Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.75392667
Using the more variable activation domain of c Jun as a bait , we identified a protein , JAB 1 , that interacts with c Jun and JunD , but not with JunB or 5 Jun . 0.75392667^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The transcription factor junB belongs to the jun family of protooncogenes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 transcription factor JunB is a transcriptional regulator of myelopoiesis . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Transcriptional activation of the c jun , junB and c fos genes following TPA / serum induction was unaffected and efficient transactivation of AP 1 reporter constructs was demonstrated in these cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Here , we show that the growth factor inducible proto oncogenes c fos , c jun , and junB mimic the effects of exogenous growth factors and suppress trans activation of the muscle creatine kinase ( MCK ) enhancer by myogenin and MyoD . ^^^ In contrast , JunD , which shares DNA binding specificity with JunB and c Jun but is expressed constitutively in muscle cells , is an inefficient inhibitor of the trans activating capacity of myogenin and MyoD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
ET isopeptides induced a subset of fos and jun mRNAs in mesangial cells , including c fos , fra 1 , c jun , and JunB . fos and jun mRNAs were induced as members of the immediate early gene response . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Two AP 1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes . ^^^ However , in nuclear extracts prepared from human keratinocytes , JunB was the predominant Jun component bound to the DNA probe containing this cis element . ^^^ These results implicate JunB as an important factor in human papillomavirus type 18 transcription in keratinocytes and strongly suggest a potential role of this Jun gene product in the tissue specific transcription of the genital papillomaviruses . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We studied levels of mRNAs for several immediate early genes : c fos , NGFI A , NGFI B , c jun , junB and junD , before and after light exposure at these phases . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To examine the biological role of the various components in signal transduction we analyzed the expression of two of them ( cJun , JunB ) and collagenase in response to phorbol esters , cAMP and TGF beta . ^^^ In contrast expression of cJun and collagenase is reduced by cAMP indicating that cJun and JunB are not coordinately regulated . ^^^ In addition JunB is not an efficient activator of the cJun and collagenase promoters although both cJun and JunB exhibit similar DNA binding properties , indicating that the differences in biological activity is due to differences in their activation domains . ^^^ Expression of cJun and collagenase is inhibited under certain conditions of high levels of JunB . ^^^ This suggests a negative regulatory function of JunB which greatly expands the potential of the Jun protein family in changing the transcription of specific genes involved in triggering complex biological processes . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In primary cultures of bovine glomerulosa cells , AII was found to induce the expression of several early growth response genes ( c fos , c jun , JunB , and Krox 24 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In MCF 7 cells , OA elicited within 5 min an increase in the levels of a set of phosphorylated cellular proteins , within hours expression of the early response genes junB , c jun , and c fos , and within days manifestation of differentiation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
LR was also shown to induce the mRNA levels for junB , suggesting possible involvement of the AP 1 complex in the regulation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Insulin resulted in an early and prominent increase in the transcription of genes encoding the AP 1 components of JunA , JunB , and c Fos , as has been observed for other growth factors . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Induction of junB expression , but not c jun , by granulocyte colony stimulating factor or macrophage colony stimulating factor in the proliferative response of human myeloid leukemia cells . ^^^ Using an established human myeloid leukemia cell line ( NKM 1 ) which can grow in serum free medium in response to G CSF or M CSF , we examined expressions of the jun family genes , c jun , junB , and junD , which are coexpressed by various growth factors in many tissues . ^^^ Transcriptional run on assays revealed that treatment of serum starved NKM 1 with 50 ng / ml G CSF or M CSF increased the transcription rate of the junB gene and the c fos gene by 1 . 8 fold and 2 . 9 fold , respectively , but did not induce any transcript of the c jun gene . ^^^ These findings suggest that the signal activating c jun expression might not be involved in the proliferative action of G CSF and M CSF but junB may be one of important elements in early response events of the signal transduction system in human CSF responsive hematopoietic cells . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In addition , RAR alpha overexpression selectively inhibits the serum stimulated expression of the c fos gene , but does not affect the expression of a number of other serum and polyomavirus inducible genes including c jun , junB , c myc and actin . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We studied the expression of six nuclear proto oncogenes ( Egr 1 , c fos , fosB , c jun , junB , and c myc ) in myocardium subjected to ischemia and reperfusion in anesthetized pigs . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Our data indicate that the rat adrenal gland contains a basally expressed elevated level of AP 1 proteins and mRNAs ( 40 and 35 kDa fos related antigens , a 39 kDa c jun protein , c jun , junB , and junD mRNA ) , as well as high basal AP 1 DNA binding activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The expression of C jun and junB mRNA in renal cell cancer and in vitro regulation by transforming growth factor beta 1 and tumor necrosis factor alpha 1 . ^^^ JunB inhibits c jun ' s transforming activities . ^^^ The constitutive expression of c jun was detected in 39 of 43 fresh frozen RCC , 5 of 10 normal kidneys , and the expression of junB detected in 28 of 34 RCC , 5 of 6 normal kidneys . ^^^ C jun was also found expressed in all 10 RCC tumor lines examined and junB was expressed at low levels in 6 of 10 renal tumor lines . ^^^ We found that TGF b 1 highly augmented the expression of junB ( mean of 34 folds , p less than . 05 ) , but did not significantly alter the expression of c jun , the transforming gene . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
LRF 1 / c Jun , c Fos / c Jun , and c Fos / JunB activate specific AP 1 and ATF site containing promoters , and in contrast , LRF 1 / JunB potently represses c Fos and c Jun mediated activation of these promoters . ^^^ As the relative level of LRF 1 / JunB complexes increases posthepatectomy , c Fos / Jun mediated ATF and AP 1 site activation is likely to decrease with simultaneous transcriptional activation of the many liver specific genes whose promoters contain cyclic AMP response element sites . ^^^ Interactions among LRF 1 , JunB , c Jun , and c Fos define a regulatory program in the G 1 phase of liver regeneration . ^^^ In regenerating liver , a physiologically normal model of cell growth , LRF 1 , JunB , c Jun , and c Fos among Jun / Fos / LRF 1 family members are induced posthepatectomy . ^^^ In liver cells , high levels of c Fos / c Jun , c Fos / JunB , LRF 1 / c Jun , and LRF 1 / JunB complexes are present for several hours after the G0 / G1 transition , and the relative level of LRF 1 / JunB complexes increases during G 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have shown that while c Fos is the major Fos protein associated with the Jun proteins ( c Jun , JunB , and JunD ) soon after serum stimulation , at later times Fra 1 and Fra 2 are the predominant Fos proteins associated with the different Jun proteins . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We evaluated the ability of these and other agents to induce the expression of a variety of transcription factor genes including c fos , c myc , junB , and c jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The present paper describes the effect of capsaicin induced stressful stimulus on the expression of immediate early genes ( IEGs ) c fos , c jun , junB and junD in the hypothalamic paraventricular nucleus ( PVN ) and the central amygdaloid nucleus ( ACe ) using in situ hybridization . ^^^ Stress caused an intense expression of c fos , c jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We also show that c Fos does not affect the inhibitory function of CREM on c Jun and that the transcriptional activation elicited by the other members of the jun family ( JunB , JunD , and 5 Jun ) is also down regulated by CREM . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Whereas the AP 1 proteins junB , junD , and fosB did not show differential basal or TPA inducible levels in P+ and P cells , a 46 kDa species precipitated by anti fra 1 antibody was TPA inducible in P cells but not in P+ cells , and c jun protein was present at higher levels in TPA treated and untreated P+ cells than in P cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this study , we have found that stimulation of T cells by IL 1 and TPA is accompanied by activation of a subset of immediate early genes that comprise the AP 1 transcription factor complex . junB and fosB were rapidly induced following stimulation with TPA . ^^^ The expression of fos and jun during T cell activation was accompanied by increased specific binding of JunB , FosB , and fos related antigen containing complexes to the TPA responsive element . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The expression of the early response genes junB , c fos , and c jun was attenuated in PMA treated HL 525 and HL 534 cells as compared to the PMA treated HL 60 and HL 205 cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The activity of this intermediary factor ( s ) is restricted to TADs characterized by an abundance of negatively charged amino acids , as demonstrated by the abilities of the TADs of JunB , GAL 4 , and VP 16 to repress c Jun activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Thus , treatment of cells with TPA results in a reduction in the levels of c myb and c myc mRNA , while the expression of c fos , c jun , and junB is greatly enhanced . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Transcription factors junB and c jun are selectively up regulated and functionally implicated in fibrosarcoma development . ^^^ In both tissue biopsies and derivative cell lines , the proto oncogenes junB and c jun are induced in the latter two stages , in contrast to junD and fos . ^^^ Overexpression of junB or c jun by transfection into the mild fibromatosis stage elicited changes in cell shape and anchorage independence , whereas junD did not . ^^^ Thus , junB and c jun represent progression factors whose activities are necessary at an intermediate stage of tumor development , subsequent to the initiation of aberrant proliferation . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Hence , the ratio of c Jun to JunB induction may determine whether proenkephalin is repressed or further activated . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Phorbol ester tumor promoters activate gene transcription by regulating both the synthesis and posttranslational modification of the activator protein 1 ( AP 1 ) transcription factor , c Jun and JunB are components of the mammalian AP 1 complex . ^^^ Here we demonstrate that in U 937 human leukemic cells , phorbol esters stimulate the phosphorylation of the amino terminus of human c Jun ( JUN ) but not human JunB ( JUNB ) . ^^^ Phorbol ester induced amino terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation . ^^^ To determine the functional role of this N terminal phosphorylation , we prepared several chimeric proteins containing the N terminal 84 amino acids ( positions 5 89 ) of human JUN or murine JUNB fused to the yeast GAL 4 DNA binding domain . ^^^ This region was found to be sufficient for the phorbol ester inducible transcriptional activity of JUN , but not JUNB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using quantitative RT PCR , we have monitored mRNA expression levels of c fos , c jun , JunB , c myc , p 53 , H ras , and histone H 4 during the replicative senescence of human fibroblasts . ^^^ The basal level of c fos mRNA decreased to one ninth that of the early passage levels , while junB declined to one third and c jun expression remained constant . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To determine the contribution of other transcription regulators such as JUN family members in the control of c myb expression , transient expression assays were carried out which revealed a 6 to a 15 fold enhancement by c Jun and JunD , but not JunB , in chloramphenicol acetyltransferase reporter gene expression driven by different segments of the human c myb 5 ' flanking region . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The c jun cDNA used for the construction of the vector was modified so as to prevent the nonspecific targeting of junB and junD transcripts . ^^^ When these cells were recultured in the absence of DEX , c jun protein rapidly reappeared and the immediate early response genes egr 1 , junB , and c myc were transiently expressed . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Administration of kainate or pentylenetetrazole increased c fos , c jun , junB , and junD mRNA levels in rat brain in a dose dependent manner . ^^^ Adrenalectomy significantly potentiated kainate induced increases , compared with increases caused by kainate ( 4 mg / kg ) alone , in the hippocampal mRNA levels of c fos and junB by 6 . 5 fold and of junD by twofold and tended to augment c jun mRNA . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB does not inhibit the induction of c Jun during the retinoic acid induced differentiation of F 9 cells . ^^^ JunB , a member of the jun gene family of transcription factors , is distinguished from c Jun by its differential activity on certain arrangements of promoter regulatory elements and the ability of JunB to inhibit the action of cJun in both transforming and trans activating assays . ^^^ Constitutive expression of high levels of JunB in F 9 cells failed to inhibit the differentiation dependent induction of c Jun or the coincident expression of differentiation markers keratin 8 and 18 , tissue plasminogen activator , and laminin B 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We therefore examined changes in the mRNA levels for the IEGs c fos , c jun , fosB , junB , and zif 268 in the NAc of rats treated acutely and chronically with cocaine . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
TPA induced c fos and junB mRNAs transiently and preceding NGF mRNA induction but c jun mRNA remained undetectable . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
By use of okadaic acid , an inhibitor of protein phosphatases 1 ( PP 1 ) and 2A ( PP 2A ) , we present evidence that expression of distinct members of the jun family of genes , c jun , junB , and junD , are regulated differentially by serine / threonine specific phosphoprotein phosphatases . ^^^ Treatment of cells with okadaic acid induces the expression of junB , and to a lesser extent c jun , but has only a marginal effect on junD expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
These include zif / 268 ( also termed NGFI A , Krox 24 , TIS 8 , and egr l ) , c fos related genes , c jun , junB , and junD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Increased levels of junB and c jun mRNAs in male germ cells following testicular cell dissociation . ^^^ We have examined the relative transcript levels of the junB and c jun proto oncogenes during development of the mouse testis . junB and c jun mRNA levels are low in total RNA from intact immature or mature testes . ^^^ Dissociation of testicular cells , however , increases the levels of junB and c jun mRNAs , with higher increases in the dissociated cells from testes of 8 day old mice than from 17 day old or sexually mature mice . ^^^ These differences in junB and c jun mRNA levels localize to specific cell types . ^^^ In testes of 17 day old mice , the highest mRNA levels for both proto oncogenes are seen in preleptotene spermatocytes and interstitial cells , with decreasing levels in leptotene / zygotene spermatocytes and prepuberal pachytene spermatocytes . junB and c jun mRNAs are nearly undetectable in pachytene spermatocytes , round spermatids , and residual bodies / cytoplasts . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The relative stimulation of zif 268 mRNA by RA was much larger than that of other early genes , including c fos , c jun , and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The product of the junB gene , a gene homologous to the proto oncogene c jun , is a component of transcription factor AP 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Unlike its counterparts c jun and junB , junD expression is hardly inducible by growth factors and phorbol esters . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We studied the transcript distribution of c jun , junB and junD in the rat brain . ^^^ The spatiotemporal pattern of expression of c jun , junB and junD offers clues to the understanding of the links between gene regulation and neuronal processes . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
AMP dependent regulation of proenkephalin by JunD and JunB : positive and negative effects of AP 1 proteins . ^^^ Another component of the AP 1 transcription complex , JunB , is shown to inhibit activation mediated by JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Northern analysis indicates that mRNAs for at least six members of the Fos / Jun family ( c fos , fosB , fra 1 , c jun , junB , and junD ) are expressed in activated Ar 5 cells ; thus the AP 1 sites of the IL 2 promoter may bind different dimeric Fos / Jun complexes at different times after T cell activation , perhaps mediating both positive and negative regulation of the IL 2 promoter . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this paper , we show that neuronal differentiation of mouse N1E 115 neuroblastoma cells by dimethyl sulfoxide is accompanied by a prolonged rise in c jun , junB , and junD expression and AP 1 activity . ^^^ Furthermore , we show that c jun and junD , but not junB , are expressed at high levels in the neuronal cell types obtained after dimethyl sulfoxide treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Induction of smooth muscle alpha actin was delayed and sustained after aortic constriction , whereas the nuclear oncogenes c jun and junB were expressed rapidly and transiently , providing potential dimerization partners for transcriptional control by c fos . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have previously shown that the adenovirus type 5 E1A protein ( E1A5 ) induces c jun and junB expression in a number of different cell types . ^^^ By contrast , adenovirus type 12 E1A ( E1A12 ) , like retinoic acid ( RA ) , strongly induces c jun expression , while expression of junB and junD is not altered . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto oncogenes including c jun , junD , and junB and to a lesser extent the fos family including c fos and fra 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The murine homolog of 5 jun , Jun , was mapped to chromosome ( Chr ) 4 , and a locus containing jun B related sequences ( Junb ) was mapped to Chr 8 . ^^^ Probes for jun D identified two genetic loci ; one , Jund 1 , is near Junb on Chr 8 , and a second , previously unidentified locus termed Jund 2 , was mapped to Chr 2 . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have characterized the expression of c Jun , JunB , JunD , c Fos , and FosB proteins following serum stimulation of quiescent Swiss 3T3 cells by immunoprecipitation analyses . ^^^ We have shown that c Fos and FosB form complexes in vivo with the different Jun proteins and that JunB complexes are predominant . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Consistent with this result , these cell lines expressed increased levels of mRNAs encoding the AP 1 proteins , c Fos , Fra 1 , c Jun , JunB , and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To determine whether these proteins are required for cell cycle progression , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , c Jun , JunB , and JunD , and antibodies that recognize either the Fos or the Jun family of proteins , into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The PMA induction of c fos mRNA correlated well with TNF gene induction ; expression of genes encoding other proteins in the AP 1 complex ( junB and junD ) were also induced by PMA . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Overexpression of c jun , junB , or junD affects cell growth differently . ^^^ The coding sequences of murine c jun , junB , or junD , which code for proteins with practically identical dimerization and DNA binding properties , were introduced into a nondefective retroviral vector , and the phenotype of primary avian fibroblasts chronically infected with each of these viruses was studied . ^^^ Cells expressing junB grew in agar , with a reduced efficiency as compared to c jun , but did not grow in low serum medium . ^^^ Analysis of c jun deletion mutants and of c jun / junB and c jun / junD chimeric genes showed that the N terminal portion ( amino acids 2 168 ) of the c Jun protein that is involved in transcriptional activation is required for efficient transformation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Short term stimulation ( up to 16 hours ) of interleukin 3 ( IL 3 ) dependent mouse bone marrow derived mast cells , Abelson transformed mouse liver derived mast cells , or rat basophilic leukemia cells by either IgE Ag or calcium ionophore A 23187 resulted in inhibition of their proliferation as measured by 3H thymidine incorporation and MTT ( tetrazolium ) assays , and in accumulation of the mRNAs of c fos , c jun , junB and slightly of junD proto oncogenes . ^^^ In addition , the expression of the mRNA of c jun and junB proto onogenes is not coordinately regulated with that of c fos during immunologic stimulation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Like c Fos and Fra 1 , Fra 2 formed stable heterodimers with c Jun , JunB or JunD in vitro and all these complexes had specific DNA binding activity to AP 1 binding sites ( AP 1 sites ) or related sequences . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The induction of transcription of c fos , fosB , c jun , junB and collagenase was studied as well as the mutation rate in the progeny of treated cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast to the dramatic effects of TGF beta on junB expression , c jun showed only a 2 . 5 fold increase in expression in response to TGF beta . ^^^ From this screen , a new jun related gene product was identified which shared a high degree of homology with regions of c jun and junB which have been implicated in transcriptional activation , dimerization , and DNA binding . ^^^ The goal of the present study was to determine whether TGF beta dependent repression of muscle specific genes was preceded by modulation in expression of members of the jun proto oncogene family , which function as growth factor inducible transcription factors . junB mRNA was expressed at a basal level in differentiated BC3H1 myocytes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The related gene junB increased only 50 % , whereas c jun expression increased 13 fold compared with sham operated controls . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Transfection with amplifiable c jun , junB , or junD expression plasmids inhibited differentiation , whereas transfection with an egr 1 expression plasmid was without effect . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Here we show , however , that omission of a single essential amino acid from the medium caused a marked rise in the mRNA levels of c myc , c jun , junB and c fos oncogenes and ornithine decarboxylase ( ODC ) in CHO cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
