzed the outcome of 50 consecutive individuals in remission of acute lymphoblastic leukemia ( n=13 ; 8 in complete remission [ CR ] 1 ) or acute myeloblastic leukemia ( n=37 ; 33 in CR 1 ) , who had received marrow grafts from HLA identical siblings . ^^^ Overall , 11 patients ( 22 % ) relapsed ( 4 of 33 acute myeloblastic leukemia in CR 1 ) at a median of 235 ( range 46 528 ) days . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Here we describe the involvement of a growth factor with an EGF like domain , Cripto 1 ( Cr 1 ) , in cardiac differentiation . ^^^ During embryonic development , Cr 1 is expressed in the mouse blastocyst , primitive streak , and later is restricted to the developing heart . ^^^ To investigate the role of Cr 1 , we have generated Cr 1 negative embryonic stem ( ES ) cell lines by homologous recombination . ^^^ The resulting double `` knockout ' ' ES cells have selectively lost the ability to form beating cardiac myocytes , a process that can be rescued by reintroducing Cr 1 gene back into the Cr ( / ) cells . ^^^ Furthermore , the lack of functional Cr 1 is correlated with absence of expression of cardiac specific myosin light and heavy chain genes during differentiation . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Disease status at the time of ASCT was first partial response ( PR ) in 85 , first complete remission ( CR 1 ) in 45 or primary refractory in 28 cases . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Of the patients < 60 years of age , only four remain alive , and all received noncytarabine based intensive chemotherapy , followed in three cases by autologous ( n = 2 ) or allogeneic ( n = 1 ) stem cell transplant in CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Detailed clinical and laboratory data was collected from the centers concerned on all who were reported to have had a recurrence of their leukemia after 10 or more years from the time of achieving first complete remission ( CR 1 ) . ^^^ A total of 1 , 134 of 2 , 746 children had survived 10 years or more ( range , 10 to 24 years ) in CR 1 and of those , 12 ( approximately 1 % ) had subsequently relapsed . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
AlloBMT was performed during CR 1 in 180 ( 61 % ) out of 295 patients with a donor . ^^^ ABMT was performed in 130 ( 34 % ) out of 377 patients without a donor in CR 1 , in six ( 2 % ) patients during relapse and in 38 ( 10 % ) patients during CR 2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Nineteen patients were transplanted in first complete remission ( CR 1 ) and 45 in second or subsequent CR . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We sequenced 1709 base pairs ( bp ) of mitochondrial DNA including parts of cytochrome b , ND 2 , and the control region ( CR 1 , 2 ) for seven members of the avian genus Pipilo ( towhees ) , Melozone kieneri ( rusty crowned ground sparrow ) , and Arremonops rufivirgatus ( olive sparrow ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
DFS in CR 1 patients transplanted after full dose induction and high dose consolidation was significantly longer if compared to those who received dose / time reduced or postponed treatment . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Status at transplant was : second complete remission ( CR 2 ) : n = 12 ; further CR ( CR > 2 ) : n = 3 , partial remission ( PR ) : n = 2 , relapse : n = 2 and first CR ( CR 1 ) : n = 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Three patients were grafted with evolutive disease , four were in partial remission after several courses of chemotherapy , two were in CR 2 and four were in CR 1 after initial therapy . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
ASCT had been performed in CR 1 for 23 patients and in CR 2 for three . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We found a beneficial effect of purging in patients over 15 years of age and in patients needing more than 1 month to reach CR 1 . ^^^ Patients in CR 1 receiving purged marrow had a longer DFS and a lower relapse probability ( 52 % vs 12 % , P = 0 . 02 and 35 % vs 86 % , P = 0 . 005 , respectively ) which were related to the efficacy of the purging procedure ( more or less than one log of depletion ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We conclude that the use of high dose thiotepa , busulfan and cyclophosphamide is an effective conditioning regimen for childhood myeloid malignancies and may be tested in patients with less advanced disease ( eg CR 1 ) . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Using DEAE Sepharose FF column chromatography , we separated the enzyme that synthesizes tetrahydrobiopterin from 6 pyruvoyl tetrahydropterin [ which is different from sepiapterin reductase ( EC 1 . 1 . 1 . 153 ) ] in the lemon mutant of the silkworm Bombyx mori into two fractions , which were named carbonyl reductase 1 ( CR 1 ) and carbonyl reductase 2 ( CR 2 ) . ^^^ The CR 1 enzyme converted 6 pyruvoyl tetrahydropterin to 6 lactoyl tetrahydropterin , while CR 2 converted 6 pyruvoyl tetrahydropterin to 1 ' hydroxy 2 ' oxopropyl tetrahydropterin , both reactions occurring only in the presence of NADPH . ^^^ However , when CR 1 was mixed with CR 2 in the reaction mixture , 6 pyruvoyl tetrahydropterin was reduced to tetrahydrobiopterin in the presence of NADPH . ^^^ Moreover , CR 1 catalyzed the formation of tetrahydrobiopterin from 1 ' hydroxy 2 ' oxopropyl tetrahydropterin , while CR 2 converted 6 lactoyl tetrahydropterin to tetrahydrobiopterin , both reactions occurring only in the presence of NADPH . ^^^ In the first route , 1 ' hydroxy 2 ' oxopropyl tetrahydropterin is formed from 6 pyruvoyl tetrahydropterin by CR 2 and then reduced to tetrahydrobiopterin by CR 1 , both reactions occurring only in the presence of NADPH . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In the present study , we evaluated the incidence of MDM 2 overexpression by ALL cells from pediatric patients at first relapse and compared MDM 2 protein levels with in vitro response to adriamycin and with duration of initial complete remission ( CR 1 ) . ^^^ Overexpression of MDM 2 ( > / =10 fold ) was significantly correlated with adriamycin resistance and decreased duration of CR 1 . ^^^ The median CR 1 for MDM 2 overexpressers was 20 . 5 months ( range : 3 75 months ) compared to 41 months ( range : 8 98 months ) for non overexpressers ( P < 0 . 01 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In the present study the in vitro growth of CFU GM from PBPC of patients with AML ( n = 11 ) , purged with mafosfamide alone or a combination of mafosfamide and amifostine , was compared to historical controls of mafosfamide purged bone marrow ( AML CR 1 , n = 16 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The eyeblink CR in all animals showed a similar topography with at least two different components , CR 1 and CR 2 , which were expressed at different rates . ^^^ CR 1 appeared first during acquisition , had a shorter onset latency , and was more phasic and more resistant to extinction than CR 2 . ^^^ CR 1 and CR 2 were present in the rabbit eyeblink CR . ^^^ The cerebellum is implicated in the control of CRs and to study whether separate neural pathways were responsible for CR 1 and CR 2 , direct brachium pontis stimulation was used to replace the forelimb CS . ^^^ CR 1 and CR 2 were present in the CR elicited by the brachium pontis CS . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Lower extremity angiographic procedures ( diagnostic and diagnostic / intervention ) were performed in 40 patients with CRI ( baseline serum creatinine [ Cr ] > 1 . 5 mg / dL ) using CO 2 alone or CO 2 supplemented with the use of either nonionic contrast material or gadodiamide ( up to 0 . 4 mmol / kg ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
METHODS : A series of 48 obstructed coronary segments were compressed / decompressed at CR 1 : 1 ( uncompressed ) , 6 : 1 , 10 : 1 and 16 : 1 and analyzed blindly and in random order using the QCA CMS analytical software . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Of the patients showing a partial response ( PR ) after 12 weeks of treatment , 25 % in Group 1 and 52 % in Group 2 improved to CR 1 year later ( p < 0 . 05 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Sixteen of 18 ( 89 % ) survive at median of 854 . 5 days from bone marrow transplantation , 4 in CR 1 and 10 in CR 2 at a median disease free survival ( for remission 2 ) duration of 341 days . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
