| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| It appears now that the syndecan 4 core protein , a transmembrane proteoglycan shown previously to bind phosphatidylinositol 4 , 5 bisphosphate ( PIP ( 2 ) ) and activate PKC alpha , participates in mediating the effects of fibroblast growth factor ( FGF ) 2 on cell function . ^^^ In both cases , the molecular mechanism was determined to consist of a decrease in the syndecan 4 dependent activation of PKC alpha . ^^^ |
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| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| Unlike other members of syndecan family , syndecan 4 mediates phosphatidylinositol 4 , 5 bisphosphate 2 ( PIP ( 2 ) ) dependent PKC alpha activation , and overexpression of syndecan 4 in vitro results in enhanced FGF 2 signaling . ^^^ |
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| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| Direct binding of syndecan 4 cytoplasmic domain to the catalytic domain of protein kinase C alpha ( PKC alpha ) increases focal adhesion localization of PKC alpha . ^^^ The central region of syndecan 4 cytoplasmic domain ( 4V ; LGKKPIYKK ) binds phosphatidylinositol 4 , 5 bisphosphate , and together they regulate protein kinase C alpha ( PKC alpha ) activity . ^^^ A mutated 4V sequence ( 4V ( YF ) : LGKKPIFKK ) did not interact with PKC alpha , indicating that tyrosine 192 in the syndecan 4 cytoplasmic domain might be critical for this interaction . ^^^ The interaction of syndecan 4 with PKC alpha appears unique since PKC delta and epsilon did not interact with 4V in yeast two hybrid assays or coimmunoprecipitate with syndecan 4 . ^^^ Finally , overexpression of syndecan 4 in rat embryo fibroblast cells , but not expression of the YF mutant , increased PKC alpha localization to focal adhesions . ^^^ |
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| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| We speculated that the reason for changes after TPA treatment was the interactions with activated PKC alpha , which provoked syndecan 4 / PKC alpha complex translocation to integrins . ^^^ |
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| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P31431 and P17252 |
Pubmed |
SVM Score :0.0 |
| NA |
|