Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.66920915
In addition , the association between connexin 43 and c Src was blocked by inhibition of connexin 43 dephosphorylation , suggesting that the interaction between connexin 43 and c Src can be regulated by alterations in the phosphorylation state of connexin 43 . 0.66920915^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Phosphorylation of connexin 43 in cells containing mutant src oncogenes . ^^^ Disruption of gap junctional communication ( measured by intercellular dye transfer ) in cultured fibroblasts by pp60v src is correlated with phosphorylation of the gap junction protein , connexin 43 ( cx 43 ) , on tyrosine . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
To determine whether connexin 43 , a major gap junction protein expressed in fibroblasts , is a target for the 5 src protein tyrosine kinase activity , we examined the phosphorylation state of connexin 43 in cells expressing variants of src . ^^^ Using an antipeptide serum that recognizes connexin 43 , we demonstrate that this protein is phosphorylated on serine and tyrosine residues in avian and mammalian cells expressing activated src proteins . ^^^ Connexin 43 from control cells and cells expressing nonactivated variants of the src protein was phosphorylated solely on serine residues . ^^^ In lysates from 5 src transformed cells , all phosphorylated connexin 43 molecules were cleared from the lysate by sequential immunoprecipitations using the phosphotyrosine antibodies , suggesting that each molecule of phosphorylated connexin 43 contains both phosphoserine and phosphotyrosine . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
In this report we used a connexin 43 ( Cx 43 ) antisense gene construct to study the role that heterologous gap junctional intracellular communication ( GJIC ) plays in the ability of untransformed fibroblasts to suppress the foci forming ability of src oncogene transformed cells . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Src probably downregulates GJC in fibroblasts by tyrosine phosphorylation of connexin 43 . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Tyrosine phosphorylation of connexin 43 by 5 Src is mediated by SH 2 and SH 3 domain interactions . ^^^ Reduction of gap junctional communication in 5 src transformed cells is accompanied by tyrosine phosphorylation of the gap junction protein , connexin 43 ( Cx 43 ) . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Thus , G protein coupled receptors use a Src tyrosine kinase pathway to transiently inhibit connexin 43 based cell cell communication . . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
The functional consequences of tyrosine phosphorylation of connexin 43 in gap junction were assessed using transfected cells expressing constitutively active c Src . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Src phosphorylation of connexin 43 on Tyr 247 and Tyr 265 disrupts gap junctional communication . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Bisphosphonate induced , hemichannel mediated , anti apoptosis through the Src / ERK pathway : a gap junction independent action of connexin 43 . ^^^ We report herein a mechanism by which connexin 43 hemichannel opening by bisphosphonates triggers the activation of the kinases Src and ERKs and promotes cell survival . ^^^ The signal transducing property of connexin 43 requires the pore forming , as well as the C terminal domains of the protein , the interaction of connexin 43 with Src . and the activation of both Src and ERK kinases . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
We have now identified the tyrosine kinase c Src as a possible pathway between the mediators of inflammation and the gap junction protein connexin 43 ( Cx 43 ) . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Recent reports utilizing new methodologies combined with the latest genome information have shown that activation of several kinases including protein kinase A , protein kinase C , p 34 ( cdc 2 ) / cyclin B kinase , casein kinase 1 , mitogen activated protein ( MAP ) kinase and pp 60 ( src ) kinase can lead to phosphorylation at 12 of the 21 serine and two of the six tyrosine residues in the C terminal region of connexin 43 . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
Structural changes in the carboxyl terminus of the gap junction protein connexin 43 indicates signaling between binding domains for c Src and zonula occludens 1 . ^^^ In particular , c Src can disrupt the connexin 43 ( Cx 43 ) zonula occludens 1 ( ZO 1 ) interaction , leading to down regulation of gap junction intercellular communication . ^^^ Here , we have characterized the structure of the connexin 43 carboxyl terminal domain ( Cx43CT ) to assess its ability to interact with domains from ZO 1 and c Src . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
These events include alterations in connexin 43 ( Cx 43 ) phosphorylation , disruption of beta actin binding to Cx 43 , and the induced interaction of Cx 43 with the c Src tyrosine kinase , extracellular signal regulated kinase 1 and 2 , and mitogen activated protein kinase phosphatase 1 . . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
The inhibition of tyrosine phosphorylation and down regulation of src protein observed may also contribute to Connexin 43 dephosphorylation and GJIC restoration by TSA and NaBu partly through depletion of src protein pool . ^^^
Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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Interacting proteins: P17302 and P12931	Pubmed	SVM Score :0.0
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