One hundred and ten patients were in CR ( CR 1 : 23 ; CR2 / 3 : 87 ) and 28 were in first relapse ( R 1 ) at ABMT . ^^^ CR 1 patients treated with CY / TBI ( n = 7 ) had 3 and 5 year disease free survival ( DFS ) rates of 71 % and 57 % . ^^^ CR 1 patients treated with BU / CY ( n = 12 ) , had 3 and 5 year DFS rates of 45 % . ^^^ For CR2 / 3 patients , the length of CR 1 was a significant predictor of DFS . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Of the 119 cases ( 63 % ) presenting with CRI since the first urine screening and blood sampling , only 14 had serum Cr levels higher than 6 . 0 mg / dl . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Patients in complete remission ( CR ) by EP were further subclassified as CR 1 when IF was negative and CR 2 when it remained positive . ^^^ CR 1 patients showed a significantly better event free survival ( EFS ) [ 35 % at 5 years , 95 % confidence interval ( CI ) 17 53 , median 46 months ] and overall survival ( OS ) ( 72 % at 5 years , CI 57 86 , median not reached ) compared with any other response group ( univariate comparison P < 0 . 00000 to P = 0 . 004 ) . ^^^ Multivariate analysis confirmed both the absence of differences among CR 2 , PR 1 and PR 2 and the highly discriminatory prognostic capacity of a three category classification : ( 1 ) CR 1 ( 2 ) CR 2 + PR 1 + PR 2 , and ( 3 ) non response ( EFS P < 0 . 00000 ; OS P < 0 . 00000 ; both Cox models P < 0 . 00000 ) . ^^^ In the logistic regression analysis , the factors significantly associated with failure to achieve CR 1 were the use of two or more up front chemotherapy lines , status of non response pre ASCT and inclusion of total body irradiation ( TBI ) in the preparative regimen . ^^^ Tandem transplants or the use of multiple agents ( busulphan and melphalan ) in the preparative regimen resulted in a higher CR 1 level ; none of the biological factors explored influenced the possibility of achieving CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Among the 17 autografted patients still in CR 2 , nine patients have already reached a longer CR 2 than first CR ( CR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Fifteen were newly diagnosed cases ( CR 1 ) and one was studied after first relapse ( CR 2 ) . ^^^ By contrast , conversion to a repeatedly PCR negative status was observed in the seven patients who remained in CR 1 after a median follow up of 48 months ( range 31 79 months ) , as well as in the transplanted patient who was monitored in CR 2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Levels of CR protein were assessed by CR immunoreactivity ( CR 1 ) using a calcium independent CR antiserum and immunohistochemistry . ^^^ At survival times of 1 day or less , cochlea removal did not change relative levels of CR mRNA or CR 1 in NM between the deafferented and the unoperated sides of the brain . ^^^ Additionally , bilateral cochlea removal had no apparent effect on CR 1 in NM neurons when compared to those in normal animals . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Twenty six AML patients ( 18 males / eight females ) were treated , only eight of whom were in CR 1 . ^^^ The disease free survival in the high risk subgroup ( all patients not in CR 1 ) at 1 and 2 years post transplant was 44 % and 31 % , respectively . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Twenty two patients were in their first complete response ( CR 1 ) , three were in their second CR , and one was in relapse . ^^^ In multivariate analysis , the single factor associated with better DFS was an interval between CR 1 and SCT of less than 4 months ( P : < . 025 ) . ^^^ This study suggests that SCT should be performed in CR 1 in the early phase of the disease . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Previous work has shown that erythrocytes deficient in complement receptor ( CR ) 1 ( CR 1 , CD 35 ; C3b / C4b receptor ) have greatly reduced rosetting capacity , indicating an essential role for CR 1 in rosette formation . ^^^ Mapping of the region of complement receptor ( CR ) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR 1 in rosetting in field isolates . ^^^ Using deletion mutants and mAbs , we have localized the region of CR 1 required for the formation of P . falciparum rosettes to the area of long homologous repeat regions B and C that also acts as the binding site for the activated complement component C3b . ^^^ This result raises the possibility that C3b could be an intermediary in rosetting , bridging between the infected erythrocyte and CR 1 . ^^^ We have also shown in this report that rosettes can be reversed by mAb J3B11 that recognizes the C3b binding site of CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The standard molar enthalpies of formation of chloro , bromo , and iodoacetic acids in the crystalline state , at 298 . 15 K , were determined as deltafH ( o ) m ( C2H3O2Cl , cr alpha ) = ( 509 . 74+ / 0 . 49 ) kJ 10 mol ( 1 ) , deltafH ( o ) m ( C2H3O2Br , cr 1 ) ( 466 . 98 + / 1 . 08 ) kJ 10 mol ( 1 ) , and deltafH ( o ) m ( C2H3O2I , cr ) = ( 415 . 44 + / 1 . 53 ) kJ 10 mol ( 1 ) , respectively , by rotating bomb combustion calorimetry . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Response rates in patients with noninflammatory disease ( n = 14 ; CR 10 patients , partial response [ PR ] 3 patients ) were far better than in patients with inflammatory disease ( n = 11 ; CR 1 patient , PR 6 patients ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
A comparative alignment analysis between these regions and those of the bovine Oct 4 ortholog reveals four conserved regions of homology ( CR 1 to 4 ) between these species ( 66 94 % conservation ) . ^^^ A putative Sp1 / Sp3 binding site and the overlapping hormone responsive element ( HRE ) in CR 1 are identical in all three species . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Confirmed responses were observed with both agents : CAELYX : complete response ( CR ) 1 ( uterine ) , partial response ( PR ) 4 ( response rate ( RR ) 10 % ) ; and doxorubicin : CR 1 , PR 3 ( RR of 9 % ) ; with the best response being stable disease ( NC ) in 16 and 18 patients , respectively . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
From October 1987 to December 1990 , 101 patients with acute myeloid leukemia ( AML ) were randomized to be transplanted in first complete remission ( CR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The values of mean fluorescence intensity ( MFI ) of CR 3 expression on unstimulated monocytes were 12 . 6+ / 1 . 3 ( n = 3 ) , whereas those on b FGF stimulated monocytes were 59 . 2+ / 7 . 1 ( n = 3 ) . b FGF also up regulated the expression of CR 1 on monocytes in a dose and time dependent manner . ^^^ The MFI values of CR 1 expression on unstimulated monocytes were 2 . 5+ / 0 . 1 ( n = 3 ) , whereas those on b FGF stimulated monocytes were 11 . 1+ / 0 . 6 ( n=3 ) . ^^^ The magnitude of CR 1 expression by monocytes was significantly smaller than that of CR 3 expression . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The Cr 1 bond is tilted 2 . 51 ( 4 ) degrees to the N ( 4 ) isoindole plane . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
As to patients given CHT , a CR 1 duration of more than 12 months was the only parameter significantly related to a better clinical outcome ( survival from relapse : 8 vs . 4 months , p=0 . 002 ; CR 2 duration : 11 vs . 5 months , p=0 . 001 , respectively ) . ^^^ INTERPRETATION AND CONCLUSIONS : Aggressive chemotherapy results in an actual survival advantage only for a minority of elderly patients with relapsed AML , i . e . those with CR 1 lasting for more than 12 months . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Twenty eight of 39 patients ( 72 % ) with a donor were allografted in CR 1 , including 2 patients who underwent transplantation in CR 1 without a consolidation course . ^^^ Thirty six of 59 patients ( 61 % ) without a donor received ASCT in CR 1 . ^^^ This treatment approach leads to a relatively high remission rate , and the majority of patients in remission received the SCT in CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These results lead us to the conclusion that [ ( 1 ( 0 ) / I ( infinity ) ) 1 ] might be applicable to cross relaxation rate ( CR ) like imaging , i . e . equivalent CRI . ( B ) W ( % ) ( dry weight ) profiles of [ ( 1 ( 0 ) / I ( infinity ) ) 1 ] and 1 / T ( IS ) ( H2O ) , obtained by near resonance f 2 irradiation , seem to indicate participation of molecular rigidity and an amount of bound water . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
To investigate whether K / BxN serum induced RA involves complement activation and / or the complement receptors ( CR ) 1 and 2 , we analyzed the role of complement C 4 and of CR 1 and CR 2 . ^^^ For this purpose we used C 4 ( / ) mice impaired in the classical and the lectin complement pathways ; Cr 2 ( / ) mice lacking CR 1 and CR 2 and , as control strains , BALB / c , C57BL / 6 , KRN and NOD . ^^^ The lack of protection in Cr 2 ( / ) mice suggests that absence of CR 1 had no significant affect , considering its role in immune complex clearance , inhibition of C 3 and C 5 convertase and as receptor for C3b / C4b . ^^^ Hence we conclude that the transmission of K / BxN serum induced RA is independent of the classical and the lectin complement pathways and CR 1 and CR 2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