H 35 cells treated with either insulin or phorbol 12 myristate 13 acetate express elevated levels of the jun genes , and phorbol 12 myristate 13 acetate pretreatment fails to abolish the insulin response , indicating that it does not depend on protein kinase C . jun family gene expression in regenerating liver differs from that in mitogen treated fibroblasts in that the time course of expression of c jun and junB is prolonged , and junD mRNA levels distinctly increase . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this study , a set of known ( junB , c jun , ICAM 1 , H 1 ( 0 ) , and H3 . 3 histone variants ) and novel ( MyD 88 , MyD 116 ) MyD genes were used as immediate early molecular markers to further dissect the primary genetic response of myeloid cells to various differentiation and growth inhibitory stimuli . ^^^ No increase in the expression of any of these MyD genes was seen in a clone of WEHI 3B D myelomonocytic cells following stimulation with interleukin 6 , which neither induced it for differentiation nor inhibited its growth . 12 O Tetradecanoylphorbol 13 acetate , known to be a potent inducer of jun expression in many cell types , failed to induce high or stable expression of junB and c jun in M1D+ cells , where it did not induce differentiation . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The heterodimer formation between CREB and Jun proteins is highly specific ; only one of the two CREB proteins would heterodimerize with cJun and it would not form dimers with JunB or cFos . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The expression of c jun , junB , and junD was not altered in the revertants , and they could not be transformed by transfection with a c jun expression vector . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Tissue specific expression of c jun and junB during organogenesis in the mouse . c jun and junB are cellular genes related to the viral oncogene 5 jun and encode members of the AP 1 transcription factor gene family . ^^^ Here , we have investigated the potential roles of c jun and junB during fetal growth and organogenesis in the mouse by in situ hybridization analysis of their expression patterns . c jun expression is detected throughout organogenesis , and transcripts are detected in many tissues , although in restricted cell populations within developing cartilage , gut and the central nervous system ( CNS ) . ^^^ In cartilage , c jun expression is associated with rapidly proliferating perichondrial cells , but occurs in postmitotic motor neurones in the CNS . junB expression is initiated between 14 . 5 and 17 . 5 days of development , and is restricted to differentiating epidermal cells and endodermal gut epithelium . ^^^ These data suggest that c jun and junB have distinct , tissue specific roles in cell proliferation and differentiation during fetal development . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This prompted us to examine also potential changes in the expression of the serum and tumour promoter induced transcription factor genes junB and c jun after induction of the hsp c Ha ras construct . ^^^ The junB mRNA was enhanced approximately 10 fold and the c jun oncogene mRNA to a lesser degree in the hsp c Ha ras transfected cells after zinc activation of the hsp 70 promoter . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Two of them were carrying c jun and junB sequences respectively , whereas the sequence of the third group of clones ( junD ) was distinct from these two and from 5 jun . ^^^ Contrary to c jun and junB transcription , which are strongly stimulated by serum or TPA treatment of quiescent 3T3 cells , junD transcription is not significantly stimulated in these conditions . ^^^ The tissue distribution and levels of expression of junD mRNA differ from that of c jun and junB mRNA . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We report here that an early effect of TGF beta is an enhancement of the expression of two genes encoding serum and phorbol ester tumor promoter regulated transcription factors : the junB gene and the c jun proto oncogene , respectively . ^^^ Thus , one of the earliest genomic responses to TGF beta may involve nuclear signal transduction and amplification by the junB and c jun transcription factors in concert with c fos , which is also induced . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
It led to an accumulation of milk in the glands and was accompanied by an induction of protein kinase A , AP 1 DNA binding activity and elevated c fos , junB , and junD mRNA levels . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the present study we analysed , by in situ hybridization , the effects of an extremely localized mechanical brain injury , obtained by the simple needle insertion ( 30 g ) in rat hippocampus or cortex , on the expression of several immediate early genes ( c fos , fosB , c jun , junB , junD , zif / 268 ) . ^^^ Maximal effects are detected between 30 and 60 min with the following rank order of induction : zif / 268 > c fos > junB > fosB > c jun > junD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Colocalization of NDP with c Jun , JunB , JunD , c Fos , FosB and Krox 24 transcription factors was investigated in neurons of lumbar spinal cord . c Jun , JunB , c Fos and Krox 24 reached their maximal levels of expression 2 h after FOR and returned to basal levels after 10 h . ^^^ In a low number of NDP neurons , suprabasal immunoreactivity of JunB , c Fos and Krox 24 proteins was visible up to 10 h , and of JunD and FosB up to 24 h in sDH neurons ; c Jun was not expressed in NDP labelled neurons of sDH , but , similar as JunD , showed basal colocalization in preganglionic sympathetic and parasympathetic neurons . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activation of GnRH receptors in cultured pituitary cells and alpha T 3 1 gonadotrophs caused prominent , but transient , increases in messenger RNAs for primary response genes ( PRGs ) including c fos , c jun , and junB . ^^^ GnRH induced stimulation peaked at 30 min and was dose related , with similar EC 50 values ( approximately 1 nM ) for all three PRGs and higher maximum responses for junB than for c jun and c fos . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have used primary neuronal cultures prepared from fetal cerebral hemispheres to investigate the effects of different glutamate receptor agonists and antagonists on the expression of transcription factor encoding genes , such as c fos , fosB , c jun , junB , junD , c myc , and zif / 268 . ^^^ The addition of glutamate ( 100 microM ) to the culture medium rapidly activated c fos , fosB , c jun , junB and zif / 268 gene expression , reaching the maximal level at 30 60 minutes for zif / 268 and at 60 minutes for the other genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RNA levels of ETS 2 , c Jun , and JunB increase upon the differentiation of ES cells and correlate with increased expression of K 18 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
They also indicate that separate intracellular pathways may be used for induction of jun and fos gene products and that the same transcription factor ( junB ) may be triggered by two surface receptors through separate pathways that differ in PKC dependence . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB and JunD were poorer inhibitors . c Fos expression did not potentiate the negative effect of Jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Additionally , HGF induced increased transcription of c fos , c jun , junB , junD , and c myc early response genes in both cell lines . ^^^ We therefore suggest that the second messenger proteins PI3K , GAP and NCK , and possibly the protein products of the c fos , c jun , junB , junD and c myc genes , are important elements in the HGF induced mitogenic pathway in the normal mouse epithelial cell lines M 23 and MM55 . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In electrophoretic mobility shift assays using nuclear extracts from cultured cells and primary tissues , several AP 1 proteins ( c Jun , JunB , JunD , and c Fos ) bound the cyclin D 1 954 region . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Further investigations using supershift and shift Western analysis showed that c Fos and JunB bind to the AP 1 element during hypoxia and that these protein levels are stimulated by hypoxia . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
While a large body of literature describes the induction of immediate early genes , including c fos , fosB , c jun , junB , zif / 268 , and krox genes by glutamate and agonists in neurons , very little is known about preexisting transcription factors controlling the induction of such genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Differential induction and regulation of c jun , junB , junD and c fos by human papillomavirus type 11 E5a oncoprotein . ^^^ Our results show that the expression of c jun and junB , but not junD , was activated by HPV 11 E5a in NIH 3T3 cells and human epidermal keratinocytes . ^^^ We further investigated the mechanism of c jun and junB induction by E5a . ^^^ The amount of c jun and junB RNAs correlated with the amount of E5a RNA in the heavy metal inducible system . ^^^ E5a constitutively activated the expression of c jun and junB at the initiation of transcription level . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Basal expression of the inducible transcription factors c Jun , JunB , JunD , c Fos , FosB , and Krox 24 in the adult rat brain . ^^^ The expression of c Jun , JunB , JunD , c Fos , FosB , and Krox 24 was investigated in the brain of untreated male Sprague Dawley and female BDIX rats by immunocytochemistry using specific antibodies . ^^^ JunD was expressed at high levels in those areas that also exhibit c Jun , JunB , c Fos , and FosB IR , such as locus coeruleus , periolivary nuclei ( ncl . ) , pontine and central gray , lateral lemniscal ncl . , inferior and superior colliculi , leaflet of geniculate ncl . , midline nuclei of thalamus , dorsomedial and paraventricular ncl . of hypothalamus , ncl . supraopticus , dorsolateral part of caudate putamen and lateral septal ncl . ^^^ In contrast to the high number of JunD positive neurons , c Jun , JunB , c Fos , and FosB proteins were detected in rather low numbers of neurons in these brain areas ; the rank of the number of immunopositive neurons was c Fos > JunB > c Jun > FosB . ^^^ Particularly high levels of expression were observed for c Jun in medullary motoneurons , medial geniculate ncl . , arcuate ncl . , and dentate gyrus , and for JunB in the CA 1 area of the hippocampus and islands of Calleja . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To investigate the role of the Jun transcription factors in neuronal differentiation , programmed neuronal cell death , and neuronal plasticity , we used phosphorothioate oligodeoxynucleotides ( S ODN ) to inhibit selectively the expression of c Jun , JunB , and JunD . 2 . ^^^ We have shown previously that in contrast to c Jun , the JunB and JunD transcription factors are negative regulators of cell growth in various cell lines . ^^^ Here we confirm this finding in primary human fibroblasts . 3 . c Jun and JunB are counterplayers not only with respect to proliferation , but also in cell differentiation . ^^^ Thus , while cell proliferation is associated with c Jun phosphorylation , cell differentiation is correlated with JunB phosphorylation . ^^^ This supports the finding that c Jun and JunB play antagonistic roles in both proliferation and differentiation . 5 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RESULTS : Negative growth control elements , including transcriptional repressors ( WT 1 , junB , myn , HNF 1 , p 53 , RB , Dr 1 , gas 2 , gadd 153 ) were induced 1 . 7 to 4 . 7 fold within 1 hour after uninephrectomy , as were positive growth control elements ( egr 1 , c jun , cyclin C , cyclin E ; 1 . 9 to 4 . 2 fold induction ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this report , we show that the 1 . 2 kb RNA promoter contains a cis acting AP 1 site , critical for its activation by IE 2 86 in vivo , and that IE 2 86 , purified as a glutathione S transferase IE 86 fusion protein , can interact with c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Moreover , immunoprecipitation of nondenatured Bal 17 B cell extracts indicated that FosB forms complexes in vivo with JunB and JunD and to a lesser extent with cJun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In undifferentiated Tera 2 cells FGF stimulation caused an increase of c fos mRNA , and c jun mRNAs , but no increase of junB mRNA , whereas in the differentiated cells , FGFs strongly stimulated the expression of all three genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We now report that in both quiescent and non quiescent mouse bone marrow derived cultured mast cells ( BMCMC ) rrSCF 164 induces increased mRNA levels for the `` early response genes ' ' c fos , c jun and junB but has only slight effects on the expression of junD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RNAs from several brain regions were analyzed by Northern blot hybridization for their relative concentrations of nine IEG mRNAs ( c fos , c jun , junB , TIS 1 ( nur 77 ) , TIS 7 , TIS 8 ( zif 268 ) , TIS 10 , TIS 11 , and TIS 21 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Likewise , expression of fra 1 , c jun and junB continued to be high in serum stimulated senescent cells , while induction of fosB was reduced approximately fivefold . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The mRNA for the transcription factors ATF 3 , c fos , c jun , junB , and zif / 268 is induced by A 23187 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Okadaic acid induced rapid increase in the mRNA levels of both c jun and junB and results indicate that the inhibition of phosphatase by okadaic acid induces apparent activation of protein phosphorylation and may cause the expression of differentiation marker genes in F 9 cells via the activation of AP 1 . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Differential expression of c jun , junB and junD in rat hippocampal slices . ^^^ All three jun genes were expressed in a circumscribed , independent fashion with respect to distribution , intensity and time course . c jun and junD were expressed strongly throughout the hippocampus with a shift from DG to CA 1 to CA 3 . junB expression was confined to DG and CA 1 , but substitution of Ca2+ by Mg2+ led to profound changes : the signal rose earlier , was prolonged , strongly enhanced and more widespread . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This allowed analysis of the expression of functional glutamate receptor subtypes , examination of their role in controlling intracellular free calcium ( [ Ca2+ ] 1 ) , and determination of their relative contributions to the transcriptional regulation of six immediate early genes c fos , fosB , c jun , junB , zif / 268 ( also termed Egr 1 ; NGFI A ; Krox 24 ) and nur / 77 ( also termed NGFI B ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activation of TRE regulated genes by NO releasing agents and cGMP analogs appeared to be mediated by the AP 1 ( Jun / Fos ) transcription factor complex because we observed increased DNA binding of AP 1 and increased junB and c fos mRNA in cells treated with these agents . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the present study we have investigated the induction of immediate early gene ( IEG ) c fos , c jun , junB and junD mRNAs and proteins in interstitial cells of rat testis after hCG treatment in vivo using in situ hybridization and immunocytochemistry . ^^^ A prominent induction of c fos , c jun and junB mRNAs and proteins in Leydig cells was seen after hCG treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The effect of a single injection of caffeine on the expression of c fos , c jun , junB , and junD , on activator protein 1 ( AP 1 ) and on the levels of preproenkephalin mRNA in rat striatum was studied . ^^^ Increased expression of c jun , junB , AP 1 , and preproenkephalin mRNA in rat striatum following a single injection of caffeine . ^^^ Furthermore , by using gel shift assay we found an induction of AP 1 by caffeine ( 100 mg / kg ) in striatum , which peaked 2 hr after administration and was clearly increased after 4 hr . c Fos , c Jun , and JunB proteins were components of the AP 1 . ^^^ The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c fos , c jun , and junB induction , followed by changes in AP 1 and preproenkephalin mRNA . ^^^ By using in situ hybridization of adjacent sections we found a rapid , transient , and dose dependent increase of c fos , c jun , and junB by caffeine in striatum , especially in the lateral part . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The expression of seven immediate early gene encoded transcription factors ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif / 268 ) was assessed simultaneously . ^^^ FosB expression was induced four hours after icv injection of the highest dose of angiotensin 2 in the median preoptic area and paraventricular nucleus , c Jun expression was restricted to the median preoptic area , subfornical organ and paraventricular nucleus , and JunB was only induced in the median preoptic area and subfornical organ . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Fos related antigen ( Fra 1 ) , junB , and junD activate human involucrin promoter transcription by binding to proximal and distal AP 1 sites to mediate phorbol ester effects on promoter activity . ^^^ We conclude that ( 1 ) two AP 1 sites in the hINV promoter are important elements required for keratinocyte specific expression , ( 2 ) these AP 1 1 sites mediate the phorbol ester dependent increase in promoter activity , and ( 3 ) Fra 1 , junB , and junD may be important regulators of hINV expression in epidermis . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
BHQ induced expression of c jun , junB , fra 1 , and fra 2 , which encode AP 1 components , but was a poor inducer of c fos and had no effect on fosB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In order to explore the importance of c Fos and JunB , the predominantly expressed AP 1 proteins for the phase shifting effects of light , we blocked the expression of c Fos and JunB in the suprachiasmatic nucleus of male rats , housed under constant darkness , by intracerebroventricular application of 2 microliters of 1 mM antisense phosphorothioate oligodeoxynucleotides ( ASO ) specifically directed against c fos and junB mRNA . ^^^ Light induced phase shifts of circadian rhythmic locomotor activity are associated with the expression of c Jun , JunB , c Fos and FosB transcription factors in the rat suprachiasmatic nucleus , as shown in the present study . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using model spontaneously reverting cell lines , c jun , junB , junD and c fos oncogene expression was investigated . c jun , but not junB , junD or c fos , was overexpressed in highly tumorigenic clones . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This study was undertaken to assess the effects of a single or two sequential topical applications of 12 O tetradecanoylphorbol 13 acetate ( TPA ) on the expression of c fos , c jun , junB , c myc , and ornithine decarboxylase ( ODC ) in promotion sensitive SSIN mice and the relatively promotion resistant C57BL / 6 strain . ^^^ In contrast , two treatments of SSIN mice with TPA caused a rapid , strong c fos induction 1 2 h after treatment , whereas C57BL / 6 mice responded no more strongly than after a single treatment . c jun mRNA and protein were induced only slightly in either strain , but junB was induced about fivefold in SSIN mice and tenfold in C57BL / 6 mice . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A daily rhythm of activator protein 1 activity in the rat pineal is dependent upon trans synaptic induction of JunB . ^^^ The nocturnal activator protein 1 protein complex is induced through a trans synaptic , beta adrenoceptor linked mechanism and is characterized by the prolonged participation of JunB as demonstrated using antibodies for specific activator protein 1 proteins . ^^^ Indeed , JunB appears to be a major component of nocturnal changes in activator protein 1 activity , JunD forming an additional , constitutive component which is not affected by the nocturnal adrenergic signal . ^^^ The alpha 1 adrenoreceptor linked c Fos protein , which is coordinately induced with JunB , does not form a stable component of nocturnal activator protein 1 activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The closely related proteins c Jun , JunB and JunD form a family of transcription factors which require dimerization for DNA binding and transcriptional activity . ^^^ When expressed at high levels in primary chicken cells , each mouse Jun displays distinct transforming capacities : c Jun transforms efficiently , JunB transforms poorly , and JunD does not transform at all . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The ability of the N terminal activation domains of c Jun , JunB , JunD and 5 Jun to interact with TBP in vitro correlates with their transcriptional activity in vivo . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The results indicate that induction of collagenase gene expression by OA is mediated by enhanced JunB expression , as well as enhanced trans activating capacity of AP 1 complexes containing c Jun and JunB . ^^^ Exposure of HT 1080 cells to OA resulted in marked and persistent induction of junB , junD , and c fos mRNA levels up to 24 h , while c jun mRNA levels were only slightly elevated . ^^^ Overexpression of JunB in HT 1080 cells enhanced collagenase promoter activity by 10 fold , and OA augmented trans activation of collagenase promoter by c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB , but not c jun , mRNA expression was found under these conditions in addition to a transient c fos mRNA increase . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The present results demonstrate that neurotransmitters released from splanchnic nerve terminals induce expression of c fos , c jun , and junB in adrenal chromaffin cells which results in increased AP 1 DNA binding activity . ^^^ Neuronal regulation of c fos , c jun , and junB immediate early genes in rat adrenal medulla . ^^^ We have applied in situ hybridization histochemistry , Northern analysis , and immunocytochemistry to study the regulation of the immediate early gene ( IEG ) c fos , c jun , and junB mRNAs and the respective proteins in the rat adrenal medulla . ^^^ Stimulation with nicotine also caused a drastic increase in the mRNA levels , whereas muscarine only induced moderate elevations . c fos and c jun were induced strongly in adrenaline cells and only weakly in noradrenaline cells . junB was upregulated mainly in adrenaline cells . ^^^ Although stimulation of both nicotinic and muscarinic cholinergic receptors may mediate the induction of these IEGs , it is possible that also another neurotransmitter ( s ) , in addition to ACh , released from splanchnic nerve terminals is involved in the regulation of their expression , especially of c jun and junB . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The product of the junB gene is a member of the AP 1 family of transcription factors that activate transcription by binding to TPA responsive elements ( TREs ) within the promoters of target genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Rat hearts infused with the beta adrenergic agonist isoproterenol were examined for the expression of several nuclear proto oncogenes ( c fos , fosB , c jun , junB , and junD ) and the immediate early gene Egr 1 . ^^^ Expression of c jun and junD were not elevated whereas junB was . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Other receptor initiated events including induction of 1 kappa B alpha phosphorylation , expression of c jun and junB mRNA , and costimulatory effects on IL 2 synthesis also are altered by IL 1 receptor desensitization . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast , levels of c jun , junB and junD mRNA were unaffected by the peptide . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Differential regulation of c fos , fosB , c jun , junB , bcl 2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion . ^^^ To obtain information in vivo about a possible relationship between u . v . induced proto oncogene expression and cellular alterations , we have analysed the expression of c fos , fosB , c jun , junB , bcl 2 and bax in rat epidermis after single and chronic u . v . irradiation . ^^^ Single u . v . irradiation causes a rapid and sustained increase in c jun , junB and c fos mRNA and a decline in bcl 2 transcripts , whereas expression of bax remained unchanged . c Fos and c Jun immunoreactivity was localized throughout the epidermal cell layers 1 . 5 h after single irradiation , but restricted to basal cells at 48 h suggesting an involvement in both u . v . induced apoptosis and hyperproliferation . 48 h after chronic exposure a significantly higher induction and a totally different pattern of epidermal proto oncogene expression was detectable which may be associated with malignancy . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To determine if axotomy induced immediate early gene ( IEG ) expression accompanies regenerative efforts in central nervous system ( CNS ) neurons , immunohistochemistry using antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins was used to examine gene expression in identified adult rat retinal ganglion cells ( RGCs ) under two conditions : ( 1 ) after axotomy alone , and ( 2 ) 1 month after replacement of the optic nerve with an autologous peripheral nerve graft to allow axonal regrowth . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Repression was relatively selective for c fos / c jun ; induction of other immediate early transcription factors ( junB , c myc , and egr 1 ) was not downregulated by RA . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 site binding complex ( es ) induced by all three treatments reacted with antibodies directed broadly against fos and jun protooncogene families and against the specific family members c fos , junB , and junD but not c jun proteins . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A mechanism is suggested whereby expression of c jun and junB , in the absence of members of the fos family , can prevent inappropriate activation of T cells caused by ligation of CD 28 in the absence of a specific antigenic stimulus . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Time dependence analysis of the expression of the mRNAs for c jun and junB indicated that the induction of these genes persisted significantly longer in cells treated with both PMA and cyclosporin A than in cells treated with PMA alone . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Although CREB , c Fos , c Jun , and JunD did not have significant effects , JunB inhibited the Tax dependent transactivation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Our results showed that EGF treatment caused rapid increases in c fos , c jun , and junB expression ( P < 0 . 001 ) in both cell lines . c fos and c jun followed similar time courses , peaking at 30 min , whereas junB levels plateaued at 1 hr . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast , acute administration of the atypical antipsychotic drug clozapine ( CLOZ , 30 mg / kg ) induced only FRAs , JunB and Krox 24 IEGPs in the striatum , and c Fos , FRAs , and Krox 24 IEGPs in the nucleus accumbens . c Jun was not induced by acute administration of HAL or CLOZ in the rat brain . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Assignment of rat Jun family genes to chromosome 19 ( Junb ) , chromosome 5q31 33 ( Jun ) , and chromosome 16 ( Jund ) . ^^^ By means of somatic cell hybrids segregating rat chromosomes , we determined the chromosome localization of three rat genes of the Jun family : Junb ( Chr 19 ) , Jun ( =c Jun ) ( Chr 5 ) and Jund ( Chr 16 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Induction of c fos , junB , c jun , and hsp 70 mRNA in cortex , thalamus , basal ganglia , and hippocampus following middle cerebral artery occlusion . ^^^ Middle cerebral artery ( MCA ) occlusion in halothane anesthetized rats induced c fos , junB , and c jun immediate early gene mRNAs and hsp 70 heat shock gene mRNA in brain . ^^^ By 24 h , there was little expression of c fos , junB , c jun , and hsp 70 in the core of the MCA infarct ; there was modest induction of hsp 70 at the margins of the infarct ; and there was diffuse induction of c fos , junB , and c jun in all of the cortex outside the infarct . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Adhesion of hepatocytes to the EHS gel for the same period of time dramatically alters this program : it arrests growth and inhibits AP 1 DNA binding activity and the expression of c jun , junB , and c myc mRNAs , but , in addition , it restores C / EBP alpha mRNA and protein as well as C / EBP alpha and C / EBP beta DNA binding activities to the abundant levels present in freshly isolated hepatocytes . ^^^ We demonstrate that isolation of hepatocytes from the normal quiescent rat liver by collagenase perfusion activates the immediate early growth response program , as indicated by increased expression of c jun , junB , c fos , and c myc mRNAs . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Although several members of the AP 1 family were able to activate the PLF gene promoter in transient cotransfection experiments , the predominant AP 1 components interacting with the PLF gene promoter in serum stimulated cells were Fra 1 , JunB , and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
IGF 1 stimulates the expression of c fos , c jun , junB , and egr 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Transcription of a variety of genes , including c fos , c jun , and junB , is increased in these cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
SCH 23390 attenuated morphine induction of AP 1 binding in striatum , suggesting that c fos and junB contribute to AP 1 binding . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In MCT cells , an SV 40 transformed mouse proximal tubule cell line , incubation in acid media led to transient increases in c fos , c jun , junB , and egr 1 mRNA abundance , peaking at 30 min to 1 h . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the present study we examined the possibility that the revertant phenotype resulted from mutations that altered the expression or activities of the c jun or junB proto oncogenes . ^^^ In contrast to the results obtained with c jun , the levels of junB mRNA and protein were found to be reduced two or threefold in revertant EMS 1 19 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have characterized the genomic response of astroglial cells to excitatory amino acids by using selective agonists and antagonists for the various receptor subtypes and by analyzing different primary response genes , such as members of the Fos ( c fos and fosB ) and Jun ( c jun , junB , and junD ) families , zif / 268 , and c myc . ^^^ A rapid and transient elevation of mRNA levels for c fos , fosB , c jun , junB , and zif / 268 was observed after addition of glutamate to cultured astrocytes , whereas junD and c myc expression was not affected . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Differential expression of the immediate early genes c fos , c jun , junB , and NGFI B in the rat brain following transient forebrain ischemia . ^^^ The temporospatial expression pattern of four immediate early genes ( IEGs ) ( c fos , c jun , junB , NGFI B ) following 30 min of global ischemia was investigated in rat brains by in situ hybridization and immunohistochemistry ( c fos ) . ^^^ Compared to c fos and c jun , junB induction was less pronounced and confined largely to the dentate gyrus . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We demonstrate that tetradecanoyl phorbol acetate treatment results in a marked and prolonged increase in AP 1 binding activity on these elements , which can be accounted for almost entirely by c jun and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Immediate early gene expression was examined by Northern blotting : both thrombin and PDGF induced egr 1 , c fos , c jun , junB , and fra 1 mRNAs within 15 min ; the response was maximal at 30 60 min ( increases ranging from 2 . 9 to 9 . 3 fold over control serum deprived cells ) and returned to base line levels within 2 4 h . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Elevated nuclear protein kinase A ( PKA ) activity was observed from one day post lactation , paralleled by increased c fos , junB , junD and to a lesser extent c jun mRNA levels . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In nontumorigenic D44c cells , however , transfected TGF alpha did not induce either anchorage independent growth or tumorigenicity in nude mice , in spite of overexpression of EGFR mRNA and the constitutive expression of c jun and junB mRNA . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The junD gene is much less inducible than that of the two other members of the jun family ; c jun and junB , and is constitutively expressed in most tissues . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Adipocyte differentiation selectively represses the serum inducibility of c jun and junB by reversible transcription dependent mechanisms . ^^^ We now report that in adipocytes 10 % fetal bovine serum also fails to typically induce c jun or junB . ^^^ Rather , after 10 % fetal bovine serum treatment , c jun and junB expression is markedly repressed after a brief initial slight induction . ^^^ Repression in c jun and junB inducibility in adipocytes results from transcriptional mechanisms , can be reversed by treatment with protein synthesis inhibitors or higher serum concentrations , and does not affect c fos or c myc expression . ^^^ These data suggest that adipocyte differentiation selectively and transcriptionally represses the inducibility of c jun and junB so as to decrease the cell ' s ability to proliferate in response to 10 % fetal bovine serum . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Inhibition of c jun expression by antisense transcripts in the TFP 10 cells restored their ability to undergo erythroid differentiation when exposed to DMSO while expression of junB or junD antisense vectors failed to do so . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast , the 50 train stimulus pattern resulted in a robust induction of c fos and c jun mRNA , in addition to zif 268 and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Immunohistochemistry and gel mobility shift assays suggest that AP 1 activity during the night and after a light pulse consists of constant , as well as variable , protein components ; JunD could be identified as a constituent of both dark and light activated binding complexes , whereas binding by JunB and Fos could be implicated only after photic stimulation . ^^^ Since JunD or JunB could be colocalized with Fos in individual suprachiasmatic nucleus cell nuclei , light may be acting in at least some suprachiasmatic nucleus cells by altering AP 1 protein composition rather than binding site occupancy . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In situ hybridization was used to assess regional levels of four immediate early gene messenger RNA levels ( c fos , c jun , junB , and a nerve growth factor induced gene , NGFI A ) . ^^^ Messenger RNA levels were highest at 25 min following infusion of N methyl DL aspartate . c jun messenger RNA levels remained elevated for over 2 h ; however , c fos , junB and , NGFI A messenger RNA levels had returned to control levels by this time . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
As OA did not synergize with PMA in the induction of expression of genes encoding the AP 1 proteins ( c fos , c jun , junB ) , it is likely that OA potentiates the AP 1 enhancer activity by its effect on protein phosphorylation . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Both regions of c jun are conserved within the other members of the jun family : junB and junD . ^^^ The jun proteins do not appear to inhibit insulin gene transcription by binding directly to the ICE . c jun and junB also block the trans activation potential of two skeletal muscle specific HLH proteins , MyoD and myogenin . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Although expression of c jun is induced by serum mitogens in fibroblasts and other cell lines , addition of high serum to proliferating myoblasts resulted in the activation of another immediate early gene junB , but not c jun mRNA expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using antibodies specific for different Ets and AP 1 family members , we demonstrate that the major inducible PB 1 binding activity present in activated T cell nuclear extracts is composed of the Elf 1 , c Fos , and JunB transcription factors . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Stimulation of several second messenger pathways induces the expression of immediate early genes such as c fos , c jun , junB , and junD , but little is known about their induction via the stimulation of the cyclic GMP pathway . ^^^ We found that expression of c fos and junB but not of c jun or junD is increased upon activation of cyclic GMP pathway . c fos mRNA expression was the most activated ( fourfold at 30 min ) , whereas junB response was more modest ( 2 . 2 fold activation at 60 min ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Increases in mRNA levels for c fos , c jun , junB , hsp 70 and NGFI A were observed in the dentate gyrus of the hippocampus following 7 min ischaemia in the Mongolian gerbil . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Unlike c Jun , JunB represses several AP 1 or activator of transcription factor site containing promoters , and this inhibition is greatly enhanced in the presence of LRF 1 . ^^^ Nuclear levels of c Jun , JunB , c Fos , and LRF 1 ( liver regeneration factor ) are high for a large fraction of the G 1 phase in regenerating liver and mitogen stimulated hepatic cells . ^^^ Previously , JunB was regarded as a less potent transcriptional activator than c Jun that could also function as a repressor . ^^^ However , we found that , like c Jun , JunB alone or LRF 1 / JunB strongly transactivates a cAMP responsive promoter . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Nuclear run on transcription and / or Northern blot RNA analysis indicate that c jun , junB , jun D , c fos , TIS 1 ( also called NGFI B or nur / 77 ) and TIS 8 ( zif 268 , krox 24 , egr 1 , or NGFI A ) genes are all transiently activated in the uterus ( up to 20 fold ) within 30 120 min after treatment of adult ovariectomized rats with a mitogenic dose of 17b estradiol . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In accordance with this delay , the induction of mRNA level of ' immediate early genes ' such as c myc , c fos , c jun and junB by TGF beta has slower kinetics compared with those of EGF . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This study tests the hypothesis that the protooncogenes c fos , c myc , c jun , and junB are involved in the mechanism by which polyamines modulate mucosal growth . ^^^ Cellular polyamine levels , cell growth , and relative abundance of c fos , c myc , c jun , and junB mRNAs , were measured at 1 , 2 , 4 , 6 , 8 , and 12 days after initial plating . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Although c jun expression was induced with RA , rapid and predominant induction of junB expression was specifically observed with NaB , which is regulated by both transcriptional and post transcriptional mechanisms . ^^^ These results suggest that the mechanism of differentiation induced with NaB differs from that of RA ; the former may be mediated by the junB gene and the latter by c jun . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB differs from c Jun in its DNA binding and dimerization domains , and represses c Jun by formation of inactive heterodimers . ^^^ JunB differs considerably from c Jun in its ability to activate AP 1 responsive genes and induce oncogenic transformation . ^^^ We demonstrate that the decreased ability of JunB to activate gene expression is the result of a small number of amino acid changes between its DNA binding and dimerization motifs and the corresponding regions of c Jun . ^^^ JunB can be converted into a c Jun like activator by substituting four amino acids in its DNA binding and dimerization motifs with the corresponding c Jun sequences . ^^^ JunB can also attenuate trans activation by c Jun , an activity mediated by its leucine zipper . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Moreover , serum inducibility of other immediate early genes , including c jun , junB , egr 1 , and NGFI B , also was strikingly attenuated by these same oncoproteins . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Furthermore , we show that the c Jun related proteins JunD and JunB are subject to similar regulation by GSK 3 in intact cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Similarly , the other members of the jun family , JunB , JunD and 5 Jun , are negatively regulated by GSK 3 in vivo , although to a slightly lesser extent than c Jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
J 774 cells responded to either phorbol 12 myristate 13 acetate ( PMA ) or LPS by the transient increase in the expression levels of c jun and junB mRNA , but not of junD mRNA . ^^^ JunB in nuclear fraction appears to specifically bind to 12 O tetradecanoylphorbol 13 acetate response element ( TRE ) , since preincubation of nuclear extracts with anti JunB serum reduced the amount of TRE binding proteins and since the amount of JunB , but not of c Jun or JunD , immunoprecipitated from TRE cross linked nuclear proteins increased in response to LPS . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This effect is associated with acid induced increases in a number of immediate early genes , including c fos , c jun , junB , and egr 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The results demonstrate that , in contrast to U 937 cells , the TUR line fails to respond to TPA with induction of the c jun , junB , c fos , and EGR 1 early response genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
It is reported here that IL 6 elevated the junB and c jun mRNA levels and induced the formation of a novel DNA protein complex with high sequence specificity to 12 O tetradecanoylphorbol 13 acetate response element ( TRE ) oligonucleotides . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In both human K 562 myelogenous leukemia and rat PC 12 pheochromocytoma cells , activin treatment caused transient transcription dependent and protein synthesis independent increases of junB messenger RNA ( mRNA ) within 1 h , whereas neither c jun nor c fos mRNA were inducible . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Since we previously found that activation of mast cells by IgE antigen ( Ag ) induces the mRNA accumulation of c fos , c jun , junB and junD proto oncogenes , we were prompted to investigate whether serum could affect such accumulation in these cells . ^^^ After sustained FCS deprivation both DNA synthesis and the level of c fos mRNA were significantly decreased , as expected , whereas the level of c jun , junB and junD mRNA were not affected . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
None of the gene responses to IL 6 including suppression in the levels of c myc , c myb , and cyclin A mRNA ; junB and c jun mRNA induction ; and dephosphorylation of retinoblastoma protein were rescued by the BCR ABL oncogene . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c jun , junB , junD , and c fos recently have been shown to encode for transcription factors with a leucine zipper that mediates dimerization to constitute active transcription factors ; juns were shown to dimerize with each other and with c fos , whereas fos was shown to dimerize only with juns . ^^^ Recently , c jun , junB , and junD were identified as myeloid differentiation primary response genes stably expressed following induction of terminal differentiation of myeloblastic leukemia M 1 cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Only 5 fos can transform CHP 25 , whereas c fos , 5 myc , c jun and junB are ineffective . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using a seasonal breeder , the European red fox ( Vulpes vulpes ) , as our model , we have examined the expression of five AP 1 family members ( c fos , fra 1 , fra 2 , c jun and junB ) with a view to elucidating their role in the regulation of spermatogenesis . ^^^ Unique patterns of expression , falling into three broad categories , were observed for the five genes : ( 1 ) continuous expression throughout the spermatogenic cycle ( c fos ) ; ( 2 ) expression only at times corresponding to the onset and shutdown of spermatogenesis ( fra 1 , fra 2 and c jun ) ; and ( 3 ) expression only at the onset of the cycle ( junB ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Overexpression of cJun or JunD , but not JunB , also eliminates the requirement for PMA , indicating that many but not all Jun and Fos related proteins functionally activate NF AT dependent transcription in the presence of the cytoplasmic component . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Elevated binding activity of AP 1 also correlated with elevated levels of c jun , junD , junB , and c fos mRNAs . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This phenomenon reflects an enhancement of the cellular pool of NGF mRNA , already noticeable after 3 h of treatment , which is preceded by a temporary activation of protooncogenes encoding transcription factors of the AP 1 family , such as c fos , c jun or junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Northern blots were prepared from cortex , thalamus , cerebellum , pons and hypothalamus and hybridized with cDNA probes to five IEG mRNAs ; c fos , c jun , junB , NGFI A and NGFI B . ^^^ In contrast to c fos , c jun mRNA was essentially invariant among the animals while junB mRNA was inconsistently elevated . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Within 15 minutes of balloon injury , mRNA levels of c fos , fosB , c jun , junB , and junD were elevated severalfold . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have examined the effects of motor nerve stimulation and denervation on the expression of 4 immediate early genes ( IEGs ) c jun , junB , zif 268 , and nur 77 in mature mouse gastrocnemius muscle . ^^^ Electrical stimulation of the sciatic nerve in a pattern of brisk intermittent exercise induced a marked rise in zif 268 and c jun mRNA levels within 45 min , a minimal rise in junB , and no change in nur 77 mRNA levels . ^^^ By contrast , surgical denervation resulted in a marked increase of c jun , a slight rise in junB , and no change in nur 77 or zif 268 mRNA levels . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Seizures elicited by chemoconvulsants induced expression of mRNA for c fos , c jun , and junB and Fos like immunoreactivity in lung tissue . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Cell lines isolated from Fos Jun transgenic tumors expressed high levels of both transgenes but significantly lower levels of the jun related gene junB compared with cells expressing only a c fos transgene . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using in situ hybridization , the expression of c fos , fosB , fra 1 , fra 2 , c jun and junB was studied after 15 min of normothermic and hypothermic ( 33 degrees C ) transient forebrain ischaemia in the rat , induced by common carotid occlusion combined with systemic hypotension . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^ Fra 2 is detected in all layers , but staining intensity is increased in the upper spinous layer . c jun staining is limited to the granular layer , while junB and junD are present in all layers . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Antibodies against specific peptide sequences of c Jun ( Ab 1 and Ab 2 from Oncogene Science ) and against expressed proteins of JunB and JunD ( both from Dr . ^^^ Charts were made of the distribution of each antigen , and extensive comparisons were made of previous results obtained using in situ hybridization to localize mRNAs for c jun , junB and junD . ^^^ Our results indicate a generally favorable comparison between immunoreactivity and distribution of mRNAs for JunB and JunD , but in the case of c Jun , immunoreactivity and mRNA were comparable only with the Ab 1 antibody . ^^^ Western blots of caudate putamen demonstrated that this antibody recognized a protein doublet of molecular masses approximately 37 and 34 kDa , distinct from the molecular masses of c Jun , JunB and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Prolactin ( PRL ) injected subcutaneously increased hepatic ODC activity as well as mRNA levels of ODC and the proto oncogenes c fos , c jun , junB , junD , c myc , and max . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Glutathione s transferase B ATF heterodimerizes efficiently with in vitro translated JunB , c Jun , and JunD , but only weakly associates with c Fos . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Comparison of c jun , junB , and junD mRNA expression and protein in the rat dorsal root ganglia following sciatic nerve transection . ^^^ Immunocytochemistry studies demonstrated a pattern of c Jun , JunB , and JunD immunoreactivity ( IR ) associated with the cell nuclei of DRG neurons . c Jun IR was found at very low levels in the undamaged contralateral DRG neurons , but sciatic nerve transection dramatically increased the number of c Jun immunoreactive neurons . ^^^ Similar to c Jun IR , JunB IR was minimal in the undamaged contralateral DRG . ^^^ We conclude that c jun , junB and junD mRNAs and proteins are differentially regulated in the DRG after sciatic nerve transection . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Experiments were performed on pheochromocytoma 12 ( PC 12 ) , hepatoblastoma ( Hep3B ) , neuroblastoma and fibroblast cells that were exposed either to normoxia ( 21 % O 2 ) or to hypoxia ( 5 % O 2 ) for one hour . mRNAs for c fos , c jun , junB , junD were analyzed by northern blot assay . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In neonatal cardiac ventriculocytes , both c jun and to a lesser extent , JunB stimulated hANP promoter activity ( approximately 7 and 3 fold , respectively ) . ^^^ In atriocytes , on the other hand , JunB did not itself activate the hANP promoter , and it antagonized c jun mediated transcription . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using a glutathione S transferase ( GST ) fusion protein system , we show that E 7 complexes with AP 1 transcription factors including c Jun , JunB , JunD and c Fos . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Stepwise transformation of rat embryo fibroblasts : c Jun , JunB , or JunD can cooperate with Ras for focus formation , but a c Jun containing heterodimer is required for immortalization . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
