| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| Potent inhibitors ( single digit nanomolar IC ( 50 ) ) for PKC beta and GSK 3beta were identified , and compounds showed good selectivity over PKC alpha , gamma , delta , epsilon , and zeta . ^^^ |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| ApoE 4 also activated PKC alpha and PKB possibly giving the subsequent GSK 3beta inhibition . ^^^ |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| Finally , intracerebroventricular injection of lithium increased GSK 3beta Ser 9 phosphorylation and enhanced PKC alpha activity 1 . 8 fold in mouse hippocampus , confirming this lithium response in vivo . ^^^ Our studies propose a new mechanism by which lithium indirectly inhibits GSK 3beta via phosphatidylinositol 3 kinase dependent activation of PKC alpha . . ^^^ |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| Compounds from this series have shown no detectable effect when tested against a representative set of other serine / threonine kinases such as GSK3beta , CAMKII , PKA , PKC alpha , beta , epsilon , gamma . ^^^ |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|