It was 25 . 0 % in gallbladder cancer ( CR 1 , NC 2 , PD 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Sixty four patients underwent transplantation in first remission ( CR 1 ) , 16 in CR 2 or CR 3 , and 47 patients had relapsed ALL or primary induction failure ( PIF ) . ^^^ Overall survival at 2 years from transplant was 40 % for patients in CR 1 , 17 % in CR2 / 3 , and 5 % in PIF or relapse . ^^^ Treatment related mortality ( TRM ) and relapse mortality , estimated as competing risk factors , were 54 % and 6 % , respectively , in CR 1 , 75 % and 8 % in CR2 / 3 , and 64 % and 31 % in PIF or relapse . ^^^ Currently 23 CR 1 patients are alive and free of disease with a median follow up of 24 months ( range , 3 97 ) . ^^^ Multivariable analysis showed that CR 1 , shorter interval from diagnosis to transplantation , DRB 1 match , negative cytomegalovirus ( CMV ) serology ( patient and donor ) , and presence of the Philadelphia chromosome , t ( 9 ; 22 ) , were independently associated with better disease free survival ( DFS ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Eleven patients were in CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The CR 1 , CR 2 , and CR 3 activating mutations , when combined in cis , cooperated in transforming Rat 2 fibroblasts . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
FcgammaRII and CR 1 expression on neutrophils of active SLE patients was reduced , while the expression of FcgammaRIII and CR 3 was unaffected . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
A subregion of the N terminal / CR1 fragment spanning residues 30 69 within CR 1 also inhibited yeast growth in a SAGA dependent fashion . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These findings demonstrate that abnormalities in CR 1 and CR 2 may be linked to the production of autoantibodies by modifying the effect of other systemic lupus erythematosus susceptibility genes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These analyses refine the positioning of CR 1 , 2 , and 3 ; define a fourth CR located near the carboxyl terminus of E1A ; and suggest several new functions for E1A . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Macrophages bind and phagocytose opsonized C . neoformans via three major complement receptors ( CR ) for C 3 fragments , designated CD 35 ( CR 1 ) , CD11b / CD18 ( CR 3 ) , and CD11c / CD18 ( CR 4 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
On the contrary , in the LFP after WHF group , the response rate was 38 . 9 % ( CR 1 , PR 6 ) and the one year survival rate after LFP started was 46 . 0 % . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
All but two patients were in complete remission ( CR ) at the time of transplant ( CR 1 , n = 5 ; CR 2 , n = 4 ) . ^^^ Twelve patients ( 36 % ) entered a CR 1 with a median duration of 11 months . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The five year disease free survival ( DFS ) was 63 % for 42 patients at CR 1 , 41 % for 41 patients at CR 2 and 33 % for 40 patients at other stages . ^^^ In patients at remission stage for CR 1 and CR 2 , the 5 year DFS by conditioning regimen was 63 % for regimen ( A ) , 54 % for regimen ( B ) and 54 % for regimens with melphalan and TBI . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
All were at high risk because 25 were actually in relapse at transplant , 16 were in second or later CR and even the 12 patients in CR 1 were at high risk because of the unfavourable prognostic features . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In a few hospitals ASCT was performed early in the CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Twenty patients were in first complete remission ( CR 1 ) , two in CR 2 , and all were in performance status 0 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CR 1 ( CD 35 ) , a multifunctional receptor both in its ligand specificity and in its C regulation activities , is found on circulating monocytes and neutrophils , but the major site of expression is B lymphocytes . ^^^ As a receptor , CR 1 binds to C1q , other C opsonins ( C4b , C3b , iC3b ) and MBL , and as such , has been involved in promoting phagocytosis . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Many patients with acute myeloid leukaemia ( AML ) in first complete remission ( CR 1 ) are ineligible for allogeneic transplantation as a result of age or medical problems other than leukaemia . ^^^ Eighteen patients ( median age 59 years , range 36 73 years ) with de novo ( n = 13 ) and secondary ( n = 5 ) AML in morphological CR 1 , who were not candidates for conventional allografting , received non myeloablative peripheral blood stem cell transplants from human leucocyte antigen identical sibling donors after conditioning with 2 Gy total body irradiation ( TBI ; n = 10 ) or 2 Gy TBI and 90 mg / m2 of fludarabine ( n = 8 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Disease status at transplant was the most significant factor affecting survival : patients with chemosensitive disease but not in first complete remission ( CR 1 ) were 2 . 99 times ( 95 % CI : 1 . 66 5 . 38 , P < 0 . 001 ) more likely to die than patients transplanted in CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Ways to improve patients ' outcome , using high dose therapy followed by autologous / allogeneic stem cell transplantation ( SCT ) in first complete remission ( CR 1 ) rather than consolidation / maintenance chemotherapy , have been investigated . ^^^ The largest prospective trial ever being performed in adult ALL patients , the ongoing UKALL 12 / ECOG 2993 trial , is assigning all patients who have a sibling donor to receive allogeneic SCT ( alloSCT ) in CR 1 , whereas all other patients are randomized to continue chemotherapy versus autologous SCT . ^^^ However , patients with Ph ( + ) ALL who have a donor should receive an alloSCT in CR 1 , regardless of their MRD results . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Post relapse treatment was successful in 41 cases ( 76 % ) , giving an actuarial 3 year overall survival ( OS ) of 81 % from CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia ( AML ) in first complete remission ( CR 1 ) : an intention to treat analysis of the EORTC / GIMEMAAML 10 trial . ^^^ In the European Organization for Research and Treatment of Cancer Leukemia Group and Gruppo Italiano Malattie Ematologiche dell ' Adulto ( EORTC LG / GIMEMA ) acute myeloid leukemia ( AML ) 10 trial , patients in first complete remission ( CR 1 ) received a single intensive consolidation ( IC ) course . ^^^ Median follow up was 4 years ; 289 patients relapsed , 66 died in CR 1 , and 293 died . ^^^ Intention to treat analysis revealed that the 4 year disease free survival ( DFS ) rate of patients with a donor versus those without a donor was 52 . 2 % versus 42 . 2 % , P = . 044 ; hazard ratio = 0 . 80 , 95 % confidence interval ( 0 . 64 , 0 . 995 ) , the relapse incidence was 30 . 4 % versus 52 . 5 % , death in CR 1 was 17 . 4 % versus 5 . 3 % , and the survival rate was 58 . 3 % versus 50 . 8 % ( P = . 18 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
RESULTS : For individuals transplanted in CR 1 ( n = 31 ) the median time from diagnosis to grafting was 167 ( range 92 212 ) days . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CONCLUSIONS : The findings suggest that in patients with advanced chronic renal insufficiency ( CRI ) for the same decrease in GFR the increase of S ( cyst ) is not significantly higher than that of S ( cr ) , although the tubular secretion of creatinine is significantly increased . ^^^ Further studies ( especially those focused on nonrenal elimination of cystatin C ) are needed to elucidate the lack of difference between changes in S ( cyst ) and S ( cr ) in patients with CRI . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Since 1994 the North American Pediatric Renal Transplant Cooperative Study ( NAPRTCS ) has extended its registry to include children with CRI , defined as creatinine clearance ( C ( Cr ) ) < 75 ml / min per 1 . 73 m ( 2 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We analyzed 95 children receiving UCB transplants for AML ( 20 in first complete remission [ CR 1 ] , 47 in CR 2 , and 28 in more advanced stage ) . ^^^ The 2 year leukemia free survival ( LFS ) was 42 % + / 5 % ( 59 % + / 11 % in CR 1 , 50 % + / 8 % in CR 2 , and 21 % + / 9 % for children not in CR ) . ^^^ In CR 2 , LFS was not influenced by the length of CR 1 ( 53 % + / 11 % in CR 1 < 9 . 5 months compared with 50 % + / 12 % in later relapses ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
RESULTS : Fifty eight patients from 11 centers were registered ; 50 primary resistant and eight early relapsed ( CR 1 < 6 months ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Group B showed the following responses : CR 1 , PR 14 , SD 22 , PD 23 ; ORR 25 % ; tumor growth control 62 % . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The role of MUD BMT in CR 1 is still controversial . ^^^ We compared the outcomes of two treatment strategies : BMT using an MRD or MUD vs chemotherapy in children with Ph ( + ) ALL in CR 1 . ^^^ We continue to support treating children with Ph ( + ) ALL with MRD BMT in CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