When Ba / F3 FF cells were stimulated with Epo or IL 3 , rapid induction of c myc , c fos , c jun and junB genes was observed . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
TCDD did not increase mRNA of c fos , c jun , junB or junD ( in contrast to TPA which markedly increased the expression of c fos and junB ) , nor did TCDD increase AP 1 activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We therefore cotransfected ventricular myocytes with Fos , Jun , or JunB , and SkA reporter genes . ^^^ SkA transcription was augmented by Jun , Fos / Jun , Fos / JunB , and Jun / JunB ; Fos and JunB alone were neutral or inhibitory . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In bovine chromaffin cells forskolin , phorbol ester , or high potassium levels induce a rapid increase of c fos , c jun , and junB mRNA levels , which precede an induction of proenkephalin gene expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Brief visual stimulation ( 2 hr ) added c Fos , c Jun , and JunB to this complex , whereas prolonged stimulation ( 6 24 hr ) reduced c Fos and c Jun levels significantly , leaving only FosB , JunB , and JunD as the major components of AP 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
PKC zeta interferes with the serum inducibility of an AP 1 reporter plasmid in 5 raf transformed NIH 3T3 cells , indicating that PKC zeta antagonizes transformation and proliferation by down modulating AP 1 function via induction of junB . ^^^ The induction of junB and egr 1 is linked to the 5 raf transformation suppressing effect of PKC zeta as constitutive expression of junB and egr 1 but not of c jun also abolishes anchorage independent growth of 5 raf transformed NIH 3T3 cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Nine of these genes ( H ras , c myc , c fos , c jun , junB , N myc , c abl , c yes , and p 53 ) were expressed in epithelial cells , whereas two ( RB 1 and N ras ) were not . expression of four other genes ( c src , K ras , c raf , and c myb ) was observed , but the intensity of these bands was too low for densitometric analysis . ^^^ The steady state levels of transcripts of H ras and five nuclear protooncogenes ( c myc , c fos , c jun , junB , and N myc ) were lower in epithelial cells from involved or uninvolved IBD samples than in normal epithelial cells from either sporadic colon cancer or diverticulitis patients . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The regulation mechanism of c jun and junB by human papillomavirus type 16 E 5 oncoprotein . ^^^ In this study , we show that HPV 16 E 5 induced anchorage independent growth in immortalized human epidermal keratinocytes and that HPV 16 E 5 in human keratinocytes had higher expression of c jun and junB ; also , we investigated the role of transcriptional initiation pathways in the expression elevation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
After infection with a ras expressing retrovirus , both control and ER 1 2 cell lines constitutively expressed elevated levels of the c jun , junB , fosB , c myc , collagenase , ornithine decarboxylase , osteopontin , stromelysin , cathepsin L , and insulin like growth factor 1 genes . ^^^ In contrast , only c jun , junB , c myc , and ornithine decarboxylase were expressed at a significantly elevated level in ER 1 2T cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Calcium induced AP 1 DNA binding complexes consist of Fra 1 , Fra 2 , c Jun , JunB and JunD and are independent of c Fos , since the induction of DNA binding activity and the composition of the AP 1 binding complexes are identical in differentiating keratinocytes derived from c fos null and wild type mice . ^^^ In vivo expression patterns suggest that the predominant AP 1 heterodimer in the granular layer consists of Fra 2 and JunB while a JunD and Fra 1 complex predominates the spinous layer of mouse epidermis . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Experiments with antisera to the AP 1 family of transcription factors indicated that c fos and JunB bind to the IL 5 CLE 0 in activated lymphoma cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Pretreatment with the four preventive agents commonly inhibited TNF alpha mRNA expression and TNF alpha release in BALB / 3T3 cells induced by a tumor promoter , okadaic acid , whereas the expression of early response genes ( c jun , junB , c fos , and fosB ) was enhanced . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Suppression by the PKC pathway is not mediated by the proto oncogenes c fos , c jun and junB , as the co transfection of these genes does not block the effects of the PKA stimulator 8 Br cAMP . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Irradiation dramatically increased the level of the p 53 transcription factor and the abundances of mRNAs coding for the cell cycle inhibitor p21 / Waf 1 / Cip 1 and the AP 1 associated transcription factors Fos and JunB . ^^^ These results indicate that radiation elicited apoptosis of fetal brain cells is associated with activation of the p 53 system , probable increases in AP 1 Fos / JunB heterodimers , and an increased ratio of Bax to Bcl 2 + Bcl xL . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The major proteins composing the increased AP 1 were JunB and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The PKC activation with phorbol esters induced the expression of c fos , c jun , and junB proto oncogenes in F 9 stem cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
TSH induced similar changes in the levels of c jun and junB mRNAs . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Regionally and temporally distinct patterns of induction of c fos , c jun and junB mRNAs following experimental brain injury in the rat . ^^^ Lateral ( parasagittal ) fluid percussion brain injury of mild ( 1 . 0 1 . 5 atm ) and moderate ( 2 . 1 2 . 4 atm ) severity induced expression of mRNAs for the immediate early genes ( IEGs ) c fos , c jun and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 protein complex at 21 days postnatally was composed of JunD , JunB , Fra 2 , FosB and to much lesser extent of c Fos in both cortical areas . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Bombesin treatment increased expression of both c jun and jun B mRNA by 0 . 5 hours , with maximal expression at 1 hour ; concomitant increases in steady state levels of c Jun and JunB protein were identified . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A supershift assay with specific antibodies against JunB , JunD , and c Jun ( Jun family ) showed that the antibody against c Jun supershifted the AP 1 complex after H2O2 treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Here we show that p 300 is also critical for repression by E1A of the activities of cJun and JunB , two members of the AP 1 transcriptional complexes . ^^^ Adenovirus E1A downregulates cJun and JunB mediated transcription by targeting their coactivator p 300 . ^^^ These findings thus established that p 300 is a cofactor for cJun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Western blot analysis of nuclear extracts showed that the impaired DNA protein interactions in anergic T cells were associated with poor expression of the inducible AP 1 family members c Fos , FosB , and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The PPs Wy 14643 , mono ethylhexyl phthalate , clofibrate , and ciprofibrate ethyl ester were found to be potent inducers of immediate early gene expression ( including c fos , c jun , junB , egr 1 , NUP 475 , and to a lesser extent fosB , JE , and KC , with maximal expression seen 1 h after treatment of serum deprived quiescent cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The products were characterized by immunofluorescence , immunoblotting , immunoprecipitation , and ability to bind to the in vitro translated JunB protein to form the AP 1 complex . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Similarly , JunB was shown to be a major component of AP 1 DNA binding activity in CRF stimulated AtT 20 nuclear extracts that persisted for at least 24h after stimulation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
On the other hand , junB and junD , which are involved in transactivating the transcription of earlier epidermal differentiation markers , control profilaggrin expression through a pathway which does not depend on a direct binding at the AP 1 site and is not cell type specific . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RESULTS : Cotransfection of HIV 1 provirus and expression plasmids for c Jun or JunB into SW 480 cells resulted in increased p 24 core antigen and this response was markedly increased following PMA stimulation of cells . c Fos or JunD alone did not increase p 24 production but markedly increased p 24 production in PMA stimulated cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB is the principal component of a dark phase specific activator protein 1 DNA binding complex . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Analysis of the accumulation of mRNA encoding members of the AP 1 transcription factor family demonstrated that c fos and junB are also expressed upon stimulation of NK and T cells with IL 2 , but not IL 12 , whereas expression of c jun and junD is not modified by either cytokine . ^^^ Our data provide the first demonstration that IL 12 mediated activation of T and NK cells does not involve expression of members of the immediate early activation genes family ( egr 1 , c fos , and junB ) , AP 1 transcriptional activity , or bcl 2 expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The effects of intracerebroventricular ( i . c . v . ) injections of angiotensin 2 ( Ang 2 ) on the expression of inducible transcription factors ( ITF ) ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 ) in the brain of conscious rats were assessed immunohistochemically using polyclonal antisera . ^^^ Ang 2 ( 1 , 10 , 100 ng ) induced after 90 min a dose dependent expression of c Fos , FosB , c Jun , JunB and Krox 24 , which was confined to four specific brain areas , namely the subfornical organ ( SFO ) , median preoptic area ( MnPO ) , paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
As a component of AP 1 proteins , JunB may play a role both in mediating circadian responses to photic stimuli and in spontaneous oscillation of elements of the SCN circadian pacemaker . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Middle T and ras transformed cells expressed higher levels of c jun mRNA , while the src transformed cells expressed higher levels of junB mRNA when compared to control cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Analysis of the induced binding complexes indicates that c fos , c jun , and ATF 2 were present , but also two additional jun family members , JunB and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In a previous study , we have shown that treatment of mouse hepatoma cells with TCDD or B ( a ) P results in an increase in mRNA levels of the immediate early protooncogenes c fos , c jun , junB , and junD , and the concomitant increase of the DNA binding activity of the transcription factor AP 1 , a dimer of FOS and JUN proteins . ^^^ In mouse hepatoma Hepa 1 cells , which have Ah receptor ( AHR ) and Ah receptor nuclear translocator ( ARNT ) proteins , inclusion of TRE , SRE , and the AhRE motifs from c jun and junD , but not CRE or the AhREs from c fos , fosB , and junB , causes a large TCDD dependent increase in luciferase expression . ^^^ In agreement with these results , c jun and junD , but not c fos , fosB , and junB AhREs , competed with a canonical Cyp1A1 AhRE for binding to the AHR ARNT heterodimeric complex . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To better explain these observations , we have studied compositional changes in AP 1 DNA binding activity attributed to c Jun , JunB , and JunD during the differentiation process in 3T3T and CSV 3 1 cells . ^^^ The results show that in nontransformed 3T3T cells , differentiation represses AP 1 DNA binding activity via a proportionate downregulation of c Jun , JunB , and JunD . ^^^ In contrast , in CSV 3 1 cells , AP 1 DNA binding activity increases twofold during differentiation , which is accounted for by an increase in JunD with no change in c Jun and JunB . ^^^ If c Jun and JunB serve as positive regulators and JunD serves as a negative regulator for cell proliferation as suggested by previous studies , the repression of JunD expression in differentiating CSV 3 1 cells should be mitogenic because decreasing JunD / AP 1 DNA binding activity would allow c Jun / AP 1 and JunB / AP 1 DNA binding activities to be dominant . ^^^ This is associated with the transcriptional repression of the inducibility of c jun and junB expression by serum . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the presence of CGRP , c fos and junB mRNAs accumulated in microglial cultures , whereas no significant change in c jun and TIS 11 mRNAs occurred . ^^^ In contrast to the selective induction of c fos and junB by CGRP and forskolin , ATP led to the accumulation of all four immediate early genes studied , i . e . , c fos , junB , c jun , and TIS 11 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Perhaps most interestingly , vandate induced mitogenesis is associated with the selective induction of c jun and junB expression without significantly inducing c fos or c myc . ^^^ These and related data suggest that modulation of protein tyrosine phosphorylation and c jun and junB expression may serve the critical roles in mediating vandate induced mitogenesis in SV 40 transformed cells . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Exposure of human neuroblastoma SH SY5Y cells to ethanol for 2 4 days caused a dose dependent increase in c jun and junD mRNA levels , whereas mRNAs for c fos , fosB and junB were not detectable in control or ethanol treated cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Induction of c fos , c jun , junB and junD mRNA and AP 1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) and its relationship to cell death , mutation induction and chromosomal instability . ^^^ However , for MMS and UV light , which was included in this study for comparison , c fos , c jun , junB and junD mRNA as well as AP 1 induction paralleled the dose response for induction of cell killing effects , recombination and chromosomal breakage indicating that increased expression of Fos and Jun is related to the generation of MMS and UV induced genetic changes . ^^^ To address the questions of whether ( a ) methylating agents that are powerful carcinogens are effective in induction of fos and jun mRNAs , ( b ) induction is affected by the repair capacity of the cells , and ( c ) induction is accompanied by genotoxic effects , the levels of c fos , c jun , junB and junD mRNA were analysed in isogenic Chinese hamster cell lines deficient ( phenotypically Mex ) and proficient ( Mex+ ) for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) after treatment with N methyl N ' nitro N nitrosoguanidine ( MNNG ) and methyl methanesulfonate ( MMS ) . ^^^ Most responsive were c fos and c jun ( up to 80 fold increases in mRNA level ) whereas junB ( up to ninefold ) and junD ( up to twofold ) displayed an intermediate and weak response , respectively . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Transcription factors c jun and junB , previously shown to induce partial macrophage differentiation when overexpressed in myelomonocytic leukemia cell lines , are also upregulated in M1ets2 cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JNKs phosphorylate c Jun very efficiently , JunD less efficiently , but they do not phosphorylate JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This activity was shown to involve c Fos , c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The immediate early genes , c fos , c jun and junB were observed to be bilaterally induced in the cortex and hippocampus as early as 5 min following lateral fluid percussion ( FP ) brain injury in the rat . ^^^ While levels of c fos and junB mRNA returned to control levels by 2h , c jun mRNA remained elevated up to 6h post injury . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Because both fra 1 and junB overexpression negatively interferes with c jun / c fos trans activation of AP 1 responsive genes , our results suggest that the observed block in viral transcription is mainly the consequence of an antioxidant induced reconstitution of the AP 1 transcription complex . ^^^ Additionally , there was also an increased complex formation between c jun and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression of junB also was induced when suspended cells bound RGD peptide coated microbeads that promote integrin clustering , but not when the suspended cells bound beads coated with other receptor ligands ( e . g . acetylated low density protein ) or when they were stimulated by soluble FN or FGF in the absence of substrate adhesion . c Jun exhibited a similar requirement for gene induction except that it also was partially induced by binding to soluble FN alone . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Immunoblot analyses were performed with specific antibody against BCL 2 , BCL XS / L , BAX , JUNB , c JUN , ICH 1L , c FOS , RB , CDK 2 , and p 53 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Our results demonstrated that c fos , c jun , and junB were differently expressed in the ovine trophoblast around the time of implantation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the conceptus , the steady state concentrations of c fos , c jun , junB and junD mRNAs were induced , peaking at 0 . 5 hr and returning to base line by 1 to 2 hr in the embryo and by 1 to 6 hr in the yolk sac . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In order to establish what role members of the activating protein 1 ( AP 1 ) gene families , i . e . , c fos , c jun , junB , and junD , play in thymic apoptosis , we have analyzed changes in their expression in response to three different agents : a glucocorticoid analog dexamethasone , an inhibitor of topoisomerase 2 teniposide VM 26 , and gamma radiation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Results from super shift and shift Western assays showed that a heterodimer consisting of c Fos and JunB binds to the AP 1 site during hypoxia . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RESULTS : Cotransfection of cells with Tat / Jun and the AP 1 PL LUC or LTR AP 1 CAT reporter plasmid resulted in a marked increase in reporter gene activity which was comparable with that induced by transfection of cells with several different AP 1 expression plasmids ( e . g . , JunD , JunB , c Fos ) , or that elicited by stimulation of the cells transfected with LTR AP 1 CAT plasmids with phorbol ester or tumor necrosis factor alpha . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using antibodies to transcription factors of the Fos and Jun families , we show that the nuclear proteins comprising the inducible TH AP 1 complex include c Fos , c Jun , JunB , and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
These transformed fibroblasts accumulated higher levels of cJun , JunB , Fra 1 and Fra 2 proteins relative to their normal counterparts . ^^^ Following serum stimulation of Ras clones , the elevated levels of cJun and Fral remained steady , while the induction of JunB and Fra 2 was partially attenuated . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Induction of AP 1 activity associated with c Jun and JunB is required for mitogenesis induced by insulin and vanadate in SV 40 transformed 3T3T cells . ^^^ Mitogenesis induced by insulin and vanadate in CSV 3 1 cells is associated with the induction of the expression of protooncogenes c jun and junB , two major AP 1 transcription factor components . ^^^ Gel supershift assays and Western blot analysis using specific antibodies demonstrate that the increased AP 1 binding activity induced by insulin and vanadate in CSV 3 1 cells is primarily contributed by an increase in the expression of c Jun and JunB protein levels . ^^^ These results therefore demonstrate that the induction of AP 1 binding activity associated with c Jun and JunB is required for insulin and vandate induced mitogenesis in SV 40 transformed murine 3T3T cells . ^^^ Nevertheless , the ratio of proliferation promoting c Jun / AP 1 and JunB / AP 1 binding activities to proliferation inhibiting JunD / AP 1 binding activity is significantly increased following insulin and vanadate stimulation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this report , we show that this inducible CyRE binding protein is composed of the AP 1 proteins c Fos , JunB , and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Induction of immediate early genes c jun , junB , and c fos was demonstrated during echovirus 1 infection in a human osteogenic sarcoma ( HOS ) cell line . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The mRNA levels of c fos , c jun , junB and early growth response gene 1 were markedly elevated in the tibial metaphysis as early as 15 min postinjection and returned to basal level by 180 300 min . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activation of the PAI 1 promoter by TGF beta or prostaglandin F 2 alpha , and transactivation by c Jun or JunB were not inhibited by dominant negative Smad 3 , supporting the specificity of this mutant . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Finally , immunocytochemical dual labeling was used to show that more than 75 % of all FSHbeta containing cells in ovine pituitary sections from cycling ewes contained nuclear c Jun , JunB , JunD , and Fos proteins . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Among a group of immediate early response genes , including egr 1 , junB , c jun , junD , and c fos , only egr 1 stimulation was modulated by changes in medium pH . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
