Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Transcriptional activation of the c jun , junB and c fos genes following TPA / serum induction was unaffected and efficient transactivation of AP 1 reporter constructs was demonstrated in these cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Here , we show that the growth factor inducible proto oncogenes c fos , c jun , and junB mimic the effects of exogenous growth factors and suppress trans activation of the muscle creatine kinase ( MCK ) enhancer by myogenin and MyoD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
ET isopeptides induced a subset of fos and jun mRNAs in mesangial cells , including c fos , fra 1 , c jun , and JunB . fos and jun mRNAs were induced as members of the immediate early gene response . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We studied levels of mRNAs for several immediate early genes : c fos , NGFI A , NGFI B , c jun , junB and junD , before and after light exposure at these phases . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The induction is the result of increased production of JunB and c Fos proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Carbachol and thrombin have similar effects on expression of c fos , fosB , fra 2 , junB , and junD , both acutely and over a 24 h time course . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In primary cultures of bovine glomerulosa cells , AII was found to induce the expression of several early growth response genes ( c fos , c jun , JunB , and Krox 24 ) . ^^^ ACTH , which elevates cAMP in glomerulosa cells , was a relatively weak inducer of c fos expression but was as potent as AII in stimulating the expression of JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In MCF 7 cells , OA elicited within 5 min an increase in the levels of a set of phosphorylated cellular proteins , within hours expression of the early response genes junB , c jun , and c fos , and within days manifestation of differentiation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Insulin resulted in an early and prominent increase in the transcription of genes encoding the AP 1 components of JunA , JunB , and c Fos , as has been observed for other growth factors . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Transcriptional run on assays revealed that treatment of serum starved NKM 1 with 50 ng / ml G CSF or M CSF increased the transcription rate of the junB gene and the c fos gene by 1 . 8 fold and 2 . 9 fold , respectively , but did not induce any transcript of the c jun gene . ^^^ The results indicate that the expression of the junB and c fos genes is activated , at least in part , at the transcriptional level in response to these CSFs . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Specifically , we find that brief ( 1 h ) visual experience in dark reared cats causes dramatic transient inductions of egr 1 , c fos , and junB mRNAs in the visual cortex but not in the frontal cortex . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In addition , RAR alpha overexpression selectively inhibits the serum stimulated expression of the c fos gene , but does not affect the expression of a number of other serum and polyomavirus inducible genes including c jun , junB , c myc and actin . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We studied the expression of six nuclear proto oncogenes ( Egr 1 , c fos , fosB , c jun , junB , and c myc ) in myocardium subjected to ischemia and reperfusion in anesthetized pigs . ^^^ The c fos , Egr 1 , and junB genes were highly induced , being fivefold to sevenfold higher in experimental than in control tissue . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Interactions among LRF 1 , JunB , c Jun , and c Fos define a regulatory program in the G 1 phase of liver regeneration . ^^^ In regenerating liver , a physiologically normal model of cell growth , LRF 1 , JunB , c Jun , and c Fos among Jun / Fos / LRF 1 family members are induced posthepatectomy . ^^^ In liver cells , high levels of c Fos / c Jun , c Fos / JunB , LRF 1 / c Jun , and LRF 1 / JunB complexes are present for several hours after the G0 / G1 transition , and the relative level of LRF 1 / JunB complexes increases during G 1 . ^^^ LRF 1 / c Jun , c Fos / c Jun , and c Fos / JunB activate specific AP 1 and ATF site containing promoters , and in contrast , LRF 1 / JunB potently represses c Fos and c Jun mediated activation of these promoters . ^^^ As the relative level of LRF 1 / JunB complexes increases posthepatectomy , c Fos / Jun mediated ATF and AP 1 site activation is likely to decrease with simultaneous transcriptional activation of the many liver specific genes whose promoters contain cyclic AMP response element sites . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have shown that while c Fos is the major Fos protein associated with the Jun proteins ( c Jun , JunB , and JunD ) soon after serum stimulation , at later times Fra 1 and Fra 2 are the predominant Fos proteins associated with the different Jun proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We evaluated the ability of these and other agents to induce the expression of a variety of transcription factor genes including c fos , c myc , junB , and c jun . ^^^ In contrast , no detectable induction of c fos , c myc , or junB was observed . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The present paper describes the effect of capsaicin induced stressful stimulus on the expression of immediate early genes ( IEGs ) c fos , c jun , junB and junD in the hypothalamic paraventricular nucleus ( PVN ) and the central amygdaloid nucleus ( ACe ) using in situ hybridization . ^^^ Stress caused an intense expression of c fos , c jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We also show that c Fos does not affect the inhibitory function of CREM on c Jun and that the transcriptional activation elicited by the other members of the jun family ( JunB , JunD , and 5 Jun ) is also down regulated by CREM . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The expression of fos and jun during T cell activation was accompanied by increased specific binding of JunB , FosB , and fos related antigen containing complexes to the TPA responsive element . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The expression of the early response genes junB , c fos , and c jun was attenuated in PMA treated HL 525 and HL 534 cells as compared to the PMA treated HL 60 and HL 205 cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Thus , treatment of cells with TPA results in a reduction in the levels of c myb and c myc mRNA , while the expression of c fos , c jun , and junB is greatly enhanced . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In both tissue biopsies and derivative cell lines , the proto oncogenes junB and c jun are induced in the latter two stages , in contrast to junD and fos . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
These data are consistent with a model ( figure 4 ) in which preexisting JunD mediates the rapid cAMP dependent activation of the proenkephalin enhancer , whereas IEGs such as JunB or c Fos mediate the protein synthesis dependent inactivation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using quantitative RT PCR , we have monitored mRNA expression levels of c fos , c jun , JunB , c myc , p 53 , H ras , and histone H 4 during the replicative senescence of human fibroblasts . ^^^ The earliest and the largest changes in gene expression occurred in c fos and junB at mid senescence prior to the first slowing in cell growth rates . ^^^ The basal level of c fos mRNA decreased to one ninth that of the early passage levels , while junB declined to one third and c jun expression remained constant . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Co induction of c fos and junB during the latent period preceding commitment of Friend erythroleukemia cells to differentiation . ^^^ In contrast , DMSO induced differentiation of F MELC is associated with an early and transient induction of c fos and junB mRNAs by 2 to 8 h treatment while in presence of dexamethasone , an inhibitor of F MELC commitment , c fos mRNA is not detected and junB mRNA remains at basal levels . junD mRNA is detected at low levels in untreated F MELC and remains unchanged during DMSO treatment . ^^^ Furthermore , DMSO treatment in a F MELC cell line resistant to DMSO differentiation does not result in an early induction of c fos and junB mRNAs . ^^^ Taken together , these results indicate that the DMSO induced F MELC differentiation is accompanied by an early co induction of c fos and junB during the latent period preceding the commitment to erythroid maturation . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Administration of kainate or pentylenetetrazole increased c fos , c jun , junB , and junD mRNA levels in rat brain in a dose dependent manner . ^^^ Adrenalectomy significantly potentiated kainate induced increases , compared with increases caused by kainate ( 4 mg / kg ) alone , in the hippocampal mRNA levels of c fos and junB by 6 . 5 fold and of junD by twofold and tended to augment c jun mRNA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We therefore examined changes in the mRNA levels for the IEGs c fos , c jun , fosB , junB , and zif 268 in the NAc of rats treated acutely and chronically with cocaine . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
TPA induced c fos and junB mRNAs transiently and preceding NGF mRNA induction but c jun mRNA remained undetectable . ^^^ Forskolin enhanced the induction of both junB and c fos mRNA whereas corticosterone prolonged junB mRNA induction . ^^^ Thus , TPA induction of NGF mRNA is modulated differentially by corticosterone and cyclic AMP . c fos and junB may play a role in the underlying mechanisms . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The relative stimulation of zif 268 mRNA by RA was much larger than that of other early genes , including c fos , c jun , and junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
As a homodimer JunB is unable to bind the enhancer ; however in the presence of c Fos , high affinity binding is observed . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Northern analysis indicates that mRNAs for at least six members of the Fos / Jun family ( c fos , fosB , fra 1 , c jun , junB , and junD ) are expressed in activated Ar 5 cells ; thus the AP 1 sites of the IL 2 promoter may bind different dimeric Fos / Jun complexes at different times after T cell activation , perhaps mediating both positive and negative regulation of the IL 2 promoter . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Mutation of an autophosphorylation site at tyrosine 809 in the cytoplasmic domain of human CSF 1R does not significantly reduce its ligand stimulated tyrosine kinase activity , binding to phosphatidylinositol 3 kinase , or induction of the immediate early response genes , c fos and junB ( ref . 2 ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Induction of smooth muscle alpha actin was delayed and sustained after aortic constriction , whereas the nuclear oncogenes c jun and junB were expressed rapidly and transiently , providing potential dimerization partners for transcriptional control by c fos . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto oncogenes including c jun , junD , and junB and to a lesser extent the fos family including c fos and fra 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have characterized the expression of c Jun , JunB , JunD , c Fos , and FosB proteins following serum stimulation of quiescent Swiss 3T3 cells by immunoprecipitation analyses . ^^^ We have shown that c Fos and FosB form complexes in vivo with the different Jun proteins and that JunB complexes are predominant . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Consistent with this result , these cell lines expressed increased levels of mRNAs encoding the AP 1 proteins , c Fos , Fra 1 , c Jun , JunB , and JunD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
To determine whether these proteins are required for cell cycle progression , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , c Jun , JunB , and JunD , and antibodies that recognize either the Fos or the Jun family of proteins , into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The PMA induction of c fos mRNA correlated well with TNF gene induction ; expression of genes encoding other proteins in the AP 1 complex ( junB and junD ) were also induced by PMA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Short term stimulation ( up to 16 hours ) of interleukin 3 ( IL 3 ) dependent mouse bone marrow derived mast cells , Abelson transformed mouse liver derived mast cells , or rat basophilic leukemia cells by either IgE Ag or calcium ionophore A 23187 resulted in inhibition of their proliferation as measured by 3H thymidine incorporation and MTT ( tetrazolium ) assays , and in accumulation of the mRNAs of c fos , c jun , junB and slightly of junD proto oncogenes . ^^^ In addition , the expression of the mRNA of c jun and junB proto onogenes is not coordinately regulated with that of c fos during immunologic stimulation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Like c Fos and Fra 1 , Fra 2 formed stable heterodimers with c Jun , JunB or JunD in vitro and all these complexes had specific DNA binding activity to AP 1 binding sites ( AP 1 sites ) or related sequences . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The induction of transcription of c fos , fosB , c jun , junB and collagenase was studied as well as the mutation rate in the progeny of treated cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Here we show , however , that omission of a single essential amino acid from the medium caused a marked rise in the mRNA levels of c myc , c jun , junB and c fos oncogenes and ornithine decarboxylase ( ODC ) in CHO cells . ^^^ The junB and c fos mRNAs , instead , were increased to the same extent or less by amino acid starvation than by cycloheximide treatment . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
A point mutation at tyrosine 809 in the human colony stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity , association with phosphatidylinositol 3 kinase , or induction of c fos and junB genes . ^^^ The mutant receptor was active as a tyrosine kinase in vitro and in vivo , underwent CSF 1 dependent association with a phosphatidylinositol 3 kinase , and induced expression of the protooncogenes c fos and junB , underscoring its ability to trigger some of the known cellular responses to CSF 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
However , 5 abl regulated FDC P 1 cell growth differed from IL 3 regulated growth in that c fos and junB , which are normally induced by IL 3 , were not induced by activation of 5 abl . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Cytoplasmic levels of c fos and junB mRNAs are rapidly increased by cAMP , and the induction is substantially stronger in the presence of E1A protein . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
It led to an accumulation of milk in the glands and was accompanied by an induction of protein kinase A , AP 1 DNA binding activity and elevated c fos , junB , and junD mRNA levels . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the present study we analysed , by in situ hybridization , the effects of an extremely localized mechanical brain injury , obtained by the simple needle insertion ( 30 g ) in rat hippocampus or cortex , on the expression of several immediate early genes ( c fos , fosB , c jun , junB , junD , zif / 268 ) . ^^^ Maximal effects are detected between 30 and 60 min with the following rank order of induction : zif / 268 > c fos > junB > fosB > c jun > junD . ^^^ On the other hand , when the penetration of the needle is limited to the cerebral cortex the activation of the IEGs ( c fos , fosB , junB and zif / 268 ) spreads throughout the ipsilateral cortex but does not involve the hippocampal region . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Colocalization of NDP with c Jun , JunB , JunD , c Fos , FosB and Krox 24 transcription factors was investigated in neurons of lumbar spinal cord . c Jun , JunB , c Fos and Krox 24 reached their maximal levels of expression 2 h after FOR and returned to basal levels after 10 h . ^^^ In a low number of NDP neurons , suprabasal immunoreactivity of JunB , c Fos and Krox 24 proteins was visible up to 10 h , and of JunD and FosB up to 24 h in sDH neurons ; c Jun was not expressed in NDP labelled neurons of sDH , but , similar as JunD , showed basal colocalization in preganglionic sympathetic and parasympathetic neurons . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Activation of GnRH receptors in cultured pituitary cells and alpha T 3 1 gonadotrophs caused prominent , but transient , increases in messenger RNAs for primary response genes ( PRGs ) including c fos , c jun , and junB . ^^^ GnRH induced stimulation peaked at 30 min and was dose related , with similar EC 50 values ( approximately 1 nM ) for all three PRGs and higher maximum responses for junB than for c jun and c fos . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have used primary neuronal cultures prepared from fetal cerebral hemispheres to investigate the effects of different glutamate receptor agonists and antagonists on the expression of transcription factor encoding genes , such as c fos , fosB , c jun , junB , junD , c myc , and zif / 268 . ^^^ The addition of glutamate ( 100 microM ) to the culture medium rapidly activated c fos , fosB , c jun , junB and zif / 268 gene expression , reaching the maximal level at 30 60 minutes for zif / 268 and at 60 minutes for the other genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The introduction of both murine Kit ( S ) and KitL ( isoform containing a four amino acid insert ) into Wsh / Wsh BMMC restored KL induced proliferation , survival and adhesion to fibronectin , as well as activation of PI 3 kinase , p21ras and MAPK , and induced expression of c fos , junB , c myc and c myb mRNA . ^^^ Substitution of tyrosine 719 in the kinase insert with phenylalanine ( Y719F ) abolished PI 3 kinase activation , diminished c fos and junB induction , and impaired KL induced adhesion of BMMC to fibronectin . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
They also indicate that separate intracellular pathways may be used for induction of jun and fos gene products and that the same transcription factor ( junB ) may be triggered by two surface receptors through separate pathways that differ in PKC dependence . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
JunB and JunD were poorer inhibitors . c Fos expression did not potentiate the negative effect of Jun . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Cross linking of the CD16 / Jak2 protein stimulated increases in c fos and junB similar to IL 3 but did not cause major changes in the levels of the c myc message , which normally increases after IL 3 treatment . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