METHODS : 31 patients with APL , 27 in first complete remission ( CR 1 ) , 3 in CR 2 , and 1 in partial remission ( PR ) after the second relapse , were treated with autologous transplantation of ABM . ^^^ Kaplan Meier survival analysis model was used to estimate the disease free survival ( DFS ) rate at 5 years post transplantation and COX regression model was used to analyze the DFS influencing factors , including sex , PML / RARa positive state , pre transplantation state ( CR 1 , CR 2 , or PR ) , white blood cell ( WBC ) count , and platelet ( PBC ) count . ^^^ RESULTS : The 27 patients in CR 1 had a DFS time of 3 to 113 months ( with a mean DFS time of 46 months ) , and a 5 year DFS rate of 100 % ; none of them suffered a relapse after transplantation . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The patients were retrospectively assigned to three groups on the basis of preoperative serum creatinine concentration ( Cr ) : group 1 ( n = 108 ) , Cr less than 1 . 5 mg / dL ( normal range ) ; group 2 ( n = 65 ) , Cr 1 . 5 to 2 . 0 mg / dL ; group 3 ( n = 27 ) , Cr 2 . 1 to 3 . 5 mg / dL . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
OBJECTIVE : The rationale for this retrospective study was to identify the long term overall and event free survival , relapse , and treatment related mortality rates of high risk pediatric and adult first ( CR 1 ) and second remission ( CR 2 ) patients with acute lymphoblastic leukemia ( ALL ) who were treated with a single preparatory regimen consisting of fractionated total body irradiation ( FTBI ) and high dose etoposide ( VP 16 ) prior to allogeneic hematopoietic cell transplantation . ^^^ PATIENTS AND METHODS : Over a 15 year period at Stanford University Medical Center , 85 consecutive high risk pediatric ( up to age 17 years ; n=41 ) and adult ( age 18 55 years ; n=44 ) ; patients with leukemia ( ALL ) in CR 1 ( n=55 ) and CR 2 ( n=30 ) received HLA matched sibling allogeneic bone marrow or peripheral blood progenitor grafts after being treated with FTBI ( 1320 cGy ) and high dose VP 16 ( 60 mg / kg ) as their preparatory regimen . ^^^ The majority of patients transplanted in CR 1 ( n=45 ) had high risk features , including age above 30 years , white blood cell count at presentation exceeding 25000 / microL , extramedullary disease , need for more than 4 weeks of induction chemotherapy to achieve CR , or high risk chromosomal translocations . ^^^ Most patients transplanted in CR 1 were adults ( n=39 ) , whereas patients in CR 2 were primarily children or adolescents ( n=25 ) . ^^^ RESULTS : The 10 year Kaplan Meier estimates of relapse were significantly ( p=0 . 05 ) lower in CR 1 patients ( 15 % + / 10 % ) than in CR 2 patients ( 33 % + / 20 % ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These include cC1q R / CR , or calreticulin ( CR ) , a 60 kDa protein , which is also known as collectin receptor ; gC1q R / p33 , a 33 kDa homotrimeric protein ; C1q Rp ( CD 93 ) , a 120 kDa , O sialoglycoprotein ; and CR 1 ( CD 35 ) , the receptor for C3b . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
After a median follow up of 9 months from ASCT , nine of 14 patients are alive in continuous complete remission ( CR ) , four have relapsed at 3 , 6 , 8 and 9 months , and one died in CR 1 from gastric cancer . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
METHODS : Twenty six collegiate female softball players were divided into the Cr 1 , 2 , Control ( Cont . ) 1 or 2 group , randomly . ^^^ During the 2 ( nd ) week , the subjects of the Cr 1 and 2 groups ingested 20 g Cr a day for 1 week . ^^^ Thereafter , the subjects in the Cr 2 group continued 3 g Cr ingestion a day for 2 weeks while the Cr 1 group ingested the same amount of placebo during the 3 ( rd ) and 4 ( th ) weeks . ^^^ RESULTS : Though maximal isometric strength did not differ in intra and intergroups , the isokinetic peak torque in the Cr 1 group was significantly decreased in the 4 ( th ) measurement ( p < 0 . 01 ) . ^^^ In the Cr groups , the significant decrease was detected from the 3 ( rd ) in the Cr 1 and in the 4 ( th ) measurement in the Cr 2 group . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Seventy four patients were in first complete remission ( CR 1 ) , and 125 were in later stages of the disease . ^^^ The 5 year probability of relapse and relapse free survival ( RFS ) were 32 % and 49 % , respectively , in patients in CR 1 , as compared with 53 % and 33 % in those with more advanced disease . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In Al ( 3 ) / SiO2 systems with high Al concentrations of 1 10 10 ( 3 ) , 5 10 10 ( 3 ) and 1 10 10 ( 2 ) M , three charge reversals ( CR ) are observed , separately representing , in order of increasing pH , the point of zero charge ( PZC ) on the SiO 2 substrate ( CR 1 ) , the onset of the surface precipitation of Al hydroxide ( CR 2 ) , and at a high pH , the PZC of the Al ( OH ) 3 coating ( CR 3 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Thirty two consecutive adult patients ( median age , 47 years ) with AML in CR ( 15 in CR 1 and 17 in CR > or =2 ) were treated . ^^^ Kaplan Meier estimates of overall and leukemia free survival at 3 years were 55 % + / 14 % ( mean + / SE ) and 57 % + / 14 % in CR 1 patients and were both 39 % + / 12 % in CR > or =2 patients . ^^^ Transplant related mortality was 13 % for patients in CR 1 and 41 % for those in CR > or =2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The cerebellar activation was confined to the lateral posterior cerebellar hemisphere ( lobule 6 , 7 B , Cr 1 , Cr 2 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Of 2 patients at CR 1 received APBSC , 1 relapsed after transplantation , but achieved CR and survived after salvage chemotherapy ; 1 survived all along . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
White blood cells , isolated from EDTA blood by centrifugation after cell fixation with paraformaldehyde , were labelled with FITC conjugated CD 16 ( FcgammaRIII ) , CD 32 ( FcgammaRII ) , CD 64 ( FcgammaRI ) , CD11b ( CR 3 ) and CD 35 ( CR 1 ) monoclonal antibodies and analysed by flow cytometry . ^^^ BACKGROUND : Phagocytosis of IgG or complement opsonized bacteria and antibody production by lymphocytes are regulated by cell surface receptors for IgG ( FcgammaRI , FcgammaRII and FcgammaRIII ) and complement ( CR 1 and CR 3 ) . ^^^ Furthermore , CR 1 expression on lymphocytes , important for the humoral response , was lower in children with renal failure . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In our single center study , we performed RT PCR monitoring in 14 patients with t ( 8 ; 21 ) in CR 1 ( n = 13 ) and / or CR 2 ( n = 4 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CONCLUSIONS : All relapsed elderly patients and young adults with CR 1 lasting for less than 12 months are ideal candidates for experimental therapies . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Between September 1986 and June 1997 , 24 children with high risk ALL in CR 1 were allografted after TAM ( fractionated TBI , high dose Ara C , and melphalan ; n = 10 ) or BAM protocol ( busulfan , high dose Ara C , and melphalan ; n = 14 ) . ^^^ In all , 46 other children transplanted in CR beyond CR 1 were studied for sequelae . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Of 21 patients with less advanced disease , two were in CR 1 , four were in CR 2 , and 15 were in first responding relapse . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The groups were identified on the basis of preprocedure serum Cr : group 1 ( n=108 ) , Cr less than 1 . 5 mg / dL ( normal range ) ; group 2 ( n=65 ) , Cr 1 . 5 to 2 . 0 mg / dL ; group 3 ( n=27 ) , Cr 2 . 1 to 3 . 5 mg / dL . ^^^ One hundred and eight patients had normal renal function ( group 1 ) , and 92 patients had preexisting CRI with baseline Cr 1 . 5 to 2 . 0 mg / dL ( group 2 , n=65 ) or 2 . 1 to 3 . 5 mg / dL ( group 3 , n=27 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Children were grouped following [ ( 51 ) Cr ] labelled EDTA glomerular filtration rate ( GFR , ml / min per 1 . 73 m ( 2 ) ) estimations , into ' normal ' kidney function [ GFR > 75 , mean 106 ( SD 19 . 5 ) , n =58 ] , providing baseline data only , mild ( GFR 51 75 , n =25 ) , moderate ( GFR 25 50 , n =21 ) , and severe ( GFR < 25 , n=19 ) CRI . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The qnr gene was located on a sul 1 type class 1 integron just downstream of a conserved region ( CR ) element ( CR 1 ) comprising the Orf 513 recombinase . ^^^ Promoter sequences for qnr expression overlapped the extremity of CR 1 , indicating the role of CR 1 in the expression of antibiotic resistance genes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
