| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| Proliferation of a factor dependent pre B cell line ( NAG8 / 7 ) in response to either TSLP or IL 7 was inhibited by anti IL 7R alpha mAbs , suggesting that the functional TSLP receptor complex uses IL 7R alpha . ^^^ |
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| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| This can be explained by the finding that the receptor complexes for TSLP and IL 7 both contain the IL 7R alpha chain ; IL 7Ralpha is paired with the common gamma chain ( gammac ) in the IL 7 receptor complex and the unique TSLP R chain in the TSLP receptor complex . ^^^ We also show that the TSLP receptor complex is functionally reconstituted using TSLP R and IL 7Ralpha and that TSLP mediated signal transduction requires Stat 5 . ^^^ |
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| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| As IL 7R alpha is also a receptor for thymic stromal derived lymphopoietin ( TSLP ) , we assayed the ability of TSLP to support proliferation of fetal or adult precursor B cells . ^^^ |
|
| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| More recently , it has been shown that IL 7Ralpha is also shared by the receptor for another cytokine , thymic stromal lymphopoietin ( TSLP ) . ^^^ |
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| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| Binding of TSLP to the thymic stromal lymphopoietin receptor ( TSLPR ) is increased markedly in the presence of the IL 7 receptor alpha chain ( IL 7R alpha ) . ^^^ IL 7R alpha expressing but not parental 32D cells proliferate in the presence of exogenous TSLP . ^^^ Moreover , a combination of IL 7R alpha and TSLPR is required for TSLP dependent activation of a STAT 5 dependent reporter construct . ^^^ Thus it is shown that IL 7R alpha is a component of both the IL 7 and TSLP receptors , which helps to explain why deletion of the gene that encodes IL 7R alpha affects the lymphoid system more severely than deletion of the gene encoding IL 7 does . ^^^ |
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| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| TSLP did not activate cells from IL 7Ralpha ( / ) mice , but did activate cells from gammac ( / ) mice . ^^^ |
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| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| The fact that IL 7Ralpha is a component of the receptors for both IL 7 and thymic stromal lymphopoietin ( TSLP ) suggests that IL 2 can negatively regulate signals by each of these cytokines . ^^^ |
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| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969D9 and P16871 |
Pubmed |
SVM Score :0.0 |
| NA |
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