JunB , Krox 20 , Krox 24 , c Fos , and pan Fos immunoreactivities ( IR ) were not detectable in axotomized septal neurons and CREB IR did not change compared to the intact contralateral side . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Additionally , HGF induced increased transcription of c fos , c jun , junB , junD , and c myc early response genes in both cell lines . ^^^ We therefore suggest that the second messenger proteins PI3K , GAP and NCK , and possibly the protein products of the c fos , c jun , junB , junD and c myc genes , are important elements in the HGF induced mitogenic pathway in the normal mouse epithelial cell lines M 23 and MM55 . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In electrophoretic mobility shift assays using nuclear extracts from cultured cells and primary tissues , several AP 1 proteins ( c Jun , JunB , JunD , and c Fos ) bound the cyclin D 1 954 region . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Further investigations using supershift and shift Western analysis showed that c Fos and JunB bind to the AP 1 element during hypoxia and that these protein levels are stimulated by hypoxia . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
While a large body of literature describes the induction of immediate early genes , including c fos , fosB , c jun , junB , zif / 268 , and krox genes by glutamate and agonists in neurons , very little is known about preexisting transcription factors controlling the induction of such genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Differential induction and regulation of c jun , junB , junD and c fos by human papillomavirus type 11 E5a oncoprotein . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Basal expression of the inducible transcription factors c Jun , JunB , JunD , c Fos , FosB , and Krox 24 in the adult rat brain . ^^^ The expression of c Jun , JunB , JunD , c Fos , FosB , and Krox 24 was investigated in the brain of untreated male Sprague Dawley and female BDIX rats by immunocytochemistry using specific antibodies . ^^^ JunD was expressed at high levels in those areas that also exhibit c Jun , JunB , c Fos , and FosB IR , such as locus coeruleus , periolivary nuclei ( ncl . ) , pontine and central gray , lateral lemniscal ncl . , inferior and superior colliculi , leaflet of geniculate ncl . , midline nuclei of thalamus , dorsomedial and paraventricular ncl . of hypothalamus , ncl . supraopticus , dorsolateral part of caudate putamen and lateral septal ncl . ^^^ In contrast to the high number of JunD positive neurons , c Jun , JunB , c Fos , and FosB proteins were detected in rather low numbers of neurons in these brain areas ; the rank of the number of immunopositive neurons was c Fos > JunB > c Jun > FosB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Vibratome cut sections were immunostained for the detection of c fos , JunB , Krox 24 , somatostatin , substance P , dynorphin , tyrosine hydroxylase , and enkephalin . ^^^ Cryostat cut sections from the caudate were immunostained for the detection of c fos , JunB , and Krox 24 , as well as in situ hybridization for proenkephalin mRNA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The JunB transcription factor together with the c Fos transcription factor is also induced in vivo in the suprachiasmatic nucleus ( SCN ) of rat brain after a light stimulus that induces resetting of the circadian clock . 6 . ^^^ Inhibition of JunB and c Fos expression prevented the light induced phase shift of the circadian rhythm . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Treatment of MO7e cells with SLF , GM CSF , and IL 3 induced / enhanced expression of c fos , junB , egr 1 , and c myc genes . ^^^ SLF treatment of MO7e cells led to higher expression of c fos , junB , and egr 1 genes than did treatment with GM CSF or IL 3 . ^^^ Using optimal dosages for cell proliferation , induction of c fos and junB was greater than additive with SLF plus GM CSF or IL 3 , as compared with each factor alone . ^^^ Using suboptimal amounts of SLF with optimal GM CSF or IL 3 , induction of c fos , junB , egr 1 , and c myc genes was greater than additive . ^^^ Based on nuclear run on and actinomycin D experiments , the data suggest that the synergistic effects of SLF plus GM CSF on the induction of immediate early genes may be mediated in part at the level of transcription and mRNA stabilization for c fos , at the level of mRNA stabilization for junB , and at the level of transcription for egr 1 . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In undifferentiated Tera 2 cells FGF stimulation caused an increase of c fos mRNA , and c jun mRNAs , but no increase of junB mRNA , whereas in the differentiated cells , FGFs strongly stimulated the expression of all three genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We now report that in both quiescent and non quiescent mouse bone marrow derived cultured mast cells ( BMCMC ) rrSCF 164 induces increased mRNA levels for the `` early response genes ' ' c fos , c jun and junB but has only slight effects on the expression of junD . ^^^ However , IL 3 induces increased expression of c fos and junB only in quiescent BMCMC . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
RNAs from several brain regions were analyzed by Northern blot hybridization for their relative concentrations of nine IEG mRNAs ( c fos , c jun , junB , TIS 1 ( nur 77 ) , TIS 7 , TIS 8 ( zif 268 ) , TIS 10 , TIS 11 , and TIS 21 ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The mRNA for the transcription factors ATF 3 , c fos , c jun , junB , and zif / 268 is induced by A 23187 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Indeed , TGF beta upregulated the `` early ' ' genes c myc , c fos , and junB and downregulated the growth arrest specific ( gas ) genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This allowed analysis of the expression of functional glutamate receptor subtypes , examination of their role in controlling intracellular free calcium ( [ Ca2+ ] 1 ) , and determination of their relative contributions to the transcriptional regulation of six immediate early genes c fos , fosB , c jun , junB , zif / 268 ( also termed Egr 1 ; NGFI A ; Krox 24 ) and nur / 77 ( also termed NGFI B ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Activation of TRE regulated genes by NO releasing agents and cGMP analogs appeared to be mediated by the AP 1 ( Jun / Fos ) transcription factor complex because we observed increased DNA binding of AP 1 and increased junB and c fos mRNA in cells treated with these agents . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the present study we have investigated the induction of immediate early gene ( IEG ) c fos , c jun , junB and junD mRNAs and proteins in interstitial cells of rat testis after hCG treatment in vivo using in situ hybridization and immunocytochemistry . ^^^ A prominent induction of c fos , c jun and junB mRNAs and proteins in Leydig cells was seen after hCG treatment . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The effect of a single injection of caffeine on the expression of c fos , c jun , junB , and junD , on activator protein 1 ( AP 1 ) and on the levels of preproenkephalin mRNA in rat striatum was studied . ^^^ By using in situ hybridization of adjacent sections we found a rapid , transient , and dose dependent increase of c fos , c jun , and junB by caffeine in striatum , especially in the lateral part . ^^^ A strong induction of junB , a weak induction of c fos and c jun , but not of junD , was seen in nucleus accumbens . ^^^ Furthermore , by using gel shift assay we found an induction of AP 1 by caffeine ( 100 mg / kg ) in striatum , which peaked 2 hr after administration and was clearly increased after 4 hr . c Fos , c Jun , and JunB proteins were components of the AP 1 . ^^^ The data show that a single dose of caffeine induces a temporally and spatially characteristic pattern of c fos , c jun , and junB induction , followed by changes in AP 1 and preproenkephalin mRNA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The expression of seven immediate early gene encoded transcription factors ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif / 268 ) was assessed simultaneously . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Exposure of VSMCs to rHuEpo for various times gradually increased the levels of c myc and junB and transiently induced c fos expression , as determined by Northern analysis . rHuEpo induced DNA synthesis was markedly enhanced in VSMCs from SHR compared to those from WKY . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NMDA and D 1 receptors mediate induction of c fos and junB genes in striatum following morphine administration : implications for studies of memory . ^^^ The c fos and junB immediate early genes ( IEGs ) were induced in neurons of the medial and ventral striatum following administration of morphine . ^^^ The striatal induction of c fos and junB mRNA and Fos protein was blocked by naloxone , the D 1 dopamine ( DA ) receptor antagonists , SCH 23390 and SCH 39166 , and the N methyl D aspartate ( NMDA ) glutamate receptor antagonist , MK 801 . ^^^ SCH 23390 and MK 801 did not block morphine induction of c fos and junB in septum . ^^^ Since the pattern of the morphine induction of c fos and junB in striatum and nucleus accumbens was similar to that observed with cocaine and amphetamine [ 2 , 18 , 45 , 51 ] , these data support current concepts that limbic striatum and nucleus accumbens are among the brain regions that mediate drug abuse [ 9 , 10 , 23 , 27 , 49 ] . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Addition of PDGF BB to cells expressing the PDGF beta receptor activated the PDGF beta receptor tyrosine kinase , stimulated mitogen activated protein ( MAP ) kinase , and increased the steady state levels of junB and c fos mRNAs . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
BHQ induced expression of c jun , junB , fra 1 , and fra 2 , which encode AP 1 components , but was a poor inducer of c fos and had no effect on fosB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Block of c Fos and JunB expression by antisense oligonucleotides inhibits light induced phase shifts of the mammalian circadian clock . ^^^ Light induced phase shifts of circadian rhythmic locomotor activity are associated with the expression of c Jun , JunB , c Fos and FosB transcription factors in the rat suprachiasmatic nucleus , as shown in the present study . ^^^ In order to explore the importance of c Fos and JunB , the predominantly expressed AP 1 proteins for the phase shifting effects of light , we blocked the expression of c Fos and JunB in the suprachiasmatic nucleus of male rats , housed under constant darkness , by intracerebroventricular application of 2 microliters of 1 mM antisense phosphorothioate oligodeoxynucleotides ( ASO ) specifically directed against c fos and junB mRNA . ^^^ ASO strongly reduced the light induced expression of c Fos and JunB proteins . ^^^ In contrast , light pulses with or without the control nonsense oligodeoxynucleotides evoked strong nuclear c Fos and JunB immunoreactivity in the rat suprachiasmatic nucleus . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using model spontaneously reverting cell lines , c jun , junB , junD and c fos oncogene expression was investigated . c jun , but not junB , junD or c fos , was overexpressed in highly tumorigenic clones . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
These sequences encode potential dominant negative variants of c Fos , JunB , and p44MAPK that may interfere with their growth related functions . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This study was undertaken to assess the effects of a single or two sequential topical applications of 12 O tetradecanoylphorbol 13 acetate ( TPA ) on the expression of c fos , c jun , junB , c myc , and ornithine decarboxylase ( ODC ) in promotion sensitive SSIN mice and the relatively promotion resistant C57BL / 6 strain . ^^^ In contrast , two treatments of SSIN mice with TPA caused a rapid , strong c fos induction 1 2 h after treatment , whereas C57BL / 6 mice responded no more strongly than after a single treatment . c jun mRNA and protein were induced only slightly in either strain , but junB was induced about fivefold in SSIN mice and tenfold in C57BL / 6 mice . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We examined the expression of c Fos and JunB in four immunohistochemical subtypes of enteric neurones in the guinea pig ileum . ^^^ In whole mount preparations of the myenteric and submucous plexuses from isolated segments incubated in normal Krebs ' solution , increased numbers of many cells expressed visible c Fos and JunB immunoreactivities . ^^^ Depolarizing stimulation by veratridine or 50 mM K+ induced further increases of neuronal c Fos and JunB expression with no obvious subtype preference . ^^^ This probably reflected a non specific activation of most enteric neurones by these stimuli and supports the idea that expression of c Fos and JunB in most or all enteric neurones may be a useful determinant of activation . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The alpha 1 adrenoreceptor linked c Fos protein , which is coordinately induced with JunB , does not form a stable component of nocturnal activator protein 1 activity . ^^^ Immunoblotting has demonstrated parallel accumulation of JunB and c Fos protein in pineal nuclear fractions following stimulation both in vivo and in vitro . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Middle cerebral artery ( MCA ) occlusion in rats induced c fos and junB mRNA 4h later in all ipsilateral cortex outside the MCA distribution and in many subcortical structures : medial striatum ; most of thalamus including medial and lateral geniculate nuclei : substantia nigra ; and hippocampus . ^^^ The N methyl D aspartate ( NMDA ) antagonist , MK 801 ( 4 mg / kg , i . p . ) inhibited c fos and junB mRNA induction in the cortex , striatum , thalamus , and hippocampus but not in the substantia nigra . ^^^ These data show that c fos and junB mRNA induction in cortex , striatum , thalamus , hippocampus involves the activation of NMDA receptors whereas different receptors must be implicated in the induction in substantia nigra . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Exposure of HT 1080 cells to OA resulted in marked and persistent induction of junB , junD , and c fos mRNA levels up to 24 h , while c jun mRNA levels were only slightly elevated . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
JunB , but not c jun , mRNA expression was found under these conditions in addition to a transient c fos mRNA increase . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Neuronal regulation of c fos , c jun , and junB immediate early genes in rat adrenal medulla . ^^^ We have applied in situ hybridization histochemistry , Northern analysis , and immunocytochemistry to study the regulation of the immediate early gene ( IEG ) c fos , c jun , and junB mRNAs and the respective proteins in the rat adrenal medulla . ^^^ Stimulation with nicotine also caused a drastic increase in the mRNA levels , whereas muscarine only induced moderate elevations . c fos and c jun were induced strongly in adrenaline cells and only weakly in noradrenaline cells . junB was upregulated mainly in adrenaline cells . ^^^ The present results demonstrate that neurotransmitters released from splanchnic nerve terminals induce expression of c fos , c jun , and junB in adrenal chromaffin cells which results in increased AP 1 DNA binding activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Rat hearts infused with the beta adrenergic agonist isoproterenol were examined for the expression of several nuclear proto oncogenes ( c fos , fosB , c jun , junB , and junD ) and the immediate early gene Egr 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In addition to c fos mRNA and zif / 268 mRNA , neurones in both the striatum and nucleus accumbens were found to contain high levels of junB mRNA , after treatment with either haloperidol or fluphenazine . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Differential regulation of c fos , fosB , c jun , junB , bcl 2 and bax expression in rat skin following single or chronic ultraviolet irradiation and in vivo modulation by antisense oligodeoxynucleotide superfusion . ^^^ To obtain information in vivo about a possible relationship between u . v . induced proto oncogene expression and cellular alterations , we have analysed the expression of c fos , fosB , c jun , junB , bcl 2 and bax in rat epidermis after single and chronic u . v . irradiation . ^^^ Single u . v . irradiation causes a rapid and sustained increase in c jun , junB and c fos mRNA and a decline in bcl 2 transcripts , whereas expression of bax remained unchanged . c Fos and c Jun immunoreactivity was localized throughout the epidermal cell layers 1 . 5 h after single irradiation , but restricted to basal cells at 48 h suggesting an involvement in both u . v . induced apoptosis and hyperproliferation . 48 h after chronic exposure a significantly higher induction and a totally different pattern of epidermal proto oncogene expression was detectable which may be associated with malignancy . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
To determine if axotomy induced immediate early gene ( IEG ) expression accompanies regenerative efforts in central nervous system ( CNS ) neurons , immunohistochemistry using antibodies to c Jun , JunD , JunB , c Fos , FosB and Krox 24 proteins was used to examine gene expression in identified adult rat retinal ganglion cells ( RGCs ) under two conditions : ( 1 ) after axotomy alone , and ( 2 ) 1 month after replacement of the optic nerve with an autologous peripheral nerve graft to allow axonal regrowth . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This factor bound JunB , JunD and Fos antibodies . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Repression was relatively selective for c fos / c jun ; induction of other immediate early transcription factors ( junB , c myc , and egr 1 ) was not downregulated by RA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The AP 1 site binding complex ( es ) induced by all three treatments reacted with antibodies directed broadly against fos and jun protooncogene families and against the specific family members c fos , junB , and junD but not c jun proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