With a median follow up of 6 . 5 years , eight out of 19 ( 0 . 42 ) patients remain in CR 1 without radiotherapy and another three patients are in stable second or subsequent remissions . ^^^ Three patients died from treatment related toxicity and another died in CR 1 from an uncharacterized leukoencephalopathy . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Allogeneic versus autologous versus peripheral stem cell transplantation in CR 1 pediatric AML patients : a single center experience . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Median duration of CR 1 was 30 . 3 months . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Sixty seven patients with acute myeloid leukemia ( AML ; 19 complete remission [ CR ] 1 , 14 CR 2 , nine CR > 2 , 25 in relapse ) and 37 with acute lymphoid leukemia ( ALL ; 14 CR 1 , eight CR 2 , two CR > 2 , 13 in relapse ) were conditioned with total body irradiation , thiotepa , fludarabine , and antithymocyte globulin . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The role of allogenic bone marrow transplantation from an HLA identical sibling in CR 1 was examined . ^^^ The disease free survival ( DFS ) was 52+ / 4 % for non allografted patients and 57+ / 7 % for allografted patients ( P=NS ) ; a better OS for allografted patients was shown and could be related either to allo BMT early in CR 1 or to a second allo BMT in CR 2 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Results for 128 patients given gemtuzumab ozogamicin in phase 2 trials were compared with those for 128 patients given high dose cytarabine ( HDAC ) combination therapy in different trials Multivariate logistic regression was used to analyze age , duration of first complete remission ( CR 1 ) , and cytogenetics for potential differences between the groups . rare of overall remission ) combined complete remission [ CR ] plus CR with incomplete platelet recovery [ CRp ] ) following treatment with gemtuzumab ozogamicin or HDAC therapy were 38 % and 41 % , respectively . ^^^ Gemtuzumab ozogamicin treatment was associated with a higher overall remission rate compared with HDAC treatment if CR 1 duration was 3 10 . 5 months . ^^^ In contrast , HDAC treatment was associated with a higher overall remission rate than gemtuzumab ozogamicin treatment if CR 1 duration was > 19 months . ^^^ If CR 1 duration was between 10 . 5 and 19 months , the differences in treatment responses were not statistically significant . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Gemtuzumab ozogamicin is a valuable new treatment option for patients aged > or=60 years with CD 33 positive AML in first relapse for whom other cytotoxic chemotherapy is not considered appropriate ; patients with a first CR ( CR 1 ) of > 12 months are likely to have the best outcome . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
He had a previous episode of CR 1 year ago that was treated successfully . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
E1A CR 1 binds several chromatin modifying complexes , but how this contributes to stimulation of cellular DNA synthesis and transformation is not clear . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Patients receiving transplantation in CR 1 had 2 year overall survivals of 44 % after related and 63 % after unrelated HCT , respectively . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The complement receptor 1 , CR 1 ( CD 35 ) , mediates inhibitory signals in human T lymphocytes . ^^^ In the present study we investigated the effect of antibodies to CR 1 on T cell lines and peripheral T cells of healthy donors , respectively . ^^^ Antibodies to CR 1 profoundly inhibited the proliferation of the T cells ; of note is , that exogenously added interleukin 2 , though enhancing proliferation , did not overcome the inhibitory effect mediated by anti CR 1 . ^^^ While anti CR 1 had no effect on the activation of the immediate early genes c jun or c fos nor on the early increase of gamma interferon or interleukin 2 specific RNA , the protein synthesis of those cytokines was inhibited . ^^^ Taken together , the data indicate that triggering CR 1 inhibits proliferation of T lymphocytes by a mechanism operating downstream of the initial signalling events . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Nine patients received HDC / ASCT in the first ( CR 1 ) or second complete remission ( CR 2 ) , while seven patients received HDC / ASCT as salvage . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
There were no significant differences between the two groups as age , serum LDH , duration of CR 1 and IPI at relapse are concerned . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Gemtuzumab ozogamicin is a valuable new treatment option for patients aged > or =60 years with CD 33 positive AML in first relapse for whom other cytotoxic chemotherapy is not considered appropriate ; patients with a first CR ( CR 1 ) of > 12 months are likely to have the best outcome . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In each cohort , 77 % of patients underwent allogeneic stem cell transplantation ( SCT ) in first CR ( CR 1 ) . ^^^ Both schedules of imatinib have acceptable toxicity and facilitate SCT in CR 1 in the majority of patients , but concurrent administration of imatinib and chemotherapy has greater antileukemic efficacy . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Although CD21+ ( CR 2 ) and CD35+ ( CR 1 ) cells all expressed DAF , CD11a ( LFA 1 ) levels correlated inversely with those of DAF . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CR 1 , CR 2 , DAF , MCP , factor H , C4bp , factor B , and C 3 are members of a family of structurally related molecules , the majority of which belong to the complement system . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We simultaneously determined levels of decay accelerating factor ( DAF ) and CR 1 in these tumor cells , and tested susceptibility to C 3 deposition via activation of the alternative C pathway . ^^^ Of 21 cell lines we examined , 14 lacked CR 1 and two lacked DAF ; none , however , lacked MCP . ^^^ Tumor cells bearing MCP , lacking CR 1 or DAF , and undergoing no C 3 deposition , may escape C attack due to the compensatory effect of MCP in the absence of the other regulatory proteins . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
To investigate the mechanism by which treatment of normal human erythrocytes with the sulfhydryl reagent 2 aminoethylisothiouronium bromide ( AET ) induces susceptibility to complement mediated lysis , the effects of AET on the structural and functional integrity of decay accelerating factor ( DAF ) , membrane inhibitor of reactive lysis ( MIRL ) , and complement receptor type 1 ( CR 1 ) were examined . ^^^ Following treatment with AET , erythrocyte MIRL and CR 1 were no longer recognized in situ by antibodies , and antibody binding to DAF was diminished by approximately 50 % . ^^^ These studies indicated that the structural integrity of the three complement regulatory proteins was either partially ( DAF ) or completely ( MIRL and CR 1 ) disrupted by AET . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The encoded genes and two of the gene like elements share the same orientation and are ordered ( 5 ' to 3 ' ) DAF , CR 2 , CR 1 , MCP like , CR 1 like , and MCP . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Blocking studies using antibodies suggested that C3bi receptors , CR 3 and CR 4 , but not other C 3 binding proteins , C3b / C4b receptor ( CR 1 ) , membrane cofactor protein ( MCP ) or decay accelerating factor ( DAF ) , are involved in granulocyte mediated haemolysis . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Two human T cell lines , CEM and TALL , are CR 1 and DAF . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Differences between the binding sites of the complement regulatory proteins DAF , CR 1 , and factor H on C 3 convertases . ^^^ Binding studies using purified decay accelerating factor ( DAF ) , CR 1 , and Factor H indicate that the primary interaction of DAF with C 3 convertases is with the Bb or C2a subunits , whereas CR 1 and Factor H interact primarily with the C3b or C4b subunits . ^^^ The ability of soluble DAF , CR 1 , or Factor H to decay C3b , Bb bound to zymosan was inhibited by various concentrations of fluid phase competitors ( C3b , Bb , C3b , Bb , C3b , B , C4b , or C4b , C2a ) in 0 . 1 % NP 40 at 22 degrees C . ^^^ Thus , C3b binds to DAF with a 10 fold lower affinity than to CR 1 and a 100 fold lower affinity than to Factor H . ^^^ The appKa of C3b , Bb for the three proteins were more similar : DAF ( 0 . 91 microM 1 ) , CR 1 ( 1 microM 1 ) , and Factor H ( 2 . 9 microM 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
