| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.5442113 |
| Furthermore , JunB was shown to be a substrate for JNK , and phosphorylation requires the N terminal activation domain . 0.5442113^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| JunB has a functional JNK docking site but lacks specificity conferring residues . ^^^ Insertion of such residues brings JunB under JNK control . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| In the study reported here , we determined the ability of JNK to target ubiquitination of its other substrates ( Elk 1 and activating transcription factor 2 ( ATF 2 ) ) and associated proteins ( ATF 2 and JunB ) . ^^^ We also show that association of inactive JNK with JunB or ATF 2 is necessary to target them for ubiquitination . ^^^ The implications for the dual role of JNK in the regulation of ubiquitination and stability of c Jun , ATF 2 , and JunB in normally growing versus stressed cells are discussed . . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| JunB control of IL 4 expression is mediated by the phosphorylation of JunB at Thr 102 and 104 by JNK MAP kinase . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| To understand the role of redox sensitive mechanisms in vascular smooth muscle cell ( VSMC ) growth , we have studied the effect of N acetylcysteine ( NAC ) , a thiol antioxidant , and diphenyleneiodonium ( DPI ) , a potent NADH / NADPH oxidase inhibitor , on serum , platelet derived growth factor BB , and thrombin induced ERK 2 , JNK 1 , and p 38 mitogen activated protein ( MAP ) kinase activation ; c Fos , c Jun , and JunB expression ; and DNA synthesis . ^^^ On the contrary , these compounds had differential effects on agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation and c Fos , c Jun , and JunB expression . ^^^ NAC inhibited agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation and c Fos , c Jun , and JunB expression except for platelet derived growth factor BB induced ERK 2 activation . ^^^ Together , these results strongly suggest a role for redox sensitive mechanisms in agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation ; c Fos , c Jun , and JunB expression ; AP 1 activity ; and DNA synthesis in VSMC . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| Both the inhibition of the MEKK1 / MEK4 / JNK pathway , leading to the reduction in phosphorylated c Jun , and the stimulation of JunB , are mediated through the specific VPAC 1 receptor and the cAMP / PKA pathway . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| Although TGF beta 1 and activin A had no effect on NF kappaB and JNK activities , these factors enhanced the expression of JunB , a component of the AP 1 transcriptional complex . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| PD 98059 , but not SB 203580 or JNK 1 ( ) transfection , inhibited both ERK1 / 2 phosphorylation and JunB / AP 1 activation . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| VIP / PACAP inhibit MEKK 1 activity and the subsequent phosphorylations of MEK 4 , JNK , and c Jun , which result in a decrease in the AP 1 binding and a marked change in the composition of AP 1 complexes from c Jun / c Fos to JunB / c Fos . ^^^ Both inhibition of the MEKK1 / MEK4 / JNK pathway , leading to a reduction in phosphorylated c Jun , and the stimulation of JunB are mediated through the specific VPAC 1 receptor and cAMP / PKA pathway . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| Among JNK substrates , c Jun and JunB ( but not activating transcription factor 2 ) antagonized TGF beta / SMAD signaling in a JNK dependent manner . ^^^ In junAA mouse embryo fibroblasts , in which c Jun can no longer be phosphorylated by JNK , JunB substituted for c Jun in mediating the cytokine effect against SMAD driven transcription in a JNK dependent manner . ^^^ These results suggest a critical role for JNK mediated c Jun and JunB phosphorylation in transmitting the inhibitory effect of pro inflammatory cytokines against TGF beta induced SMAD signaling . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| Activation of the Jun amino terminal kinase ( JNK ) mitogen activated protein kinase cascade after T cell stimulation accelerated degradation of c Jun and JunB through phosphorylation dependent activation of the E 3 ligase Itch . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical and in situ hybridization techniques were performed for studying phosphorylated JNK ( p JNK ) , c Jun , JunB , JunD and AP 1 in 40 cases of human HCC and corresponding nontumoral tissues . ^^^ |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17275 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|