A mechanism is suggested whereby expression of c jun and junB , in the absence of members of the fos family , can prevent inappropriate activation of T cells caused by ligation of CD 28 in the absence of a specific antigenic stimulus . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Although CREB , c Fos , c Jun , and JunD did not have significant effects , JunB inhibited the Tax dependent transactivation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Our results showed that EGF treatment caused rapid increases in c fos , c jun , and junB expression ( P < 0 . 001 ) in both cell lines . c fos and c jun followed similar time courses , peaking at 30 min , whereas junB levels plateaued at 1 hr . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Acute administration of the typical neuroleptic haloperidol ( HAL , 2 mg / kg ) induced the immediate early gene proteins ( IEGPs ) c Fos , Fos related antigens ( FRAs ) , FosB , JunB , JunD and Krox 24 in the striatum and nucleus accumbens of the rat brain . ^^^ In contrast , acute administration of the atypical antipsychotic drug clozapine ( CLOZ , 30 mg / kg ) induced only FRAs , JunB and Krox 24 IEGPs in the striatum , and c Fos , FRAs , and Krox 24 IEGPs in the nucleus accumbens . c Jun was not induced by acute administration of HAL or CLOZ in the rat brain . ^^^ Specifically , CLOZ induces FRAs in the islands of Calleja and lateral septum and this action may be involved in its therapeutic effects on the negative symptoms of schizophrenia , whereas HAL produces a coordinate induction of Fos and JunB in striatal neurons and this dimer combination may be involved in producing the extrapyramidal side effects of typical neuroleptics . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Induction of c fos , junB , c jun , and hsp 70 mRNA in cortex , thalamus , basal ganglia , and hippocampus following middle cerebral artery occlusion . ^^^ Middle cerebral artery ( MCA ) occlusion in halothane anesthetized rats induced c fos , junB , and c jun immediate early gene mRNAs and hsp 70 heat shock gene mRNA in brain . ^^^ In situ hybridization studies showed that c fos and junB were induced throughout all of the cortex at 1 and 4 h following MCA occlusion . hsp 70 was induced in the core and margins of the MCA ischemia . ^^^ By 24 h , there was little expression of c fos , junB , c jun , and hsp 70 in the core of the MCA infarct ; there was modest induction of hsp 70 at the margins of the infarct ; and there was diffuse induction of c fos , junB , and c jun in all of the cortex outside the infarct . ^^^ MCA occlusion also induced these genes in subcortical structures . c fos , junB , and hsp 70 were induced in ipsilateral medial striatum , most of thalamus including medial and lateral geniculate nuclei , substantia nigra , and hippocampus . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We demonstrate that isolation of hepatocytes from the normal quiescent rat liver by collagenase perfusion activates the immediate early growth response program , as indicated by increased expression of c jun , junB , c fos , and c myc mRNAs . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
These induced complexes in turn correlate with the activity of the c fos , egr 1 , and junB promoters . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
IGF 1 stimulates the expression of c fos , c jun , junB , and egr 1 . ^^^ In contrast , TSH stimulates c fos and junB but not egr 1 expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Transcription of a variety of genes , including c fos , c jun , and junB , is increased in these cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Morphine induces c fos and junB in striatum and nucleus accumbens via D 1 and N methyl D aspartate receptors . ^^^ Morphine induced the c fos and junB immediate early genes in neurons of the medial and ventral striatum and nucleus accumbens . ^^^ Induction of c fos and junB mRNA and Fos protein was blocked by naloxone , the D 1 dopamine ( DA ) receptor antagonists SCH 23390 and SCH 39166 , and the N methyl D aspartate ( NMDA ) glutamate receptor antagonist MK 801 . ^^^ SCH 23390 attenuated morphine induction of AP 1 binding in striatum , suggesting that c fos and junB contribute to AP 1 binding . ^^^ SCH 23390 and MK 801 did not block morphine induction of c fos and junB in septum . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In MCT cells , an SV 40 transformed mouse proximal tubule cell line , incubation in acid media led to transient increases in c fos , c jun , junB , and egr 1 mRNA abundance , peaking at 30 min to 1 h . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have characterized the genomic response of astroglial cells to excitatory amino acids by using selective agonists and antagonists for the various receptor subtypes and by analyzing different primary response genes , such as members of the Fos ( c fos and fosB ) and Jun ( c jun , junB , and junD ) families , zif / 268 , and c myc . ^^^ A rapid and transient elevation of mRNA levels for c fos , fosB , c jun , junB , and zif / 268 was observed after addition of glutamate to cultured astrocytes , whereas junD and c myc expression was not affected . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Differential expression of the immediate early genes c fos , c jun , junB , and NGFI B in the rat brain following transient forebrain ischemia . ^^^ The temporospatial expression pattern of four immediate early genes ( IEGs ) ( c fos , c jun , junB , NGFI B ) following 30 min of global ischemia was investigated in rat brains by in situ hybridization and immunohistochemistry ( c fos ) . ^^^ Compared to c fos and c jun , junB induction was less pronounced and confined largely to the dentate gyrus . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Immediate early gene expression was examined by Northern blotting : both thrombin and PDGF induced egr 1 , c fos , c jun , junB , and fra 1 mRNAs within 15 min ; the response was maximal at 30 60 min ( increases ranging from 2 . 9 to 9 . 3 fold over control serum deprived cells ) and returned to base line levels within 2 4 h . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Elevated nuclear protein kinase A ( PKA ) activity was observed from one day post lactation , paralleled by increased c fos , junB , junD and to a lesser extent c jun mRNA levels . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Exposure of VSMCs to rHuEpo for various periods gradually increased the levels of c myc and JunB mRNAs and transiently induced c fos mRNA expression as determined by Northern analysis . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Repression in c jun and junB inducibility in adipocytes results from transcriptional mechanisms , can be reversed by treatment with protein synthesis inhibitors or higher serum concentrations , and does not affect c fos or c myc expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In contrast , the 50 train stimulus pattern resulted in a robust induction of c fos and c jun mRNA , in addition to zif 268 and junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Immunohistochemistry and gel mobility shift assays suggest that AP 1 activity during the night and after a light pulse consists of constant , as well as variable , protein components ; JunD could be identified as a constituent of both dark and light activated binding complexes , whereas binding by JunB and Fos could be implicated only after photic stimulation . ^^^ Since JunD or JunB could be colocalized with Fos in individual suprachiasmatic nucleus cell nuclei , light may be acting in at least some suprachiasmatic nucleus cells by altering AP 1 protein composition rather than binding site occupancy . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In situ hybridization was used to assess regional levels of four immediate early gene messenger RNA levels ( c fos , c jun , junB , and a nerve growth factor induced gene , NGFI A ) . ^^^ Messenger RNA levels were highest at 25 min following infusion of N methyl DL aspartate . c jun messenger RNA levels remained elevated for over 2 h ; however , c fos , junB and , NGFI A messenger RNA levels had returned to control levels by this time . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
As OA did not synergize with PMA in the induction of expression of genes encoding the AP 1 proteins ( c fos , c jun , junB ) , it is likely that OA potentiates the AP 1 enhancer activity by its effect on protein phosphorylation . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using antibodies specific for different Ets and AP 1 family members , we demonstrate that the major inducible PB 1 binding activity present in activated T cell nuclear extracts is composed of the Elf 1 , c Fos , and JunB transcription factors . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Stimulation of the cyclic GMP pathway by NO induces expression of the immediate early genes c fos and junB in PC 12 cells . ^^^ Stimulation of several second messenger pathways induces the expression of immediate early genes such as c fos , c jun , junB , and junD , but little is known about their induction via the stimulation of the cyclic GMP pathway . ^^^ We found that expression of c fos and junB but not of c jun or junD is increased upon activation of cyclic GMP pathway . c fos mRNA expression was the most activated ( fourfold at 30 min ) , whereas junB response was more modest ( 2 . 2 fold activation at 60 min ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Increases in mRNA levels for c fos , c jun , junB , hsp 70 and NGFI A were observed in the dentate gyrus of the hippocampus following 7 min ischaemia in the Mongolian gerbil . ^^^ The response was rapid and transient ( 30 min to 4 hr ) for NGFI A , junB and c fos mRNA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Nuclear levels of c Jun , JunB , c Fos , and LRF 1 ( liver regeneration factor ) are high for a large fraction of the G 1 phase in regenerating liver and mitogen stimulated hepatic cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Nuclear run on transcription and / or Northern blot RNA analysis indicate that c jun , junB , jun D , c fos , TIS 1 ( also called NGFI B or nur / 77 ) and TIS 8 ( zif 268 , krox 24 , egr 1 , or NGFI A ) genes are all transiently activated in the uterus ( up to 20 fold ) within 30 120 min after treatment of adult ovariectomized rats with a mitogenic dose of 17b estradiol . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In accordance with this delay , the induction of mRNA level of ' immediate early genes ' such as c myc , c fos , c jun and junB by TGF beta has slower kinetics compared with those of EGF . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This study tests the hypothesis that the protooncogenes c fos , c myc , c jun , and junB are involved in the mechanism by which polyamines modulate mucosal growth . ^^^ Cellular polyamine levels , cell growth , and relative abundance of c fos , c myc , c jun , and junB mRNAs , were measured at 1 , 2 , 4 , 6 , 8 , and 12 days after initial plating . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This effect is associated with acid induced increases in a number of immediate early genes , including c fos , c jun , junB , and egr 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The results demonstrate that , in contrast to U 937 cells , the TUR line fails to respond to TPA with induction of the c jun , junB , c fos , and EGR 1 early response genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In both human K 562 myelogenous leukemia and rat PC 12 pheochromocytoma cells , activin treatment caused transient transcription dependent and protein synthesis independent increases of junB messenger RNA ( mRNA ) within 1 h , whereas neither c jun nor c fos mRNA were inducible . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In situ hybridization and Northern blot analysis were used to examine expression of the immediate early response genes ( IEGs ) egr 1 , junB , and c fos , and the late response gene encoding enkephalin in the brains of rats infected intranasally with Borna disease virus ( BDV ) or rabies virus . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Since we previously found that activation of mast cells by IgE antigen ( Ag ) induces the mRNA accumulation of c fos , c jun , junB and junD proto oncogenes , we were prompted to investigate whether serum could affect such accumulation in these cells . ^^^ Mast cells , which were cultured in the presence of fetal calf serum ( FCS ) , were characterized by a high proliferation rate and high accumulation of the mRNA of c fos , junB and junD proto oncogenes . ^^^ After sustained FCS deprivation both DNA synthesis and the level of c fos mRNA were significantly decreased , as expected , whereas the level of c jun , junB and junD mRNA were not affected . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The proto oncogenes c jun , junB , junD , and c fos recently have been shown to encode for transcription factors with a leucine zipper that mediates dimerization to constitute active transcription factors ; juns were shown to dimerize with each other and with c fos , whereas fos was shown to dimerize only with juns . ^^^ To gain further insights into the role of fos / jun in normal myelopoiesis and leukemogenicity , M1fos and M1junB cell lines , which constitutively express c fos and junB , respectively , were established . ^^^ It was shown that enforced expression of c fos , and to a lesser extent junB , in M 1 cells results in both an increased propensity to differentiate and a reduction in the aggressiveness of the M 1 leukemic phenotype . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The serum induction of c fos and junD as well as the serum and TPA ( 12 O tetradecanoylphorbol 13 acetate ) induction of junB and egr 1 are almost completely abolished . ^^^ Only 5 fos can transform CHP 25 , whereas c fos , 5 myc , c jun and junB are ineffective . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using a seasonal breeder , the European red fox ( Vulpes vulpes ) , as our model , we have examined the expression of five AP 1 family members ( c fos , fra 1 , fra 2 , c jun and junB ) with a view to elucidating their role in the regulation of spermatogenesis . ^^^ Unique patterns of expression , falling into three broad categories , were observed for the five genes : ( 1 ) continuous expression throughout the spermatogenic cycle ( c fos ) ; ( 2 ) expression only at times corresponding to the onset and shutdown of spermatogenesis ( fra 1 , fra 2 and c jun ) ; and ( 3 ) expression only at the onset of the cycle ( junB ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Overexpression of cJun or JunD , but not JunB , also eliminates the requirement for PMA , indicating that many but not all Jun and Fos related proteins functionally activate NF AT dependent transcription in the presence of the cytoplasmic component . ^^^ Fos proteins are not needed for this reconstitution , and although JunB is not functional , it can participate in the NF AT DNA binding complex . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Elevated binding activity of AP 1 also correlated with elevated levels of c jun , junD , junB , and c fos mRNAs . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This phenomenon reflects an enhancement of the cellular pool of NGF mRNA , already noticeable after 3 h of treatment , which is preceded by a temporary activation of protooncogenes encoding transcription factors of the AP 1 family , such as c fos , c jun or junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
PC PLC mimicked CSF 1 action by elevating c fos and junB mRNAs to 40 % of the level induced by CSF 1 ; however , PC PLC induced c myc mRNA to only 5 % of the level in CSF 1 stimulated cells . ^^^ Therefore , PC PLC is a component of a signal transduction pathway leading to transcription of c fos and junB that collaborates with c myc and is independent of PKC delta and Ras activation . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Northern blots were prepared from cortex , thalamus , cerebellum , pons and hypothalamus and hybridized with cDNA probes to five IEG mRNAs ; c fos , c jun , junB , NGFI A and NGFI B . ^^^ In contrast to c fos , c jun mRNA was essentially invariant among the animals while junB mRNA was inconsistently elevated . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Within 15 minutes of balloon injury , mRNA levels of c fos , fosB , c jun , junB , and junD were elevated severalfold . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Seizures elicited by chemoconvulsants induced expression of mRNA for c fos , c jun , and junB and Fos like immunoreactivity in lung tissue . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Presentation of a short light pulse during the subjective night [ i . e . circadian time ( CT ) 14 or 19 ] , when light induced phase shifting of activity rest cycles can be accomplished , also induces expression of the immediate early genes c fos and junB in the rodent SCN . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Cell lines isolated from Fos Jun transgenic tumors expressed high levels of both transgenes but significantly lower levels of the jun related gene junB compared with cells expressing only a c fos transgene . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using in situ hybridization , the expression of c fos , fosB , fra 1 , fra 2 , c jun and junB was studied after 15 min of normothermic and hypothermic ( 33 degrees C ) transient forebrain ischaemia in the rat , induced by common carotid occlusion combined with systemic hypotension . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
JunB was induced in the same regions of the caudate putamen as found for c Fos , but was not induced in the nucleus accumbens or thalamus . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Prolactin ( PRL ) injected subcutaneously increased hepatic ODC activity as well as mRNA levels of ODC and the proto oncogenes c fos , c jun , junB , junD , c myc , and max . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Glutathione s transferase B ATF heterodimerizes efficiently with in vitro translated JunB , c Jun , and JunD , but only weakly associates with c Fos . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Experiments were performed on pheochromocytoma 12 ( PC 12 ) , hepatoblastoma ( Hep3B ) , neuroblastoma and fibroblast cells that were exposed either to normoxia ( 21 % O 2 ) or to hypoxia ( 5 % O 2 ) for one hour . mRNAs for c fos , c jun , junB , junD were analyzed by northern blot assay . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using a glutathione S transferase ( GST ) fusion protein system , we show that E 7 complexes with AP 1 transcription factors including c Jun , JunB , JunD and c Fos . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
When Ba / F3 FF cells were stimulated with Epo or IL 3 , rapid induction of c myc , c fos , c jun and junB genes was observed . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