On the basis of the present and prior observations , we speculate that both DAF and CR 1 act endogenously to inactivate the function of autologous red cell bound C4b and prevent the progression of the cascade . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The DAF and acetylcholinesterase deficiencies contrast with the C3b / C4b receptor ( CR 1 ) deficit , which is less profound and similarly distributed in complement insensitive cell populations . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We have investigated the genetic relationships between the human decay accelerating factor ( DAF ) and a group of complement components including the C3b / C4b receptor ( CR 1 ) , C 4 binding protein ( C4bp ) , and factor H ( H ) , to which DAF is structurally and functionally related . ^^^ Segregation analysis of these polymorphic fragments in families informative for the segregation of alleles at the CR 1 , C4BP , and H loci ( RCA haplotypes ) , demonstrated that , in humans , the gene encoding DAF is located within the RCA gene cluster . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We report the organization of the human genes encoding the complement components C 4 binding protein ( C4BP ) , C3b / C4b receptor ( CR 1 ) , decay accelerating factor ( DAF ) , and C3dg receptor ( CR 2 ) within the regulator of complement activation ( RCA ) gene cluster . ^^^ A physical map of the human regulator of complement activation gene cluster linking the complement genes CR 1 , CR 2 , DAF , and C4BP . ^^^ Using pulsed field gel electrophoresis analysis these genes have been physically linked and aligned as CR 1 CR2 DAF C4BP in an 800 kb DNA segment . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The genes encoding CR 1 , CR 2 , DAF , and C4bp were aligned in that order within a region of 750 kb . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The structural gene for membrane cofactor protein ( MCP ) , a widely distributed C3b / C4b binding regulatory glycoprotein of the complement system , has been mapped to the same locus as the structural genes for CR 1 , CR 2 , DAF , and C4bp . ^^^ The order of the genes within an approximately 800 kb DNA fragment on the long arm of chromosome 1 is MCP CR 1 CR2 DAF C4bp . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Gp 58 / 68 differed from the human regulatory proteins H , DAF , MCP and CR 1 and from previously reported regulatory proteins on the parasite membrane in that it was unable to enhance decay dissociation of preformed alternative pathway C 3 convertase sites , did not serve as a co factor for 1 mediated cleavage of C3b and had no inhibitory activity on the classical pathway convertases . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Upregulation of surface DAF occurred within minutes , paralleled the upregulation of complement receptor types 1 and 3 ( CR 1 and CR 3 ) , and was not dependent on new protein synthesis . ^^^ In contrast , these cells increased CR 1 and CR 3 expression normally , suggesting that DAF deficiency in affected cells involves abnormal synthesis or packaging of DAF for intracellular storage . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
This establishes the close linkage of the DAF gene to genes for four other proteins ( C3b / C4b receptor or complement receptor 1 , C3d receptor or complement receptor 2 , factor H , and C 4 binding protein ) that share 60 amino acid homologous repeats as well as complement regulatory or receptor activity , thereby enlarging the complement regulatory gene family on the long arm of human chromosome 1 . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These molecules are factor H , CR 1 ( C3b / C4b receptor ) , CR 2 ( C3d / EBV receptor ) , C4BP ( C4b binding protein ) , DAF ( decay accelerating factor ) , MCP ( membrane cofactor protein ; earlier designated p45 / 70 ) , CR 3 ( iC3b receptor or Mac 1 ) and CR 4 ( protein 150 / 95 ) . ^^^ Due to structural , genetic and functional features these factors are members of one or several newly recognized large families of proteins : ( 1 ) molecules with 60 amino acids long repeats ( H , CR 1 , CR 2 , C4BP , DAF ) ; ( 2 ) proteins with 1 , 2 diacylglycerol membrane anchoring ( DAF ) ; ( 3 ) proteins with a heterodimer structure and preference for ligands containing the tripeptide arginine glycine asparagine ( CR 3 , CR 4 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The regulatory proteins factor H , C4BP , CR 1 and DAF , which are involved in the control of C 3 convertase activity , are encoded by closely linked genes ( termed the regulators of complement activation or RCA linkage group ) that have been mapped to human chromosome 1 . ^^^ PFGE has defined the linkage of the CR 1 , C4BP and DAF genes , together with the CR 2 gene in an 800 kb segment of DNA , and it is clear that this technique will eventually be applied to the molecular mapping of other complement genes in relation to their flanking loci . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The regulatory proteins factor H , C4BP , CR 1 , CR 2 and DAF , which are involved in the control of C 3 convertase activity , are encoded by closely linked genes , termed the regulators of complement activation ( RCA ) linkage group , that have been mapped to human chromosome 1 . cDNA clones for all these proteins have been isolated , and this has made it possible to investigate the organization and structure of the MHC class 3 genes and the genes in the RCA linkage group . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Purification and functional analysis of the polymorphic variants of the C3b / C4b receptor ( CR 1 ) and comparison with H , C4b binding protein ( C4bp ) , and decay accelerating factor ( DAF ) . ^^^ The functional activity of CR 1 was also compared with C4bp , H , and decay accelerating factor ( DAF ) in fluid phase assays designed to assess the inhibition of the C 3 convertases and co factor activity . ^^^ DAF was an approximately fourfold better inhibitor of the alternative pathway convertase than CR 1 or H , but was a fourfold less efficient inhibitor of the classical pathway convertase than CR 1 or C4bp . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Most of these CR 1 , CR 2 , CR 3 , `` CR 4 ' ' , DAF , HSV 1 c glycoprotein , Gp 45 70 , p 150 , 95 , cell surface Factor H , and a 90 kD protein interact with C 3 or C 4 and their degradation products . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The two factor H like proteins , the C3b receptor ( CR 1 ) and the decay accelerating factor ( DAF ) , were isolated from normal human erythrocytes , and specific antisera were prepared . ^^^ Selective inhibition of the two proteins on normal erythrocytes by the antisera demonstrated ( 1 ) that the factor responsible for accelerated decay of erythrocyte bound C 3 convertase is DAF and ( 2 ) that the cofactor required for inactivation of erythrocyte bound C3b by factor 1 is CR 1 . ^^^ Erythrocytes deficient in CR 1 , which were obtained from an apparently healthy individual , exhibited normal DAF activity but no factor 1 cofactor activity . ^^^ These cells were not susceptible to complement mediated lysis in acidified human serum , whereas PNH erythrocytes and Pronase treated human erythrocytes ( which lack DAF and CR 1 activities ) were lysed by this treatment . ^^^ The results suggest that the primary molecular defect underlying the clinical manifestations of PNH may be the lack of the membrane associated DAF protein and that the abnormal cells may also exhibit impaired CR 1 function . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Moreover , the inhibitory activity of intact human erythrocytes on C4b2a was not blocked by antibodies to DAF , but was abolished by antibodies to the C3b / C4b receptor ( CR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Two proteins that decrease the stability of the classical and alternative pathway C 3 convertases on target cells have been isolated from normal human E stroma : the 70 , 000 Mr decay accelerating factor of stroma ( DAF ) and the 250 , 000 Mr C3b receptor ( C3bR ) . ^^^ In contrast , specific immune precipitates of PNH E from three patients show C3bR but are deficient in DAF ; type 2 PNH E are relatively deficient and type 3 PNH E are totally deficient in DAF . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These represented membrane associated and soluble forms of DAF , which were neither recognized by mAb against membrane cofactor protein ( MCP , CD 46 ) and C3b / C4b receptor ( CR 1 , CD 35 ) nor by non immune IgG . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
When compared to young E , old E separated by density gradients on Percoll had fewer CR 1 [ six normal subjects , mean loss : 50 . 4 + / 4 . 9 ( SEM ) % ] , DAF ( 34 . 4 + / 1 . 2 % ) and CD 59 ( 34 . 5 + / 2 . 7 % ) . ^^^ The loss of CR 1 was significantly higher than the loss of DAF and CD 59 ( p < 0 . 02 ) . ^^^ CR 1 , DAF and CD 59 were lost on ATP depleted E ; however , the loss of CR 1 and DAF were identical ( six experiments , mean loss of CR 1 : 28 . 7 + / 2 . 7 % , DAF : 26 . 3 + / 4 . 6 % and CD 59 : 20 . 5 + / 4 % ) . ^^^ In vitro experiments indicated that CR 1 was more sensitive to trypsin and papain cleavage than DAF and CD 59 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Expression of other C regulatory proteins , decay accelerating factor ( DAF ) , MCP and CR 1 , was similar on both cell lines . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Immunohistochemistry was performed on all tissue samples , using monoclonal antibodies to membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , CD 59 and complement receptor 1 ( CR 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
