| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.91170706 |
| The domains responsible for the protein protein interaction between connexin 43 and ZO 1 were identified using affinity binding assays with deleted ZO 1 and connexin 43 fusion proteins . 0.91170706^^^ We therefore conclude that the linkage between connexin 43 and alpha spectrin , via ZO 1 , may serve to localize connexin 43 at the intercalated discs , thereby generating functional gap junctions in cardiac myocytes . . 0.54976081^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.81148032 |
| Connexin 43 ( Cx 43 ) , the most ubiquitously expressed vertebrate gap junction protein , has been shown to interact directly with Zonula Occludens 1 ( ZO 1 ) . 0.81148032^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.60149335 |
| Here , we have characterized the structure of the connexin 43 carboxyl terminal domain ( Cx43CT ) to assess its ability to interact with domains from ZO 1 and c Src . 0.60149335^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Several of these gene products have been identified and include the tight junction ( ZO 1 ) , Na / K ATPase ( alpha and beta subunits ) , uvomorulin , gap junction ( connexin 43 ) , and growth factors such as transforming growth factor alpha ( TGF alpha ) and epidermal growth factor ( EGF ) . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Laser scanning confocal microscope observations of connexin 32 or connexin 43 and ZO 1 double immunolabelled thyroid cells , gave evidence for a separate localization of gap junctions made of each of these two connexins . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Our recent studies have shown the presence of gap junctions and connexin 43 , E cadherin , an adhesion molecule and ZO 1 protein associated with tight junctions in the baboon and human CL . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| To do this we used antibodies directed against alpha , beta , or gamma ( plakoglobin ) catenin and junctional and cytoskeletal proteins including ZO 1 and occludin ( tight junctions ) , desmoglein 1 ( desmosomes ) , connexin 43 ( gap junctions ) , and EndoA ( cytokeratin intermediate filaments ) . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| The gap junction protein connexin 43 interacts with the second PDZ domain of the zona occludens 1 protein . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| METHODS : Corneas from neonatal ( days 1 , 3 , 7 , 10 , 13 , 14 , 17 , 21 , 28 , and 42 ) and adult rats were used for immunolocalization of the following : bromodeoxyuridine ( BrdU ) , an S phase marker ; p27kip1 and p21cip1 , G 1 phase inhibitors ; connexin 43 and ZO 1 , proteins associated with gap and tight junctions , respectively ; Na+ / K+ ATPase and beta 3 integrin , markers of plasma membrane polarity ; and fibronectin and collagen type 4 , constituents of Descemet ' s membrane . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Increased association of ZO 1 with connexin 43 during remodeling of cardiac gap junctions . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Increased co localization of connexin 43 and ZO 1 in dissociated adult myocytes . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Connexin 43 interactions with ZO 1 and alpha and beta tubulin . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Expression of connexin 43 and ZO 1 in differentiating ameloblasts and odontoblasts from rat molar tooth germs . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| CAR distribution was identical to that of ZO 1 and different from that of a gap junction protein , connexin 43 . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Expression of connexin 43 , an integral component of gap junctions , the tight junction molecules claudin 1 and zonula occludens 1 ( ZO 1 ) , and the catalytic alpha subunit of Na ( + ) K ( + ) ATPase was demonstrated by SDS PAGE and Western blotting . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| Epithelial differentiation was assessed by immunostaining and / or immunoblotting to ZO 1 , cytokeratin K 12 ( K 12 ) , connexin 43 ( Cx 43 ) , cytokeratin K 10 ( K 10 ) , and involucrin . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| RESULTS : As predicted from previous studies , ZO 1 colocalized with cadherins and connexin 43 in intercellular junctions . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| It analyzes the expressions of occludin , ZO 1 , and connexin 43 by immunoconfocal microscopy . ^^^ Seven days after injury , immunoreactivities for occludin and ZO 1 were observed , although there was no connexin 43 detected . ^^^ |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and Q07157 |
Pubmed |
SVM Score :0.0 |
| NA |
|