TCDD did not increase mRNA of c fos , c jun , junB or junD ( in contrast to TPA which markedly increased the expression of c fos and junB ) , nor did TCDD increase AP 1 activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We therefore cotransfected ventricular myocytes with Fos , Jun , or JunB , and SkA reporter genes . ^^^ SkA transcription was augmented by Jun , Fos / Jun , Fos / JunB , and Jun / JunB ; Fos and JunB alone were neutral or inhibitory . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In bovine chromaffin cells forskolin , phorbol ester , or high potassium levels induce a rapid increase of c fos , c jun , and junB mRNA levels , which precede an induction of proenkephalin gene expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have previously shown that extracellular ATP , like norepinephrine ( NE ) and many other hypertrophy inducing agents , increases expression of the immediate early genes c fos and junB in cultured neonatal cardiac myocytes but that the intracellular signaling pathways activated by ATP and responsible for these changes differ from those stimulated by NE . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Brief visual stimulation ( 2 hr ) added c Fos , c Jun , and JunB to this complex , whereas prolonged stimulation ( 6 24 hr ) reduced c Fos and c Jun levels significantly , leaving only FosB , JunB , and JunD as the major components of AP 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Nine of these genes ( H ras , c myc , c fos , c jun , junB , N myc , c abl , c yes , and p 53 ) were expressed in epithelial cells , whereas two ( RB 1 and N ras ) were not . expression of four other genes ( c src , K ras , c raf , and c myb ) was observed , but the intensity of these bands was too low for densitometric analysis . ^^^ The steady state levels of transcripts of H ras and five nuclear protooncogenes ( c myc , c fos , c jun , junB , and N myc ) were lower in epithelial cells from involved or uninvolved IBD samples than in normal epithelial cells from either sporadic colon cancer or diverticulitis patients . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Calcium induced AP 1 DNA binding complexes consist of Fra 1 , Fra 2 , c Jun , JunB and JunD and are independent of c Fos , since the induction of DNA binding activity and the composition of the AP 1 binding complexes are identical in differentiating keratinocytes derived from c fos null and wild type mice . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Experiments with antisera to the AP 1 family of transcription factors indicated that c fos and JunB bind to the IL 5 CLE 0 in activated lymphoma cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Pretreatment with the four preventive agents commonly inhibited TNF alpha mRNA expression and TNF alpha release in BALB / 3T3 cells induced by a tumor promoter , okadaic acid , whereas the expression of early response genes ( c jun , junB , c fos , and fosB ) was enhanced . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Suppression by the PKC pathway is not mediated by the proto oncogenes c fos , c jun and junB , as the co transfection of these genes does not block the effects of the PKA stimulator 8 Br cAMP . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Irradiation dramatically increased the level of the p 53 transcription factor and the abundances of mRNAs coding for the cell cycle inhibitor p21 / Waf 1 / Cip 1 and the AP 1 associated transcription factors Fos and JunB . ^^^ These results indicate that radiation elicited apoptosis of fetal brain cells is associated with activation of the p 53 system , probable increases in AP 1 Fos / JunB heterodimers , and an increased ratio of Bax to Bcl 2 + Bcl xL . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The PKC activation with phorbol esters induced the expression of c fos , c jun , and junB proto oncogenes in F 9 stem cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Regionally and temporally distinct patterns of induction of c fos , c jun and junB mRNAs following experimental brain injury in the rat . ^^^ Lateral ( parasagittal ) fluid percussion brain injury of mild ( 1 . 0 1 . 5 atm ) and moderate ( 2 . 1 2 . 4 atm ) severity induced expression of mRNAs for the immediate early genes ( IEGs ) c fos , c jun and junB . ^^^ At 5 min following mild brain injury , c fos and junB mRNA were co induced in the cortex ipsilateral to the impact site . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The AP 1 protein complex at 21 days postnatally was composed of JunD , JunB , Fra 2 , FosB and to much lesser extent of c Fos in both cortical areas . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Not altered in most hypertrophied hearts was expression of c fos , junB , p 53 , c neu , c myc , HSP 70 , HSP 27 , TGF beta or IGF 1 mRNAs . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Defective transcription of the IL 2 gene is associated with impaired expression of c Fos , FosB , and JunB in anergic T helper 1 cells . ^^^ Western blot analysis of nuclear extracts showed that the impaired DNA protein interactions in anergic T cells were associated with poor expression of the inducible AP 1 family members c Fos , FosB , and JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using IMR fibroblasts , we found that prostaglandin E 1 ( PGE 1 ) and forskolin , stimulators of cAMP accumulation in young and senescent cells , increased abundance of c fos and junB mRNA more in young than senescent cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The PPs Wy 14643 , mono ethylhexyl phthalate , clofibrate , and ciprofibrate ethyl ester were found to be potent inducers of immediate early gene expression ( including c fos , c jun , junB , egr 1 , NUP 475 , and to a lesser extent fosB , JE , and KC , with maximal expression seen 1 h after treatment of serum deprived quiescent cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Northern analysis showed increases in fosB , c fos , and junB mRNA levels in both proximal jejunum and colon . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
RESULTS : Cotransfection of HIV 1 provirus and expression plasmids for c Jun or JunB into SW 480 cells resulted in increased p 24 core antigen and this response was markedly increased following PMA stimulation of cells . c Fos or JunD alone did not increase p 24 production but markedly increased p 24 production in PMA stimulated cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Analysis of the accumulation of mRNA encoding members of the AP 1 transcription factor family demonstrated that c fos and junB are also expressed upon stimulation of NK and T cells with IL 2 , but not IL 12 , whereas expression of c jun and junD is not modified by either cytokine . ^^^ Our data provide the first demonstration that IL 12 mediated activation of T and NK cells does not involve expression of members of the immediate early activation genes family ( egr 1 , c fos , and junB ) , AP 1 transcriptional activity , or bcl 2 expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The effects of intracerebroventricular ( i . c . v . ) injections of angiotensin 2 ( Ang 2 ) on the expression of inducible transcription factors ( ITF ) ( c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 ) in the brain of conscious rats were assessed immunohistochemically using polyclonal antisera . ^^^ Ang 2 ( 1 , 10 , 100 ng ) induced after 90 min a dose dependent expression of c Fos , FosB , c Jun , JunB and Krox 24 , which was confined to four specific brain areas , namely the subfornical organ ( SFO ) , median preoptic area ( MnPO ) , paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Analysis of the induced binding complexes indicates that c fos , c jun , and ATF 2 were present , but also two additional jun family members , JunB and JunD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In a previous study , we have shown that treatment of mouse hepatoma cells with TCDD or B ( a ) P results in an increase in mRNA levels of the immediate early protooncogenes c fos , c jun , junB , and junD , and the concomitant increase of the DNA binding activity of the transcription factor AP 1 , a dimer of FOS and JUN proteins . ^^^ In mouse hepatoma Hepa 1 cells , which have Ah receptor ( AHR ) and Ah receptor nuclear translocator ( ARNT ) proteins , inclusion of TRE , SRE , and the AhRE motifs from c jun and junD , but not CRE or the AhREs from c fos , fosB , and junB , causes a large TCDD dependent increase in luciferase expression . ^^^ In agreement with these results , c jun and junD , but not c fos , fosB , and junB AhREs , competed with a canonical Cyp1A1 AhRE for binding to the AHR ARNT heterodimeric complex . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the presence of CGRP , c fos and junB mRNAs accumulated in microglial cultures , whereas no significant change in c jun and TIS 11 mRNAs occurred . ^^^ In contrast to the selective induction of c fos and junB by CGRP and forskolin , ATP led to the accumulation of all four immediate early genes studied , i . e . , c fos , junB , c jun , and TIS 11 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Perhaps most interestingly , vandate induced mitogenesis is associated with the selective induction of c jun and junB expression without significantly inducing c fos or c myc . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Exposure of human neuroblastoma SH SY5Y cells to ethanol for 2 4 days caused a dose dependent increase in c jun and junD mRNA levels , whereas mRNAs for c fos , fosB and junB were not detectable in control or ethanol treated cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Induction of c fos , c jun , junB and junD mRNA and AP 1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) and its relationship to cell death , mutation induction and chromosomal instability . ^^^ To address the questions of whether ( a ) methylating agents that are powerful carcinogens are effective in induction of fos and jun mRNAs , ( b ) induction is affected by the repair capacity of the cells , and ( c ) induction is accompanied by genotoxic effects , the levels of c fos , c jun , junB and junD mRNA were analysed in isogenic Chinese hamster cell lines deficient ( phenotypically Mex ) and proficient ( Mex+ ) for the DNA repair protein O 6 methylguanine DNA methyltransferase ( MGMT ) after treatment with N methyl N ' nitro N nitrosoguanidine ( MNNG ) and methyl methanesulfonate ( MMS ) . ^^^ Most responsive were c fos and c jun ( up to 80 fold increases in mRNA level ) whereas junB ( up to ninefold ) and junD ( up to twofold ) displayed an intermediate and weak response , respectively . ^^^ However , for MMS and UV light , which was included in this study for comparison , c fos , c jun , junB and junD mRNA as well as AP 1 induction paralleled the dose response for induction of cell killing effects , recombination and chromosomal breakage indicating that increased expression of Fos and Jun is related to the generation of MMS and UV induced genetic changes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Antisense c fos oligonucleotides injected into the neostriatum of conscious rats selectively inhibited c fos expression associated with compensatory increases in striatal c fos mRNA levels and also with increased expression of junB and NGFI A mRNA , probably as a result of regulatory phenomena . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This activity was shown to involve c Fos , c Jun and JunB . ^^^ CsA consistently augmented ionomycin induced c fos mRNA expression and more variably that of JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The immediate early genes , c fos , c jun and junB were observed to be bilaterally induced in the cortex and hippocampus as early as 5 min following lateral fluid percussion ( FP ) brain injury in the rat . ^^^ While levels of c fos and junB mRNA returned to control levels by 2h , c jun mRNA remained elevated up to 6h post injury . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
While IgM signalling recruits c Fos , JunB and Elf 1 ( NFAB 1 ) , only JunB and Elf 1 were observed following CD 40 signalling ( NFAB 2 ) . ^^^ CD 40 signalling , however , induces a Fos family related partner for JunB , which may account for the transcriptional activity observed by NFAB 2 in K 46 cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The degradation of phosphatidylcholine during G 1 signals the downstream activation of c fos and junB transcription and can be mimicked by incubation of the macrophage cells with exogenous bacterial phospholipase C . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Because both fra 1 and junB overexpression negatively interferes with c jun / c fos trans activation of AP 1 responsive genes , our results suggest that the observed block in viral transcription is mainly the consequence of an antioxidant induced reconstitution of the AP 1 transcription complex . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
However , V 3 BH10 enhanced IL 2 induced mRNA expression of c fos but not c myc or junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Immunoblot analyses were performed with specific antibody against BCL 2 , BCL XS / L , BAX , JUNB , c JUN , ICH 1L , c FOS , RB , CDK 2 , and p 53 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Our results demonstrated that c fos , c jun , and junB were differently expressed in the ovine trophoblast around the time of implantation . ^^^ Immunohistochemical studies indicated that JunB , like C Fos and interferon tau , was no longer expressed in the trophoblastic cells which had established cellular contacts with the uterine epithelium . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the conceptus , the steady state concentrations of c fos , c jun , junB and junD mRNAs were induced , peaking at 0 . 5 hr and returning to base line by 1 to 2 hr in the embryo and by 1 to 6 hr in the yolk sac . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In order to establish what role members of the activating protein 1 ( AP 1 ) gene families , i . e . , c fos , c jun , junB , and junD , play in thymic apoptosis , we have analyzed changes in their expression in response to three different agents : a glucocorticoid analog dexamethasone , an inhibitor of topoisomerase 2 teniposide VM 26 , and gamma radiation . ^^^ There was a rapid and transient increase in the steady state mRNA level of junB and c fos genes in all treatments , including control cultures , reminiscent rather of cellular stress response to the environmental changes than to the apoptotic stimuli . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Results from super shift and shift Western assays showed that a heterodimer consisting of c Fos and JunB binds to the AP 1 site during hypoxia . ^^^ We also found that the genes that encode the c Fos and JunB transcription factor proteins are regulated by reduced O 2 tension . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
RESULTS : Cotransfection of cells with Tat / Jun and the AP 1 PL LUC or LTR AP 1 CAT reporter plasmid resulted in a marked increase in reporter gene activity which was comparable with that induced by transfection of cells with several different AP 1 expression plasmids ( e . g . , JunD , JunB , c Fos ) , or that elicited by stimulation of the cells transfected with LTR AP 1 CAT plasmids with phorbol ester or tumor necrosis factor alpha . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using antibodies to transcription factors of the Fos and Jun families , we show that the nuclear proteins comprising the inducible TH AP 1 complex include c Fos , c Jun , JunB , and JunD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The three natriuretic peptides were shown to rapidly induce c fos , TIS8 / egr 1 and junB mRNA expression in both cell lines , via stimulation of the cGMP pathway . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In this report , we show that this inducible CyRE binding protein is composed of the AP 1 proteins c Fos , JunB , and JunD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Induction of immediate early genes c jun , junB , and c fos was demonstrated during echovirus 1 infection in a human osteogenic sarcoma ( HOS ) cell line . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The mRNA levels of c fos , c jun , junB and early growth response gene 1 were markedly elevated in the tibial metaphysis as early as 15 min postinjection and returned to basal level by 180 300 min . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The expression of the inducible transcription factors ( ITF ) c Fos and JunB was investigated in the dorsal cochlear nucleus ( DCN ) , ventral cochlear nucleus ( VCN ) and inferior colliculus ( IC ) of juvenile and adult rats following deprivation and repetitive stimulation paradigms using 8 kHz tone bursts at 5 min duration and 70 dB , 90 dB or 120 dB sound pressure level ( SPL ) . ( 1 ) During postnatal development without stimulation , c Fos is absent in DCN and VCN from postnatal day ( P ) 12 to adulthood , but shows a strong expression in the IC which declines during maturation . ^^^ In adult 4 month old rats , repetitive stimulation did not reduce the c Fos immunoreactivity from its moderate levels as compared with acute stimulation . ( 5 ) In some experiments , we studied also the expression of the JunB protein . ^^^ JunB paralleled the expression of c Fos following single acoustic stimulation , but was expressed in a substantially lower number of cells . ^^^ In contrast to c Fos , however , repetitive stimulation as described in section 4 did not evoke a decrease of JunB in the lower acoustic pathway . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In addition , pretreatment with PD 98059 greatly reduced the PP induced expression of immediate early genes c fos , egr 1 , and to a lesser extent junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Finally , immunocytochemical dual labeling was used to show that more than 75 % of all FSHbeta containing cells in ovine pituitary sections from cycling ewes contained nuclear c Jun , JunB , JunD , and Fos proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
With this method , we monitored cortically evoked activation of two immediate early gene protein products , c Fos and JunB , in phenotypically identified striatal neurons . ^^^ We further studied the influence of glutamate receptor antagonists on the stimulated expression of c Fos , JunB , FosB , and NGFI A . ^^^ Local disinhibition of MI elicited remarkably selective induction of c Fos and JunB in enkephalinergic projection neurons . ^^^ The dynorphin containing projection neurons of the direct pathway , with opposite effects on the thalamocortical circuits , showed very little induction of c Fos or JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Among a group of immediate early response genes , including egr 1 , junB , c jun , junD , and c fos , only egr 1 stimulation was modulated by changes in medium pH . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Quantitative solution hybridization , Northern blot , and nuclear run on analysis show that differential induction of c fos , junB , and c myc messenger RNA ( mRNA ) by these cytokines occur at transcriptional levels . ^^^ IL 6 stimulates c fos mRNA levels by 6 fold while increasing junB levels by 2 fold . ^^^ IFN gamma increases c fos message 2 fold , but has no effect on junB mRNA levels . ^^^ Furthermore , genistein treatment blocks the induction of c fos and junB gene expression , demonstrating that tyrosine phosphorylation of STAT proteins is involved in the cytokine regulation of the Sertoli immediate early genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The AP 1 DNA binding activities in all regions at all times after withdrawal were composed of FosB , c Jun , JunB , and JunD . c Fos was detected at all times in the cerebral cortex , at 16 h only in the hippocampus , and from 16 to 72 h in the cerebellum . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
