| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| Our findings are consistent with the hypothesis that the absence of an intact IL 7R ( IL 7R alpha and gamma c ) may be a critical loss that interrupts lymphopoiesis . . ^^^ |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| It is likely that higher TGF beta concentrations do not inhibit lymphopoiesis by down regulating IL 7 receptor expression , since this cytokine did not reduce IL 7R alpha or gamma c mRNA levels in normal B cell precursors . ^^^ Adhesion of human B cell precursors to stroma did not alter stromal IL 7 expression or expression of IL 7R alpha or gamma c chains by B cell precursors . ^^^ |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| In humans , although both T cell and B cell progenitors express the functional IL 7 receptor that consists of IL 7R alpha and the gamma common ( gamma c ) chain , this lymphocyte receptor system is critical for T lineage but not for B lineage development . ^^^ Indeed , complete gamma c deficiency like IL 7R alpha deficiency results in the arrest of T cell but not B cell development ( T ( ) B ( + ) SCID ) . ^^^ It was therefore plausible to assume that partial deficiency of IL 7R alpha , like partial gamma c deficiency may lead to a milder clinical and immunologic phenotype . ^^^ Surprisingly , this partial deficiency of IL 7R alpha resulted in a severe phenotype , including markedly reduced circulating T cells while sparing B cell numbers similar to gamma c chain deficiency . ^^^ Unlike partial gamma c deficiency , a partial deficiency of IL 7R alpha results in an arrest of T cell development , leading to typical severe combined immunodeficiency . ^^^ |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| Mutations in genes required for T cell development : IL7R , CD 45 , IL2RG , JAK 3 , RAG 1 , RAG 2 , ARTEMIS , and ADA and severe combined immunodeficiency : HuGE review . ^^^ Mutations in any of eight known genes : IL2RG , ARTEMIS , RAG 1 , RAG 2 , ADA , CD 45 , JAK 3 , and IL7R cause SCID . ^^^ |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| Although GC have been reported to induce the transcription of IL 7Ralpha gene in human T cells , its molecular mechanism is largely unknown . ^^^ In this study , we show that GC up regulate the levels of IL 7Ralpha mRNA and protein in mouse T cells . ^^^ These results demonstrate that GR binds to the GR motif in the CNS 1 region after GC stimulation and then activates the transcription of the IL 7Ralpha promoter . ^^^ Thus , this study identifies the IL 7Ralpha CNS 1 region as a GC responsive element . . ^^^ |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| The receptor consists of two chains : IL 7 specific alpha chain ( CD 127 ) and the common gamma ( c ) chain ( CD 132 ) which is a component of several other cytokine receptors : IL 2 , IL 4 , IL 9 and IL 15 . ^^^ |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| IL 7 acts on various cells through its receptor ( IL 7R ) , a heterodimer consisting of an alpha chain ( CD 127 ) that specifically binds IL 7 and a common gamma ( c ) chain ( CD 132 ) shared by other cytokine receptors . ^^^ |
|
| Interacting proteins: P16871 and P31785 |
Pubmed |
SVM Score :0.0 |
| Increased plasma interleukin 7 level correlates with decreased CD 127 and Increased CD 132 extracellular expression on T cell subsets in patients with HIV 1 infection . ^^^ Cell surface expression and intracellular expression of the IL 7R components CD 127 and CD 132 were measured by flow cytometry . ^^^ In vitro , exogenous IL 7 rapidly down regulated cell surface CD 127 expression , but not CD 132 expression , whereas subsequent reexpression required active protein synthesis . ^^^ |
|