| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| Major STAT complexes activated by G CSF R / IL 7R alpha contained STAT 1 or STAT 5 , while some formation of STAT 3 containing complexes was also seen . ^^^ |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| The IL 7 inducible transcription factor , STAT 5 , is not active in the fetal thymus of IL 7R alpha / compared with IL 7R alpha + / + mice . ^^^ |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| EBF expression is restored in IL 7 ( / ) pre pro B cells upon IL 7 stimulation or in IL 7R alpha ( / ) pre pro B cells by activation of STAT 5 , a major signaling molecule downstream of the IL 7R signaling pathway . ^^^ |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| To identify the function of the Raf and STAT 5 pathways in IL7R dependent B cell development , we used transgenic mice that express constitutively active forms of Raf ( Raf CAAX ) or STAT 5 ( STAT5b CA ) throughout lymphocyte development . ^^^ In contrast , STAT 5 activation selectively restores B cell expansion in IL7R ( / ) mice . ^^^ In addition , STAT 5 activation also restored B cell differentiation in IL7R ( / ) mice as determined by 1 ) the restoration of 5 ( H ) Ig gene rearrangement and 2 ) the appearance of immature and mature B cell subsets . ^^^ These findings establish STAT 5 as the key player entraining B cell development downstream of the IL7R . . ^^^ |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| To explore the role of the IL7R in this process , we generated transgenic mice that express a constitutively active form of STAT 5 ( STAT5b CA ) , a key downstream IL7R effector , throughout lymphocyte development . ^^^ |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| We also show that the TSLP receptor complex is functionally reconstituted using TSLP R and IL 7Ralpha and that TSLP mediated signal transduction requires Stat 5 . ^^^ |
|
| Interacting proteins: P16871 and P42229 |
Pubmed |
SVM Score :0.0 |
| Return to quiescence is associated with a cessation in IL 7R signaling as demonstrated by an abrogation of STAT 5 phosphorylation , despite an up regulation of surface IL 7Ralpha . ^^^ |
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