As it is not known why the strictly controlled C system starts to react against autologous heart tissue , we have analyzed the expression of various membrane regulators of C ( CR 1 , DAF , MCP , CD 59 , C 8 binding protein ) and the pattern of deposition of C components and plasma C regulators ( C4b binding protein and vitronectin ) in normal ( n = 7 ) and infarcted ( n = 13 ) human myocardium . ^^^ Little or no CR 1 , MCP , and DAF was observed on these cells . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The levels of complement regulatory molecules ( complement receptor type one [ CR 1 ] , decay accelerating factor [ DAF ] , membrane cofactor protein [ MCP ] , and an inhibitor of membrane attack complex [ CD 59 ] ) in lung cancer cells were analyzed to investigate the relation between their expression and histological subtypes , and the possibility of homologous complement deposition on cancer cells . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Comparison of the rabbit C4BP alpha chain sequence with other SCR containing C3b / C4b binding proteins revealed highest sequence similarities between the second SCRs in C4BP from rabbit , human and murine species and SCRs at corresponding position in complement receptor 1 ( CR 1 ) whereas in decay accelerating factor ( DAF ) , the third SCR was most similar . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Application of MAIEA ( monoclonal antibody specific immobilisation of erythrocyte antigen ) , a recently reported technique , to identify antigens and to assign red cell antigens to a particular membrane component is described : location of Knops system antigens on CR 1 is confirmed and provisional assignment of Cromer system antigens to the different short consensus regions of decay accelerating factor ( DAF ) is described . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We further studied the expression of C 3 step regulatory proteins ( membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , CR 1 and CD 59 ( a terminal step regulatory protein ) by cultured GEC . ^^^ Treatment of GEC by proinflammatory cytokines IL 1 beta , TGF beta , TNF alpha and IL 6 did not modify the expression of MCP , DAF and CR 1 whereas an increase in the expression of CD 59 could be observed after treatment with IL 1 beta and TGF beta . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
To determine whether these glycoproteins are expressed in human respiratory tract tissue , we studied tissue biopsies of healthy and diseased human respiratory tract from nose to alveoli for the presence of four cell membrane complement regulatory glycoproteins ( membrane cofactor protein [ MCP ] , decay accelerating factor [ DAF ] , CD 59 , and complement receptor type 1 [ CR 1 ] ) using an immunoperoxidase technique . ^^^ We found that normal human respiratory tract from nose to alveoli express MCP , DAF , and CD 59 , but not CR 1 , and that this expression increases in inflammation and in lung cancer . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
These results , taken together with the previous reports on the distribution of other complement regulatory proteins , infer that the distribution profile of MCP is rather similar to that of DAF but differs from those of CD 59 and CR 1 in the normal human kidney ; this may reflect the differences between their roles or functional properties in renal tissue . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
METHODS : We determined the distribution of four main CRP : membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , protectin , and complement receptor 1 ( CR 1 ) in 30 histologically normal livers , 13 samples from University of Wisconsin cold storage solution ( UW ) preserved tissue and 17 postoperative biopsies of UW preserved allografts . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Dot blot analysis showed the presence of mRNAs for all the complement components and regulatory proteins ( C 3 , factor B , factor D , C 5 , C 6 , C 7 , C 9 , factor H , factor 1 , S protein , SP 40 , 40 , DAF , MCP , CR 1 , CD 59 ) , except for properdin , C 8 alpha , C 8 beta and C 8 gamma in all three types of synovial membrane studied . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Other antigens have been located on proteins already identified , for instance the Cromer antigens on DAF , Knops antigens on CR 1 , Indian and AnWj antigens on CD 44 , Yt antigens on AChE , Diego , Wr , Rga and Warr on Band 3 , Colton antigens on AQP 1 ( water channel ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
For comparison , astrocyte expression of CD 59 , DAF , MCP and CR 1 was confirmed at the mRNA and protein levels . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Neuroblastoma expressed regulators MCP and CD 59 but did not express DAF or CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The expression of the complement receptors , CD 35 ( CR 1 ) and CD11b / 18 ( CR 3 ) , and inhibitory membrane proteins , DAF and MCP , was measured by flow cytometry . ^^^ M CSF increased CR 3 on polymorphonuclear cells ( PMNs ) and CR 1 , CR 3 , MCP and DAF on monocytes . ^^^ C5a increased CR 1 , CR 3 and DAF on PMNs , but did not affect the expression of those on monocytes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Firstly , all C regulators , decay accelerating factor ( DAF ) , membrane cofactor protein ( MCP ) and C3b / C4b receptor ( CR 1 ) , were diminished on the cell surface concomitantly with the apoptotic process . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
In contrast to MCP and CR 1 , which are integrative proteins , DAF , C8bp and protectin are bound to membranes with their glycophospholypid anchors . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Only DAF of the activation pathway regulators was expressed , not CR 1 or MCP . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Cardiovirulent CVB 3 did not interact with molecules functionally and / or structurally related to DAF , including CD 35 , CD 46 , Factor H , or C 4 binding protein . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Decay accelerating factor ( DAF ) , membrane cofactor protein ( MCP ) , and complement receptor type 1 ( CR 1 ) act by inactivating C3 / C5 convertase . ^^^ DAF , MCP , and CD 59 are ubiquitously expressed by all three resident glomerular cells , while CR 1 is localized exclusively in podocytes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The functions of some of these structures are known : Diego ( band 3 ) is the red cell anion exchanger ; Kidd , a urea transporter ; Colton ( aquaporin 1 ) , a water channel ; Cromer ( DAF ) and Knops ( CRI ) , complement regulators ; Diego ( band 3 ) and Gerbich ( glycophorin C / D ) link the red cell membrane and the membrane skeleton . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Neurons expressed neither DAF nor complement receptor 1 ( CR 1 ) . ^^^ DAF , MCP , and CD 59 mRNA were expressed by epithelial cells of the choroid plexus and CR 1 mRNA was found only in Kolmer cells . ^^^ The demonstration herein that neurons express only very low levels of CD 59 and MCP and lack both CR 1 and DAF might explain their susceptibility to C damage . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Purified Loxosceles toxins rendered human erythrocytes susceptible to lysis by human C but did not have an effect on the E bound C regulators DAF , CR 1 , or CD 59 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
This study assessed the expression of complement receptor 1 ( CR 1 ) , decay accelerating factor ( DAF ) and membrane inhibitor of reactive lysis ( CD 59 ) on the erythrocytes and glomerulus of diffuse proliferative glomerulonephritis ( DPGN ) of systemic lupus erythematosus ( SLE ) patients using flow cytometry and immunofluorescence techniques to elucidate their role in the pathogenesis of DPGN . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Functional domains , structural variations and pathogen interactions of MCP , DAF and CR 1 . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
