| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| JunB , c Jun , c Fos , and Fra 2 were rapidly but transiently induced by FSH in immature granulosa cells . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| FosB , Fra 2 , c Jun , JunB and , most abundantly , JunD bind the AP 1 EP in the absence and presence of serotonin . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Other components of the complex included Fra 2 , c Jun , JunB and JunD . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Regulated expression of immediate early genes c fos , fra 2 and junB was observed in the transgenic mice . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| MEKK 1 regulates the AP 1 dimer repertoire via control of JunB transcription and Fra 2 protein stability . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the rat pineal gland cAMP mediates nocturnal induction of the enzyme arylalkylamine N acetyltransferase ( AA NAT ) as well as of transcription factors such as inducible cAMP early repressor ( ICER ) , Fos related antigen 2 ( Fra 2 ) and JunB . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Carbachol and thrombin have similar effects on expression of c fos , fosB , fra 2 , junB , and junD , both acutely and over a 24 h time course . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have shown that while c Fos is the major Fos protein associated with the Jun proteins ( c Jun , JunB , and JunD ) soon after serum stimulation , at later times Fra 1 and Fra 2 are the predominant Fos proteins associated with the different Jun proteins . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Like c Fos and Fra 1 , Fra 2 formed stable heterodimers with c Jun , JunB or JunD in vitro and all these complexes had specific DNA binding activity to AP 1 binding sites ( AP 1 sites ) or related sequences . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| BHQ induced expression of c jun , junB , fra 1 , and fra 2 , which encode AP 1 components , but was a poor inducer of c fos and had no effect on fosB . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Using a seasonal breeder , the European red fox ( Vulpes vulpes ) , as our model , we have examined the expression of five AP 1 family members ( c fos , fra 1 , fra 2 , c jun and junB ) with a view to elucidating their role in the regulation of spermatogenesis . ^^^ Unique patterns of expression , falling into three broad categories , were observed for the five genes : ( 1 ) continuous expression throughout the spermatogenic cycle ( c fos ) ; ( 2 ) expression only at times corresponding to the onset and shutdown of spermatogenesis ( fra 1 , fra 2 and c jun ) ; and ( 3 ) expression only at the onset of the cycle ( junB ) . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization , the expression of c fos , fosB , fra 1 , fra 2 , c jun and junB was studied after 15 min of normothermic and hypothermic ( 33 degrees C ) transient forebrain ischaemia in the rat , induced by common carotid occlusion combined with systemic hypotension . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^ Fra 2 is detected in all layers , but staining intensity is increased in the upper spinous layer . c jun staining is limited to the granular layer , while junB and junD are present in all layers . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Calcium induced AP 1 DNA binding complexes consist of Fra 1 , Fra 2 , c Jun , JunB and JunD and are independent of c Fos , since the induction of DNA binding activity and the composition of the AP 1 binding complexes are identical in differentiating keratinocytes derived from c fos null and wild type mice . ^^^ Moreover , PKC activation is required for the increased expression of Fra 2 , JunB and JunD in the nucleus of differentiating cells in vitro . ^^^ In vivo expression patterns suggest that the predominant AP 1 heterodimer in the granular layer consists of Fra 2 and JunB while a JunD and Fra 1 complex predominates the spinous layer of mouse epidermis . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The AP 1 protein complex at 21 days postnatally was composed of JunD , JunB , Fra 2 , FosB and to much lesser extent of c Fos in both cortical areas . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| These transformed fibroblasts accumulated higher levels of cJun , JunB , Fra 1 and Fra 2 proteins relative to their normal counterparts . ^^^ Following serum stimulation of Ras clones , the elevated levels of cJun and Fral remained steady , while the induction of JunB and Fra 2 was partially attenuated . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| However , protein complexes from AtT 20 nuclear extracts that bound the GR AP 1 site were supershifted by JunD , JunB , cJun , and Fra 2 specific antibodies . ^^^ The GR AP 1 site bound protein complexes composed of JunD , JunB , Fra 2 , and Fra 1 from L 929 nuclear extracts . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the present study , overexpression of fra 1 , fra 2 , c jun , junB , and junD mRNAs was demonstrated in RCs by Northern blot analysis . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The blockade of KA induced proENK and proDYN mRNA levels by the pre treatment with L ARG was well correlated with proto oncoprotein levels , such as c Fos , Fra 2 , FosB , JunD , JunB , and c Jun , as well as AP 1 and ENKCRE 2 DNA binding activities . ^^^ The pre administration with L NAME further increased KA induced c jun and c fos mRNA levels in addition to their protein product levels , although the pre treatment with L NAME did not affect KA induced FosB , Fra 2 , JunB , and JunD protein levels at 6 h after treatment . ^^^ Our results suggest that L ARG plays an important role in inhibiting KA induced proENK or proDYN mRNA expression , and its inhibitory action may be mediated through reducing the proto oncoprotein levels , such as c Fos , Fra 2 , FosB , c Jun , JunD , and JunB . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Expression of c jun , junB , c fos , fra 1 and fra 2 mRNA in the rat brain following seizure activity and axotomy . ^^^ The patterns of c jun , junB , c fos , fra 1 and fra 2 mRNAs were studied by radioactive and non radioactive in situ hybridization in the adult rat brain following kainate induced seizure activity and axotomy . ^^^ Whereas fra 1 and fra 2 were restricted to the hippocampus , c jun , junB and c fos were additionally induced in the cortex , amygdala and thalamus . ^^^ Labeling of the junB and fra 2 probes with digoxigenin yielded similar results . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have examined the expression of members of the AP 1 transcription factor complex in response to stimulation with different doses of LPA . c Fos , c Jun , and JunB are induced rapidly in response to LPA stimulation , whereas Fra 1 and Fra 2 are induced after a significant lag . ^^^ The expression of c Fos is transient , whereas the expression of c Jun , JunB , Fra 1 , and Fra 2 is sustained . ^^^ In contrast , expression of Fra 1 , Fra 2 , and JunB and optimal expression of c Jun are observed only with doses of LPA which induce sustained MAPK activation and DNA synthesis . ^^^ LPA stimulated expression of c Fos , Fra 1 , Fra 2 , c Jun , and JunB is inhibited by the MEK 1 inhibitor PD 098059 , indicating that the Raf MEK MAPK cascade is required for their expression . ^^^ In cells expressing a conditionally active form of Raf 1 ( DeltaRaf 1 : ER ) , we observed that selective , sustained activation of Raf MEK MAPK was sufficient to induce expression of Fra 1 , Fra 2 , and JunB but , interestingly , induced little or no c Fos or c Jun . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Thrombin stimulated a rapid but transient accumulation of c Fos whereas the expression of Fra 1 , Fra 2 , c Jun and JunB was sustained throughout the G 1 phase of the cell cycle . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra 1 , Fra 2 , and c Fos bound to AP 1 but that prior treatment of the cells with TGFbeta reduced dramatically c Fos binding , suggesting that c Fos might be playing a negative regulatory role in clusterin gene expression . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The normal corneal epithelium showed no staining with antibodies against c Fos , Fra 2 , FosB , c Jun or JunB , whereas the limbal and bulbar conjunctival epithelia were positive for c Fos , Fra 2 , and c Jun . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ For c jun , junB , c fos and fra 2 , a relatively uniform expression pattern without significant differences among tumors was observed . junD protein amounts varied strongly in the tumor specimens . fosB expression levels also varied strongly in the tumors , weak / absent expression being found in 47 % , while 45 % exhibited strong / very strong levels of expression . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the expression of four AP 1 transcription factors , Jun , JunB , JunD and FRA 2 , and AP 1 DNA binding activity in the rat hippocampus to examine changes during the periods of degeneration and then of regeneration and repair after TMT induced neurotoxicity . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In addition , AA also increased several AP 1 proteins , such as c Fos , Fra 1 , Fra 2 , JunB , JunD , and c Jun , or AP 1 and ENKCRE 2 DNA binding activity . ^^^ However , as well as proto oncoprotein levels , such as Fra 1 , Fra 2 , c Jun , JunB , but not JunD , AA induced increase of proENK mRNA was significantly reduced by the pretreatment with 10 microM of PD 98059 ( 1 . 3 fold ) or 10 microM of SB 203580 ( 1 . 8 fold ) . ^^^ In addition , the activation of both the p 38 and ERK pathways appears to be involved in the AA induced increase of proENK mRNA via activating the expression of proto oncoprotein , such as Fra 1 , Fra 2 , c Jun , and JunB . . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP 1 site by c Jun , JunB , JunD , c Fos , FosB , and Fra 2 . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The data , in combination with our previous results [ Takeuchi J . et al . ( 1993 ) Neuron 11 , 825 836 ] , suggest that activator protein 1 binding sites on ventrolateral suprachiasmatic nucleus target genes are constitutively occupied by DeltaFosB / JunD complexes , and that c Fos , Fra 2 , FosB and JunB compete for binding after photic stimulation . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of c Fos , Fra 2 , FosB , c Jun , and JunB protein levels , which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We also observed increased expression of mRNAs for Fos and Jun transcription factor family members c Fos , FosB , Fra 2 , and JunB , as well as Fos family proteins in the entorhinal cortex after MK 801 administration . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^ The labeling intensity of the c Jun , JunD , and Fra 2 antibodies was stronger than that of JunB , FosB , and Fra 1 . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Human PTH ( 1 34 ) and hPTH ( 1 84 ) increased steady state mRNA expression of c jun , junB , c fos , and fra 2 in an equivalent dose and time dependent manner . ^^^ Expression of c jun , junB , and c fos peaked 30 minutes after the injection while fra 2 expression peaked 30 minutes later . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| While c Fos , Fra 2 and JunB were increased in response to either stimuli , only Fra 1 , c Jun and JunD were increased by PMA . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Activation of transcription through the AP 1 site in Jurkat cells by JunD and / or Fra 2 was weak . c Jun , JunB , and c Fos activation was greater , although the level was still less than that with Tax . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of JunB was diminished in the undifferentiated , more aggressive tumour phenotype compared with the well differentiated , less aggressive keratinocytes , whereas the expression of other AP 1 family members ( c jun , junD , c fos , fra 1 , fra 2 and fosB ) was either very weak or variable . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| PMA significantly induced binding of JunB and Fra 1 in normal cells , while JunB and Fra 2 bound to TREs in the malignant cells . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The 138T allelic variant binds AP 1 complexes consisting primarily of c Jun , JunB and its partners Fra 1 and Fra 2 in rat VSMC . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Expression of egr 1 ( krox 24 ) , egr 2 ( krox 20 ) , egr 3 , c jun , junB , c fos , fosB , fra 1 , fra 2 , and CREB genes was analyzed by reverse transcription polymerase chain reaction ( RT PCR ) in Schwann cells isolated from neonatal rat sciatic nerves and in the cell lines MSC 80 ( mouse Schwann cells ) , NIH 3T3 ( mouse fibroblasts ) , and CHO ( Chinese hamster ovary cells ) . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| This result correlated with the observed loss of binding of the transcriptionally inactive JunB Fra 2 AP 1 complex from B 9 ( SQ ) cells , being replaced primarily by the more active JunD Fra 2 complex in A 5 ( SP ) cells . ^^^ The higher level of JunB binding to both DNA and Fra 2 correlated with its hyperphosphorylation by Jun N terminal kinase , an activity that was significantly higher in B 9 ( SQ ) cells . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^ RESULTS : Of the seven AP 1 factors , three ( c fos , fra 2 , and junB ) clearly showed higher expression levels in tumors when compared to matched normal endometrial samples . ^^^ These factors also correlated significantly with cell cycle promoters ( c fos with cyclin E , cyclin B 1 , cdk 2 , and cdk 4 ; fra 2 with cyclin B 1 ; and junB with cyclin D 1 ) . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The defect is secondary to an inability to phosphorylate CREB and to induce CREB dependent immediate early genes , including c jun , fosB , fra 2 , and junB , which are required for cytokine gene induction . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The DNA binding activities of c Fos , FosB / Delta FosB , Fra 1 , Fra 2 , and JunB were up regulated whereas JunD activity was decreased . c Fos , FosB / Delta FosB , and JunB were associated with Smad 4 . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Ribonuclease protection assays demonstrated that increases in mRNA levels of the early response protooncogenes c jun , junB , fra 1 , and fra 2 accompanied cell proliferation at low concentrations of PM whereas apoptotic concentrations of PM caused transient increases in expression of fos and jun family members and dose responsive increases in mRNA levels of receptor interacting protein , Fas associated death domain , and caspase 8 . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We observed that withdrawal of IL 7 induced increased expression of jun and fos family member genes including c jun , junB , junD , c fos and fra 2 . ^^^ |
|
| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Expression of c fos , fosB , fra 1 , fra 2 , and junB was low during early gestation , with a 5 to 10 fold increase on Day 23 during labor , and returned to low levels 1 day postpartum . ^^^ Administration of progesterone ( P 4 ; 16 mg / kg s . c . / day ) beginning on Day 20 ( to maintain elevated plasma P 4 levels ) prevented the onset of labor and blocked the expected rise in c fos , fosB , fra 1 , fra 2 , and junB expression on Day 23 . ^^^ In contrast , administration of the progesterone receptor antagonist RU 486 ( 10 mg / kg s . c . ) on Day 19 induced preterm labor and a premature increase in mRNA levels of c fos , fra 1 , fra 2 , and junB . ^^^ In unilaterally pregnant rats , stretch imposed by the growing fetus was found to increase the expression of c fos , fosB , fra 1 , fra 2 , and junB only in the gravid horn on the day of labor . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We have characterized the effects of chronic clozapine and haloperidol treatments on the expression of fos ( c fos , fosB , fra 2 ) and jun ( c jun , junB , junD ) family genes in the rat forebrain . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We found that the zinc finger region of BCL 6 interacts with c Jun , JunB , and JunD proteins but does not bind c Fos or Fra 2 proteins . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Supershift EMSA revealed that VT preferentially induced JunB , JunD , phosphorylated c Jun , c Fos , and Fra 2 binding activities of the AP 1 family . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| We found that there is a lack of induction of c Fos , FosB , Fra 2 and JunB by acute cocaine exposure , and of DeltaFosB by repeated cocaine administration in both the NAc and CPu of D 1 receptor mutant mice compared with wild type control mice . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| This effect was specific because palytoxin had little effect on c Jun , JunB , JunD , FosB , Fra 1 , or Fra 2 binding or on overall levels of transcription factor binding . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ Nuclear extracts from granulosa cells from 1 2 mm or 8 10 mm antral follicles bound an AP 1 DNA consensus sequence and complexes consisted predominantly of c Jun , JunD , JunB , c Fos , and Fra 2 . ^^^ In CL , c Jun , JunD , JunB , and Fra 2 were present in DNA binding complexes , and c Fos binding was not detected . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Among the early response genes analyzed , c myc , junB , junD , c jun , c fos , fosB , fra , as well as max , mad 1 4 , sin 3 , only c jun and fra 2 mRNAs were up regulated after 1 , 25 ( OH ) ( 2 ) D ( 3 ) exposure . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In a Gal 4 fusion assay , Pdcd 4 specifically inhibited activation of c Jun and c Fos activation domains , but did not inhibit activation of JunB , JunD , Fra 1 , or Fra 2 . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the current study , we examined the expression of seven fos / jun family member mRNAs ( c fos , fosB , fos related antigen ( fra ) 1 , fra 2 , junB , c jun , and junD ) and three other IEG mRNAs ( egr 1 , egr 3 , and nur 77 ) in mouse brain following short term ( 6 h ) sleep deprivation ( SD ) and 4 h recovery sleep ( RS ) after SD . ^^^ In the cerebral cortex , junB mRNA was also elevated during SD whereas , in the basal forebrain , fra 1 and fra 2 mRNA levels increased in this condition . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Transcriptionally active AP 1 in combinations of c Jun , JunD and JunB with Fra 1 , Fra 2 and possibly FosB , are expressed in cardiac myocytes . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| The mechanism of tumor suppressor action of JDP 2 can be partially explained by the generation of inhibitory AP 1 complexes via the increase of JunB , JunD , and Fra 2 expression and decrease of c Jun expression . . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In the present study , we used immunohistochemistry with specific antibodies against all members of the AP 1 family ( c Jun , JunB , JunD and c Fos , FosB , Fra 1 , Fra 2 ) to investigate their expression pattern and tissue localization in the human placenta . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| It was demonstrated that stellate cells possess nuclear TRE binding proteins that were identified as JunB , JunD , Fra 1 , and Fra 2 , which were unaffected by either electrophiles or PMA treatment . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Dimers comprising Fos / Jun proteins conferred greater transcriptional activity than Jun dimmers , with Fra 2 / JunB combination conferring greatest activity . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Deoxynivalenol was found to readily induce expression of cytokines ( IL 1alpha , IL 1beta , and IL 6 and IL 11 ) , chemokines ( MCP 1 , MCP 3 , CINC 1 and MIP 2 ) , components of the activator protein 1 ( AP 1 ) transcription factor complex ( c Fos , Fra 2 , c Jun and JunB ) , as well as two hydrolases ( MKP 1 , CnAbeta ) . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^ There was only a weak expression of JunB and Fra 2 in small fractions of villous cyto and syncytiotrophoblast nuclei . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Immunodepletion gel shift assays demonstrated that GP 5 EpRE bound JunB , c Jun , FosB , and Fra 2 from unstimulated cells , and that after exposure to HNE , EpRE binding complexes contained nuclear factor erythroid 2 related factor ( Nrf ) 1 , Nrf 2 , JunB , c Jun , FosB , c Fos , Fra 1 , and Fra 2 . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Ischemia induced the expression and binding of c Fos , c Jun , JunB , FosB , and Fra 2 to a noncanonical activating protein 1 ( AP 1 ) site present in the MMP 2 promoter and decreased binding of the transcriptional repressor JunD . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Converging results consolidate activator protein 1 ( AP 1 ) transcription factor as the pivotal downstream effector in the early response of stress sensitive cells to mechanical loading , and the Fra 1 , Fra 2 , JunB and JunD members of the AP 1 transcription factor family , as mediators in bone remodelling and apoptotic phenomena . ^^^ The aim of the present study was to examine the involvement of the Fra 1 , Fra 2 , JunB and JunD proteins in the biochemical response of functionally loaded mandibular condylar cartilage , and the subsequent initiation of cartilage maturation and apoptotic phenomena . ^^^ The condylar cartilage of both groups was immunostained using specific antibodies against Fra 1 , Fra 2 , JunB and JunD . ^^^ Statistical analysis of the data revealed over expression of Fra 1 , Fra 2 , JunB and JunD proteins in all stages of differentiation of chondrocytes derived from the mandibular condylar cartilage of animals fed on a hard diet . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| Embryonic lethality of various AP 1 knock outs , e . g . for Jun , JunB , Fra 1 and Fra 2 largely prevented functional studies in vivo . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| PTH enhanced mRNA expression of c fos , junB , and fra 2 in the distal femur metaphyses of both genotypes ; expression of these transcripts was consistently lower in PTH treated Nf 1 ( + / ) mice . ^^^ |
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| Interacting proteins: P15408 and P17275 |
Pubmed |
SVM Score :0.0 |
| For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^ |
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