It leads to reduced induction of c Fos and JunB proteins and to a failure to form and phosphorylate the activator protein ( AP ) 1 heterodimers required for IL 2 gene transcriptional activation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We examined the effects of this detergent on neurons and glia , including expression of c Myc , c Jun , JunB , and c Fos , and on immunocytes in the guinea pig ileum . ^^^ Neuronal c Myc began to disappear while c Fos , c Jun , and JunB were evident in some neuronal nuclei after 2 or 3 days . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Under similar experimental conditions , L 929 cell supernatant modulated proto oncogene expression , as assessed by Northern blot analysis of c fos , c myc , egr 1 and junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift assays , using Jun and Fos family member specific antibodies , showed that protein complexes formed by AtT 20 cell nuclear extracts bound to the c jun AP 1 site were comprised of Jun family members , JunD , JunB , and cJun . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
LIF significantly induced an immediate early response of genes c fos and junB 3 hr after stimulation , but not of c jun during the process of proliferation of MCF 7 and Hs 700T cells , with maximum levels at 30 60 min . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Three and 6 h after irradiation , the Fos and Jun proteins and their binding activity to an AP 1 consensus sequence were strongly induced by high doses of gamma rays . c Fos , c Jun and JunB proteins were found to be present in gel shift complexes by probing with specific antibodies . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of the proto oncogenes c myc , c fos , and c jun and histone 2A decreased rapidly in the first 24 h of culture in both cell preparations , followed by an increase in expression of c fos and junB over the next 3 days of culture . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The distribution of SRF and ATF 2 suggests that their putative target genes c fos , junB , krox 24 and c jun can be independently regulated from SRF and ATF 2 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The mRNA contents for genes associated with transcriptional activation [ c fos , c jun , JunB , nuclear respiratory factor 1 ( NRF 1 ) ] , mitochondrial proliferation [ cytochrome c ( Cyt c ) , cytochrome oxidase ] , and mitochondrial differentiation [ carnitine palmitoyltransferase 1 ( CPT 1 ) isoforms ] were measured . ^^^ The results establish a temporal pattern of mRNA induction beginning with c fos ( 0 . 25 3 hr ) and followed sequentially by c jun ( 0 . 5 3 hr ) , JunB ( 0 . 5 6 hr ) , NRF 1 ( 1 12 hr ) , Cyt c ( 12 72 hr ) , and muscle specific CPT 1 ( 48 72 hr ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Induction of c fos and junB mRNA following in vivo brain irradiation . ^^^ In this study , expression of c fos , c jun and junB immediate early genes were followed in mouse brain after irradiation . ^^^ C fos and junB , but not c jun , mRNA was induced within 15 min in unanesthetized irradiated mice . ^^^ The response was dose dependent with increases in c fos and junB mRNA levels after dose of > or = 2 and 7 Gy , respectively . ^^^ Pre treatment of mice with dexamethasone , in a schedule which suppressed acute phase gene expression after brain irradiation , did not significantly change c fos and junB induction . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The cAMP induced NF kappaB complex contained p 50 and RelB ; in co transfection assays , p 50 and RelB transactivated a reporter construct containing the c myb intronic NF kappaB site upstream of a minimal promoter . 8 Br cAMP and forskolin also increased the DNA binding activity of AP 1 complexes containing JunB , JunD and c Fos in MEL cells which could cooperate with NF kappaB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Among other IEGs examined , the expression of NGFI A and junB are similar to c fos , but of lesser magnitude , whereas c jun appears to be invariant in the rat but is increased during the active phase in squirrels . ^^^ Among other IEGs , junB and NGFI A again were similar to c fos while c jun and junD were more constant . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
SB 203580 , an inhibitor of p38 / RK , has been used to analyse the role of this kinase in the induction of five IE genes ( c fos , fosB , c jun , junB and junD ) under diverse conditions of stimulation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
EGF treatment triggered almost identical programs of fos and jun gene activation at the messenger RNA ( mRNA ) level in both cell types , with an early accumulation of c fos , c jun , and junB mRNAs , but no change in junD mRNA levels . ^^^ In both cell types , c Fos and Fra 1 proteins increased after EGF treatment , but differences in the induction of Jun proteins were noted , with an increase of c Jun in hepatocytes and an increase of JunB in 7777 cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
When expressed in A 431 cells , the wild type receptor and to a lesser extent the mutant receptor that associates with PLCgamma ( Y 1021 ) was able to up regulate c fos , junB , and KC mRNA expression . ^^^ In contrast , the receptor mutant that engages PI3K ( Y740 / 51 ) poorly stimulated c fos mRNA expression and did not significantly stimulate expression of either JunB or KC . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The effect of c jun is exerted through interactions with c fos at the AP 1 motifs in the target promoters , whereas both junB and junD act independently of the binding at the AP 1 sites . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of the transcription factors c Jun and JunB , but not c Fos , was induced in SFFV infected cells in the absence of Epo , suggesting that constitutive activation of the Raf 1 / MAP kinase pathway by the virus may result in deregulation of AP 1 activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The expression of inducible transcription factors was studied following repetitive electroconvulsive seizures ( ECS ) , c Fos , c Jun , JunB , and JunD immunoreactivities were investigated following a single ( 1 10 ECS ) or repetitive ECS evoked once per day for 4 , 5 , or 10 days ( 4 10 ECS , 5 10 ECS , or 10 10 ECS ) . ^^^ In contrast to c Fos , intense JunB expression was inducible in the cortex and hippocampus , but not CA 4 subfield , after 1 10 ECS , 5 10 ECS , and 10 10 ECS . ^^^ In a second model of systemic excitation of the brain , repetitive daily injection of kainic acid for 4 days completely failed to express c Fos , c Jun , and JunB after the last application whereas injection of kainic acid once per week did not alter the strong expressions compared to a single application of kainic acid . ^^^ Infusion of BDNF completely reinduced c Fos expression during 5 10 ECS or 10 10 ECS in the cortex ipsilaterally to the cannula and , to a less extent , also increased the expression of c Jun and JunB when compared to saline treated controls . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We therefore tested whether local administration of the neuroprotective cytokine fibroblast growth factor type 2 in vivo has an effect on the axotomy induced nuclear expression patterns of the activator protein 1 transcription factors c Fos and JunB , or c Jun in the spinal cord intermedolateral nucleus adrenal axis lesion paradigm in the rat . ^^^ By contrast , c Fos and JunB induction did not occur in the intermediolateral nucleus in the lesion paradigm investigated . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We studied the time course of expression of the inducible transcription factors ( ITF ) c Fos , FosB , c Jun , JunB , JunD , Krox 20 and Krox 24 , induced by a single intracerebroventricular injection of angiotensin 2 , in the subfornical organ ( SFO ) , median preoptic nucleus ( MnPO ) paraventricular nucleus ( PVN ) and supraoptic nucleus ( SON ) . c Fos and Krox 24 were expressed rapidly in neurons of all four areas but completely disappeared after 4 h . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The expression of c Jun , JunB , JunD , c Fos and ATF 2 transcription factors was studied in L4 / L5 dorsal root ganglion neurons of adult rats , in order to determine the extent to know to which extend the expression of transcription factors in vitro parallels the pathophysiological expression in vivo . ^^^ JunB and c Fos , which were also visible in the majority of neurons , strongly decreased with culture time in both small and large neurons . ^^^ Incubation with brain derived neurotrophic factor for 15 days reduced JunB expression and raised c Fos expression , but did not affect c Jun or JunD labelings . ^^^ As with culture , incubation of explanted dorsal root ganglia with brain derived neurotrophic factor prevented the initial rise in JunB , accelerated and enhanced c Fos expression , but did not alter c Jun and JunD expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Stimulation with carbachol induced expression of c fos , fosB , c jun , junB , and junD . ^^^ Inhibition of protein kinase C with GF109203X suppressed the carbachol stimulated increase in mRNA levels of c fos , fosB , and junB by approximately 70 % but had only minor effects on the expression of c jun and junD . ^^^ On the other hand , preincubation with KN 62 attenuated the carbachol induced increase in c jun and junD expression by 70 % but had no effect on c fos , fosB , and junB mRNA levels . ^^^ Simultaneous inhibition of both protein kinase C and Ca2+ / calmodulin dependent kinase 2 completely abolished the carbachol stimulated expression of c jun and junD , but c fos , fosB , and junB were still expressed to a certain extent under this condition . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Adenovirus type 5 E 4 open reading frame 4 ( E4orf4 ) protein has been previously shown to counteract transactivation of the junB and c fos genes by cyclic AMP plus E1A protein and to interact with protein phosphatase 2A ( PP2A ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Anisomycin desensitization of a panel of IE genes ( c fos , fosB , c jun , junB , and junD ) , using epidermal growth factor ( EGF ) , basic fibroblast growth factor , ( bFGF ) , tumor necrosis factor alpha ( TNF alpha ) , anisomycin , tetradecanoyl phorbol acetate ( TPA ) , and UV radiation as secondary stimuli , was found to be extremely specific both with respect to the secondary stimuli and at the level of individual genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
HCG induced a rapid and transient expression of c fos , fosB , c jun , junB , junD and c myc with a peak at 30 min to 1 h . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We found a rapid induction of c fos , c jun and junB at the mRNA level after about 30 min of EGF treatment and a more delayed upregulation of fosB and fra 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Temporal differences in c fos , junB , and inducible cAMP early repressor ( ICER ) steady state mRNA levels were observed after forskolin exposure . ^^^ Maximal induction of c fos and junB occurred within 1 h , returning to basal levels by 3 . 5 h . ^^^ This rise in expression , correlating with the decrease in c fos and junB levels , preceded apoptotic DNA fragmentation by 1 . 5 h . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Activation of cytochrome c ( cyt c ) transcription in electrically stimulated neonatal rat cardiac myocytes is preceded by transient expression of the activating protein 1 family of transcription factors , c Fos , c Jun , and JunB , as well as nuclear respiratory factor 1 ( NRF 1 ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The blockade of KA induced proENK and proDYN mRNA levels by the pre treatment with L ARG was well correlated with proto oncoprotein levels , such as c Fos , Fra 2 , FosB , JunD , JunB , and c Jun , as well as AP 1 and ENKCRE 2 DNA binding activities . ^^^ The pre administration with L NAME further increased KA induced c jun and c fos mRNA levels in addition to their protein product levels , although the pre treatment with L NAME did not affect KA induced FosB , Fra 2 , JunB , and JunD protein levels at 6 h after treatment . ^^^ Our results suggest that L ARG plays an important role in inhibiting KA induced proENK or proDYN mRNA expression , and its inhibitory action may be mediated through reducing the proto oncoprotein levels , such as c Fos , Fra 2 , FosB , c Jun , JunD , and JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Alterations in levels of the immediate early gene ( IEG ) proteins Fos , FosB , DeltaFosB , Jun , JunB , JunD , and NGFI A were investigated in rat hippocampus by immunohistochemistry 2 , 12 , 24 , and 48 h after forebrain ischemia . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
UVB irradiation potently induced c jun , junB and c fos mRNA levels in vitro in HaCaT cells . ^^^ IL 6 mRNA was induced in response to UVB irradiation 2 3 h later than c jun , junB and c fos mRNAs . ^^^ The results of this study provide evidence that in addition to c jun and c fos , junB is also an essential component of the human UV response . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The delayed increase in COX 2 mRNA expression was accompanied by the induction of the proto oncogenes c jun , junB , junD , and c fos ( but not FosB or Fra 1 ) . ^^^ Supershift analysis in the presence of antibodies to c Jun , c Fos , JunD , and JunB suggested that AP 1 complexes were composed of c Fos , JunB , and possibly c Jun . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
A rapid and transient increase in c fos , junB , c jun and Tis 11 messenger RNA was observed in cultured astrocytes after treatment with adenosine 5 ' O ( 2 thiodiphosphate ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of c jun , junB , c fos , fra 1 and fra 2 mRNA in the rat brain following seizure activity and axotomy . ^^^ The patterns of c jun , junB , c fos , fra 1 and fra 2 mRNAs were studied by radioactive and non radioactive in situ hybridization in the adult rat brain following kainate induced seizure activity and axotomy . ^^^ In the same animals , the expression of c Jun , JunB and c Fos proteins was compared with the respective mRNA signals . ^^^ Whereas fra 1 and fra 2 were restricted to the hippocampus , c jun , junB and c fos were additionally induced in the cortex , amygdala and thalamus . ^^^ The expression patterns between c jun , junB and c fos mRNA were virtually congruent with the respective protein . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
FOS and JUNB expression by 5 FMS transfected cells showed a similar pattern to FMS wild type cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Amylin treatment results in time and concentration dependent inductions of oxidative stress genes , such as cox 2 and IkappaB alpha . `` Apoptotic ' ' genes are also induced in a time and concentration dependent manner , including c jun , junB , c fos , and fosB , followed temporally by a gene known to be modulated by these transcription factors , i . e . , transin . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The concentration of c fos , c jun , c myc , junB , and fra 1 mRNAs was increased in activated peripheral blood lymphocytes incubated with ciprofloxacin compared to that in untreated controls . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of c fos and junB increased nine and fourfold , respectively , in the right lung within 30 min after left pneumonectomy in rats . ^^^ When isolated lungs were subjected to elevated airway pressures in vitro , expression of c fos and junB was induced in a time and dose dependent manner similar to that observed in vivo . ^^^ Similarly , in vitro lung perfusion induced c fos and junB expression in the absence of increasing lung inflation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the present study , we investigated the expression pattern of the inducible transcription factors ( ITF ) c Fos , c Jun , JunB , JunD , and Krox 24 following intracerebroventricular injections of hyperosmolar saline ( 0 . 2 , 0 . 3 , and 0 . 6 M NaCl ) and its mediation via angiotensin and / or muscarinic receptors . c Fos , c Jun , and Krox 24 were differentially expressed in organum vasculosum laminae terminalis , median preoptic area , subfornical organ ( SFO ) , and paraventricular and supraoptic nuclei . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Electroconvulsive shock does not induce c fos and junB , but TIS 1 and TIS8 / zif 268 , in neonatal rat hippocampus . ^^^ ECS did not induce c fos and junB in the hippocampus of 7 day old rat , but these genes were weakly induced at postnatal 14 days and to an adult level at postnatal 21 days ; two other IEGs , TIS 1 ( NGFI B , nur 77 ) and TIS 8 ( zif 268 , Egr 1 , Krox 24 , NGFI A ) , were induced at postnatal 7 days , however . ^^^ Our results suggested that during the neonatal period , signaling pathways for TIS 1 and TIS 8 induction in rat hippocampus after ECS are complete , while those for c fos and junB are immature . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The levels of c jun , c fos , junB , and fosB mRNA in ZG and ZFR were also rapidly maximally elevated within 0 . 5 1 h after ACTH administration and fell to near control levels 5 h posttreatment . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Glucose and glucoincretin peptides synergize to induce c fos , c jun , junB , zif 268 , and nur 77 gene expression in pancreatic beta ( INS 1 ) cells . ^^^ Glucose causes a coordinated transcriptional activation of the IEGs c fos , c jun , JunB , zif 268 , and nur 77 in the pancreatic beta cell line INS 1 . ^^^ The accumulation of c fos , JunB , and nur 77 mRNA occurs at physiological concentrations of glucose ( 3 to 11 mM ) , requires a 1 2 h period , and is mimicked by other nutrient stimuli including mannose , leucine plus glutamine , and pyruvate . ^^^ The results indicate that GLP 1 and PACAP 38 act as competence factors for the action of glucose on c fos , JunB , and nur 77 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^ In the current study we show that the AP 1 complex isolated from insulin stimulated cells contained c Fos , Fra 1 , c Jun and JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We previously demonstrated that expression of transcription factors ( e . g . , Egr 1 , JunB , and c Fos ) is differentially regulated by IL 2 and IL 12 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Here we provide further evidence that the induction of junB , c jun , and c fos genes is due to active viral macromolecular synthesis rather than to the interaction of EV 1 with its receptor , alpha2beta1 integrin . ^^^ Studies with selective MAPK inhibitors revealed that p 38 was the main inducer of junB expression , whereas both MAPK pathways were involved in the induction of c fos . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Galanin was found to induce c fos , junB , and Tis 11 mRNA in cultured astrocytes , providing evidence for the presence of functional galanin receptors on neuroglial cells . ^^^ In contrast , CGRP only led to the induction of c fos and junB mRNA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Growth hormone stimulates phosphorylation and activation of elk 1 and expression of c fos , egr 1 , and junB through activation of extracellular signal regulated kinases 1 and 2 . ^^^ The MEK inhibitor PD 098059 attenuated GH induced expression of the endogenous SRE regulated genes c fos , egr 1 , and junB as well as transcriptional activation mediated by the c fos promoter . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Previous studies from this laboratory have demonstrated that acute administration of morphine induces the immediate early genes ( IEGs ) c Fos and JunB in the rat caudate putamen ( CPu ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have examined the expression of members of the AP 1 transcription factor complex in response to stimulation with different doses of LPA . c Fos , c Jun , and JunB are induced rapidly in response to LPA stimulation , whereas Fra 1 and Fra 2 are induced after a significant lag . ^^^ The expression of c Fos is transient , whereas the expression of c Jun , JunB , Fra 1 , and Fra 2 is sustained . ^^^ LPA stimulated expression of c Fos , Fra 1 , Fra 2 , c Jun , and JunB is inhibited by the MEK 1 inhibitor PD 098059 , indicating that the Raf MEK MAPK cascade is required for their expression . ^^^ In cells expressing a conditionally active form of Raf 1 ( DeltaRaf 1 : ER ) , we observed that selective , sustained activation of Raf MEK MAPK was sufficient to induce expression of Fra 1 , Fra 2 , and JunB but , interestingly , induced little or no c Fos or c Jun . ^^^ However , in contrast to the case for Fra 1 , Fra 2 , and JunB , activation of the MAPK cascade alone is not sufficient to induce c Fos expression , which rather requires cooperation with other signals such as Ca2+ mobilization . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The most active compound identified was used to examine the role played by protein kinase C alpha in mediating the phorbol ester induced changes in c fos , c jun , and junB expression in A 549 lung epithelial cells . ^^^ Depletion of protein kinase C alpha protein expression by this oligonucleotide lead to a reduction in c jun expression but not c fos or junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift analysis identified CREB 1 , JunB , c Fos , Fra 1 , and c Jun in protein complexes isolated from differentiated rabbit tracheal epithelial cells binding to this site . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
To determine nuclear proto oncogene changes mediating these events , c myc , c fos , c jun and junB were measured in spontaneously differentiating cells and in cells exposed to EGF . c myc showed a transient rise in expression at 4 8 h with augmented expression by EGF , occurring even in the absence of serum or attachment . c myc and c jun declined during culture , but c fos and particularly junB showed increased expression by day 3 with marked responses to EGF stimulation . ^^^ Syncytia induced to form by EGF exposure for 48 h demonstrated marked junB expression after rechallenge with 40 min EGF exposure , but negligible responses of c fos and c jun . c myc showed increased expression after 6 h EGF exposure throughout the culture period and in syncytia . ^^^ The results indicate EGF promotes a syncytial phenotype characterized by c fos and junB expression during syncytial formation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
There were significant increases in JunD mRNA and protein in DFMO treated cells , although expression of the c fos , c jun , and junB genes decreased . ^^^ The proteins of c Jun , JunB , and Fos are essential for initiation of the cell cycle . ^^^ The increased AP 1 complexes in polyamine deficient cells were dramatically supershifted by the anti JunD antibody but not by antibodies against c Jun , JunB , or Fos proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
To understand the role of redox sensitive mechanisms in vascular smooth muscle cell ( VSMC ) growth , we have studied the effect of N acetylcysteine ( NAC ) , a thiol antioxidant , and diphenyleneiodonium ( DPI ) , a potent NADH / NADPH oxidase inhibitor , on serum , platelet derived growth factor BB , and thrombin induced ERK 2 , JNK 1 , and p 38 mitogen activated protein ( MAP ) kinase activation ; c Fos , c Jun , and JunB expression ; and DNA synthesis . ^^^ On the contrary , these compounds had differential effects on agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation and c Fos , c Jun , and JunB expression . ^^^ NAC inhibited agonist induced ERK 2 , JNK 1 , and p 38 MAP kinase activation and c Fos , c Jun , and JunB expression except for platelet derived growth factor BB induced ERK 2 activation . ^^^ In contrast , DPI only inhibited agonist induced p 38 MAP kinase activation and c Fos and JunB expression . ^^^ Antibody supershift assays indicated the presence of c Fos and JunB in the AP 1 complex formed in response to all three agonists . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Other immediate early response genes , c fos and junB , were also induced following glucose stimulation with kinetics similar to egr 1 , whereas c jun and junD expression were not affected . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The immediate early genes ( IEGs ) , c jun , junB and c fos are expressed after global ischemia in the gerbil . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Activation of neurons in the inferior mesenteric ganglion ( IMG ) was assessed using c fos , JunB , and c Jun expression in the guinea pig IMG and colonic myenteric plexus during mechanosensory stimulation and acute colitis in normal and capsaicin treated animals . ^^^ Lower doses of capsaicin or vehicle were used to activate primary afferent fibers during balloon passage . c Jun did not respond to any of the stimuli in the study . c fos and JunB were absent from the IMG and myenteric plexus of untreated and saline treated animals . ^^^ Balloon passage induced c fos and JunB in only a small subset of IMG neurons and no myenteric neurons . ^^^ However , balloon passage induced c fos and JunB in IMG neurons ( notably those containing somatostatin ) and the myenteric plexus of acetic acid treated animals . ^^^ After capsaicin treatment , c fos and JunB induction by balloon passage was inhibited in the IMG , but there was enhanced c fos expression in the myenteric plexus . c fos and JunB induction by balloon stimulation was also mimicked by acute activation of capsaicin sensitive nerves . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The cell death process is accompanied by induction of JunB , c Jun , JunD and Fos proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
H2O2 preferentially induced the expression of c fos , c jun , c myc and egr 1 , while JunB and JunD levels remained almost unchanged . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of c fos , junB , c jun , MKP 1 and hsp 72 following traumatic neocortical lesions in rats relation to spreading depression . ^^^ The effects of a traumatic neocortical lesion on c fos , junB , c jun , MKP 1 and hsp 72 expression were examined by in situ hybridization and immunocytochemistry 1 6 h following transcranial cold injury . ^^^ In animals without spreading depressions , only a short lasting response of c fos , junB , c jun and MKP 1 messenger RNAs as well as c Fos protein was bilaterally found in the piriform cortex , and with ipsilateral dominance the dentate gyrus and hippocampal CA3 / 4 fields at 1 h after lesioning . ^^^ Messenger RNA levels for c fos , junB and MKP 1 were closely related to the time interval between the last depolarization and the end of experiment . ^^^ Levels were highest shortly after transient direct current shifts , and decreased thereafter mono exponentially with half lives of 48 , 75 and 58 min for c fos , junB and MKP 1 messenger RNAs , respectively . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using transcription analysis , such as multiplex messenger assays , we show here that natural cytotoxicity exerted by the human NKL cell line correlates with mRNA accumulation of very early activator protein ( AP ) 1 transcription factor genes such as JunB , FosB and c Fos . ^^^ Interaction between immunoglobulin like transcript 2 / leukocyte Ig like receptor 1 on NKL cells and HLA B 27 on target cells leads to an impairment of NKL natural cytotoxicity , which correlates with an absence of JunB , FosB , and c Fos transcription , as well as an absence of their DNA binding activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We also found that there are two independent rhythms of expression of junB messenger RNA and JunB protein , as well as c fos messenger RNA and c Fos protein , in the suprachiasmatic nucleus of hamsters : a rhythm of photic sensitivity expressed throughout the night and a spontaneous rhythm of expression triggered around dawn . ^^^ Induction of NGFI A messenger RNA and c fos messenger RNA and c Fos protein in response to a light pulse were found throughout the suprachiasmatic nucleus , with the highest levels of expression in the ventrolateral subdivision ; however , the spontaneous expression of JunB and c Fos proteins was confined mainly to the dorsomedial suprachiasmatic nucleus . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift assays revealed that fra 1 participates in the activator protein 1 complex together with c fos , c jun and junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Effects of mild traumatic brain injury on immunoreactivity for the inducible transcription factors c Fos , c Jun , JunB , and Krox 24 in cerebral regions associated with conditioned fear responding . ^^^ In the present study , we examined the expression patterns of immunoreactivity ( IR ) for four ITFs ( c Fos , c Jun , JunB , and Krox 24 ) at 3 h after mild fluid percussion TBI . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
However , a more direct approach , investigating expression of putative hibernation responsive genes by Northern analysis , revealed an increase in expression of transcription factors c fos , junB , and c Jun , but not junD , commencing during late torpor and peaking during the arousal phase of individual hibernation bouts . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Our results demonstrated that : ( 1 ) PGN induced phosphorylation of the transcription factors ATF 1 and CREB ; ( 2 ) ATF 1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid , which was inhibited by dominant negative CREB and ATF 1 ; ( 3 ) PGN induced phosphorylation of c Jun , protein synthesis of JunB and c Fos , and transcriptional activation of the AP 1 reporter plasmid , which was inhibited by dominant negative c Fos ; and ( 4 ) PGN induced activation of CREB / ATF and AP 1 was mediated through CD 14 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Thrombin stimulated a rapid but transient accumulation of c Fos whereas the expression of Fra 1 , Fra 2 , c Jun and JunB was sustained throughout the G 1 phase of the cell cycle . ^^^ We focussed our analysis on c Fos ( typical of AP 1 genes which are expressed rapidly and transiently ) and Fra 1 and JunB ( typical of AP 1 genes expressed after a delay but in a sustained manner ) . ^^^ The expression of c Fos , Fra 1 and JunB was dependent upon the activation of MAPK since these responses were inhibited by PD 098059 . ^^^ However , a comparison of responses to FBS , thrombin , TRPs , LPA and EGF revealed that Fra 1 and JunB expression required sustained activation of MAPK whereas c Fos expression was strongly induced even by non mitogenic stimuli which elicited only transient MAPK activation . ^^^ The expression of c Fos ( in response to thrombin , TRP or LPA ) or Fra 1 , JunB and cyclin D 1 ( thrombin only ) was also inhibited by pertussis toxin . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
These effects were preceded by a transient augmentation of junB , c fos and c jun mRNA contents . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Dexamethasone treatment induced transiently c jun mRNAs , in contrast to the sustained expression of c fos , whereas its effect on junB expression resulted in a later increase . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The presence of several transcription factor proteins , including JunB , JunD , c Fos , Fra 1 , CREB 1 , activating transcription factor 2 , NF KB p 50 , p 52 , and p 65 , and CAAT / enhancer binding protein delta , was demonstrated by supershift analysis . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra 1 , Fra 2 , and c Fos bound to AP 1 but that prior treatment of the cells with TGFbeta reduced dramatically c Fos binding , suggesting that c Fos might be playing a negative regulatory role in clusterin gene expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
RESULTS : The normal corneal epithelium showed no staining with antibodies against c Fos , Fra 2 , FosB , c Jun or JunB , whereas the limbal and bulbar conjunctival epithelia were positive for c Fos , Fra 2 , and c Jun . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The repression of serum induced mitogenesis by differentiation correlates with repression of the serum inducible transcription of junB and c fos . ^^^ In contrast , the differentiation of neoplastically transformed cells does not repress mitogenic responsiveness or junB or c fos inducibility . ^^^ Because the junB and c fos promoters both contain serum response elements ( SREs ) , the current studies tested the possibility that differentiation might repress the ability of serum response factor ( SRF ) to bind to the SRE in normal cells but not in transformed cells . ^^^ Adipocyte differentiation of nontransformed cells also markedly represses the ability of SRF to bind to the junB SRE , the c fos SRE , and other SREs , as determined by mobility shift and gel supershift assays , without affecting the DNA binding characteristics of the nuclear protein SP 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
To investigate whether both patterns of IEG expression are observed in the rat SCN , the authors studied the expression of NGFI A , junB , c fos , and fosB near the time of subjective dawn in rats entrained to a light dark 12 : 12 cycle and then maintained in constant total darkness for approximately 48 h . ^^^ They found that there were two independent rhythms of expression for junB and c fos mRNAs in the SCN : ( 1 ) a rhythm of photic sensitivity expressed throughout the night and ( 2 ) a spontaneous rhythm of expression triggered around dawn and persisting for at least 2 h into the day . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
However , NPY did not inhibit the induction of c fos , FosB or junB mRNA in any hippocampal region examined in the same animals , showing lack of correlation between immediate early gene induction and seizure activity . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
On the other hand , insulin clearly enhances the effects of TSH , phorbol ester , and EGF on c myc , junB , and c fos expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ For c jun , junB , c fos and fra 2 , a relatively uniform expression pattern without significant differences among tumors was observed . junD protein amounts varied strongly in the tumor specimens . fosB expression levels also varied strongly in the tumors , weak / absent expression being found in 47 % , while 45 % exhibited strong / very strong levels of expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Although GLP 2 stimulated the expression of c fos , c jun , junB , and zif 268 , and transiently increased p 70 S6 kinase in quiescent BHK GLP 2R cells , GLP 2 also inhibited extracellular signal regulated kinase 1 / 2 and reduced serum stimulated Elk 1 activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In Rat 1 fibroblasts , we measured the effect of IL 6 on matrix metalloproteinase 13 ( MMP 13 ) , c jun , junB , and c fos gene expression , binding of activator protein 1 ( AP 1 ) to DNA , amount of AP 1 proteins , immunoreactive MMP 13 and TIMP 1 proteins , and Jun N terminal kinase activity . ^^^ This effect was accompanied by a marked increase in c Jun , JunB , and c Fos mRNA , as well as in c Jun protein and its phosphorylated form . ^^^ This effect seems to be mediated by the induction of c jun , junB , and c fos gene expression , by the binding of AP 1 to DNA , by increasing phosphorylated c Jun , and by the inhibition of serine / threonine phosphatase activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Moreover , the brain dopamine and serotonin balance , but not norepinephrine turnover , was dependent on alpha2C AR expression , and the expression of c fos and junB mRNA was increased in alpha2C KO mice . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
To determine if the periaqueductal gray ( PAG ) and the dorsal raphe nucleus ( DRN ) are involved in morphine induced c Fos and JunB expression in the caudate putamen ( CPu ) , the mu receptor antagonist , beta funaltrexamine ( beta FNA ) , was unilaterally infused into the PAG adjacent to DRN prior to morphine . ^^^ In the CPu of beta FNA treated rats , morphine induced c Fos and JunB were attenuated compared to vehicle infused rats . ^^^ These results suggest that morphine acts within the PAG DRN to exert rapid behavioral effects and to induce c Fos and JunB in the striatum . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts indicated that the AP 1 complex consists of c Jun , c Fos , JunD , and possibly JunB proteins , and that the NF kappaB complex contains p 50 , p 65 , and c Rel proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Gel shift analysis in the presence of specific antibodies to c Jun , JunB , JunD , c Fos , and CREB / ATF showed that the AP 1 complexes were probably c Jun / c Jun , c Fos / c Jun , c Fos / JunB , or c Jun / JunB dimers . ^^^ Northern blot analysis confirmed that c jun , junB , and c Fos were the principal proto oncogenes induced by CalC . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Double immunofluorescence labelling revealed that LiCl causes a coordinate upregulation of c Fos , FosB and JunB , and these proteins are colocalized in a majority of cells examined in NTS , parabrachial nucleus ( PBN ) , and central nucleus of the amygdala ( CeA ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
