| Interacting proteins: P17275 and Q96J02 |
Pubmed |
SVM Score :0.5165777 |
| Importantly , tyrosine phosphorylation of Itch appears to reduce its interaction with its substrate JunB . 0.5165777^^^ |
|
| Interacting proteins: P17275 and Q96J02 |
Pubmed |
SVM Score :0.0 |
| Molecularly , Itch associated with and induced ubiquitination of JunB , a transcription factor that is involved in TH 2 differentiation . ^^^ |
|
| Interacting proteins: P17275 and Q96J02 |
Pubmed |
SVM Score :0.0 |
| Atrophin 1 interacting protein 4 ( AIP 4 ) is the human homolog of the mouse Itch protein ( hItch ) , an E 3 ligase for Notch and JunB . ^^^ |
|
| Interacting proteins: P17275 and Q96J02 |
Pubmed |
SVM Score :0.0 |
| Activation of the Jun amino terminal kinase ( JNK ) mitogen activated protein kinase cascade after T cell stimulation accelerated degradation of c Jun and JunB through phosphorylation dependent activation of the E 3 ligase Itch . ^^^ |
|
| Interacting proteins: P17275 and Q96J02 |
Pubmed |
SVM Score :0.0 |
| The E 3 ubiquitin ( Ub ) ligase Itch is a critical regulator of T helper 2 ( Th 2 ) cytokine production through its ability to induce Ub dependent JunB degradation . ^^^ |
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