ETS 1 also markedly potentiated enhancement of MMP 1 promoter by both c Jun and JunB , whereas ERGB / Fli 1 augmented only the effect of c Jun . ^^^ Interestingly , PU . 1 abolished induction of MMP 1 promoter by both c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
While no change in the distribution patterns of other members of the AP 1 family ( c Jun , JunB , and JunD ) was observed in photoreceptors , Mller cell nuclei were transiently immunoreactive for c Jun on P 11 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 DNA binding activities in all regions at all times after withdrawal were composed of FosB , c Jun , JunB , and JunD . c Fos was detected at all times in the cerebral cortex , at 16 h only in the hippocampus , and from 16 to 72 h in the cerebellum . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We examined the effects of this detergent on neurons and glia , including expression of c Myc , c Jun , JunB , and c Fos , and on immunocytes in the guinea pig ileum . ^^^ Neuronal c Myc began to disappear while c Fos , c Jun , and JunB were evident in some neuronal nuclei after 2 or 3 days . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift assays , using Jun and Fos family member specific antibodies , showed that protein complexes formed by AtT 20 cell nuclear extracts bound to the c jun AP 1 site were comprised of Jun family members , JunD , JunB , and cJun . ^^^ However , protein complexes from AtT 20 nuclear extracts that bound the GR AP 1 site were supershifted by JunD , JunB , cJun , and Fra 2 specific antibodies . ^^^ The GR AP 1 site bound protein complexes composed of JunD , JunB , Fra 2 , and Fra 1 from L 929 nuclear extracts . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
LIF significantly induced an immediate early response of genes c fos and junB 3 hr after stimulation , but not of c jun during the process of proliferation of MCF 7 and Hs 700T cells , with maximum levels at 30 60 min . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Three and 6 h after irradiation , the Fos and Jun proteins and their binding activity to an AP 1 consensus sequence were strongly induced by high doses of gamma rays . c Fos , c Jun and JunB proteins were found to be present in gel shift complexes by probing with specific antibodies . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression of the proto oncogenes c myc , c fos , and c jun and histone 2A decreased rapidly in the first 24 h of culture in both cell preparations , followed by an increase in expression of c fos and junB over the next 3 days of culture . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The distribution of SRF and ATF 2 suggests that their putative target genes c fos , junB , krox 24 and c jun can be independently regulated from SRF and ATF 2 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The mRNA contents for genes associated with transcriptional activation [ c fos , c jun , JunB , nuclear respiratory factor 1 ( NRF 1 ) ] , mitochondrial proliferation [ cytochrome c ( Cyt c ) , cytochrome oxidase ] , and mitochondrial differentiation [ carnitine palmitoyltransferase 1 ( CPT 1 ) isoforms ] were measured . ^^^ The results establish a temporal pattern of mRNA induction beginning with c fos ( 0 . 25 3 hr ) and followed sequentially by c jun ( 0 . 5 3 hr ) , JunB ( 0 . 5 6 hr ) , NRF 1 ( 1 12 hr ) , Cyt c ( 12 72 hr ) , and muscle specific CPT 1 ( 48 72 hr ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this study , expression of c fos , c jun and junB immediate early genes were followed in mouse brain after irradiation . ^^^ C fos and junB , but not c jun , mRNA was induced within 15 min in unanesthetized irradiated mice . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The cAMP induced NF kappaB complex contained p 50 and RelB ; in co transfection assays , p 50 and RelB transactivated a reporter construct containing the c myb intronic NF kappaB site upstream of a minimal promoter . 8 Br cAMP and forskolin also increased the DNA binding activity of AP 1 complexes containing JunB , JunD and c Fos in MEL cells which could cooperate with NF kappaB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Among other IEGs examined , the expression of NGFI A and junB are similar to c fos , but of lesser magnitude , whereas c jun appears to be invariant in the rat but is increased during the active phase in squirrels . ^^^ Among other IEGs , junB and NGFI A again were similar to c fos while c jun and junD were more constant . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
SB 203580 , an inhibitor of p38 / RK , has been used to analyse the role of this kinase in the induction of five IE genes ( c fos , fosB , c jun , junB and junD ) under diverse conditions of stimulation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
However , whereas normal hepatocytes contained only JunD , both JunD and JunB were present in the AP 1 complex of 7777 cells . ^^^ EGF treatment triggered almost identical programs of fos and jun gene activation at the messenger RNA ( mRNA ) level in both cell types , with an early accumulation of c fos , c jun , and junB mRNAs , but no change in junD mRNA levels . ^^^ In both cell types , c Fos and Fra 1 proteins increased after EGF treatment , but differences in the induction of Jun proteins were noted , with an increase of c Jun in hepatocytes and an increase of JunB in 7777 cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the present study , overexpression of fra 1 , fra 2 , c jun , junB , and junD mRNAs was demonstrated in RCs by Northern blot analysis . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The implications for the dual role of JNK in the regulation of ubiquitination and stability of c Jun , ATF 2 , and JunB in normally growing versus stressed cells are discussed . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Increase of JunB mRNA correlates with a higher AP 1 binding activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The effect of c jun is exerted through interactions with c fos at the AP 1 motifs in the target promoters , whereas both junB and junD act independently of the binding at the AP 1 sites . ^^^ We have found that c jun and junD activate and junB downregulates the transcription of both basal and suprabasal genes . ^^^ Thus c jun and junD act as general positive regulators whereas junB acts as a general suppressor of epidermal specific genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression of the transcription factors c Jun and JunB , but not c Fos , was induced in SFFV infected cells in the absence of Epo , suggesting that constitutive activation of the Raf 1 / MAP kinase pathway by the virus may result in deregulation of AP 1 activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A transient up regulation of junB was detected by immunoblotting 5 days after peripheral axotomy , coincident with a slight decrease in c jun protein levels . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The expression of inducible transcription factors was studied following repetitive electroconvulsive seizures ( ECS ) , c Fos , c Jun , JunB , and JunD immunoreactivities were investigated following a single ( 1 10 ECS ) or repetitive ECS evoked once per day for 4 , 5 , or 10 days ( 4 10 ECS , 5 10 ECS , or 10 10 ECS ) . ^^^ In a second model of systemic excitation of the brain , repetitive daily injection of kainic acid for 4 days completely failed to express c Fos , c Jun , and JunB after the last application whereas injection of kainic acid once per week did not alter the strong expressions compared to a single application of kainic acid . ^^^ Infusion of BDNF completely reinduced c Fos expression during 5 10 ECS or 10 10 ECS in the cortex ipsilaterally to the cannula and , to a less extent , also increased the expression of c Jun and JunB when compared to saline treated controls . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Whereas insulin stimulates prolonged induction of c jun , but not of junB mRNA , resulting in c jun expression during the entire G 1 period , the growth inhibitor TPA induces junB much longer than c jun . ^^^ Inhibition of the Erk 2 pathway by PD 98059 , specific for the upstream MAP kinase kinase ( MEK 1 ) , abolishes TPA stimulated junB but not insulin induced c jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
IL 6 increased c jun mRNA , c Jun protein , and AP 1 binding activity but did not affect either junD or junB expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We therefore tested whether local administration of the neuroprotective cytokine fibroblast growth factor type 2 in vivo has an effect on the axotomy induced nuclear expression patterns of the activator protein 1 transcription factors c Fos and JunB , or c Jun in the spinal cord intermedolateral nucleus adrenal axis lesion paradigm in the rat . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We studied the time course of expression of the inducible transcription factors ( ITF ) c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 , induced by a single intracerebroventricular injection of angiotensin 2 , in the subfornical organ ( SFO ) , median preoptic nucleus ( MnPO ) paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . c Fos and Krox 24 were expressed rapidly in neurons of all four areas but completely disappeared after 4 h . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The expression of c Jun , JunB , JunD , c Fos and ATF 2 transcription factors was studied in L4 / L5 dorsal root ganglion neurons of adult rats , in order to determine the extent to know to which extend the expression of transcription factors in vitro parallels the pathophysiological expression in vivo . ^^^ Incubation with brain derived neurotrophic factor for 15 days reduced JunB expression and raised c Fos expression , but did not affect c Jun or JunD labelings . ^^^ As with culture , incubation of explanted dorsal root ganglia with brain derived neurotrophic factor prevented the initial rise in JunB , accelerated and enhanced c Fos expression , but did not alter c Jun and JunD expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Stimulation with carbachol induced expression of c fos , fosB , c jun , junB , and junD . ^^^ Inhibition of protein kinase C with GF109203X suppressed the carbachol stimulated increase in mRNA levels of c fos , fosB , and junB by approximately 70 % but had only minor effects on the expression of c jun and junD . ^^^ On the other hand , preincubation with KN 62 attenuated the carbachol induced increase in c jun and junD expression by 70 % but had no effect on c fos , fosB , and junB mRNA levels . ^^^ Simultaneous inhibition of both protein kinase C and Ca2+ / calmodulin dependent kinase 2 completely abolished the carbachol stimulated expression of c jun and junD , but c fos , fosB , and junB were still expressed to a certain extent under this condition . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Anisomycin desensitization of a panel of IE genes ( c fos , fosB , c jun , junB , and junD ) , using epidermal growth factor ( EGF ) , basic fibroblast growth factor , ( bFGF ) , tumor necrosis factor alpha ( TNF alpha ) , anisomycin , tetradecanoyl phorbol acetate ( TPA ) , and UV radiation as secondary stimuli , was found to be extremely specific both with respect to the secondary stimuli and at the level of individual genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
HCG induced a rapid and transient expression of c fos , fosB , c jun , junB , junD and c myc with a peak at 30 min to 1 h . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We found a rapid induction of c fos , c jun and junB at the mRNA level after about 30 min of EGF treatment and a more delayed upregulation of fosB and fra 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Following each treatment , the expression of cfos , cjun , junB , and zif 268 mRNA changed distinctively and dynamically between 1 and 48 hours . cfos mRNA was induced in cortical areas at early times after either dose of PCP or of MK 801 ; the change was especially prominent in cingulate and auditory cortices . zif 268 mRNA showed an early ( 1 hour ) activation and a delayed ( 24 48 hour ) suppression after PCP and MK 801 in neocortical areas . ^^^ PCP also caused cjun and junB mRNA induction in cortical areas at early times , with a distribution and time course similar to its effects on cfos mRNA . ^^^ No alterations in cfos , cjun , or junB mRNA were found in neocortical or hippocampal areas at any delayed time ( > 6 hours ) after PCP treatment , whereas suppression of zif 268 expression was prominent even at 48 hours post treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activation of cytochrome c ( cyt c ) transcription in electrically stimulated neonatal rat cardiac myocytes is preceded by transient expression of the activating protein 1 family of transcription factors , c Fos , c Jun , and JunB , as well as nuclear respiratory factor 1 ( NRF 1 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The blockade of KA induced proENK and proDYN mRNA levels by the pre treatment with L ARG was well correlated with proto oncoprotein levels , such as c Fos , Fra 2 , FosB , JunD , JunB , and c Jun , as well as AP 1 and ENKCRE 2 DNA binding activities . ^^^ The pre administration with L NAME further increased KA induced c jun and c fos mRNA levels in addition to their protein product levels , although the pre treatment with L NAME did not affect KA induced FosB , Fra 2 , JunB , and JunD protein levels at 6 h after treatment . ^^^ Our results suggest that L ARG plays an important role in inhibiting KA induced proENK or proDYN mRNA expression , and its inhibitory action may be mediated through reducing the proto oncoprotein levels , such as c Fos , Fra 2 , FosB , c Jun , JunD , and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Ischemia induced CA 1 neuronal death is preceded by elevated FosB and Jun expression and reduced NGFI A and JunB levels . ^^^ Alterations in levels of the immediate early gene ( IEG ) proteins Fos , FosB , DeltaFosB , Jun , JunB , JunD , and NGFI A were investigated in rat hippocampus by immunohistochemistry 2 , 12 , 24 , and 48 h after forebrain ischemia . ^^^ In contrast to FosB and Jun , JunB expression declined significantly below basal levels in CA 1 neurons at 48 h , yet remained unaltered in CA 3 neurons . ^^^ Given that JunB can inhibit the transactivating properties of Jun , decreased JunB levels may contribute to the apoptotic death of CA 1 neurons by enhancing the transcriptional regulating activity of Jun . ^^^ These findings suggest that persistent elevations in FosB and Jun expression , concurrent with reductions in JunB and NGFI A levels , contribute to the apoptotic death of CA 1 neurons after forebrain ischemia . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast to c jun and junB , the junD gene is constitutively expressed in quiescent cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
UVB irradiation potently induced c jun , junB and c fos mRNA levels in vitro in HaCaT cells . ^^^ IL 6 mRNA was induced in response to UVB irradiation 2 3 h later than c jun , junB and c fos mRNAs . ^^^ Genistein , a tyrosine kinase inhibitor , augmented the induction of c jun and junB by UVB irradiation in HaCaT cells . ^^^ The results of this study provide evidence that in addition to c jun and c fos , junB is also an essential component of the human UV response . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift analysis in the presence of antibodies to c Jun , c Fos , JunD , and JunB suggested that AP 1 complexes were composed of c Fos , JunB , and possibly c Jun . ^^^ The delayed increase in COX 2 mRNA expression was accompanied by the induction of the proto oncogenes c jun , junB , junD , and c fos ( but not FosB or Fra 1 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A rapid and transient increase in c fos , junB , c jun and Tis 11 messenger RNA was observed in cultured astrocytes after treatment with adenosine 5 ' O ( 2 thiodiphosphate ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression of c jun , junB , c fos , fra 1 and fra 2 mRNA in the rat brain following seizure activity and axotomy . ^^^ The patterns of c jun , junB , c fos , fra 1 and fra 2 mRNAs were studied by radioactive and non radioactive in situ hybridization in the adult rat brain following kainate induced seizure activity and axotomy . ^^^ In the same animals , the expression of c Jun , JunB and c Fos proteins was compared with the respective mRNA signals . ^^^ Whereas fra 1 and fra 2 were restricted to the hippocampus , c jun , junB and c fos were additionally induced in the cortex , amygdala and thalamus . ^^^ The expression patterns between c jun , junB and c fos mRNA were virtually congruent with the respective protein . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB is a major binding protein in the AP 1 complex observed upon EPO withdrawal ; JunB but not c Jun was present in the AP 1 complex 3 h after EPO withdrawal in HCD 57 cells , with a concurrent increase in junB message and protein . ^^^ Furthermore , analysis of AP 1 DNA binding activity in an apoptosis resistant subclone of HCD 57 revealed a lack of induction in AP 1 DNA binding activity and no change in junB mRNA levels upon EPO withdrawal . ^^^ AP 1 DNA binding activity increased over the first 3 h following EPO stimulation of HCD 57 cells , and suppression of AP 1 activity partially inhibited EPO induced proliferation . c Jun but not JunB was present in the AP 1 complex 3 h after EPO addition . ^^^ These results implicate AP 1 in the regulation of proliferation and survival of erythroid cells and suggest that different AP 1 factors may play distinct roles in both triggering apoptosis ( JunB ) and protecting erythroid cells from apoptosis ( c Jun ) . . ^^^ AP 1 DNA binding activity increased over the first 3 h following EPO stimulation of HCD 57 cells , and suppression of AP 1 activity partially inhibited EPO induced proliferation . c Jun but not JunB was present in the AP 1 complex 3 h after EPO addition . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Constitutive expression of 5 src did not alter the mRNA levels of c jun and junB , suggesting that the effects of the oncogene are not mediated by AP 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift and Western blot analysis with specific antisera , indicate that JunB and cJun , but not cFos or FosB are present in the AP 1 complex . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This AP 1 transcriptional activity appears to correlate with the presence of JunB complexes , which accumulate differentially in effector Th 2 cells , but not in precursor CD4+ T cells or effector Th 1 cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Amylin treatment results in time and concentration dependent inductions of oxidative stress genes , such as cox 2 and IkappaB alpha . `` Apoptotic ' ' genes are also induced in a time and concentration dependent manner , including c jun , junB , c fos , and fosB , followed temporally by a gene known to be modulated by these transcription factors , i . e . , transin . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The concentration of c fos , c jun , c myc , junB , and fra 1 mRNAs was increased in activated peripheral blood lymphocytes incubated with ciprofloxacin compared to that in untreated controls . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the present study , we investigated the expression pattern of the inducible transcription factors ( ITF ) c Fos , c Jun , JunB , JunD , and Krox 24 following intracerebroventricular injections of hyperosmolar saline ( 0 . 2 , 0 . 3 , and 0 . 6 M NaCl ) and its mediation via angiotensin and / or muscarinic receptors . c Fos , c Jun , and Krox 24 were differentially expressed in organum vasculosum laminae terminalis , median preoptic area , subfornical organ ( SFO ) , and paraventricular and supraoptic nuclei . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Conversely , c Jun and JunD proteins , rather than JunB , accumulated in human thyroid carcinoma cell lines . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The authors studied the gene expression of junB , a member of the Jun family of transcription factors , and the production of fibrinogen in response to IL 6 and sIL 6R . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The levels of c jun , c fos , junB , and fosB mRNA in ZG and ZFR were also rapidly maximally elevated within 0 . 5 1 h after ACTH administration and fell to near control levels 5 h posttreatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Untreated M1Egr 1 cells also exhibited cell adherence , expression of Fc and C 3 receptors , and upregulation of the myeloid differentiation primary response genes c Jun , junD , and junB and the late genetic markers ferritin light chain and lysozyme . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Glucose and glucoincretin peptides synergize to induce c fos , c jun , junB , zif 268 , and nur 77 gene expression in pancreatic beta ( INS 1 ) cells . ^^^ Glucose causes a coordinated transcriptional activation of the IEGs c fos , c jun , JunB , zif 268 , and nur 77 in the pancreatic beta cell line INS 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^ In the current study we show that the AP 1 complex isolated from insulin stimulated cells contained c Fos , Fra 1 , c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This increase in AP 1 activity occurred in the absence of significant changes in the steady state protein levels of c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
However , c Jun , JunB , and JunD protein levels were not affected by PGE 2 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Members of the Jun family ( c Jun , JunB , and JunD ) caused a dose dependent inhibition of the 890 / +24 apoCIII promoter activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Here we provide further evidence that the induction of junB , c jun , and c fos genes is due to active viral macromolecular synthesis rather than to the interaction of EV 1 with its receptor , alpha2beta1 integrin . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have examined the expression of members of the AP 1 transcription factor complex in response to stimulation with different doses of LPA . c Fos , c Jun , and JunB are induced rapidly in response to LPA stimulation , whereas Fra 1 and Fra 2 are induced after a significant lag . ^^^ These results suggest that kinetically distinct phases of MAPK activation serve to regulate the expression of distinct AP 1 components such that sustained MAPK activation is required for the induced expression of Fra 1 , Fra 2 , c Jun , and JunB . ^^^ The expression of c Fos is transient , whereas the expression of c Jun , JunB , Fra 1 , and Fra 2 is sustained . ^^^ In contrast , expression of Fra 1 , Fra 2 , and JunB and optimal expression of c Jun are observed only with doses of LPA which induce sustained MAPK activation and DNA synthesis . ^^^ LPA stimulated expression of c Fos , Fra 1 , Fra 2 , c Jun , and JunB is inhibited by the MEK 1 inhibitor PD 098059 , indicating that the Raf MEK MAPK cascade is required for their expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The most active compound identified was used to examine the role played by protein kinase C alpha in mediating the phorbol ester induced changes in c fos , c jun , and junB expression in A 549 lung epithelial cells . ^^^ Depletion of protein kinase C alpha protein expression by this oligonucleotide lead to a reduction in c jun expression but not c fos or junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Here we show that JunB , but not the other Jun family members , was selectively induced in Th 2 cells and not in Th 1 cells during differentiation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift analysis identified CREB 1 , JunB , c Fos , Fra 1 , and c Jun in protein complexes isolated from differentiated rabbit tracheal epithelial cells binding to this site . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To determine nuclear proto oncogene changes mediating these events , c myc , c fos , c jun and junB were measured in spontaneously differentiating cells and in cells exposed to EGF . c myc showed a transient rise in expression at 4 8 h with augmented expression by EGF , occurring even in the absence of serum or attachment . c myc and c jun declined during culture , but c fos and particularly junB showed increased expression by day 3 with marked responses to EGF stimulation . ^^^ Syncytia induced to form by EGF exposure for 48 h demonstrated marked junB expression after rechallenge with 40 min EGF exposure , but negligible responses of c fos and c jun . c myc showed increased expression after 6 h EGF exposure throughout the culture period and in syncytia . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The increased AP 1 complexes in polyamine deficient cells were dramatically supershifted by the anti JunD antibody but not by antibodies against c Jun , JunB , or Fos proteins . ^^^ The proteins of c Jun , JunB , and Fos are essential for initiation of the cell cycle . ^^^ There were significant increases in JunD mRNA and protein in DFMO treated cells , although expression of the c fos , c jun , and junB genes decreased . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
