| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| In the present studies exposure of fetal hippocampal neurons to glutamate ( 100 microM ) for 5 min resulted in increases in the neuron specific growth associated genes T alpha 1 alpha tubulin ( T alpha 1 ) , microtubule associated protein 2 ( MAP 2 ) and growth associated protein 43 ( GAP 43 ) . mRNA levels peaked at between 8 and 12 h following exposure as determined by competitive reverse transcription polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Other genes that have putative roles in mammalian sleep or specific brain functions , including somatostatin , enkephalin , growth associated protein 43 , glutamate acid decarboxylases 65 / 67 , histidine decarboxylase , and a sleep related transcript SD 464 did not change significantly during individual hibernation bouts . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The present study investigated whether in Sprague Dawley rats a single , behavioural sensitizing dose of cocaine is sufficient to induce changes in the mRNA levels of growth associated protein 43 ( GAP 43 ) , an important protein in mediating experience dependent plasticity and synaptic reorganization , and of glutamate receptor 1 ( GluR 1 ) , a subunit of AMPA glutamate receptors , a protein that is up regulated with repeated cocaine . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| From studies on the distribution of three further neuroactive substances in rat superior collicular tissue : the calcium binding protein calretinin , the growth and plasticity related protein neuromodulin ( GAP 43 ) , and a glutamate receptor of the NMDA type , we were led to conclude ( 1 ) that the intermediate layers of the superior colliculus are composed not of two , but of at least three disjunct types of modules , ( 2 ) that not just the intermediate layers but more or less the whole superior colliculus is an assemblage of modules , and ( 3 ) that , besides topographic connectivity and laminar structuring , the modules constituting an iterative partitioning represent a third major feature of superior collicular architecture . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| As the epsilon PKC could be activated by arachidonic acid , it is strongly suggested that in the case of LTP , the presynaptic epsilon PKC is activated by arachidonic acid released postsynaptically and phosphorylates GAP 43 , resulting in the increase in glutamate release . . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the epsilon subspecies of protein kinase C ( PKC ) was demonstrated to be exclusively located at the presynaptic terminals in the hippocampus and activated by arachidonic acid , and this enzyme is suggested to be involved in the production of LTP through a phosphorylation of GAP 43 , while the gamma subspecies of PKC may be postsynaptically involved in LTP through an activation of NMDAR 1 . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The role of several biological molecules in learning and memory are considered , for example , protein kinase C ( PKC ) , Ca ( ++ ) Calmodulin kinase 2 ( CaMKII ) , GAP 43 , and glutamate receptors . . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We propose a model wherein RC 3 and GAP 43 regulate calmodulin availability in dendritic spines and axons , respectively , and calmodulin regulates their ability to amplify the mobilization of Ca2+ in response to metabotropic glutamate receptor stimulation . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Modulation of GAP 43 mRNA by GABA and glutamate in cultured cerebellar granule cells . ^^^ To determine if the cerebellar neurotransmitters , GABA ( gamma amino butyric acid ) and glutamate are involved in the modulation of GAP 43 expression , cultured cerebellar granule cells were exposed to these transmitters . ^^^ Results from these studies also indicated that exposure to non NMDA ( CNQX ) and NMDA ( CPP , MK 801 ) glutamate receptor antagonists , and a metabotropic receptor glutamate agonist ( ACPD ) , decreased the level of GAP 43 mRNA . ^^^ The involvement of GABA and glutamate in the modulation of GAP 43 expression was corroborated by Northern hybridization . ^^^ These studies revealed that a 5 day exposure to GABA decreased the cellular content of GAP 43 mRNA by 21 % whereas exposure to glutamate resulted in a 37 % increase . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Anti B 50 ( GAP 43 ) antibodies decrease exocytosis of glutamate in permeated synaptosomes . ^^^ The involvement of the protein kinase C substrate , B 50 ( GAP 43 ) , in the release of glutamate from small clear cored vesicles in streptolysin O permeated synaptosomes was studied by using anti B 50 antibodies . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Studies of gene transcription have provided replicable evidence of decreased expression of mRNAs for synaptophysin , GAP 43 , cholecystokinin , and non NMDA glutamate receptor subunits ( GLU R 1 and 2 ) , particularly in CA 3 4 . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Seven days after exposure , GAP 43 decreased to 15 % and SNAP 25 to 30 % in the glutamate injured , untreated neurons . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| The expression of neural and stem cell genes , including GLUR 1 , GABA B1a , NMDA 1 , GAP 43 , ChAT , BDNF , nestin , BMP 2 , BMP 4 , and EGR 1 , was increased , approximately 10 to 1000 fold , during the course of differentiation from 0 to 11 days after induction with retinoic acid . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| Furthermore , many functional families of genes previously shown to play roles in the pathophysiology of axonal injury , including SNAP 25A , SV2B , Ras related ras3a / 4b , ERK1 / 2 , 14 3 3 proteins , proteasome proteins , oncogenes , GAP 43 , and NMDAR 1 , were altered after either distal axotomy or avulsion injury . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| We conclude that GAP 43 is not required for normal excitatory synaptic transmission or the potentiation of presynaptic glutamate release mediated by activation of protein kinase C in the hippocampus . . ^^^ |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17677 and Q05586 |
Pubmed |
SVM Score :0.0 |
| NA |
|