PACAP potently stimulated the expression of c fos , fosB junB and junD , but not c jun mRNAs , at doses of 0 . 1 10 nM , as revealed by Northern blot analysis . ^^^ PACAP administration induced maximum expression of c fos , fosB and junB mRNA after 60 min , and of junD mRNA after 8 h . ^^^ Gel shift and supershift analyses showed that the TRE binding factors and CRE binding factors comprised fosB , c fos , junB , and junD , and CRE binding protein ( CREB ) and junD , respectively . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Furthermore , treatment of THP 1 cells with amyloid fibrils resulted in an elevated expression of the immediate early genes c fos and junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The observed changes were correlated with the expression of the mRNA of hsp 70 , c fos , c jun , and junB , as well as the distribution of DNA double strand breaks visualized by terminal deoxynucleotidyl transferase mediated dUTP biotin nick end labelling ( TUNEL ) . ^^^ Expression of the immediate early genes c jun , c fos , and junB increased both in the penumbra and the periinfarct normal tissue already at 1 hour after vascular occlusion , with slightly different regional and temporal patterns for each of these genes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We examined if the induction of immediate early gene ( c fos , c myc , c jun , and junB ) and HSP 70 mRNAs by ischemia is affected by ischemic preconditioning . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Interestingly , this complex was not affected by the addition of any antibodies against ER , c Jun , c Fos , JunB , or JunD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In addition , AA also increased several AP 1 proteins , such as c Fos , Fra 1 , Fra 2 , JunB , JunD , and c Jun , or AP 1 and ENKCRE 2 DNA binding activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We identified AP 1 factors c Fos and JunB as MFNLP binding proteins , whose binding is abolished by introducing point mutations in the 3 ' half of the MFNLP sequence . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This rapid induction of arc in the striatum is similar to that of other early response genes such as c fos , junB , deltafosB , fra , and NGFI A , which code for transcription factors . ^^^ The contrasting patterns of Arc expression evoked by cocaine and amphetamine parallel those of c Fos , JunB , FRA , and NGFI A expression induced by these two psychomotor stimulants . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
JunB , but not c fos , also enhanced the EGFR promoter activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift analysis of nuclear extracts revealed that bFGF stimulates the occupancy of AP 1 site by c Jun , JunB , JunD , c Fos , FosB , and Fra 2 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In contrast , the expression of JunB , c jun and c fos , but not JunD , was increased by LPS , TNF alpha , IFN gamma and IL 1 , albeit with different kinetics and magnitude of induction . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Whilst the expression of JunD was not affected by any of the mediators , the mRNA levels of c fos and JunB were induced by LPS , IL 6 , IFN gamma , PDGF and TNF alpha , and that of c jun by LPS , IFN gamma , PDGF and TNF alpha . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression profiles of JunB and c Fos proteins in the rat circadian system . ^^^ The immediate early genes c Fos and JunB are implicated in light signaling within the suprachiasmatic nucleus ( SCN ) , the mammalian circadian clock . ^^^ Light induces phase dependent expression of c Fos and JunB within the retinorecipient SCN . ^^^ The present study examined the pattern of induction of c Fos and JunB in the SCN and intergeniculate leaflet ( IGL ) of rats housed in constant conditions , under light dark cycles , or in dark adapted light stimulated animals . ^^^ In contrast with previous studies , no evidence of expression of c Fos and JunB was observed within the dorsal SCN , regardless of circadian time . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The data , in combination with our previous results [ Takeuchi J . et al . ( 1993 ) Neuron 11 , 825 836 ] , suggest that activator protein 1 binding sites on ventrolateral suprachiasmatic nucleus target genes are constitutively occupied by DeltaFosB / JunD complexes , and that c Fos , Fra 2 , FosB and JunB compete for binding after photic stimulation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The observed changes were correlated with the expression of the mRNAs of hsp 70 , c fos , and junB , as well as the distribution of DNA double strand breaks , visualized by TUNEL . ^^^ Hsp 70 mRNA was selectively expressed in the cortical penumbra , whereas c fos and junB mRNAs were increased both in the lateral part of the penumbra and in the ipsilateral cingulate cortex with normal metabolism . ^^^ Hsp 70 mRNA , but not c fos and junB , was strongly expressed during reperfusion , peaking at 3 hours after reperfusion . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The increases of proENK and proDYN mRNA levels induced by KA were well correlated with the increases of c Fos , Fra 2 , FosB , c Jun , and JunB protein levels , which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We also observed increased expression of mRNAs for Fos and Jun transcription factor family members c Fos , FosB , Fra 2 , and JunB , as well as Fos family proteins in the entorhinal cortex after MK 801 administration . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This type of stimulation led to a specific and statistically significant increase in the expression of the protein products of the inducible transcription factors c Fos , JunB , inducible cyclic AMP early repressor and Krox 24 ( also frequently named Zif 268 or Egr 1 ) , but not c Jun . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We found that expression of c Fos , c Jun , and JunB was induced upon LIF treatment whereas that of JunD , the tyrosine phosphatase ESP , and the components of the LIF receptor remained unaffected . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
JunB , c Jun , c Fos , and Fra 2 were rapidly but transiently induced by FSH in immature granulosa cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The p 56 ( dok 2 ) overexpressing cells showed an impaired induction of c myc but not of c jun , junB or c fos when stimulated with M CSF . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Moreover , LIF activated STAT 3 indirectly mediates LIF corticotroph action by inducing and potentiating CRH induced c fos and JunB expression and binding to the POMC AP 1 element . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Human PTH ( 1 34 ) and hPTH ( 1 84 ) increased steady state mRNA expression of c jun , junB , c fos , and fra 2 in an equivalent dose and time dependent manner . ^^^ Expression of c jun , junB , and c fos peaked 30 minutes after the injection while fra 2 expression peaked 30 minutes later . ^^^ When individual comparisons for each dose between peptides were made , the minimum effective dose necessary to stimulate a significant increase in c fos and junB expression was equivalent for both peptides . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
While c Fos , Fra 2 and JunB were increased in response to either stimuli , only Fra 1 , c Jun and JunD were increased by PMA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Atopic dermatitis keratinocyte nuclear lysates had higher constitutive levels of c Jun , and phorbol myristate acetate promoted an earlier and stronger expression of c Jun , JunB , and of the phosphorylated forms of c Fos . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In osteoblastic cells , transforming growth factor beta 1 ( TGF beta 1 ) has been found to regulate the expression of a variety of proto oncogenes including c fos , c jun , and junB . ^^^ In ROS 17 / 2 . 8 cells , TGF beta 1 as well as BMP 2 up regulated the expression of junB and c fos messenger RNAs ( mRNAs ) , and this increase was correlated in both cases with an increase in activator protein 1 ( AP 1 ) DNA binding activity involving JunB and c Fos proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Activation of transcription through the AP 1 site in Jurkat cells by JunD and / or Fra 2 was weak . c Jun , JunB , and c Fos activation was greater , although the level was still less than that with Tax . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
There was no change in the expression of c jun and junB , members of the AP 1 transcriptional complex in MRC 5v fos cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using knock out strategies it was found that some components , such as c Fos , FosB and JunD are dispensable , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic development and / or in the adult organism . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of egr 1 ( krox 24 ) , egr 2 ( krox 20 ) , egr 3 , c jun , junB , c fos , fosB , fra 1 , fra 2 , and CREB genes was analyzed by reverse transcription polymerase chain reaction ( RT PCR ) in Schwann cells isolated from neonatal rat sciatic nerves and in the cell lines MSC 80 ( mouse Schwann cells ) , NIH 3T3 ( mouse fibroblasts ) , and CHO ( Chinese hamster ovary cells ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using glutathione S transferase pull down assays , we demonstrated that ERalpha bound directly to c Jun and JunB but not to FOS family members , in a ligand independent manner . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
METHODS : Before the onset of treatment and at 1 , 3 , 6 , and 24 hours of recirculation , animals were frozen in situ and hsp 70 , c fos , junB , and NSE mRNAs were imaged on cryostat sections using in situ hybridization autoradiography . ^^^ RESULTS : hsp 70 mRNA was upregulated in the penumbral cortex of untreated animals and in the MCA core region of animals receiving rtPA ( ie , regions characterized by a mismatch between high ATP levels and suppressed CPS ) . c fos and junB mRNAs were transiently expressed mainly in the peri infarct intact cortex for up to 3 to 6 hours in the treated and up to 24 hours in the untreated animals . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^ RESULTS : Of the seven AP 1 factors , three ( c fos , fra 2 , and junB ) clearly showed higher expression levels in tumors when compared to matched normal endometrial samples . ^^^ These factors also correlated significantly with cell cycle promoters ( c fos with cyclin E , cyclin B 1 , cdk 2 , and cdk 4 ; fra 2 with cyclin B 1 ; and junB with cyclin D 1 ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Activation of mu opioid receptor induces expression of c fos and junB via mitogen activated protein kinase cascade . ^^^ Expression of c fos and junB genes was analyzed by RNA blot hybridization . ^^^ To explore the mechanism of MOR mediated c fos and junB expression , activity of a transcription factor , Elk 1 , was assessed by reporter assay . ^^^ Furthermore , to investigate the functional consequences of c fos and junB induction , MOR mediated formation of the functional transcription factor complex AP 1 was examined by reporter assay and electrophoretic mobility shift assay . ^^^ RESULTS : Mu opioid receptor activation induced c fos and junB messenger RNAs , which were inhibited by pretreatment of the cells with pertussis toxin and PD 98059 , an inhibitor of extracellular signal regulated kinase cascade . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Melatonin induced protein kinase C activity by 1 . 65 fold over basal levels , increased the phosphorylation of extracellular signal regulated kinase 1 and 2 proteins , and activated c fos and junB mRNA expression in GT 1 7 cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift experiments and Western blots confirmed that the binding of c Fos , JunB , and JunD , but not of FosB , was reduced in anergized cells . ^^^ Anergy is accompanied by a reduction in AP 1 binding to the IL 2 promoter , with selective reduction in binding of c Fos , JunB , and JunD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
However , ascorbate increased the mRNA levels of c jun , junB , and c fos in 1 alpha , 25 ( OH ) 2D3 induced cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The Wnt mediated repression of c Fos , FosB , and JunB expression was consistent with a decrease in their binding to an AP 1 promoter element and decreased target gene transcription . ^^^ Further analysis demonstrated that serum or 12 O tetradecanoylphorbol 13 acetate activation of several immediate early genes including fos , fosB , junB , and egr 1 was inhibited by Wnt signaling . ^^^ The expression of fos , fosB , junB , and egr 1 was also repressed in human colon tumors relative to patient matched normal tissue . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Forty six globes were processed for in situ hybridization with oligonucleotide probes for c fos , fosB , c jun , junB and junD mRNAs , and 60 globes were immunohistochemically analysed using anti c Fos and anti c Jun antibodies . ^^^ Normal lens epithelial cells expressed mRNA signals for junD , but not for c fos , fosB , c jun , and junB . mRNAs for c fos , fosB , c jun , and junB were detected in the whole lens epithelium from the vicinity to the wound to the equator from 30 min to 8 hr post injury with their peaks after 30 min to 1 hr , but were no longer detected at 10 hr or later . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The DNA binding activities of c Fos , FosB / Delta FosB , Fra 1 , Fra 2 , and JunB were up regulated whereas JunD activity was decreased . c Fos , FosB / Delta FosB , and JunB were associated with Smad 4 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In contrast , DMSO reduced the expression of immediate early genes ( IEG ) expression ( c myc , c jun , c fos , junB , egr 1 ) and inhibited mitogen activated protein kinase ( MEK ) kinase / extracellular signal regulated kinases ( ERKs ) and p 38 phosphorylation . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using in situ hybridization , the present report demonstrates that CNP regulates egr 1 , c fos and junB immediate early gene expression in rat brain . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of c Fos , ICER , Krox 24 and JunB in the whisker to barrel pathway of rats : time course of induction upon whisker stimulation by tactile exploration of an enriched environment . ^^^ Our data demonstrate that upon whisker stimulation by exploration of a novel , enriched environment , ( 1 ) subcortical relay stations in the whisker to barrel pathway are able to express elevated levels of c Fos and ( 2 ) in the barrel cortex c Fos , JunB , Krox 24 and ICER are differentially regulated in the temporal domain . . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Ribonuclease protection assays demonstrated that increases in mRNA levels of the early response protooncogenes c jun , junB , fra 1 , and fra 2 accompanied cell proliferation at low concentrations of PM whereas apoptotic concentrations of PM caused transient increases in expression of fos and jun family members and dose responsive increases in mRNA levels of receptor interacting protein , Fas associated death domain , and caspase 8 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
RT PCR analysis of nerve growth factor mediated changes in AP 1 transcription factors showed rapid increases in c fos and junB mRNA in PC 12 and B5P cells , while increases in c jun were small . ^^^ Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The mitogen and stress induced phosphorylation of CREB at Ser 133 has been linked to the transcription of several immediate early genes , including c fos , junB , and egr 1 . ^^^ The knockout of both MSK 1 and MSK 2 resulted in a 50 % reduction in c fos and junB gene transcription in response to anisomycin or UV C radiation but only a small reduction in response to tetradecanoyl phorbol acetate or epidermal growth factor in fibroblasts . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We observed that withdrawal of IL 7 induced increased expression of jun and fos family member genes including c jun , junB , junD , c fos and fra 2 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Activation of ERK1 / 2 resulted in induction of c jun , junB , and c fos expression , whereas activation of p 38 alone had no effect . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression of c fos , fosB , fra 1 , fra 2 , and junB was low during early gestation , with a 5 to 10 fold increase on Day 23 during labor , and returned to low levels 1 day postpartum . ^^^ Administration of progesterone ( P 4 ; 16 mg / kg s . c . / day ) beginning on Day 20 ( to maintain elevated plasma P 4 levels ) prevented the onset of labor and blocked the expected rise in c fos , fosB , fra 1 , fra 2 , and junB expression on Day 23 . ^^^ In contrast , administration of the progesterone receptor antagonist RU 486 ( 10 mg / kg s . c . ) on Day 19 induced preterm labor and a premature increase in mRNA levels of c fos , fra 1 , fra 2 , and junB . ^^^ In unilaterally pregnant rats , stretch imposed by the growing fetus was found to increase the expression of c fos , fosB , fra 1 , fra 2 , and junB only in the gravid horn on the day of labor . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have characterized the effects of chronic clozapine and haloperidol treatments on the expression of fos ( c fos , fosB , fra 2 ) and jun ( c jun , junB , junD ) family genes in the rat forebrain . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using in situ hybridization , the present report demonstrates that NO released by sodium nitroprusside regulates egr 1 , c fos , and junB immediate early gene expression in rat forebrain . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