During infection , the activated AP 1 consisted mainly of JunB and JunD with a simultaneous decrease in the cellular levels of Jun protein . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Lack of JunB , an immediate early gene product and member of the AP 1 transcription factor family causes embryonic lethality between E8 . 5 and E10 . 0 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB forms the majority of the AP 1 complex and is a target for redox regulation by receptor tyrosine kinase and G protein coupled receptor agonists in smooth muscle cells . ^^^ Antibody supershift assays indicated the presence of c Fos and JunB in the AP 1 complex formed in response to all three agonists . ^^^ In addition , cotransfection of VSMC with expression plasmids for c Fos and members of the Jun family along with the AP 1 dependent reporter gene revealed that AP 1 with c Fos and JunB composition exhibited a higher transactivating activity than AP 1 with other compositions tested . ^^^ Together , these results strongly suggest a role for redox sensitive mechanisms in agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation ; c Fos , c Jun , and JunB expression ; AP 1 activity ; and DNA synthesis in VSMC . ^^^ These results also suggest a role for NADH / NADPH oxidase activity in some subset of early signaling events such as p 38 MAP kinase activation and c Fos and JunB induction , which appear to be important in agonist induced AP 1 activity and DNA synthesis in VSMC . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Other immediate early response genes , c fos and junB , were also induced following glucose stimulation with kinetics similar to egr 1 , whereas c jun and junD expression were not affected . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The immediate early genes ( IEGs ) , c jun , junB and c fos are expressed after global ischemia in the gerbil . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activation of neurons in the inferior mesenteric ganglion ( IMG ) was assessed using c fos , JunB , and c Jun expression in the guinea pig IMG and colonic myenteric plexus during mechanosensory stimulation and acute colitis in normal and capsaicin treated animals . ^^^ Lower doses of capsaicin or vehicle were used to activate primary afferent fibers during balloon passage . c Jun did not respond to any of the stimuli in the study . c fos and JunB were absent from the IMG and myenteric plexus of untreated and saline treated animals . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the fetal rat SCN we show that NGFI A and junB are also induced by nicotine , but not c jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The cell death process is accompanied by induction of JunB , c Jun , JunD and Fos proteins . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This study describes the effects of acute ethanol exposure on the mRNA levels of c jun , junB and junD in the human neuroblastoma SH SY5Y cell line . ^^^ An acute exposure to 100 mM ethanol did not influence the basal and phorbol ester induced expression of c jun and junB , whereas the basal mRNA level of junD was attenuated by 30 % . ^^^ These results indicate that acute ethanol exerts different effects on expression of Jun transcription factors , suggesting that as compared to c jun and junB , the junD gene may be more sensitive to acute ethanol treatment in neuronal cells . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
H2O2 preferentially induced the expression of c fos , c jun , c myc and egr 1 , while JunB and JunD levels remained almost unchanged . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression of c fos , junB , c jun , MKP 1 and hsp 72 following traumatic neocortical lesions in rats relation to spreading depression . ^^^ The effects of a traumatic neocortical lesion on c fos , junB , c jun , MKP 1 and hsp 72 expression were examined by in situ hybridization and immunocytochemistry 1 6 h following transcranial cold injury . ^^^ In animals without spreading depressions , only a short lasting response of c fos , junB , c jun and MKP 1 messenger RNAs as well as c Fos protein was bilaterally found in the piriform cortex , and with ipsilateral dominance the dentate gyrus and hippocampal CA3 / 4 fields at 1 h after lesioning . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift assays revealed that fra 1 participates in the activator protein 1 complex together with c fos , c jun and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In vitro binding studies demonstrate that both Smad 3 and Smad 4 bind all three Jun family members : JunB , cJun , and JunD . ^^^ The Smad interacting region of JunB maps to a C terminal 20 amino acid sequence that is partially conserved in cJun and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Effects of mild traumatic brain injury on immunoreactivity for the inducible transcription factors c Fos , c Jun , JunB , and Krox 24 in cerebral regions associated with conditioned fear responding . ^^^ In the present study , we examined the expression patterns of immunoreactivity ( IR ) for four ITFs ( c Fos , c Jun , JunB , and Krox 24 ) at 3 h after mild fluid percussion TBI . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
However , a more direct approach , investigating expression of putative hibernation responsive genes by Northern analysis , revealed an increase in expression of transcription factors c fos , junB , and c Jun , but not junD , commencing during late torpor and peaking during the arousal phase of individual hibernation bouts . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Our results demonstrated that : ( 1 ) PGN induced phosphorylation of the transcription factors ATF 1 and CREB ; ( 2 ) ATF 1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid , which was inhibited by dominant negative CREB and ATF 1 ; ( 3 ) PGN induced phosphorylation of c Jun , protein synthesis of JunB and c Fos , and transcriptional activation of the AP 1 reporter plasmid , which was inhibited by dominant negative c Fos ; and ( 4 ) PGN induced activation of CREB / ATF and AP 1 was mediated through CD 14 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We focussed our analysis on c Fos ( typical of AP 1 genes which are expressed rapidly and transiently ) and Fra 1 and JunB ( typical of AP 1 genes expressed after a delay but in a sustained manner ) . ^^^ Thrombin stimulated a rapid but transient accumulation of c Fos whereas the expression of Fra 1 , Fra 2 , c Jun and JunB was sustained throughout the G 1 phase of the cell cycle . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^ In nuclear extracts obtained from non tumorigenic cells , Jun family members ( in the order c Jun > JunD > JunB ) were mainly heterodimerized with Fra 1 , a protein , known to be involved in the abrogation of AP 1 activity under certain experimental conditions . ^^^ AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
These effects were preceded by a transient augmentation of junB , c fos and c jun mRNA contents . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
BMP2 / 4 rapidly induced transcript levels of the homeobox genes Msx 1 and Msx 2 and the proto oncogene JunB , whereas c jun transcripts displayed delayed albeit prolonged increase . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In comparison to normal cells , these transformants displayed increased AP 1 DNA binding activity with higher levels of junB and variable levels of c jun in the AP 1 complex . ^^^ Dexamethasone treatment induced transiently c jun mRNAs , in contrast to the sustained expression of c fos , whereas its effect on junB expression resulted in a later increase . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra 1 , Fra 2 , and c Fos bound to AP 1 but that prior treatment of the cells with TGFbeta reduced dramatically c Fos binding , suggesting that c Fos might be playing a negative regulatory role in clusterin gene expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RESULTS : The normal corneal epithelium showed no staining with antibodies against c Fos , Fra 2 , FosB , c Jun or JunB , whereas the limbal and bulbar conjunctival epithelia were positive for c Fos , Fra 2 , and c Jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This mitogenic effect induced by insulin in CSV 3 1 cells requires an induction of AP 1 activity associated with c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ For c jun , junB , c fos and fra 2 , a relatively uniform expression pattern without significant differences among tumors was observed . junD protein amounts varied strongly in the tumor specimens . fosB expression levels also varied strongly in the tumors , weak / absent expression being found in 47 % , while 45 % exhibited strong / very strong levels of expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the present study we show that the Sp 1 occupied promoter region mediates transactivation of the p 21 promoter by c Jun and the related proteins JunB , JunD , and ATF 2 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift analysis with antibodies specific for NF kappaB , AP 1 , and NF IL 6 binding proteins showed that the NF kappaB binding protein included p65 / Rel A and p 50 ; AP 1 activity included c jun , junB , junD , and Fra 1 ; and NF IL 6 included C / EBPbeta . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Although GLP 2 stimulated the expression of c fos , c jun , junB , and zif 268 , and transiently increased p 70 S6 kinase in quiescent BHK GLP 2R cells , GLP 2 also inhibited extracellular signal regulated kinase 1 / 2 and reduced serum stimulated Elk 1 activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In Rat 1 fibroblasts , we measured the effect of IL 6 on matrix metalloproteinase 13 ( MMP 13 ) , c jun , junB , and c fos gene expression , binding of activator protein 1 ( AP 1 ) to DNA , amount of AP 1 proteins , immunoreactive MMP 13 and TIMP 1 proteins , and Jun N terminal kinase activity . ^^^ This effect seems to be mediated by the induction of c jun , junB , and c fos gene expression , by the binding of AP 1 to DNA , by increasing phosphorylated c Jun , and by the inhibition of serine / threonine phosphatase activity . ^^^ This effect was accompanied by a marked increase in c Jun , JunB , and c Fos mRNA , as well as in c Jun protein and its phosphorylated form . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Overexpression of Jun causes significant alterations in the composition of AP 1 , decreased junB and increased fra 1 expression and results in an increased biologic aggressiveness . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts indicated that the AP 1 complex consists of c Jun , c Fos , JunD , and possibly JunB proteins , and that the NF kappaB complex contains p 50 , p 65 , and c Rel proteins . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this study , we examined the expression of four AP 1 transcription factors , Jun , JunB , JunD and FRA 2 , and AP 1 DNA binding activity in the rat hippocampus to examine changes during the periods of degeneration and then of regeneration and repair after TMT induced neurotoxicity . ^^^ Levels of Jun in the hippocampus significantly increased at 12 hours after TMT while JunB and JunD expression did not change . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The induction of AP 1 DNA binding activity composed of c Jun , JunB , JunD , and ATF 2 proteins preceded apoptosis . ^^^ The compositional changes of AP 1 were associated with an elevation of c Jun and JunB protein levels and the appearance of phosphorylated c Jun and ATF 2 at 15 40 h posttreatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Gel shift analysis in the presence of specific antibodies to c Jun , JunB , JunD , c Fos , and CREB / ATF showed that the AP 1 complexes were probably c Jun / c Jun , c Fos / c Jun , c Fos / JunB , or c Jun / JunB dimers . ^^^ Northern blot analysis confirmed that c jun , junB , and c Fos were the principal proto oncogenes induced by CalC . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Mutant animals lack JunD mRNA and protein and showed no evidence of upregulation of c Jun and JunB mRNA levels . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
PACAP potently stimulated the expression of c fos , fosB junB and junD , but not c jun mRNAs , at doses of 0 . 1 10 nM , as revealed by Northern blot analysis . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The neuropeptides VIP and PACAP inhibit IL 2 transcription by decreasing c Jun and increasing JunB expression in T cells . ^^^ VIP / PACAP downregulate c Jun , and upregulate JunB mRNA and protein . ^^^ The effects of VIP / PACAP on c Jun and JunB expression lead to changes in the composition of the AP l complexes , from c Jun / Fos to JunB / Fos dimers , with a subsequent decrease in DNA binding and loss of transactivating activity . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The observed changes were correlated with the expression of the mRNA of hsp 70 , c fos , c jun , and junB , as well as the distribution of DNA double strand breaks visualized by terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labelling ( TUNEL ) . ^^^ Expression of the immediate early genes c jun , c fos , and junB increased both in the penumbra and the periinfarct normal tissue already at 1 hour after vascular occlusion , with slightly different regional and temporal patterns for each of these genes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
However , supershift analyses demonstrated that the relative contributions of JunD and JunB to the AP 1 complex exhibited positive and negative correlations , respectively , with the phases of increased NGF expression after HL . ^^^ These results suggest that AP 1 complexes containing JunD promote NGF transactivation and that transient changes in the relative contributions of JunD and JunB to AP 1 binding underlie the biphasic increase in NGF gene expression induced by HL seizures . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB , a member of the AP 1 family of transcription factors , has been implicated in the control of proliferation and differentiation of various cell types including myeloid cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We examined if the induction of immediate early gene ( c fos , c myc , c jun , and junB ) and HSP 70 mRNAs by ischemia is affected by ischemic preconditioning . ^^^ The induction of c jun and junB mRNAs showed no change in both EI 12 and EI 24 compared with that in C . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Interestingly , this complex was not affected by the addition of any antibodies against ER , c Jun , c Fos , JunB , or JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In addition , AA also increased several AP 1 proteins , such as c Fos , Fra 1 , Fra 2 , JunB , JunD , and c Jun , or AP 1 and ENKCRE 2 DNA binding activity . ^^^ However , as well as proto oncoprotein levels , such as Fra 1 , Fra 2 , c Jun , JunB , but not JunD , AA induced increase of proENK mRNA was significantly reduced by the pretreatment with 10 microM of PD 98059 ( 1 . 3 fold ) or 10 microM of SB 203580 ( 1 . 8 fold ) . ^^^ In addition , the activation of both the p 38 and ERK pathways appears to be involved in the AA induced increase of proENK mRNA via activating the expression of proto oncoprotein , such as Fra 1 , Fra 2 , c Jun , and JunB . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We identified AP 1 factors c Fos and JunB as MFNLP binding proteins , whose binding is abolished by introducing point mutations in the 3 ' half of the MFNLP sequence . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Since JunB represses and c Jun activates the cyclin D 1 promoter , these modifications of AP 1 activity during the M G ( 1 ) transition could provide an impetus for G ( 1 ) progression by a temporal increase in cyclin D 1 transcription . ^^^ Cell cycle dependent variations in c Jun and JunB phosphorylation : a role in the control of cyclin D 1 expression . ^^^ Here we report that the quantity and the phosphorylation state of the c Jun and JunB proteins vary at the M G ( 1 ) transition . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP 1 site by c Jun , JunB , JunD , c Fos , FosB , and Fra 2 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast , the expression of JunB , c jun and c fos , but not JunD , was increased by LPS , TNF alpha , IFN gamma and IL 1 , albeit with different kinetics and magnitude of induction . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays showed a time dependent increase in AP 1 DNA binding activity with JunB representing the major mediator inducible member involved in DNA protein interactions . ^^^ Whilst the expression of JunD was not affected by any of the mediators , the mRNA levels of c fos and JunB were induced by LPS , IL 6 , IFN gamma , PDGF and TNF alpha , and that of c jun by LPS , IFN gamma , PDGF and TNF alpha . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The data , in combination with our previous results [ Takeuchi J . et al . ( 1993 ) Neuron 11 , 825 836 ] , suggest that activator protein 1 binding sites on ventrolateral suprachiasmatic nucleus target genes are constitutively occupied by DeltaFosB / JunD complexes , and that c Fos , Fra 2 , FosB and JunB compete for binding after photic stimulation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The products of the Jun family genes , c Jun , JunB and JunD , are essential components of the activating protein 1 transcription factor complexes that are critically important in the control of cell growth , differentiation and neoplastic transformation . ^^^ Although increased c Jun expression has been reported in human colorectal tumors , expression of JunB and JunD in these tumors has not previously been characterized . ^^^ In the current study , we examined 24 cases of human colorectal adenocarcinoma by western immunoblotting analysis and immunohistochemical staining for the expression of c Jun , JunB and JunD proteins . ^^^ The results showed that both c Jun and JunB proteins were undetectable or barely detectable in normal mucosa but their expression levels were significantly increased in human colorectal adenocarcinomas . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of c Fos , Fra 2 , FosB , c Jun , and JunB protein levels , which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
On the other hand , c Jun and JunB , both induced by TNF alpha , block Smad 3 mediated transcription . ^^^ We provide evidence for off DNA interactions between Smad 3 and both c Jun and JunB accompanied with reduced Smad 3 DNA interactions . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We also observed increased expression of mRNAs for Fos and Jun transcription factor family members c Fos , FosB , Fra 2 , and JunB , as well as Fos family proteins in the entorhinal cortex after MK 801 administration . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 sequence specifically bound to fra 1 , junD , and junB in H 441 lung adenocarcinoma nuclear extracts . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This type of stimulation led to a specific and statistically significant increase in the expression of the protein products of the inducible transcription factors c Fos , JunB , inducible cyclic AMP early repressor and Krox 24 ( also frequently named Zif 268 or Egr 1 ) , but not c Jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We found that expression of c Fos , c Jun , and JunB was induced upon LIF treatment whereas that of JunD , the tyrosine phosphatase ESP , and the components of the LIF receptor remained unaffected . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB , c Jun , c Fos , and Fra 2 were rapidly but transiently induced by FSH in immature granulosa cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The p 56 ( dok 2 ) overexpressing cells showed an impaired induction of c myc but not of c jun , junB or c fos when stimulated with M CSF . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Treatment with VIP or PACAP results in a decrease in AP 1 binding , and a marked change in the composition of the AP 1 complexes from c Jun / c Fos to JunB / c Fos . ^^^ Both the inhibition of the MEKK1 / MEK4 / JNK pathway , leading to the reduction in phosphorylated c Jun , and the stimulation of JunB , are mediated through the specific VPAC 1 receptor and the cAMP / PKA pathway . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^ The labeling intensity of the c Jun , JunD , and Fra 2 antibodies was stronger than that of JunB , FosB , and Fra 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Moreover , LIF activated STAT 3 indirectly mediates LIF corticotroph action by inducing and potentiating CRH induced c fos and JunB expression and binding to the POMC AP 1 element . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Human PTH ( 1 34 ) and hPTH ( 1 84 ) increased steady state mRNA expression of c jun , junB , c fos , and fra 2 in an equivalent dose and time dependent manner . ^^^ Expression of c jun , junB , and c fos peaked 30 minutes after the injection while fra 2 expression peaked 30 minutes later . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
While c Fos , Fra 2 and JunB were increased in response to either stimuli , only Fra 1 , c Jun and JunD were increased by PMA . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To elucidate dimer specific functions of the AP 1 family of transcription factors , we reconstituted skin by combining primary human keratinocytes and mouse wild type , c jun ( / ) , and junB ( / ) fibroblasts . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Atopic dermatitis keratinocyte nuclear lysates had higher constitutive levels of c Jun , and phorbol myristate acetate promoted an earlier and stronger expression of c Jun , JunB , and of the phosphorylated forms of c Fos . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In ROS 17 / 2 . 8 cells , TGF beta 1 as well as BMP 2 up regulated the expression of junB and c fos messenger RNAs ( mRNAs ) , and this increase was correlated in both cases with an increase in activator protein 1 ( AP 1 ) DNA binding activity involving JunB and c Fos proteins . ^^^ In osteoblastic cells , transforming growth factor beta 1 ( TGF beta 1 ) has been found to regulate the expression of a variety of proto oncogenes including c fos , c jun , and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Antisense transfection experiments indicated that c Jun and JunB were involved in the synergistic effect , and endogenous c Jun physically associated with Smad 3 during a combined EGF / TGF beta treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activation of transcription through the AP 1 site in Jurkat cells by JunD and / or Fra 2 was weak . c Jun , JunB , and c Fos activation was greater , although the level was still less than that with Tax . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
