| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Carbachol and thrombin have similar effects on expression of c fos , fosB , fra 2 , junB , and junD , both acutely and over a 24 h time course . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We studied the expression of six nuclear proto oncogenes ( Egr 1 , c fos , fosB , c jun , junB , and c myc ) in myocardium subjected to ischemia and reperfusion in anesthetized pigs . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Whereas the AP 1 proteins junB , junD , and fosB did not show differential basal or TPA inducible levels in P+ and P cells , a 46 kDa species precipitated by anti fra 1 antibody was TPA inducible in P cells but not in P+ cells , and c jun protein was present at higher levels in TPA treated and untreated P+ cells than in P cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In this study , we have found that stimulation of T cells by IL 1 and TPA is accompanied by activation of a subset of immediate early genes that comprise the AP 1 transcription factor complex . junB and fosB were rapidly induced following stimulation with TPA . ^^^ The expression of fos and jun during T cell activation was accompanied by increased specific binding of JunB , FosB , and fos related antigen containing complexes to the TPA responsive element . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We therefore examined changes in the mRNA levels for the IEGs c fos , c jun , fosB , junB , and zif 268 in the NAc of rats treated acutely and chronically with cocaine . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Northern analysis indicates that mRNAs for at least six members of the Fos / Jun family ( c fos , fosB , fra 1 , c jun , junB , and junD ) are expressed in activated Ar 5 cells ; thus the AP 1 sites of the IL 2 promoter may bind different dimeric Fos / Jun complexes at different times after T cell activation , perhaps mediating both positive and negative regulation of the IL 2 promoter . . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have characterized the expression of c Jun , JunB , JunD , c Fos , and FosB proteins following serum stimulation of quiescent Swiss 3T3 cells by immunoprecipitation analyses . ^^^ We have shown that c Fos and FosB form complexes in vivo with the different Jun proteins and that JunB complexes are predominant . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| To determine whether these proteins are required for cell cycle progression , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , c Jun , JunB , and JunD , and antibodies that recognize either the Fos or the Jun family of proteins , into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The induction of transcription of c fos , fosB , c jun , junB and collagenase was studied as well as the mutation rate in the progeny of treated cells . ^^^ It was found that mRNA levels of fosB , junB and collagenase , all known to be involved in the growth factor signal transduction pathway , were enhanced . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the present study we analysed , by in situ hybridization , the effects of an extremely localized mechanical brain injury , obtained by the simple needle insertion ( 30 g ) in rat hippocampus or cortex , on the expression of several immediate early genes ( c fos , fosB , c jun , junB , junD , zif / 268 ) . ^^^ Maximal effects are detected between 30 and 60 min with the following rank order of induction : zif / 268 > c fos > junB > fosB > c jun > junD . ^^^ On the other hand , when the penetration of the needle is limited to the cerebral cortex the activation of the IEGs ( c fos , fosB , junB and zif / 268 ) spreads throughout the ipsilateral cortex but does not involve the hippocampal region . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Colocalization of NDP with c Jun , JunB , JunD , c Fos , FosB and Krox 24 transcription factors was investigated in neurons of lumbar spinal cord . c Jun , JunB , c Fos and Krox 24 reached their maximal levels of expression 2 h after FOR and returned to basal levels after 10 h . ^^^ In a low number of NDP neurons , suprabasal immunoreactivity of JunB , c Fos and Krox 24 proteins was visible up to 10 h , and of JunD and FosB up to 24 h in sDH neurons ; c Jun was not expressed in NDP labelled neurons of sDH , but , similar as JunD , showed basal colocalization in preganglionic sympathetic and parasympathetic neurons . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have used primary neuronal cultures prepared from fetal cerebral hemispheres to investigate the effects of different glutamate receptor agonists and antagonists on the expression of transcription factor encoding genes , such as c fos , fosB , c jun , junB , junD , c myc , and zif / 268 . ^^^ The addition of glutamate ( 100 microM ) to the culture medium rapidly activated c fos , fosB , c jun , junB and zif / 268 gene expression , reaching the maximal level at 30 60 minutes for zif / 268 and at 60 minutes for the other genes . ^^^ Similar results were obtained for junB and fosB after kainate and quisqualate stimulation . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| While a large body of literature describes the induction of immediate early genes , including c fos , fosB , c jun , junB , zif / 268 , and krox genes by glutamate and agonists in neurons , very little is known about preexisting transcription factors controlling the induction of such genes . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Basal expression of the inducible transcription factors c Jun , JunB , JunD , c Fos , FosB , and Krox 24 in the adult rat brain . ^^^ The expression of c Jun , JunB , JunD , c Fos , FosB , and Krox 24 was investigated in the brain of untreated male Sprague Dawley and female BDIX rats by immunocytochemistry using specific antibodies . ^^^ JunD was expressed at high levels in those areas that also exhibit c Jun , JunB , c Fos , and FosB IR , such as locus coeruleus , periolivary nuclei ( ncl . ) , pontine and central gray , lateral lemniscal ncl . , inferior and superior colliculi , leaflet of geniculate ncl . , midline nuclei of thalamus , dorsomedial and paraventricular ncl . of hypothalamus , ncl . supraopticus , dorsolateral part of caudate putamen and lateral septal ncl . ^^^ In contrast to the high number of JunD positive neurons , c Jun , JunB , c Fos , and FosB proteins were detected in rather low numbers of neurons in these brain areas ; the rank of the number of immunopositive neurons was c Fos > JunB > c Jun > FosB . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Moreover , immunoprecipitation of nondenatured Bal 17 B cell extracts indicated that FosB forms complexes in vivo with JunB and JunD and to a lesser extent with cJun . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Lastly , haloperidol induced increases in nerve growth factor 1 A , JunB and FosB like immunoreactivity and fosB messenger RNA were not decreased by intrastriatal injection of either the sense or antisense phosphorothioate oligodeoxynucleotides . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Likewise , expression of fra 1 , c jun and junB continued to be high in serum stimulated senescent cells , while induction of fosB was reduced approximately fivefold . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In this study , using in situ hybridization histochemistry , we further extended the research to other IEGs , and the results showed that prior exposure to IMO for 6 days suppressed the induction of fosB , junB and NGFI B , but NGFI A , mRNAs in response to a challenge IMO on day 7 , suggesting that repeated stress has different effects on the transcription of NGFI A and the other IEGs , in the PVH . . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| This allowed analysis of the expression of functional glutamate receptor subtypes , examination of their role in controlling intracellular free calcium ( [ Ca2+ ] 1 ) , and determination of their relative contributions to the transcriptional regulation of six immediate early genes c fos , fosB , c jun , junB , zif / 268 ( also termed Egr 1 ; NGFI A ; Krox 24 ) and nur / 77 ( also termed NGFI B ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The expression of seven immediate early gene encoded transcription factors ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif / 268 ) was assessed simultaneously . ^^^ FosB expression was induced four hours after icv injection of the highest dose of angiotensin 2 in the median preoptic area and paraventricular nucleus , c Jun expression was restricted to the median preoptic area , subfornical organ and paraventricular nucleus , and JunB was only induced in the median preoptic area and subfornical organ . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| BHQ induced expression of c jun , junB , fra 1 , and fra 2 , which encode AP 1 components , but was a poor inducer of c fos and had no effect on fosB . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Light induced phase shifts of circadian rhythmic locomotor activity are associated with the expression of c Jun , JunB , c Fos and FosB transcription factors in the rat suprachiasmatic nucleus , as shown in the present study . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Rat hearts infused with the beta adrenergic agonist isoproterenol were examined for the expression of several nuclear proto oncogenes ( c fos , fosB , c jun , junB , and junD ) and the immediate early gene Egr 1 . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of c fos , fosB , c jun , junB , bcl 2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion . ^^^ To obtain information in vivo about a possible relationship between u . v . induced proto oncogene expression and cellular alterations , we have analysed the expression of c fos , fosB , c jun , junB , bcl 2 and bax in rat epidermis after single and chronic u . v . irradiation . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| To determine if axotomy induced immediate early gene ( IEG ) expression accompanies regenerative efforts in central nervous system ( CNS ) neurons , immunohistochemistry using antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins was used to examine gene expression in identified adult rat retinal ganglion cells ( RGCs ) under two conditions : ( 1 ) after axotomy alone , and ( 2 ) 1 month after replacement of the optic nerve with an autologous peripheral nerve graft to allow axonal regrowth . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Acute administration of the typical neuroleptic haloperidol ( HAL , 2 mg / kg ) induced the immediate early gene proteins ( IEGPs ) c Fos , Fos related antigens ( FRAs ) , FosB , JunB , JunD and Krox 24 in the striatum and nucleus accumbens of the rat brain . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have characterized the genomic response of astroglial cells to excitatory amino acids by using selective agonists and antagonists for the various receptor subtypes and by analyzing different primary response genes , such as members of the Fos ( c fos and fosB ) and Jun ( c jun , junB , and junD ) families , zif / 268 , and c myc . ^^^ A rapid and transient elevation of mRNA levels for c fos , fosB , c jun , junB , and zif / 268 was observed after addition of glutamate to cultured astrocytes , whereas junD and c myc expression was not affected . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Within 15 minutes of balloon injury , mRNA levels of c fos , fosB , c jun , junB , and junD were elevated severalfold . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization , the expression of c fos , fosB , fra 1 , fra 2 , c jun and junB was studied after 15 min of normothermic and hypothermic ( 33 degrees C ) transient forebrain ischaemia in the rat , induced by common carotid occlusion combined with systemic hypotension . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Brief visual stimulation ( 2 hr ) added c Fos , c Jun , and JunB to this complex , whereas prolonged stimulation ( 6 24 hr ) reduced c Fos and c Jun levels significantly , leaving only FosB , JunB , and JunD as the major components of AP 1 . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| After infection with a ras expressing retrovirus , both control and ER 1 2 cell lines constitutively expressed elevated levels of the c jun , junB , fosB , c myc , collagenase , ornithine decarboxylase , osteopontin , stromelysin , cathepsin L , and insulin like growth factor 1 genes . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Pretreatment with the four preventive agents commonly inhibited TNF alpha mRNA expression and TNF alpha release in BALB / 3T3 cells induced by a tumor promoter , okadaic acid , whereas the expression of early response genes ( c jun , junB , c fos , and fosB ) was enhanced . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The AP 1 protein complex at 21 days postnatally was composed of JunD , JunB , Fra 2 , FosB and to much lesser extent of c Fos in both cortical areas . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Defective transcription of the IL 2 gene is associated with impaired expression of c Fos , FosB , and JunB in anergic T helper 1 cells . ^^^ Western blot analysis of nuclear extracts showed that the impaired DNA protein interactions in anergic T cells were associated with poor expression of the inducible AP 1 family members c Fos , FosB , and JunB . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The PPs Wy 14643 , mono ethylhexyl phthalate , clofibrate , and ciprofibrate ethyl ester were found to be potent inducers of immediate early gene expression ( including c fos , c jun , junB , egr 1 , NUP 475 , and to a lesser extent fosB , JE , and KC , with maximal expression seen 1 h after treatment of serum deprived quiescent cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Northern analysis showed increases in fosB , c fos , and junB mRNA levels in both proximal jejunum and colon . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The effects of intracerebroventricular ( i . c . v . ) injections of angiotensin 2 ( Ang 2 ) on the expression of inducible transcription factors ( ITF ) ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 ) in the brain of conscious rats were assessed immunohistochemically using polyclonal antisera . ^^^ Ang 2 ( 1 , 10 , 100 ng ) induced after 90 min a dose dependent expression of c Fos , FosB , c Jun , JunB and Krox 24 , which was confined to four specific brain areas , namely the subfornical organ ( SFO ) , median preoptic area ( MnPO ) , paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In mouse hepatoma Hepa 1 cells , which have Ah receptor ( AHR ) and Ah receptor nuclear translocator ( ARNT ) proteins , inclusion of TRE , SRE , and the AhRE motifs from c jun and junD , but not CRE or the AhREs from c fos , fosB , and junB , causes a large TCDD dependent increase in luciferase expression . ^^^ In agreement with these results , c jun and junD , but not c fos , fosB , and junB AhREs , competed with a canonical Cyp1A1 AhRE for binding to the AHR ARNT heterodimeric complex . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Exposure of human neuroblastoma SH SY5Y cells to ethanol for 2 4 days caused a dose dependent increase in c jun and junD mRNA levels , whereas mRNAs for c fos , fosB and junB were not detectable in control or ethanol treated cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We further studied the influence of glutamate receptor antagonists on the stimulated expression of c Fos , JunB , FosB , and NGFI A . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The AP 1 DNA binding activities in all regions at all times after withdrawal were composed of FosB , c Jun , JunB , and JunD . c Fos was detected at all times in the cerebral cortex , at 16 h only in the hippocampus , and from 16 to 72 h in the cerebellum . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| SB 203580 , an inhibitor of p38 / RK , has been used to analyse the role of this kinase in the induction of five IE genes ( c fos , fosB , c jun , junB and junD ) under diverse conditions of stimulation . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In contrast , apomorphine induced increases in JunB , NGFI A and Fos 2 16 like immunoreactivities were unaffected by either the antisense or random oligonucleotides , indicating that the antisense oligonucleotide attenuated apomorphine induced priming by selectively blocking the synthesis of FosB proteins . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We studied the time course of expression of the inducible transcription factors ( ITF ) c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 , induced by a single intracerebroventricular injection of angiotensin 2 , in the subfornical organ ( SFO ) , median preoptic nucleus ( MnPO ) paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . c Fos and Krox 24 were expressed rapidly in neurons of all four areas but completely disappeared after 4 h . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Ethanol exposure potentiates fosB and junB expression induced by muscarinic receptor stimulation in neuroblastoma SH SY5Y cells . ^^^ Muscarinic receptor stimulation and activation of protein kinase C cause an increase in fosB and junB transcripts in human neuroblastoma SH SY5Y cells . ^^^ Carbachol stimulated fosB and junB expression was elevated in ethanol exposed cells compared with control cells . ^^^ Preincubation with muscarinic antagonists or protein kinase C inhibitor demonstrated that the carbachol stimulated increase in fosB and junB mRNA levels was primarily mediated via M 1 receptors and dependent on the activity of protein kinase C in both control and ethanol exposed cells . ^^^ Long term ethanol exposure did not influence the expression of fosB and junB induced by activation of protein kinase C with phorbol ester . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Stimulation with carbachol induced expression of c fos , fosB , c jun , junB , and junD . ^^^ Inhibition of protein kinase C with GF109203X suppressed the carbachol stimulated increase in mRNA levels of c fos , fosB , and junB by approximately 70 % but had only minor effects on the expression of c jun and junD . ^^^ On the other hand , preincubation with KN 62 attenuated the carbachol induced increase in c jun and junD expression by 70 % but had no effect on c fos , fosB , and junB mRNA levels . ^^^ Simultaneous inhibition of both protein kinase C and Ca2+ / calmodulin dependent kinase 2 completely abolished the carbachol stimulated expression of c jun and junD , but c fos , fosB , and junB were still expressed to a certain extent under this condition . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Anisomycin desensitization of a panel of IE genes ( c fos , fosB , c jun , junB , and junD ) , using epidermal growth factor ( EGF ) , basic fibroblast growth factor , ( bFGF ) , tumor necrosis factor alpha ( TNF alpha ) , anisomycin , tetradecanoyl phorbol acetate ( TPA ) , and UV radiation as secondary stimuli , was found to be extremely specific both with respect to the secondary stimuli and at the level of individual genes . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| HCG induced a rapid and transient expression of c fos , fosB , c jun , junB , junD and c myc with a peak at 30 min to 1 h . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We found a rapid induction of c fos , c jun and junB at the mRNA level after about 30 min of EGF treatment and a more delayed upregulation of fosB and fra 1 . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The blockade of KA induced proENK and proDYN mRNA levels by the pre treatment with L ARG was well correlated with proto oncoprotein levels , such as c Fos , Fra 2 , FosB , JunD , JunB , and c Jun , as well as AP 1 and ENKCRE 2 DNA binding activities . ^^^ The pre administration with L NAME further increased KA induced c jun and c fos mRNA levels in addition to their protein product levels , although the pre treatment with L NAME did not affect KA induced FosB , Fra 2 , JunB , and JunD protein levels at 6 h after treatment . ^^^ Our results suggest that L ARG plays an important role in inhibiting KA induced proENK or proDYN mRNA expression , and its inhibitory action may be mediated through reducing the proto oncoprotein levels , such as c Fos , Fra 2 , FosB , c Jun , JunD , and JunB . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Ischemia induced CA 1 neuronal death is preceded by elevated FosB and Jun expression and reduced NGFI A and JunB levels . ^^^ Alterations in levels of the immediate early gene ( IEG ) proteins Fos , FosB , DeltaFosB , Jun , JunB , JunD , and NGFI A were investigated in rat hippocampus by immunohistochemistry 2 , 12 , 24 , and 48 h after forebrain ischemia . ^^^ In contrast to FosB and Jun , JunB expression declined significantly below basal levels in CA 1 neurons at 48 h , yet remained unaltered in CA 3 neurons . ^^^ These findings suggest that persistent elevations in FosB and Jun expression , concurrent with reductions in JunB and NGFI A levels , contribute to the apoptotic death of CA 1 neurons after forebrain ischemia . . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Furthermore , JunB , JunD , FosB and cFos form part of the DNA protein complex in Bal 17 B cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The delayed increase in COX 2 mRNA expression was accompanied by the induction of the proto oncogenes c jun , junB , junD , and c fos ( but not FosB or Fra 1 ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershift and Western blot analysis with specific antisera , indicate that JunB and cJun , but not cFos or FosB are present in the AP 1 complex . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Amylin treatment results in time and concentration dependent inductions of oxidative stress genes , such as cox 2 and IkappaB alpha . `` Apoptotic ' ' genes are also induced in a time and concentration dependent manner , including c jun , junB , c fos , and fosB , followed temporally by a gene known to be modulated by these transcription factors , i . e . , transin . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The levels of c jun , c fos , junB , and fosB mRNA in ZG and ZFR were also rapidly maximally elevated within 0 . 5 1 h after ACTH administration and fell to near control levels 5 h posttreatment . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Using transcription analysis , such as multiplex messenger assays , we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein ( AP ) 1 transcription factor genes such as JunB , FosB and c Fos . ^^^ Interaction between immunoglobulin like transcript 2 / leukocyte Ig like receptor 1 on NKL cells and HLA B 27 on target cells leads to an impairment of NKL natural cytotoxicity , which correlates with an absence of JunB , FosB , and c Fos transcription , as well as an absence of their DNA binding activity . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We assessed the role of NMDA receptors in the expression of NGFI A , junB and fosB mRNAs induced by light pulses of different intensities late in the night ( Zeitgeber Time [ ZT ] 18 ) . ^^^ Both dim ( 5 lx ) and bright ( 100 lx ) light pulses induced similar levels of expression of NGFI A and junB in the SCN late in the night . fosB mRNA was strongly induced by bright light but was less sensitive to dim light . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The normal corneal epithelium showed no staining with antibodies against c Fos , Fra 2 , FosB , c Jun or JunB , whereas the limbal and bulbar conjunctival epithelia were positive for c Fos , Fra 2 , and c Jun . ^^^ Anti FosB and JunB antibodies reacted weakly with the conjunctival epithelium . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| To investigate whether both patterns of IEG expression are observed in the rat SCN , the authors studied the expression of NGFI A , junB , c fos , and fosB near the time of subjective dawn in rats entrained to a light dark 12 : 12 cycle and then maintained in constant total darkness for approximately 48 h . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| However , NPY did not inhibit the induction of c fos , FosB or junB mRNA in any hippocampal region examined in the same animals , showing lack of correlation between immediate early gene induction and seizure activity . . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ For c jun , junB , c fos and fra 2 , a relatively uniform expression pattern without significant differences among tumors was observed . junD protein amounts varied strongly in the tumor specimens . fosB expression levels also varied strongly in the tumors , weak / absent expression being found in 47 % , while 45 % exhibited strong / very strong levels of expression . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Changes in the regional and compartmental distribution of FosB and JunB like immunoreactivity induced in the dopamine denervated rat striatum by acute or chronic L dopa treatment . ^^^ This study was carried out in order to examine the effects of acute or chronic L DOPA treatment on striatally expressed FosB and JunB like proteins in a rat model of Parkinson ' s disease . ^^^ Like FosB , JunB was induced in the DA denervated striatum by both acute and chronic L DOPA treatment , and exhibited similar distribution patterns . ^^^ The present results show that L DOPA administration produces a long lasting increase in the levels of FosB , but not JunB like immunoreactivity in the dopamine denervated striatum . ^^^ More importantly , these data show that striatal induction of FosB and JunB like proteins by chronic L DOPA treatment exhibits both regional and compartmental specificity . . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Double immunofluorescence labelling revealed that LiCl causes a coordinate upregulation of c Fos , FosB and JunB , and these proteins are colocalized in a majority of cells examined in NTS , parabrachial nucleus ( PBN ) , and central nucleus of the amygdala ( CeA ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| PACAP potently stimulated the expression of c fos , fosB junB and junD , but not c jun mRNAs , at doses of 0 . 1 10 nM , as revealed by Northern blot analysis . ^^^ PACAP administration induced maximum expression of c fos , fosB and junB mRNA after 60 min , and of junD mRNA after 8 h . ^^^ Gel shift and supershift analyses showed that the TRE binding factors and CRE binding factors comprised fosB , c fos , junB , and junD , and CRE binding protein ( CREB ) and junD , respectively . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP 1 site by c Jun , JunB , JunD , c Fos , FosB , and Fra 2 . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The data , in combination with our previous results [ Takeuchi J . et al . ( 1993 ) Neuron 11 , 825 836 ] , suggest that activator protein 1 binding sites on ventrolateral suprachiasmatic nucleus target genes are constitutively occupied by DeltaFosB / JunD complexes , and that c Fos , Fra 2 , FosB and JunB compete for binding after photic stimulation . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of c Fos , Fra 2 , FosB , c Jun , and JunB protein levels , which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We also observed increased expression of mRNAs for Fos and Jun transcription factor family members c Fos , FosB , Fra 2 , and JunB , as well as Fos family proteins in the entorhinal cortex after MK 801 administration . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^ The labeling intensity of the c Jun , JunD , and Fra 2 antibodies was stronger than that of JunB , FosB , and Fra 1 . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| FosB , Fra 2 , c Jun , JunB and , most abundantly , JunD bind the AP 1 EP in the absence and presence of serotonin . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of JunB was diminished in the undifferentiated , more aggressive tumour phenotype compared with the well differentiated , less aggressive keratinocytes , whereas the expression of other AP 1 family members ( c jun , junD , c fos , fra 1 , fra 2 and fosB ) was either very weak or variable . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Using knock out strategies it was found that some components , such as c Fos , FosB and JunD are dispensable , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic development and / or in the adult organism . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Expression of egr 1 ( krox 24 ) , egr 2 ( krox 20 ) , egr 3 , c jun , junB , c fos , fosB , fra 1 , fra 2 , and CREB genes was analyzed by reverse transcription polymerase chain reaction ( RT PCR ) in Schwann cells isolated from neonatal rat sciatic nerves and in the cell lines MSC 80 ( mouse Schwann cells ) , NIH 3T3 ( mouse fibroblasts ) , and CHO ( Chinese hamster ovary cells ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershift experiments and Western blots confirmed that the binding of c Fos , JunB , and JunD , but not of FosB , was reduced in anergized cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The defect is secondary to an inability to phosphorylate CREB and to induce CREB dependent immediate early genes , including c jun , fosB , fra 2 , and junB , which are required for cytokine gene induction . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Further analysis demonstrated that serum or 12 O tetradecanoylphorbol 13 acetate activation of several immediate early genes including fos , fosB , junB , and egr 1 was inhibited by Wnt signaling . ^^^ The Wnt mediated repression of c Fos , FosB , and JunB expression was consistent with a decrease in their binding to an AP 1 promoter element and decreased target gene transcription . ^^^ The expression of fos , fosB , junB , and egr 1 was also repressed in human colon tumors relative to patient matched normal tissue . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Forty six globes were processed for in situ hybridization with oligonucleotide probes for c fos , fosB , c jun , junB and junD mRNAs , and 60 globes were immunohistochemically analysed using anti c Fos and anti c Jun antibodies . ^^^ Normal lens epithelial cells expressed mRNA signals for junD , but not for c fos , fosB , c jun , and junB . mRNAs for c fos , fosB , c jun , and junB were detected in the whole lens epithelium from the vicinity to the wound to the equator from 30 min to 8 hr post injury with their peaks after 30 min to 1 hr , but were no longer detected at 10 hr or later . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The DNA binding activities of c Fos , FosB / Delta FosB , Fra 1 , Fra 2 , and JunB were up regulated whereas JunD activity was decreased . c Fos , FosB / Delta FosB , and JunB were associated with Smad 4 . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Expression of c fos , fosB , fra 1 , fra 2 , and junB was low during early gestation , with a 5 to 10 fold increase on Day 23 during labor , and returned to low levels 1 day postpartum . ^^^ Administration of progesterone ( P 4 ; 16 mg / kg s . c . / day ) beginning on Day 20 ( to maintain elevated plasma P 4 levels ) prevented the onset of labor and blocked the expected rise in c fos , fosB , fra 1 , fra 2 , and junB expression on Day 23 . ^^^ In unilaterally pregnant rats , stretch imposed by the growing fetus was found to increase the expression of c fos , fosB , fra 1 , fra 2 , and junB only in the gravid horn on the day of labor . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have characterized the effects of chronic clozapine and haloperidol treatments on the expression of fos ( c fos , fosB , fra 2 ) and jun ( c jun , junB , junD ) family genes in the rat forebrain . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Similarly , in the second experiment it was found that the D1R dependent induction by AMPH of Fos , FosB , and JunB , but not NGFI A , in the NAc was enhanced in rats exposed 1 week earlier to repeated VTA AMPH . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Serum response factor ( SRF ) is a transcription factor , which binds to a serum response element ( SRE ) associated with a variety of genes including immediate early genes such as c fos , fosB , junB , egr 1 and 2 , neuronal genes such as nurr 1 and nur 77 and muscle genes such as actins and myosins . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| MafG , ATF 2 , FosB , and JunB were also detected in the arsenite complex . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We found that there is a lack of induction of c Fos , FosB , Fra 2 and JunB by acute cocaine exposure , and of DeltaFosB by repeated cocaine administration in both the NAc and CPu of D 1 receptor mutant mice compared with wild type control mice . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| A functional activating protein 1 ( AP 1 ) site regulates matrix metalloproteinase 2 ( MMP 2 ) transcription by cardiac cells through interactions with JunB Fra 1 and JunB FosB heterodimers . ^^^ Nuclear extracts isolated from hypoxic rat cardiac fibroblasts contained Fra 1 , JunB and also included FosB . ^^^ Co transfection of cardiac fibroblasts with Fra 1 JunB and FosB JunB expression plasmids led to significant increases in transcriptional activity . ^^^ These studies demonstrate that a functional AP 1 site mediates MMP 2 transcription in cardiac cells through the binding of distinctive Fra 1 JunB and FosB JunB heterodimers . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Gene disruption studies indicate that the AP 1 family members c jun , junB , and fra 1 are essential for embryonic development , whereas junD , c fos , and fosB are required for normal postnatal growth . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| This effect was specific because palytoxin had little effect on c Jun , JunB , JunD , FosB , Fra 1 , or Fra 2 binding or on overall levels of transcription factor binding . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Among the early response genes analyzed , c myc , junB , junD , c jun , c fos , fosB , fra , as well as max , mad 1 4 , sin 3 , only c jun and fra 2 mRNAs were up regulated after 1 , 25 ( OH ) ( 2 ) D ( 3 ) exposure . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| We further studied the expression of fosB , c jun and junB , in the AP 1 complex . fosB was up regulated 20 fold , but only minor effects on jun variants were observed . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the current study , we examined the expression of seven fos / jun family member mRNAs ( c fos , fosB , fos related antigen ( fra ) 1 , fra 2 , junB , c jun , and junD ) and three other IEG mRNAs ( egr 1 , egr 3 , and nur 77 ) in mouse brain following short term ( 6 h ) sleep deprivation ( SD ) and 4 h recovery sleep ( RS ) after SD . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Transcriptionally active AP 1 in combinations of c Jun , JunD and JunB with Fra 1 , Fra 2 and possibly FosB , are expressed in cardiac myocytes . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Our results reveal that c fos , fosB , c jun , and junB levels were upregulated at 24 hr . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Functional classification of the 25 genes demonstrated alterations of expression of several kinds of biological pathways , regulating transcription ( Bhlhb 2 , Jun , c fos , Egr 1 , Egr 2 , Fosb , Junb , Ifrd 1 , Neurod 6 ) , the cell cycle ( c fos , Fosb , Jun , Junb , Dusp 1 ) , stress response ( Dusp 1 , Dnajb 1 , Dnaja 4 ) , chaperone activity ( Dnajb 1 , Dnaja 4 ) and cell death ( Ptgs 2 , Gadd45g , Tdag 51 ) , in the mouse hippocampus by 24 h of reperfusion . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the present study , we used immunohistochemistry with specific antibodies against all members of the AP 1 family ( c Jun , JunB , JunD and c Fos , FosB , Fra 1 , Fra 2 ) to investigate their expression pattern and tissue localization in the human placenta . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Static stretch induced an increase in the expression of c fos , fosB , fra 1 , c jun , and junB . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| These two cytokines used alone induced their nuclear translocation in 30 min , except for FosB and JunB . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The 27 up regulated genes mainly encoded transcription factors ( JUN , EGR 1 , JUNB , FOS , FOSB , MYCN , and SNAIL 1 ) , growth factors ( VEGF , DTR / HB EGF , IGFBP 7 , IL 6 , ANGPT 2 , EREG , CCL3 / MIP1A , and CCL5 / RANTES ) and growth factor receptors ( TBXA2R , TNFRSF10A / TRAILR1 , and ROBO 2 ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : The NO donor SNAP ( 100 microM ) , which is a pro apoptotic stimulus in cardiomyocytes , activated AP 1 within 2 h . c Jun , JunB and FosB are identified as the main components of this AP 1 complex . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| The proto oncogenes c fos , fosB , and c jun were not detected , whereas junB was induced by IL 5 stimulation in both types of cells . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We found sex and tissue specific changes in the expression of Ras superfamily members ( Nras , Rab 2 , Rab 34 , Vav 2 ) , protein kinase C ( PKC ) isoforms ( PKCbeta , PKCmu ) , AP 1 factor components ( Jun , JunB and FosB ) , Wnt signaling pathway members as well as in a variety of other cellular proto oncogenes and oncogenes . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Exposure of HEK 293 cells for 90 min to 15 microM PAT elevated the levels of early growth response gene 1 ( egr 1 ) mRNA , but not of c fos , fosB , and junB mRNAs . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Immunodepletion gel shift assays demonstrated that GP 5 EpRE bound JunB , c Jun , FosB , and Fra 2 from unstimulated cells , and that after exposure to HNE , EpRE binding complexes contained nuclear factor erythroid 2 related factor ( Nrf ) 1 , Nrf 2 , JunB , c Jun , FosB , c Fos , Fra 1 , and Fra 2 . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Ischemia induced the expression and binding of c Fos , c Jun , JunB , FosB , and Fra 2 to a noncanonical activating protein 1 ( AP 1 ) site present in the MMP 2 promoter and decreased binding of the transcriptional repressor JunD . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| SL 327 pre treatment , however , reduces the DNA binding activity of the activator protein 1 complex induced six hours after an acute cocaine treatment as well as one hour after the last of the chronic cocaine injections , a phenomenon that results from the concomitant reduction of all cocaine induced proteins ( c Fos , FosB , deltaFosB , JunB ) . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Real time reverse transcription polymerase chain reaction and Western blot analyses revealed quantitative increases in c Jun , JunB , JunD , and FosB expression associated with increased AP 1 activity . ^^^ Electrophoretic mobility shift assay further revealed significant increases in AP 1 binding activity in rhR 4 treated cells , with increased supershift in the presence of antibodies to JunB , JunD , and FosB . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| Cardiac ischemia reperfusion injury induces matrix metalloproteinase 2 expression through the AP 1 components FosB and JunB . ^^^ Nuclear extracts demonstrated increased abundance of two activator proteins 1 ( AP 1 ) components JunB and FosB following I / R injury . ^^^ Immunohistochemical staining localized JunB and FosB proteins to the nuclei of all three cardiac cell types following I / R injury , consistent with enhanced nuclear transport of these transcription factors . ^^^ Chromatin immunoprecipitation ( ChIP ) of the AP 1 binding site in the intrinsic murine MMP 2 promoter yielded only JunB under control conditions , whereas ChIP following I / R injury recovered both JunB and FosB , consistent with a change in occupancy from JunB homodimers in controls to JunB / FosB heterodimers following I / R injury . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^ |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|