| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| Inhibition of connexin 43 gap junctional intercellular communication by TPA requires ERK activation . ^^^ TPA treatment ( 10 ng / ml for 30 min ) of WB F 344 rat liver epithelial cells strongly activated p 42 and p 44 ERK 1 and 2 , blocked gap junction mediated fluorescent dye coupling , and induced connexin 43 hyperphosphorylation and gap junction internalization . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| Bisphosphonate induced , hemichannel mediated , anti apoptosis through the Src / ERK pathway : a gap junction independent action of connexin 43 . ^^^ The signal transducing property of connexin 43 requires the pore forming , as well as the C terminal domains of the protein , the interaction of connexin 43 with Src . and the activation of both Src and ERK kinases . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| Rather , the decreased GJIC was found to be because of phosphorylation of connexin 43 , the major connexin in the used cell line , which was mediated by MAPK / ERK kinase ( MEK ) 1 and MEK 2 as well as by activation of their direct substrates , extracellular signal regulated kinase ( ERK ) 1 and ERK 2 . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK / mitogen activated protein kinase pathway . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| ERK activation resulted in phosphorylation at Ser 279 and Ser 282 of the gap junctional protein , connexin 43 , known to result in the loss of gap junctional intercellular communication . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| In dyssynchronous failing hearts , the lateral LV endocardium displayed a 2 fold increase in phosphorylated erk mitogen activated protein kinase expression ( with no change in phospho p 38 or phospho jnk ) , a 30 % decline in sarcoplasmic reticulum Ca2+ ATPase , an 80 % reduction in phospholamban , and a 60 % reduction in the gap junction protein connexin 43 , relative to neighboring myocardial segments . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| These data establish that ERK / PI3K signaling is required for the optimal elaboration of transcription from the osteocalcin CxRE , and that disruption of gap junctional communication attenuates the ability of cells to respond to an extracellular cue , presumably by limiting the propagation of second messengers among adjacent cells by connexin 43 gap junctions . . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK 1 mediated phosphorylation of GJA 1 ( connexin 43 ) and inhibition of myometrial gap junctions . ^^^ The present study examined the hypothesis that inhibition of myometrial gap junctions through MAPK 1 induced phosphorylation of GJA 1 ( connexin 43 ) leads to inhibition of spontaneous phasic uterine contractions by 2 , 2 ' dichlorobiphenyl ( 2 , 2 ' DCB ) . ^^^ Western blotting showed about a 4 . 5 fold increase in phosphorylation of GJA 1 at S 255 , a MAPK 1 site , after exposure to 100 microM 2 , 2 ' DCB compared to untreated and solvent controls . ^^^ Therefore , this study suggests that 2 , 2 ' DCB decreases amplitude and synchronization of uterine contractions mediated through MAPK 1 mediated phosphorylation of GJA 1 and subsequent inhibition of myometrial gap junctions . . ^^^ |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17302 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
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