| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.60015295 |
| Evidence that phospholipase C gamma 2 interacts with SLP 76 , Syk , Lyn , LAT and the Fc receptor gamma chain after stimulation of the collagen receptor glycoprotein 6 in human platelets . 0.60015295^^^ |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Furthermore , treatment of SLP 76 deficient platelets with collagen fails to elicit tyrosine phosphorylation of phospholipase C gamma 2 ( PLC gamma 2 ) , suggesting that SLP 76 functions upstream of PLC gamma 2 activation . ^^^ |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of PLC gamma 2 and Ca2+ mobilization is markedly attenuated in SLP 76 deficient platelets following CRP stimulation , suggesting that the adapter plays a critical role in the regulation of the phospholipase . ^^^ This work identifies SLP 76 as an important adapter molecule that is regulated by Syk and lies upstream of SLAP 130 and PLC gamma 2 in CRP stimulated platelets . . ^^^ |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| SLP 76 and BLNK link immunoreceptor tyrosine based activation motif containing receptors to signaling molecules that include phospholipase C gamma , mitogen activated protein kinases , and the GTPases Ras and Rho . ^^^ SLP 76 ( / ) bone marrow derived macrophages display FcgammaR mediated tyrosine phosphorylation of Syk , phospholipase C gamma 2 , and extracellular signal regulated kinases 1 and 2 , and normal FcgammaR dependent phagocytosis . ^^^ |
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| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| In the present study , we have shown that cross linking of GPVI by JAQ 1 results in tyrosine phosphorylation of the same profile of proteins as that induced by collagen , including the Fc receptor ( FcR ) gamma chain , Syk , LAT , SLP 76 , and phospholipase C gamma 2 . ^^^ |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| In this study , it was discovered that 4N1 1 or its derivative peptide , 4N1K , induces rapid phosphorylation of the Fc receptor ( FcR ) gamma chain , Syk , SLP 76 , and phospholipase C gamma 2 in human platelets . ^^^ |
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| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| In the Syk Y342F expressing cells there was dramatically impaired receptor induced phosphorylation of multiple signaling molecules , including LAT , SLP 76 , phospholipase C gamma 2 , but not Vav . ^^^ |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , however , BMM from SLP 76 ( / ) mice activate ERK 2 and phosphorylate PLC gamma 2 following Fc gamma R ligation . ^^^ |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Whereas tyrosine phosphorylation of Fc ( epsilon ) RI , Syk , and Vav was intact in LAT deficient BMMCs following Fc ( epsilon ) RI engagement , tyrosine phosphorylation of SLP 76 , PLC gamma 1 , and PLC gamma 2 and calcium mobilization were dramatically reduced . ^^^ |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|