FosB , Fra 2 , c Jun , JunB and , most abundantly , JunD bind the AP 1 EP in the absence and presence of serotonin . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The role of the Jun family of proteins ( c Jun , JunB , and JunD ) in oncogenesis has been extensively studied , but the distinct biological roles of each Jun protein is not known . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Mice with tissue specific loss of JunB develop a myeloproliferative disorder , emphasizing the important roles that Jun proteins play in regulating life and death decisions in disease . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast , basal levels of JunB , an inhibitor of the trans activating function of c Jun and repressor of AP 1 dependent transcription , were significantly elevated in adrenals from old rats compared to young rats . ^^^ The observed decrease in AP 1 binding activity in ageing adrenals is most likely due to decreased expression of the AP 1 activating components ( c Fos , c Jun , JunD , etc . ) and increased expression of JunB , resulting in a switch from transcriptionally active AP 1 complexes observed in young rats to less efficient JunB containing complexes in old rats . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Induction of the AP 1 members c Jun and JunB by TGF beta / Smad suppresses early Smad driven gene activation . ^^^ Among the latter are c jun and junB , which encode members of the AP 1 family of transcription factors . ^^^ We demonstrate that overexpression of either junB or c jun prevents TGF beta or Smad 3 induced transactivation of the Smad specific promoter construct ( SBE ) ( 4 ) Lux . ^^^ Inversely , Smad driven promoter transactivation by TGF beta / Smad is significantly enhanced when c jun expression is abolished in HaCaT keratinocytes , and when junB expression is prevented in fibroblasts , consistent with the cell type specific induction of jun members by TGF beta . ^^^ Finally , we have determined that off DNA interactions between Smad 3 and both c Jun and JunB result in the reduction of Smad3 / DNA interactions . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using knock out strategies it was found that some components , such as c Fos , FosB and JunD are dispensable , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic development and / or in the adult organism . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We demonstrate that Smad and AP 1 complexes specifically bind to their cognate cis elements and do not interact with each other on DNA , whereas off DNA interactions occur between Smad 3 and both c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The 138T allelic variant binds AP 1 complexes consisting primarily of c Jun , JunB and its partners Fra 1 and Fra 2 in rat VSMC . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Northern blot analyses characterized changes in levels of the c jun and junB expressions of the AP 1 family . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression of egr 1 ( krox 24 ) , egr 2 ( krox 20 ) , egr 3 , c jun , junB , c fos , fosB , fra 1 , fra 2 , and CREB genes was analyzed by reverse transcription polymerase chain reaction ( RT PCR ) in Schwann cells isolated from neonatal rat sciatic nerves and in the cell lines MSC 80 ( mouse Schwann cells ) , NIH 3T3 ( mouse fibroblasts ) , and CHO ( Chinese hamster ovary cells ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This result correlated with the observed loss of binding of the transcriptionally inactive JunB Fra 2 AP 1 complex from B 9 ( SQ ) cells , being replaced primarily by the more active JunD Fra 2 complex in A 5 ( SP ) cells . ^^^ The higher level of JunB binding to both DNA and Fra 2 correlated with its hyperphosphorylation by Jun N terminal kinase , an activity that was significantly higher in B 9 ( SQ ) cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using glutathione S transferase pull down assays , we demonstrated that ERalpha bound directly to c Jun and JunB but not to FOS family members , in a ligand independent manner . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This region shares highest similarities to the C terminal DNA binding domain and the basic zipper ( bZIP ) motifs of transcription factors like CPCA from A . niger , Gcn4p from Saccharomyces cerevisiae , human JUNB and c JUN . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^ RESULTS : Of the seven AP 1 factors , three ( c fos , fra 2 , and junB ) clearly showed higher expression levels in tumors when compared to matched normal endometrial samples . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Furthermore , to investigate the functional consequences of c fos and junB induction , MOR mediated formation of the functional transcription factor complex AP 1 was examined by reporter assay and electrophoretic mobility shift assay . ^^^ Electrophoretic mobility shift assay revealed that AP 1 binding activity in the nuclear extract was elevated by MOR activation and further showed that products of c fos and junB genes are involved in formation of AP 1 complex . ^^^ CONCLUSIONS : Mu opioid receptor activation induces c fos and junB expression and elevates AP 1 mediated transcriptional activities via the mitogen activated protein kinase cascade . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 factors present at high levels in the more invasive stages of the tumor may in part allow for increased PLF expression , as cells from the mild stage in which c jun and junB are stably expressed secrete levels of PLF comparable to that of the advanced stages . ^^^ Activator protein 1 factors present at high levels in the more invasive stages of the tumor may in part allow for increased PLF expression , as cells from the mild stage in which c jun and junB are stably expressed secrete levels of PLF comparable to that of the advanced stages . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Anergy is accompanied by a reduction in AP 1 binding to the IL 2 promoter , with selective reduction in binding of c Fos , JunB , and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Interestingly , confirmation of the expression of activating protein 1 family members by reverse transcriptase polymerase chain reaction revealed a preferential increase in junB , a known transcriptional antagonist of c jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
However , ascorbate increased the mRNA levels of c jun , junB , and c fos in 1 alpha , 25 ( OH ) 2D3 induced cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The defect is secondary to an inability to phosphorylate CREB and to induce CREB dependent immediate early genes , including c jun , fosB , fra 2 , and junB , which are required for cytokine gene induction . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Although TGF beta 1 and activin A had no effect on NF kappaB and JNK activities , these factors enhanced the expression of JunB , a component of the AP 1 transcriptional complex . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The Wnt mediated repression of c Fos , FosB , and JunB expression was consistent with a decrease in their binding to an AP 1 promoter element and decreased target gene transcription . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The Jun and JunB components of the AP 1 transcription factor are known to have antagonistic functions . ^^^ Thus , the transcriptionally less active JunB has the potential to substitute for Jun , indicating that the spatial and temporal regulation of expression of the transcription factor AP 1 may be more important than the coding sequence of its components . . ^^^ JunB can substitute for Jun in mouse development and cell proliferation . ^^^ Here we show , by a knock in strategy and a transgenic complementation approach , that Junb can substitute for absence of Jun during mouse development . ^^^ Junb can rescue both liver and cardiac defects in Jun null mice in a manner dependent on gene dosage . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Forty six globes were processed for in situ hybridization with oligonucleotide probes for c fos , fosB , c jun , junB and junD mRNAs , and 60 globes were immunohistochemically analysed using anti c Fos and anti c Jun antibodies . ^^^ Normal lens epithelial cells expressed mRNA signals for junD , but not for c fos , fosB , c jun , and junB . mRNAs for c fos , fosB , c jun , and junB were detected in the whole lens epithelium from the vicinity to the wound to the equator from 30 min to 8 hr post injury with their peaks after 30 min to 1 hr , but were no longer detected at 10 hr or later . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast , DMSO reduced the expression of immediate early genes ( IEG ) expression ( c myc , c jun , c fos , junB , egr 1 ) and inhibited mitogen activated protein kinase ( MEK ) kinase / extracellular signal regulated kinases ( ERKs ) and p 38 phosphorylation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB negatively regulates AP 1 activity and cell proliferation of malignant mouse keratinocytes . ^^^ OBJECTIVE : Previously we have shown that a malignant mouse keratinocyte cell line , 10Gy5 , has elevated AP 1 transactivation and reduced JunB protein levels compared to its parental benign cell line , 308 , and that the tumorigenicity in the 10Gy5 cells could be blocked by a dominant negative c Jun mutant protein . ^^^ We wished to determine whether the change in JunB protein levels could account for the elevated AP 1 activity and whether re expression of JunB in malignant 10Gy5 cells altered their proliferative capacity . ^^^ RESULTS : Increased AP 1 activity was detected after treatment of the benign 308 cell line with JunB antisense oligonucleotides that reduced JunB protein levels . ^^^ Stably JunB transfected clones of malignant 10Gy5 cells showed decreased AP 1 activity , slowed in vitro cell proliferation and reduced tumor growth when xenografted to athymic nude mice . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Ribonuclease protection assays demonstrated that increases in mRNA levels of the early response protooncogenes c jun , junB , fra 1 , and fra 2 accompanied cell proliferation at low concentrations of PM whereas apoptotic concentrations of PM caused transient increases in expression of fos and jun family members and dose responsive increases in mRNA levels of receptor interacting protein , Fas associated death domain , and caspase 8 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Treatment with exogenous TGF beta 1 resulted in a failure to induce transcription from an artificial Smad dependent promoter and a failure to down regulate c myc , but resulted in an up regulation of AP 1 associated genes ( Fra 1 , JunB and fibronectin ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RT PCR analysis of nerve growth factor mediated changes in AP 1 transcription factors showed rapid increases in c fos and junB mRNA in PC 12 and B5P cells , while increases in c jun were small . ^^^ Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 binding was interfered by the use of an antibody directed against JunB . ^^^ This is the indication that IL 4 overactivated AP 1 is composed of JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Since these full length fusions have bzip domains , the results suggest that JunB and / or Fra 1 containing dimers may constitute one target of RA for transrepression of AP 1 . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Other components of the complex included Fra 2 , c Jun , JunB and JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB / AP 1 and NF kappa B mediated induction of nitric oxide synthase by bovine type 1 collagen in serum stimulated murine macrophages . ^^^ Bovine type 1 collagen in combination with serum activated JunB and JunB / AP 1 transcription complex , as evidenced by supershift and immunodepletion of the retarded AP 1 band with anti JunB antibody . ^^^ PD 98059 , but not SB 203580 or JNK 1 ( ) transfection , inhibited both ERK1 / 2 phosphorylation and JunB / AP 1 activation . ^^^ These results demonstrated that bovine type 1 collagen induces iNOS in serum stimulated murine macrophages through JunB / AP 1 and NF kappa B activation and that activation of ERK1 / 2 plays an essential role in JunB / AP 1 activation . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In contrast , ERK1 / 2 , p 38 ( MAPK ) and src kinases treatment blocked nuclear translocation of almost all the AP 1 members in both models , except Fra 1 , JunD after deformation and Fra 1 , JunB after clinorotation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We observed that withdrawal of IL 7 induced increased expression of jun and fos family member genes including c jun , junB , junD , c fos and fra 2 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The JunD transcription factor is one member of the Jun family of proteins that also includes c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
VIP / PACAP inhibit MEKK 1 activity and the subsequent phosphorylations of MEK 4 , JNK , and c Jun , which result in a decrease in the AP 1 binding and a marked change in the composition of AP 1 complexes from c Jun / c Fos to JunB / c Fos . ^^^ Both inhibition of the MEKK1 / MEK4 / JNK pathway , leading to a reduction in phosphorylated c Jun , and the stimulation of JunB are mediated through the specific VPAC 1 receptor and cAMP / PKA pathway . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activation of ERK1 / 2 resulted in induction of c jun , junB , and c fos expression , whereas activation of p 38 alone had no effect . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
These events are mediated through the VIP / PACAP effects on de novo expression or nuclear translocation of several transcription factors , i . e . , NFkappaB , CREB , c Jun , JunB , and IRF 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We have characterized the effects of chronic clozapine and haloperidol treatments on the expression of fos ( c fos , fosB , fra 2 ) and jun ( c jun , junB , junD ) family genes in the rat forebrain . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunD , a member of the Jun family of nuclear transcription proteins , dimerizes with Fos family members or other Jun proteins ( c Jun or JunB ) to form the activator protein 1 ( AP 1 ) transcription factor . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB , a major component of the AP 1 transcription factor , is known to act antagonistically to c Jun in transcriptional regulation and is proposed to be a negative regulator of cell proliferation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Here , we show that constitutively activated AP 1 with robust c Jun and JunB overexpression is found in all tumor cells of patients with classical Hodgkin ' s disease . ^^^ Aberrantly expressed c Jun and JunB are a hallmark of Hodgkin lymphoma cells , stimulate proliferation and synergize with NF kappa B . ^^^ Whereas c Jun is up regulated by an autoregulatory process , JunB is under control of NF kappa B . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We found that small regions from c Jun , JunB , and JunD containing this sequence also function as transcriptional inhibitory domains . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We found that the zinc finger region of BCL 6 interacts with c Jun , JunB , and JunD proteins but does not bind c Fos or Fra 2 proteins . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift EMSA revealed that VT preferentially induced JunB , JunD , phosphorylated c Jun , c Fos , and Fra 2 binding activities of the AP 1 family . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) is a dimeric protein , consisting either of homodimers between c Jun , JunB , and JunD of by heterodimers with members of the Fos family by physically interacting via a `` leucine zipper ' ' region . ^^^ Activator protein 1 ( AP 1 ) is a dimeric protein , consisting either of homodimers between c Jun , JunB , and JunD of by heterodimers with members of the Fos family by physically interacting via a `` leucine zipper ' ' region . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this work we investigated the effect of measles virus ( MV ) infection on the expression of immediate early genes junB , c jun and c fos mRNA as well as AP 1 DNA binding activity in the lung epithelial like adenocarcinoma cell line A 549 . ^^^ The expression of junB and c jun mRNA was rapidly induced by MV . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using an in vitro skin equivalent model strong evidence was provided for a critical and specific function of c Jun and JunB in mesenchymal epithelial interaction in the skin by regulating the expression of interleukin 1 ( IL 1 ) induced keratinocyte growth factor ( KGF ) and GM CSF in fibroblasts . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Since null mutations of c Jun cause embryonic lethality , this study was designed to investigate the impact of two c Jun modulating proteins on neuronal survival after axotomy in transgenic mice : JunB , a Jun family member affecting c Jun expression , and Bcl 2 , an antiapoptotic protooncogene interacting among others with the c Jun N terminal kinases . ^^^ These effects were obviously achieved by cellular modulations directly following axotomy : Whereas JunB overexpression attenuated c Jun induction and simultaneously led to a higher phosphorylation rate of c Jun in SNC neurons , Bcl 2 overexpression did not influence c Jun expression , but resulted in a reduced phosphorylation state of c Jun in transected SNC neurons . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A functional activating protein 1 ( AP 1 ) site regulates matrix metalloproteinase 2 ( MMP 2 ) transcription by cardiac cells through interactions with JunB Fra 1 and JunB FosB heterodimers . ^^^ These studies demonstrate that a functional AP 1 site mediates MMP 2 transcription in cardiac cells through the binding of distinctive Fra 1 JunB and FosB JunB heterodimers . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Data obtained from knockout mice revealed that some components , such as c Fos are key regulators of bone cell differentiation , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic and / or postnatal development . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This elevated phosphorylation of c Jun correlated with enhanced DNA binding and transcriptional activation of an AP 1 complex consisting of c Jun and Fos but lacking the c Jun antagonist JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The expression of c Fos , c Jun and JunB proteins was determined by the Western blot analysis . ^^^ A decrease in the expression of c Fos on the 1st and 4th day after trauma had no significant effect on c Jun expression ; the increase in expression of JunB was only on the 1st day after injury . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Elevated levels of AP 1 complexes , including significant increases in c Jun , JunB and Fra 1 , were found in asbestos exposed RPM cells , but only Fra 1 expression was significantly increased and protracted in both asbestos exposed RPM cells and mesothelioma cell lines . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Gene disruption studies indicate that the AP 1 family members c jun , junB , and fra 1 are essential for embryonic development , whereas junD , c fos , and fosB are required for normal postnatal growth . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Among JNK substrates , c Jun and JunB ( but not activating transcription factor 2 ) antagonized TGF beta / SMAD signaling in a JNK dependent manner . ^^^ In junAA mouse embryo fibroblasts , in which c Jun can no longer be phosphorylated by JNK , JunB substituted for c Jun in mediating the cytokine effect against SMAD driven transcription in a JNK dependent manner . ^^^ These results suggest a critical role for JNK mediated c Jun and JunB phosphorylation in transmitting the inhibitory effect of pro inflammatory cytokines against TGF beta induced SMAD signaling . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Further EMSA analysis using antibodies to various AP 1 components revealed that junB antibodies partially depleted the increase in binding to the PRE 1 seen in UK / rap1 cells while antibodies to other AP 1 constituents such as c jun , c fos , and ATF 1 had no effect on binding . ^^^ Mutation of the AP 1 site inhibited junB mediated or rap 1 mediated increases in RII promoter activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
This effect was specific because palytoxin had little effect on c Jun , JunB , JunD , FosB , Fra 1 , or Fra 2 binding or on overall levels of transcription factor binding . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB is a component of the Jun family genes of the activating protein 1 transcription factors that are important in the control of cell growth and differentiation and neoplastic transformation . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift analysis revealed that the major AP 1 complex contains JunB . ^^^ Exogenous JunB restored AP 1 DNA binding but did not prevent inhibition of macrosialin expression by C / EBPalpha ER , indicating that JunB is not the only target relevant to inhibition of monopoiesis by C / EBPalpha . . ^^^ Activation of C / EBPalpha ER specifically reduced endogenous JunB RNA and protein and exogenous JunB levels without affecting endogenous or exogenous c Jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