JunD , a member of the Jun family of nuclear transcription proteins , dimerizes with Fos family members or other Jun proteins ( c Jun or JunB ) to form the activator protein 1 ( AP 1 ) transcription factor . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Similarly , in the second experiment it was found that the D1R dependent induction by AMPH of Fos , FosB , and JunB , but not NGFI A , in the NAc was enhanced in rats exposed 1 week earlier to repeated VTA AMPH . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Serum response factor ( SRF ) is a transcription factor , which binds to a serum response element ( SRE ) associated with a variety of genes including immediate early genes such as c fos , fosB , junB , egr 1 and 2 , neuronal genes such as nurr 1 and nur 77 and muscle genes such as actins and myosins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We found that the zinc finger region of BCL 6 interacts with c Jun , JunB , and JunD proteins but does not bind c Fos or Fra 2 proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershift EMSA revealed that VT preferentially induced JunB , JunD , phosphorylated c Jun , c Fos , and Fra 2 binding activities of the AP 1 family . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In this work we investigated the effect of measles virus ( MV ) infection on the expression of immediate early genes junB , c jun and c fos mRNA as well as AP 1 DNA binding activity in the lung epithelial like adenocarcinoma cell line A 549 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We found that there is a lack of induction of c Fos , FosB , Fra 2 and JunB by acute cocaine exposure , and of DeltaFosB by repeated cocaine administration in both the NAc and CPu of D 1 receptor mutant mice compared with wild type control mice . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Data obtained from knockout mice revealed that some components , such as c Fos are key regulators of bone cell differentiation , whereas others , like c Jun , JunB and Fra 1 are essential in embryonic and / or postnatal development . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This elevated phosphorylation of c Jun correlated with enhanced DNA binding and transcriptional activation of an AP 1 complex consisting of c Jun and Fos but lacking the c Jun antagonist JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The expression of c Fos , c Jun and JunB proteins was determined by the Western blot analysis . ^^^ A decrease in the expression of c Fos on the 1st and 4th day after trauma had no significant effect on c Jun expression ; the increase in expression of JunB was only on the 1st day after injury . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Gene disruption studies indicate that the AP 1 family members c jun , junB , and fra 1 are essential for embryonic development , whereas junD , c fos , and fosB are required for normal postnatal growth . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In natural killer ( NK ) cells , interleukin 2 ( IL 2 ) differentially regulates the expression of several transcription factors , including JunB and c fos . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Further EMSA analysis using antibodies to various AP 1 components revealed that junB antibodies partially depleted the increase in binding to the PRE 1 seen in UK / rap1 cells while antibodies to other AP 1 constituents such as c jun , c fos , and ATF 1 had no effect on binding . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
On the other hand , expressions of proto oncogene c jun , junB and c fos were induced by TPA and Saikosaponin a during 30 min to 6 h of treatment . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ Nuclear extracts from granulosa cells from 1 2 mm or 8 10 mm antral follicles bound an AP 1 DNA consensus sequence and complexes consisted predominantly of c Jun , JunD , JunB , c Fos , and Fra 2 . ^^^ In CL , c Jun , JunD , JunB , and Fra 2 were present in DNA binding complexes , and c Fos binding was not detected . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Among the early response genes analyzed , c myc , junB , junD , c jun , c fos , fosB , fra , as well as max , mad 1 4 , sin 3 , only c jun and fra 2 mRNAs were up regulated after 1 , 25 ( OH ) ( 2 ) D ( 3 ) exposure . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Towards this end , we characterized the effect pharmacological disruption of the MAPK cascade has on the expression of the immediate early genes c Fos , JunB and EGR 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In a Gal 4 fusion assay , Pdcd 4 specifically inhibited activation of c Jun and c Fos activation domains , but did not inhibit activation of JunB , JunD , Fra 1 , or Fra 2 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Acute injection of morphine induces expression of the immediate early genes c Fos and JunB in several forebrain regions of the rat , in part through an N methyl D aspartate ( NMDA ) receptor dependent mechanism . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Electrophoretic mobility supershift assay indicated that the JunB , JunD , and c Fos components of AP 1 were particularly affected . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Memory retrieval after contextual fear conditioning induces c Fos and JunB expression in CA 1 hippocampus . ^^^ Using specific polyclonal antisera against c Fos , JunB , c Jun and JunD , we tried to identify the candidate transcription factors of the immediate early gene family which may contribute to the molecular processes during contextual memory reconsolidation . ^^^ In these mice context dependent memory retrieval evoked a marked induction of c Fos and JunB , but not of c Jun and JunD , in pyramidal CA 1 neurons of the dorsal hippocampus . ^^^ In contrast , mice exposed and re exposed only to the context , without foot shock , did not show behavioral signs of contextual fear conditioning and exhibited significantly less expression of c Fos and JunB in CA 1 neurons . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Here we surveyed human lymphoma samples for expression of JunB and other AP 1 members ( c Jun , c Fos , Fra 1 , JunD ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In the current study , we examined the expression of seven fos / jun family member mRNAs ( c fos , fosB , fos related antigen ( fra ) 1 , fra 2 , junB , c jun , and junD ) and three other IEG mRNAs ( egr 1 , egr 3 , and nur 77 ) in mouse brain following short term ( 6 h ) sleep deprivation ( SD ) and 4 h recovery sleep ( RS ) after SD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Our results reveal that c fos , fosB , c jun , and junB levels were upregulated at 24 hr . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In situ hybridization was used to evaluate depolarization thresholds for induction of mRNAs encoding the 70 kDa heat shock / stress protein , hsp 72 , as well as several immediate early genes ( c fos , c jun , junB , and junD ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We demonstrated previously that c Jun , JunB and c Fos RNA were dysregulated in metastatic melanoma cells compared with normal human melanocytes . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Ischemic tolerance was associated with transient up regulation of transcription factors ( c Fos , JunB Egr 1 , 2 , 4 , NGFI B ) , Hsp 70 and MAP kinase cascade related genes ( MKP 1 ) , which are implicated cell survival . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Functional classification of the 25 genes demonstrated alterations of expression of several kinds of biological pathways , regulating transcription ( Bhlhb 2 , Jun , c fos , Egr 1 , Egr 2 , Fosb , Junb , Ifrd 1 , Neurod 6 ) , the cell cycle ( c fos , Fosb , Jun , Junb , Dusp 1 ) , stress response ( Dusp 1 , Dnajb 1 , Dnaja 4 ) , chaperone activity ( Dnajb 1 , Dnaja 4 ) and cell death ( Ptgs 2 , Gadd45g , Tdag 51 ) , in the mouse hippocampus by 24 h of reperfusion . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Quantitative reverse transcriptase polymerase chain reaction ( RT PCR ) analysis revealed increases in the expression in the SCN of immediate early genes , such as c fos , NGFI A , NGFI B , and JunB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Changes in the mRNA expression levels of seven genes , Tbp , Eef1a , Fos , Junb , Myc , Vegf , and Glut 2 , were determined by real time reverse transcription polymerase chain reaction . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Static stretch induced an increase in the expression of c fos , fosB , fra 1 , c jun , and junB . ^^^ The expression of both c fos and junB was maximally induced at 30 min by static stretch . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
RT PCR analysis confirmed up regulation of transgene , mouse endogenous Ha ras , N ras , raf , Mekk 2 , c fos , junB , c myc and cyclin D 1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
PRL activation of these pathways leads to increased c Jun protein and phosphorylation , JunB protein , and phosphorylation of c Fos , elevating the levels of AP 1 complexes able to bind DNA . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The upregulated genes fall into several categories including antioxidants : ceruloplasmin , metallothionein , and heme oxygenase ; antiapoptotic gene : bag 3 , chloride channels : clic 1 and clic 4 ; transcription factors : c fos , fra 1 , junB , stat 1 , krox 24 and c / ebp ; secreted signaling molecules : chitinase 3 like protein 1 and osteopontin ; inflammation related genes : MCP 1 and ICAM 1 and others . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In analogous fashion , DON upregulated expression of the chemokines macrophage inhibitory protein 2 ( MIP 2 ) , cytokine induced chemoattractant protein 1 ( CINC 1 ) , monocyte chemoattractant protein ( MCP ) 1 , MCP 3 , and cytokine responsive gene 2 ( CRG 2 ) . c Fos , Fra , c Jun , and JunB , components of the activator protein 1 ( AP 1 ) transcription factor complex , were induced by DON as well as another transcription factor , NR4A1 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Furthermore , experiments revealed that the protein and mRNA expression of the AP 1 subunits c Fos , Fra 1 and c Jun was reduced in lesional psoriatic skin compared with nonlesional psoriatic skin , whereas the protein and mRNA expression of the subunit JunB was increased . ^^^ Topical application of the vitamin D analogue calcipotriol under occlusion to involved psoriatic skin for 4 days resulted in an increase in AP 1 DNA binding activity , and an increase in the protein and mRNA expression of c Fos , Fra 1 and c Jun , together with a decrease in JunB protein and mRNA expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The 27 up regulated genes mainly encoded transcription factors ( JUN , EGR 1 , JUNB , FOS , FOSB , MYCN , and SNAIL 1 ) , growth factors ( VEGF , DTR / HB EGF , IGFBP 7 , IL 6 , ANGPT 2 , EREG , CCL3 / MIP1A , and CCL5 / RANTES ) and growth factor receptors ( TBXA2R , TNFRSF10A / TRAILR1 , and ROBO 2 ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Constitutive expression of the AP 1 transcription factors c jun , junD , junB , and c fos and the marginal zone B cell transcription factor Notch 2 in splenic marginal zone lymphoma . ^^^ The AP 1 transcription factors c jun , junD , junB , and c fos as well as Notch 2 were found to be specifically up regulated . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^ Interestingly , despite very low or absent AP 1 binding in normal as well as in premalignant lesions , AP 1 transcription and its binding activity was found to be very high in malignant tissues showing a preferential heterodimerization of c fos with JunB instead of its canonical dimerization partner c jun . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Regulated expression of immediate early genes c fos , fra 2 and junB was observed in the transgenic mice . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Expression levels of activator protein 1 family members ( c jun , junB , junD , and c fos ) and transforming growth factor ( TGF ) alpha were significantly lower in TPA treated Smad 3 ( / ) skin , cultured keratinocytes , and papillomas , as compared with Smad 3 ( + / + ) controls . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Transfection with c Jun or JunB had no effect on transcription from the Cx 43 promoter , whereas transfection with JunD or combinations of Jun and Fos family members led to significant increases in transcription . ^^^ Dimers comprising Fos / Jun proteins conferred greater transcriptional activity than Jun dimmers , with Fra 2 / JunB combination conferring greatest activity . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Deoxynivalenol was found to readily induce expression of cytokines ( IL 1alpha , IL 1beta , and IL 6 and IL 11 ) , chemokines ( MCP 1 , MCP 3 , CINC 1 and MIP 2 ) , components of the activator protein 1 ( AP 1 ) transcription factor complex ( c Fos , Fra 2 , c Jun and JunB ) , as well as two hydrolases ( MKP 1 , CnAbeta ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Supershifts with antibodies against c Fos and JunB identified these as the responsible proteins . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
We have examined the transcriptional activities of four IEGs ( c fos , junB , NGFI A and NGFI B ) and of the arginine vasopressin ( AVP ) gene in the hypothalamic paraventicular ( PVN ) and supraoptic nuclei ( SON ) of rats after acute osmotic stimuli , using in situ hybridization histochemistry . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Here , we report the alterations in mRNAs levels of c Fos , JunB , and Krox 20 proteins induced in the rat brain and liver by the acute exposure to 3 NPA at 30 mg / kg , s . c . ^^^ While the increase of c fos transcripts was observed in both the hippocampus and liver , the junb transcript increased in the hippocampus but decreased in the liver . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The proto oncogenes c fos , fosB , and c jun were not detected , whereas junB was induced by IL 5 stimulation in both types of cells . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The mRNA expressions of C / EBPbeta , C / EBPdelta , C / EBPgamma , c Jun , JunB , c Fos , Fra 1 and IkappaBalpha and protein level of IkappaBalpha were all unaffected by VIP . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Exposure of HEK 293 cells for 90 min to 15 microM PAT elevated the levels of early growth response gene 1 ( egr 1 ) mRNA , but not of c fos , fosB , and junB mRNAs . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The patterns of cocaine induced c Fos , JunB and Zif 268 protein expression were investigated , using an immunohistochemical approach , within distinct nuclei of the amygdala , either in the presence or absence of a selective inhibitor of the ERK pathway , SL 327 . ^^^ In particular , whereas c Fos and JunB expressions were augmented following chronic cocaine treatment , as compared with acute treatment , Zif 268 expression was decreased by this chronic treatment . ^^^ Additionally , chronic blocking of ERK activation affected cocaine induced c Fos and JunB but not Zif 268 expression . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
A robust increase in expression of 10 immediate early genes including Egr 1 4 , Hes 1 , Junb , Jun and Fos was observed already after 1 h treatment with NGF alone . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Immunodepletion gel shift assays demonstrated that GP 5 EpRE bound JunB , c Jun , FosB , and Fra 2 from unstimulated cells , and that after exposure to HNE , EpRE binding complexes contained nuclear factor erythroid 2 related factor ( Nrf ) 1 , Nrf 2 , JunB , c Jun , FosB , c Fos , Fra 1 , and Fra 2 . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Ischemia induced the expression and binding of c Fos , c Jun , JunB , FosB , and Fra 2 to a noncanonical activating protein 1 ( AP 1 ) site present in the MMP 2 promoter and decreased binding of the transcriptional repressor JunD . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
This phenomenon results from simultaneous decrease of c Fos protein level and increases in JunB and deltaFosB protein levels . ^^^ SL 327 pre treatment , however , reduces the DNA binding activity of the activator protein 1 complex induced six hours after an acute cocaine treatment as well as one hour after the last of the chronic cocaine injections , a phenomenon that results from the concomitant reduction of all cocaine induced proteins ( c Fos , FosB , deltaFosB , JunB ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Lesion of the lateral entorhinal cortex amplifies odor induced expression of c fos , junB , and zif 268 mRNA in rat brain . ^^^ To test this hypothesis , expression of the immediate early genes c fos , junB , and zif 268 was studied in response to an olfactory stimulation in several brain areas in control and in EC lesioned rats . ^^^ Olfactory stimulation in control rats induced the expression of the three genes in the granular / mitral and glomerular layers of the olfactory bulb , as well as c fos and junB expression in the piriform cortex . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
PTHrP increased mRNA and protein levels of all Fos members , but only one Jun member ( JunB ) was increased . ^^^ RESULTS : PTHrP treatment in vitro resulted in a time dependent upregulation of mRNA and proteins for the Fos family members , but only JunB of the Jun family . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The Jun proteins Jun , JunB and JunD are core members of activator protein 1 ( AP 1 ) , a dimeric transcription factor complex consisting of homo and heterodimers of the Jun , Fos , activating transcription factor ( ATF ) and musculoaponeurotic fibrosarcoma ( Maf ) families . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The present study has shown that cell preparation procedure , i . e . , cell collection by centrifugation and the subsequent adjustment and culture of cell density at the desired concentrations , transiently induced gene expression of plasminogen activator inhibitor 1 ( PAI 1 ) and the AP 1 components ( c fos , c jun , and junB ) . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Furthermore , almost all kinds of the AP 1 family genes including c jun , c fos , junD , junB , atf 2 and b atf were successfully selected from an mRNA display library constructed from a mouse brain poly A ( + ) RNA after six rounds of selection . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
PTH enhanced mRNA expression of c fos , junB , and fra 2 in the distal femur metaphyses of both genotypes ; expression of these transcripts was consistently lower in PTH treated Nf 1 ( + / ) mice . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
In addition , hnRNP G overexpression led to up regulation of the expression of TXNIP , a cell cycle inhibitory gene , and significantly reduced the expression of the genes that promote cellular proliferation , such as EGR 1 , JUND , JUNB , FOS , FOSL 1 , ROS , and KIT . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Treatment with TGF beta in mast cells resulted in the differential gene induction of the AP 1 components , i . e . , transient induction of c fos but not of c jun and junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
Using rat mixed glial cultures containing oligodendrocytes , microglia , and astrocytes , we found that the Fc portion of human IgM shifts microglia to an activated phenotype , reduces glial proliferation , upregulates a variety of immediate early genes , including JunB , Egr 1 , and c Fos , and stimulates microglial production and release of IL 1beta . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
The DHPG induced expression of immediate early genes ( c fos , junB , egr 1 and nr4a1 ) was subsequently verified by TaqMan polymerase chain reaction . ^^^ Indeed , here we could show a DHPG dependent binding of SRF at the SRF response element ( SRE ) site within the promoter region of c fos and junB . ^^^
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
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Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA
Interacting proteins: P17275 and P01100	Pubmed	SVM Score :0.0
NA