We investigated the structural and functional similarities among short consensus repeats ( SCRs ) of the following human proteins : the alpha chain of the C4b binding protein ( C4bpalpha ) , factor H ( FH ) , factor H related proteins ( FHR 1 through FHR 4 ) , complement receptors type 1 ( CR 1 ) and type 2 ( CR 2 ) , the CR 1 like protein ( CR1L ) , membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , and the sand bass proteins , the cofactor protein ( SBP 1 ) and its homolog , the cofactor related protein ( SBCRP 1 ) . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Decay accelerating factor ( DAF ) , complement receptor 1 ( CR 1 ) , and factor H dissociate the complement AP C 3 convertase ( C3bBb ) via sites on the type A domain of Bb . ^^^ The AP C 3 convertase , C3bBb ( Mg ( 2+ ) ) , is subject to irreversible dissociation ( decay acceleration ) by three proteins : DAF , CR 1 , and factor H . ^^^ Two critical fB sites were identified with a structural model . 1 ) Several mutations centered at adjacent alpha helices 4 and 5 ( Gln 335 , Tyr 338 , Ser 339 , Asp 382 ) caused substantial resistance to DAF and CR 1 mediated decay acceleration but not factor H . 2 ) Several mutations centered at the alpha 1 helix and adjoining loops ( especially D254G ) caused resistance to decay acceleration mediated by all three regulators and also increased C3b binding affinity and C3bBb stability . ^^^ In the simplest interpretation of these results , DAF and CR 1 directly interact with C3bBb at alpha 4 / 5 ; factor H likely interacts at some other location , possibly on the C3b subunit . ^^^ Bb interface interfere with the normal dissociation of C3b from Bb , whether it is spontaneous or promoted by DAF , CR 1 , or factor H . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Microvesicles enriched in CR 1 and DAF are released from erythrocytes matured in vitro , leading to the same loss of both molecules . ^^^ When comparing reticulocytes and erythrocytes , CR 1 and DAF were lost similarly in 15 normal individuals , suggesting that vesiculation may be at the origin of CR 1 loss in vivo . ^^^ However , the enhanced loss of CR 1 in 3 patients with factor 1 deficiency was contrasted with a normal loss of DAF , raising the possibility that , in this pathological condition , CR 1 might be proteolytically cleaved , leaving small CR 1 fragments on the erythrocytes . ^^^ These data suggest that cell surface domains rich in CR 1 , but not in DAF , are specifically lost in factor 1 deficiency . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
METHODS : DAF , CD 59 , and complement receptor 1 ( CR 1 ) levels were analyzed for a group of 95 HD patients and compared with those of a control group . ^^^ RESULTS : In the 95 HD patients , three factors correlated significantly : DAF and CD 59 ( r = 0 . 642 ) , DAF and CR 1 ( r = 0 . 503 ) , and CD 59 and CR 1 ( r = 0 . 324 ) , whereas no correlations were found in the group of 42 healthy controls . ^^^ DAF and CD 59 levels increased in all 8 patients after rEPO treatment was reinitiated ( P < 0 . 01 ) , and CR 1 levels increased in 5 of 8 patients . ^^^ In these patients , DAF , CD 59 , and CR 1 levels did not change before or after withholding rEPO therapy . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Dissociation ( decay acceleration ) of these central enzymes by the regulators decay accelerating factor ( DAF ) , complement receptor 1 ( CR 1 ) , factor H , and C 4 binding protein ( C4BP ) controls their function . ^^^ In a previous investigation , we obtained evidence implicating the alpha4 / 5 region of the type A domain of Bb ( especially Tyr 338 ) in decay acceleration of C3bBb and proposed this site as a potential interaction point with DAF and long homologous repeat A of CR 1 . ^^^ CCPs 1 3 of CR 1 ) , DAF / C4b2a provides the simplest structural model for this reaction . ^^^ Functional C4b2a complexes made with the C 2 Y327A mutant , the C 2 homolog to factor B Y338A , were highly resistant to DAF , C4BP , and long homologous repeat A of CR 1 , whereas C 2 substitutions in two nearby residues ( N324A and L328A ) resulted in partial resistance . ^^^ Our new findings indicate that the alpha4 / 5 region of C2a is critical to decay acceleration mediated by DAF , C4BP , and CR 1 and suggest that decay acceleration of C4b2a and C3bBb requires interaction of the convertase alpha4 / 5 region with a CCP2 / CCP3 site of DAF or structurally homologous sites of CR 1 and C4BP . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Surface expression of beta 2 integrins , l selectin , complement receptor 1 ( CR 1 ) , decay accelerating factor ( DAF ) , C5a receptor , intercellular adhesion molecule 1 ( ICAM 1 ) and ICAM 3 was compared by flow cytometry on isolated neutrophils stimulated with phorbol 12 myristate 13 acetate ( PMA ) , N formyl methionyl leucyl phenylalanine ( FMLP ) , endotoxin or interleukin 8 and on neutrophils in whole blood anti coagulated with the thrombin inhibitor lepirudin and stimulated with cobra venom factor to induce complement activation . ^^^ With high enough doses , all stimulants induced significant upregulation of beta 2 integrins , CR 1 and DAF and downregulation of l selectin . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The aje set is a feature of several CCPs including human CR 1 and DAF and murine Crry and appears to be associated with the success or failure of implantation inter alia . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Linkage disequilibrium analyses suggest that this SNP haplotype also includes the CR 1 , DAF and C4BP genes . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
Recent studies in children with severe P . falciparum anemia have demonstrated elevated levels of E bound Abs , reduced E associated complement receptor 1 ( CR 1 ) and decay accelerating factor ( DAF ) , and pronounced splenic enlargement , suggesting a mechanism for E loss involving Abs , complement , and phagocytosis . ^^^ Motivated by these reports , we have developed an in vitro model in which human E with Abs and complement bound to CR 1 , DAF , or glycophorin A are incubated with model human macrophages ( the THP 1 cell line ) . ^^^ DAF is lost from the E during the transfer of DAF bound IC , but the transfer of CR 1 bound IC does not lead to a significant loss of DAF . ^^^ We also examined the organization of CR 1 and DAF in the presence of E bound Ab / complement . ^^^ We find that CR 1 , but not DAF , colocalizes with IgM mAb C3b and IC C3b substrates attached to glycophorin A . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
However , C system regulators CD 59 , CR 1 , DAF , and MCP were not detected on plaques or tangles at any stage , indicating that C activation related to AD is incompletely controlled . . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The human complement RCA proteins analyzed were factor H ( FH ) , C 4 binding protein alpha chain , membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , and complement receptors type 1 ( CR 1 ) and 2 ( CR 2 ) . ^^^ Sequences of key poxvirus regulators of complement activation , vaccinia virus complement control protein ( VCP ) , smallpox inhibitor of complement enzymes ( SPICE ) , and cowpox inflammation modulatory protein ( IMP ) were similar to SCRs 1 through 5 of C 4 binding protein , alpha chain , and they were also clustered with other homologous repeats of MCP , DAF , CR 1 , CR 2 , and FH . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The present study describes the temporal expression of complement regulatory molecules membrane cofactor protein ( MCP ) , decay accelerating factor ( DAF ) , CR 1 , and CD 59 in the human endometrium throughout the normal menstrual cycle and in patients submitted to ovarian hyperstimulation . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
The levels of decay accelerating factor ( DAF ) and CD 59 on erythrocytes ( E ) were also determined to ascertain whether the loss of CR 1 is a specific phenomenon or other complement regulatory proteins are also affected . ^^^ METHODS : The levels of CR 1 , DAF , and CD 59 on E were analyzed in 176 HD patients with DMN , 101 HD patients with non diabetes mellitus renal diseases ( non DMN ) , and 108 healthy individuals . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
CONCLUSION Lower HDL C and higher CRI values were associated with more severe and intensive CAD ; TC < 200 mg / dl is compatible with CAD , specially if there is a low HDL C level . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
During one year treatment with KN SR there were observed the decrease of total cholesterol ( TC ) by 18 % , LDL C by 22 % , triglycerides by 36 % , Lp ( a ) by 56 % , and the increase of HDL C by 12 % . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
RESULTS : In CR 1 A and CR 1 B dyslipoproteinemia was found at different stages of renal insufficiency which was manifested by the significant increase of TG , TC , LDL C , apo B levels and TC / HDL C , LDL C / HDL C ratios and significant decrease of HDL C level and apo AI / apoB , HDL C / apoAI ratios in comparison with controls . ^^^ We also observed decreased TG , TC , LDL C , apo AI , apo B levels and TC / HDL C , LDL C / HDL C ratios and unchanged HDL C level and apo AI / apoB , HDL C / apoAI ratios in cm c in comparison to CR 1 A . ^^^
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
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Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA
Interacting proteins: P08174 and P17927	Pubmed	SVM Score :0.0
NA