| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.63535539 |
| GnRH stimulation caused translocation of PKC alpha and epsilon to the cell membrane and enhanced the association of Src with PKC alpha and PKC epsilon , Pyk 2 , and the EGF receptor . 0.63535539^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| Based on the subcellular distribution of PKC alpha and epsilon , and that PKC substrates like GAP 43 and pp60c src are enriched in SH SY5Y growth cones , a role during neurite growth is suggested . . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| The negative effect on Src kinase activity upon FGFR stimulation was mimicked by activation of PKC in FGFR 1 / PAE or CCL 39 cells using phorbol 12 myristate 13 acetate ( PMA ) and Src was phosphorylated in vitro by purified recombinant PKC alpha . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| Mutation of serine at this position or at residue 259 does not abrogate Raf 1 stimulation by a combination of Ras plus the src tyrosine kinase Lck , but severely impedes Raf 1 activation by PKC alpha . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| In conclusion , the tumorigenic progression induced by oncogenic p21ras or the Py MT / pp60c src complex in Caco 2 cells is associated with increased PKC alpha gene transcription and PKC alpha expression as well as with constitutive PKC activation . ^^^ These results provide the first evidence that the PKC alpha gene is a target for the signaling pathways of oncogenically activated p21ras and pp60c src in human colonic cells . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| High selectivity toward a panel of nonreceptor tyrosine kinases ( c Src , 5 Abl ) and serine / threonine kinases ( PKC alpha , PKA ) was observed . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| High selectivity towards a panel of non receptor tyrosine kinases ( c SRC , 5 Abl ) and serine / threonine kinases ( PKC alpha , PKA ) was observed . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| High selectivity toward a panel of nonreceptor tyrosine kinases ( c Src , 5 Abl and serine / threonine kinases ( PKC alpha , CDK 1 ) was observed . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , 1 , 25 dihydroxyvitamin D 3 specifically induced the translocation of PKC betaII , but not PKC alpha , to the basolateral , but not brush border plasma membranes of rat colonocytes , via a pp 60 ( c src ) dependent mechanism . . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| PTx , moreover , inhibited the stimulation of pp 60 ( c src ) and PKC alpha by 1 , 25 ( OH ) 2D3 . ^^^ These findings , taken together with those of the accompanying paper , indicate that although 1 , 25 ( OH ) 2D3 and TPA each activate PLD in Caco 2 cells in part via PKC alpha , their stimulation of PLD differs in a number of important aspects , including the requirement for pp 60 ( c src ) and RhoA in the activation of PLD by 1 , 25 ( OH ) 2D3 , but not TPA . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| It is not active against kinases from other receptor families such as EGFR , FGFR 1 , c Met and Tie 2 or intracellular kinases like c Src , c Abl , PKC alpha . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| Thus , in NCI H 292 epithelial cells , IFN gamma activates PLC gamma 2 via an upstream tyrosine kinase to induce activation of PKC alpha and c Src or Lyn , resulting in activation of STAT1alpha , and GAS in the ICAM 1 promoter , followed by initiation of ICAM 1 expression and monocyte adhesion . . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| Stimulated caveolar endocytosis required src kinase and PKC alpha activity as shown by 1 ) use of pharmacological inhibitors , 2 ) expression of kinase inactive src or dominant negative PKCalpha , and 3 ) stimulation of src kinase activity upon addition of GSLs or cholesterol . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| Upregulation and activation of PKC alpha by ErbB 2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| Further studies revealed that thrombin induced PKC alpha , c Src , and IKK alphabeta complex formation . ^^^ These results show for the first time that thrombin , acting through PAR 1 and PAR 4 , activates the phosphoinositide phospholipase C / PKC alpha / c Src / IKK alphabeta signaling pathway to induce NF kappaB activation , which in turn induces IL 8 / CXCL8 expression and release in human lung EC . . ^^^ |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P17252 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|