On the other hand , expressions of proto oncogene c jun , junB and c fos were induced by TPA and Saikosaponin a during 30 min to 6 h of treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Supershift EMSAs and Western blot analysis identified specific VT inducible DNA binding proteins for AP 1 ( cJun , phospho c jun , JunB , and JunD ) , C / EBP ( C / EBPbeta ) , CREB ( CREB 1 and ATF 2 ) , and NF kappaB ( p 50 and cRel ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Nuclear extracts from granulosa cells from 1 2 mm or 8 10 mm antral follicles bound an AP 1 DNA consensus sequence and complexes consisted predominantly of c Jun , JunD , JunB , c Fos , and Fra 2 . ^^^ Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ In CL , c Jun , JunD , JunB , and Fra 2 were present in DNA binding complexes , and c Fos binding was not detected . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Among the early response genes analyzed , c myc , junB , junD , c jun , c fos , fosB , fra , as well as max , mad 1 4 , sin 3 , only c jun and fra 2 mRNAs were up regulated after 1 , 25 ( OH ) ( 2 ) D ( 3 ) exposure . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NFkB , CREB , c Jun , JunB , and IRF 1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Western blot analysis , as well as supershift experiments , revealed that the AP 1 activation was associated with a change of AP 1 composition toward an increase of JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In a Gal 4 fusion assay , Pdcd 4 specifically inhibited activation of c Jun and c Fos activation domains , but did not inhibit activation of JunB , JunD , Fra 1 , or Fra 2 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We further studied the expression of fosB , c jun and junB , in the AP 1 complex . fosB was up regulated 20 fold , but only minor effects on jun variants were observed . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility supershift assay indicated that the JunB , JunD , and c Fos components of AP 1 were particularly affected . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 complex contained JunB , whose overexpression activated reporter constructs driven by the CD 30 promoter including the MSs , and was dependent on the AP 1 site . ^^^ Taken together , overexpression and binding of JunB to the AP 1 site appear to relieve the repression of the core promoter by the CD 30 MS in H RS cells , which provide one basis for the constitutive overexpression of CD 30 in Hodgkin ' s lymphoma . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Using specific polyclonal antisera against c Fos , JunB , c Jun and JunD , we tried to identify the candidate transcription factors of the immediate early gene family which may contribute to the molecular processes during contextual memory reconsolidation . ^^^ In these mice context dependent memory retrieval evoked a marked induction of c Fos and JunB , but not of c Jun and JunD , in pyramidal CA 1 neurons of the dorsal hippocampus . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The c Jun and JunB mRNA levels were higher in untreated p 50 / mice than in untreated control mice ; c Jun mRNA levels increased , whereas JunB mRNA levels decreased in both groups after ciprofibrate treatment . ^^^ The c Jun and JunB protein levels were the same in untreated wild type and p 50 / mice and increased in both groups after ciprofibrate treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The activator protein 1 ( AP 1 ) member JunB has recently been implicated in leukemogenesis . ^^^ Here we surveyed human lymphoma samples for expression of JunB and other AP 1 members ( c Jun , c Fos , Fra 1 , JunD ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Electrophoretic mobility shift assays using [ 32P ] labeled synthetic oligonucleotides encoding the consensus binding motif of activator protein 1 demonstrated that interleukin 4 induced binding of activator protein 1 composed of JunB was interfered by terfenadine . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the current study , we examined the expression of seven fos / jun family member mRNAs ( c fos , fosB , fos related antigen ( fra ) 1 , fra 2 , junB , c jun , and junD ) and three other IEG mRNAs ( egr 1 , egr 3 , and nur 77 ) in mouse brain following short term ( 6 h ) sleep deprivation ( SD ) and 4 h recovery sleep ( RS ) after SD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Comparison of conventional and real time RT PCR for the quantitation of jun protooncogene mRNA and analysis of junB mRNA expression in synovial membranes and isolated synovial fibroblasts from rheumatoid arthritis patients ] . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The HBZ factor of human T cell leukemia virus type 1 dimerizes with transcription factors JunB and c Jun and modulates their transcriptional activity . ^^^ In searching for other cellular targets of HBZ , we identified two members of the Jun family , JunB and c Jun . ^^^ Co immunoprecipitation and cellular colocalization confirmed that HBZ interacts in vivo with JunB and c Jun . ^^^ Consistent with the structure of its basic domain , we demonstrate that HBZ decreases the DNA binding activity of c Jun and JunB . ^^^ On the other hand , the combination of HBZ with Jun B had higher transcriptional activity than JunB alone . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
AP 1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets . ^^^ AP 1 complexes enriched with cJun and JunB result in morphological alterations and anchorage independent cell growth consistent with a transformation like phenotype , whereas complexes enriched with JunD had an antiproliferative effect . ^^^ These results suggest that genes regulated by both cJun and JunB are potentially involved in transformation and that they can be distinguished from those regulated by AP 1 complexes containing JunD . ^^^ AP 1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets . ^^^ AP 1 complexes enriched with cJun and JunB result in morphological alterations and anchorage independent cell growth consistent with a transformation like phenotype , whereas complexes enriched with JunD had an antiproliferative effect . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RESULTS : Transcriptionally active AP 1 in combinations of c Jun , JunD and JunB with Fra 1 , Fra 2 and possibly FosB , are expressed in cardiac myocytes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Functional analysis in mice has established an absolute requirement of JunB , a member of the AP 1 transcription factor family , during early embryonic development . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
However , other Jun family members such as JunD was expressed constitutively and JunB was not expressed . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Our results reveal that c fos , fosB , c jun , and junB levels were upregulated at 24 hr . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The mechanism of tumor suppressor action of JDP 2 can be partially explained by the generation of inhibitory AP 1 complexes via the increase of JunB , JunD , and Fra 2 expression and decrease of c Jun expression . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
They included c JUN , JUNB , JUND , FREAC 1 / FoxF1 , ZNF 44 / KOX7 , plectin , filamin , keratin 13 , G ( 0 ) S 2 , and the putative tumor suppressors NES 1 and protease M . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Exogenous JunB restores AP 1 DNA binding but does not overcome inhibition of monopoiesis by C / EBPalpha ER . ^^^ In 32DPKCdelta cells , C / EBPalpha ER strongly inhibits endogenous or exogenous JunB induction , dependent upon the outer surface of the C / EBPalpha basic region , but does not inhibit c Jun , PU . 1 , or C / EBPbeta expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In situ hybridization was used to evaluate depolarization thresholds for induction of mRNAs encoding the 70 kDa heat shock / stress protein , hsp 72 , as well as several immediate early genes ( c fos , c jun , junB , and junD ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We demonstrated previously that c Jun , JunB and c Fos RNA were dysregulated in metastatic melanoma cells compared with normal human melanocytes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A detailed analysis of AP 1 complex composition revealed that phenotypic transition of PSCs towards myofibroblasts was accompanied by an increase of the JunD content relative to the one of JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Functional classification of the 25 genes demonstrated alterations of expression of several kinds of biological pathways , regulating transcription ( Bhlhb 2 , Jun , c fos , Egr 1 , Egr 2 , Fosb , Junb , Ifrd 1 , Neurod 6 ) , the cell cycle ( c fos , Fosb , Jun , Junb , Dusp 1 ) , stress response ( Dusp 1 , Dnajb 1 , Dnaja 4 ) , chaperone activity ( Dnajb 1 , Dnaja 4 ) and cell death ( Ptgs 2 , Gadd45g , Tdag 51 ) , in the mouse hippocampus by 24 h of reperfusion . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A gel mobility supershift analysis revealed interaction of the AP 1 factors , Fra 1 , Fra 2 , and JunB , with this element . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Static stretch induced an increase in the expression of c fos , fosB , fra 1 , c jun , and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression levels of c fos , c jun , junB , jun D , Nrf 2 , and OPN proteins increased in all treated mice . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
After skin injury , the release of IL 1 from keratinocytes induces the activity of the AP 1 subunits c Jun and JunB in fibroblasts leading to a global change in gene expression . ^^^ To identify AP 1 target genes in fibroblasts , which are involved in the process of cutaneous repair , we performed gene expression profiling of wild type , c jun and junB deficient fibroblasts in response to IL 1 , mimicking the initial phase of wound healing . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
PRL activation of these pathways leads to increased c Jun protein and phosphorylation , JunB protein , and phosphorylation of c Fos , elevating the levels of AP 1 complexes able to bind DNA . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Moreover , supershift analysis identified that JunB and Fra 1 are major components involved in the PG mediated induction of AP 1 DNA binding . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In the case of c Jun and JunB , we found that extracellular stimuli also modulate protein turnover by regulating the activity of an E 3 ligase by means of its phosphorylation . ^^^ Activation of the Jun amino terminal kinase ( JNK ) mitogen activated protein kinase cascade after T cell stimulation accelerated degradation of c Jun and JunB through phosphorylation dependent activation of the E 3 ligase Itch . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In analogous fashion , DON upregulated expression of the chemokines macrophage inhibitory protein 2 ( MIP 2 ) , cytokine induced chemoattractant protein 1 ( CINC 1 ) , monocyte chemoattractant protein ( MCP ) 1 , MCP 3 , and cytokine responsive gene 2 ( CRG 2 ) . c Fos , Fra , c Jun , and JunB , components of the activator protein 1 ( AP 1 ) transcription factor complex , were induced by DON as well as another transcription factor , NR4A1 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Furthermore , experiments revealed that the protein and mRNA expression of the AP 1 subunits c Fos , Fra 1 and c Jun was reduced in lesional psoriatic skin compared with nonlesional psoriatic skin , whereas the protein and mRNA expression of the subunit JunB was increased . ^^^ Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP 1 DNA binding activity , and an increase in the protein and mRNA expression of c Fos , Fra 1 and c Jun , together with a decrease in JunB protein and mRNA expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The 27 up regulated genes mainly encoded transcription factors ( JUN , EGR 1 , JUNB , FOS , FOSB , MYCN , and SNAIL 1 ) , growth factors ( VEGF , DTR / HB EGF , IGFBP 7 , IL 6 , ANGPT 2 , EREG , CCL3 / MIP1A , and CCL5 / RANTES ) and growth factor receptors ( TBXA2R , TNFRSF10A / TRAILR1 , and ROBO 2 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Constitutive expression of the AP 1 transcription factors c jun , junD , junB , and c fos and the marginal zone B cell transcription factor Notch 2 in splenic marginal zone lymphoma . ^^^ The AP 1 transcription factors c jun , junD , junB , and c fos as well as Notch 2 were found to be specifically up regulated . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^ Interestingly , despite very low or absent AP 1 binding in normal as well as in premalignant lesions , AP 1 transcription and its binding activity was found to be very high in malignant tissues showing a preferential heterodimerization of c fos with JunB instead of its canonical dimerization partner c jun . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
All of the mouse and most human mammary tumors also displayed decreased expression of genes known to inhibit cell proliferation , including NFKBIA ( IKBalpha ) , GADD45B , and CDKN1A ( p 21 ) ; transcription related genes such as CEBP , JUN , JUNB , and ELF 1 ; and apoptosis related transcripts such as IER 3 and GADD34 / PPP1R15A . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Expression levels of activator protein 1 family members ( c jun , junB , junD , and c fos ) and transforming growth factor ( TGF ) alpha were significantly lower in TPA treated Smad 3 ( / ) skin , cultured keratinocytes , and papillomas , as compared with Smad 3 ( + / + ) controls . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
MEKK 1 regulates the AP 1 dimer repertoire via control of JunB transcription and Fra 2 protein stability . ^^^ Upregulation of JunB expression in MEKK 1 / cells forms an inhibitory AP 1 complex that binds to the uPA promoter and inhibits uPA transcription . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
KAI 1 promoter activity is dependent on p 53 , junB and AP 2 : evidence for a possible mechanism underlying loss of KAI 1 expression in cancer cells . ^^^ Roles of individual p 53 , junB and AP 2 proteins , as well as functional synergy between p 53 and junB , were confirmed in transfection experiments . ^^^ Western blotting analysis showed that an absence of wild type p 53 , and / or a loss of junB and AP 2 protein expression , correlated with downregulation of KAI 1 mRNA levels in a series of prostate cancer cell lines . ^^^ A loss of p 53 function and / or expression of junB , combined with reduced expression of specific AP 2 proteins may underly downregulated KAI 1 expression in tumour cells . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Dmp 1 promoter activation by Ras ( V 12 ) was strikingly impaired in c Jun as well as in JunB knock down cells , suggesting the critical role of Jun proteins in the activation of the Dmp 1 promoter . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Transfection with c Jun or JunB had no effect on transcription from the Cx 43 promoter , whereas transfection with JunD or combinations of Jun and Fos family members led to significant increases in transcription . ^^^ Dimers comprising Fos / Jun proteins conferred greater transcriptional activity than Jun dimmers , with Fra 2 / JunB combination conferring greatest activity . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Deoxynivalenol was found to readily induce expression of cytokines ( IL 1alpha , IL 1beta , and IL 6 and IL 11 ) , chemokines ( MCP 1 , MCP 3 , CINC 1 and MIP 2 ) , components of the activator protein 1 ( AP 1 ) transcription factor complex ( c Fos , Fra 2 , c Jun and JunB ) , as well as two hydrolases ( MKP 1 , CnAbeta ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The CNS 3 region contains an AP 1 site that binds JunB and c Jun proteins specifically in Th 2 cells and not in Th 1 cells . ^^^ Retroviral mediated expression of either c Jun or JunB in primary T cells led to a large increase in IL 10 expression , and inhibition of AP 1 activity by a dominant negative form of c Jun in primary T cells strongly repressed IL 10 expression . ^^^ The CNS 3 element activates transcription from the IL 10 promoter after P / I stimulation and is responsive to c Jun and JunB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A gel mobility supershift analysis revealed interaction of the AP 1 factors , Fra 1 and JunB , with this element . ^^^ Treatment with 12 O tetradecanoylphorbol 13 acetate ( TPA ) , a protein kinase C activator , increased hINV gene expression , a response that correlates with increased AP 1 factor ( Fra 1 and JunB ) binding to the hINV gene AP 1 5 response element . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB is a member of the Jun family of proteins that are components of the AP 1 transcription factor complex . ^^^ Recent evidence suggests that Hodgkin and Reed Sternberg cells overexpress JunB and that JunB facilitates constitutive CD 30 expression by binding to an AP 1 site in the CD 30 promoter . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Immunohistochemical and in situ hybridization techniques were performed for studying phosphorylated JNK ( p JNK ) , c Jun , JunB , JunD and AP 1 in 40 cases of human HCC and corresponding nontumoral tissues . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
METHODS AND RESULTS : The NO donor SNAP ( 100 microM ) , which is a pro apoptotic stimulus in cardiomyocytes , activated AP 1 within 2 h . c Jun , JunB and FosB are identified as the main components of this AP 1 complex . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The proto oncogenes c fos , fosB , and c jun were not detected , whereas junB was induced by IL 5 stimulation in both types of cells . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Levels of other AP 1 and NF kappaB family members were either unaffected ( i . e . , JunB ) or increased ( i . e . , Fra 1 ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RESULTS : We found sex and tissue specific changes in the expression of Ras superfamily members ( Nras , Rab 2 , Rab 34 , Vav 2 ) , protein kinase C ( PKC ) isoforms ( PKCbeta , PKCmu ) , AP 1 factor components ( Jun , JunB and FosB ) , Wnt signaling pathway members as well as in a variety of other cellular proto oncogenes and oncogenes . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The mRNA expressions of C / EBPbeta , C / EBPdelta , C / EBPgamma , c Jun , JunB , c Fos , Fra 1 and IkappaBalpha and protein level of IkappaBalpha were all unaffected by VIP . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
BACKGROUND : The Jun family of activator protein 1 ( AP 1 ) transcription factors ( c Jun , JunB , and JunD ) is involved in fundamental biological processes such as proliferation , apoptosis , tumor angiogenesis , and hypertrophy . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
We propose that the abrogation of JunB / activator protein 1 ( AP 1 ) in keratinocytes triggers chemokine / cytokine expression , which recruits neutrophils and macrophages to the epidermis thereby contributing to the phenotypic changes observed in psoriasis . ^^^ Likewise , inducible epidermal deletion of JunB and its functional companion c Jun in adult mice leads ( within two weeks ) to a phenotype resembling the histological and molecular hallmarks of psoriasis , including arthritic lesions . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
A robust increase in expression of 10 immediate early genes including Egr 1 4 , Hes 1 , Junb , Jun and Fos was observed already after 1 h treatment with NGF alone . ^^^ Blocking Egr 3 and Junb function by dominant negative constructs reduced neurite outgrowth under stimulating conditions , proving that activation of members of both the Egr and Jun families is necessary for maximal PC 12 cell response to NGF and BMP4 . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Immunodepletion gel shift assays demonstrated that GP 5 EpRE bound JunB , c Jun , FosB , and Fra 2 from unstimulated cells , and that after exposure to HNE , EpRE binding complexes contained nuclear factor erythroid 2 related factor ( Nrf ) 1 , Nrf 2 , JunB , c Jun , FosB , c Fos , Fra 1 , and Fra 2 . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Ischemia induced the expression and binding of c Fos , c Jun , JunB , FosB , and Fra 2 to a noncanonical activating protein 1 ( AP 1 ) site present in the MMP 2 promoter and decreased binding of the transcriptional repressor JunD . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
SL 327 pre treatment , however , reduces the DNA binding activity of the activator protein 1 complex induced six hours after an acute cocaine treatment as well as one hour after the last of the chronic cocaine injections , a phenomenon that results from the concomitant reduction of all cocaine induced proteins ( c Fos , FosB , deltaFosB , JunB ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Cutting edge : the AP 1 subunit JunB determines NK cell mediated target cell killing by regulation of the NKG2D ligand RAE 1epsilon . ^^^ In this study , we report that cell surface expression of RAE 1epsilon is greatly enhanced on cells lacking JunB , a subunit of the transcription complex AP 1 . ^^^ Furthermore , tissue specific junB knockout mice respond to 12 O tetradecanoyl phorbol 13 acetate , a potent AP 1 activator , with markedly increased and sustained epidermal RAE 1epsilon expression . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Converging results consolidate activator protein 1 ( AP 1 ) transcription factor as the pivotal downstream effector in the early response of stress sensitive cells to mechanical loading , and the Fra 1 , Fra 2 , JunB and JunD members of the AP 1 transcription factor family , as mediators in bone remodelling and apoptotic phenomena . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Real time reverse transcription polymerase chain reaction and Western blot analyses revealed quantitative increases in c Jun , JunB , JunD , and FosB expression associated with increased AP 1 activity . ^^^ Electrophoretic mobility shift assay further revealed significant increases in AP 1 binding activity in rhR 4 treated cells , with increased supershift in the presence of antibodies to JunB , JunD , and FosB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The purpose of this study was to determine the impact of PTH related protein ( PTHrP ) on AP 1 transcription factors in cementoblasts and the role of JunB in the actions of PTHrP . ^^^ PTHrP increased mRNA and protein levels of all Fos members , but only one Jun member ( JunB ) was increased . ^^^ RESULTS : PTHrP treatment in vitro resulted in a time dependent upregulation of mRNA and proteins for the Fos family members , but only JunB of the Jun family . ^^^ CONCLUSIONS : JunB was the only Jun family member increased by PTHrP , and its overexpression showed similar patterns of gene expression and OPG production as PTHrP treatment of controls . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The Jun proteins Jun , JunB and JunD are core members of activator protein 1 ( AP 1 ) , a dimeric transcription factor complex consisting of homo and heterodimers of the Jun , Fos , activating transcription factor ( ATF ) and musculoaponeurotic fibrosarcoma ( Maf ) families . ^^^ Embryonic lethality of various AP 1 knock outs , e . g . for Jun , JunB , Fra 1 and Fra 2 largely prevented functional studies in vivo . ^^^ Furthermore , it has been demonstrated in patient ' s samples and an inducible mouse model that down regulation of JunB / AP 1 in keratinocytes is one initiating event in the aetiology of psoriasis which is characterized by increased cell proliferation and deregulated cytokine expression . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
In this study , we demonstrate that JunB , a member of the activator protein 1 transcription factor family , is an important regulator of cytokine expression and thus critically involved in the cutaneous response to injury and stress . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
RT PCR analysis of RNA from Tg mice revealed increased JunB and c Jun in pre BII cells associated with decreased S phase entry . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
JunB and JunD also inhibits the additive effect exerted on the TAp63alpha activation by c Jun . ^^^ Co immunoprecipitation assays demonstrate a complex formation of c Jun , JunB and JunD with TAp63alpha through the SAM domain mediating protein protein interactions , which is characteristic for p63alpha . ^^^ Co expression of p 53 mutant R248W not only downregulates the differential modulation of the viral promoter by TAp63alpha alone and in the presence of the Jun family members , but leads to a reduction in the protein levels of the overexpressed c Jun , JunB , JunD , as well as TAp63alpha . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
The present study has shown that cell preparation procedure , i . e . , cell collection by centrifugation and the subsequent adjustment and culture of cell density at the desired concentrations , transiently induced gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) and the AP 1 components ( c fos , c jun , and junB ) . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Furthermore , almost all kinds of the AP 1 family genes including c jun , c fos , junD , junB , atf 2 and b atf were successfully selected from an mRNA display library constructed from a mouse brain poly A ( + ) RNA after six rounds of selection . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Moreover , the levels of both c Jun and JunB , two components of the AP 1 complex , and those of FasL and Bim , two transcriptional targets of AP 1 , also increased during anandamide treatment . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Cardiac ischemia reperfusion injury induces matrix metalloproteinase 2 expression through the AP 1 components FosB and JunB . ^^^ Nuclear extracts demonstrated increased abundance of two activator proteins 1 ( AP 1 ) components JunB and FosB following I / R injury . ^^^ Chromatin immunoprecipitation ( ChIP ) of the AP 1 binding site in the intrinsic murine MMP 2 promoter yielded only JunB under control conditions , whereas ChIP following I / R injury recovered both JunB and FosB , consistent with a change in occupancy from JunB homodimers in controls to JunB / FosB heterodimers following I / R injury . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Treatment with TGF beta in mast cells resulted in the differential gene induction of the AP 1 components , i . e . , transient induction of c fos but not of c jun and junB . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
Loss of pVHL leads to up regulation of JunB , which antagonizes c Jun and blunts apoptosis . . ^^^
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P05412	Pubmed	SVM Score :0.0
NA