Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Interleukin 7 ( IL 7 ) receptor ( CDw 127 ) was detected by flow cytometric analysis . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Growth inhibitory and agonistic signals of interleukin 7 ( IL 7 ) can be mediated through the CDw 127 IL 7 receptor . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Surface expression of interleukin 7 ( IL 7 ) receptor alpha ( IL 7R alpha ) , a component of the high affinity receptor for the lymphoid precursor growth factor IL 7 , defined a CD34+ progenitor subset lacking the CD19+ pro B phenotype but demonstrating markedly enhanced lymphoid clonogenic capacity and the ability to differentiate into pro B cells in short term culture . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Interleukin 7 receptor alpha chain knockout ( IL 7R / ) mice are severely deficient in B lymphocytes and alpha beta T cells and completely lack the gamma delta T cell lineage . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
D J joining occurs normally in immature B lymphocytes from mice lacking the alpha chain of the interleukin 7 receptor ( IL 7Ralpha ) . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Distinct roles of the interleukin 7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin 7 receptor alpha deficient mice . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
The BCP cell lines display surface receptors for interferon gamma ( CD 119 ) , interleukin 7 ( CD 127 ) and FLT 3 ligand ( CD 135 ) . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Here , we present detailed data on the expression of the interleukin 7 receptor alpha chain ( IL 7Ralpha ) in leukaemic cells from 210 children with acute lymphoblastic leukaemia ( ALL ) and describe two novel alternatively spliced transcripts of human IL 7Ralpha coding for truncated receptor proteins which are still capable of binding IL 7 . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Physical mapping of the interleukin 7 receptor gene ( IL7R ) to bovine chromosome 20q15 q 17 . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
The high affinity human interleukin 7 ( IL 7 ) R is a heterodimeric complex consisting of the IL 7Ralpha and common interleukin 2 receptor gamma ( IL 2Rgamma ( c ) ) chains . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
The interleukin 7 receptor ( IL7R ) , which contains a unique alpha chain and a gamma chain shared by other cytokine receptors , is indispensable for normal lymphocyte development . ^^^ The interleukin 7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Interleukin 7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF 3 cells involves activation of STAT 1 and STAT 5 mediated via the interleukin 7 receptor alpha chain . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Here , this chimeric human mouse FTOC was used to address the role of interleukin 7 ( IL 7 ) and of the alpha chain of the IL 7 receptor ( IL 7R alpha ) in early human T cell development . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Interleukin 7 ( IL 7 ) receptor alpha chain deficient ( IL 7R alpha / ) mice have severely depleted lymphocyte populations and thymocyte development is arrested at the double negative ( DN ) stage . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Although pro B cells are well represented in IL 7 knockout ( KO ) mice , they express abnormally low concentrations of the interleukin 7 receptor alpha chain ( IL 7Ralpha ) and do not generate pre B cells . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Interleukin 7 ( IL 7 ) is important for thymopoiesis in mice and humans because IL 7 receptor alpha ( IL 7Ralpha ) mutations result in a severe combined immunodeficiency phenotype with severe thymic hypoplasia . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
In this study we report the molecular and functional characterization of very early interleukin 7 receptor alpha ( IL 7Ralpha ) + CD79a+CD19 B cell progenitors , produced by human CD34+CD19 CD 10 cord blood cells grown in the presence of stromal cells and cytokines . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
However , reduced expression of both the interleukin 7 receptor alpha ( IL 7Ralpha ) ( CD 127 ) chain and the antiapoptotic protein Bcl 2 was observed . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
In this study we show that increased expression of the interleukin 7 receptor alpha chain ( IL 7Ralpha ) identifies the effector CD 8 T cells that will differentiate into memory cells . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
The interleukin 7 receptor alpha chain ( IL 7Ralpha ) is essential for T cell development in both humans and mice and for B cell development in mice . ^^^ GA binding protein regulates interleukin 7 receptor alpha chain gene expression in T cells . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Although it has been suggested that defective interleukin 7 receptor ( IL 7R ) signaling is one of the principal causes of severe combined immunodeficiency disease ( SCID ) in mice and humans , little is known about the molecular and clinical characteristics of human IL 7Ralpha mutations . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Interleukin 7 receptor alpha ( IL 7Ralpha ) deficiency : cellular and molecular bases . ^^^ Analysis of gene targeted mice and patients with severe combined immunodeficiency due to mutations of the alpha chain of the interleukin 7 receptor ( IL 7Ralpha ) has shown important differences between mice and humans in the role played by IL 7 in lymphoid development . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
All pDCs expressed terminal deoxynucleotidyl transferase ( TdT ) , the ETS transcription factor Spi B , the nuclear factor kappaB transcription factor RelB , toll like receptor 9 ( TLR 9 ) , and interferon consensus sequence binding protein ( ICSBP ) / interferon regulatory factor 8 ( IRF 8 ) transcripts ; lacked CD 16 and granulocyte colony stimulating factor receptor ( G CSFR ) ; and were uniformly interleukin 7 receptor alpha ( IL 7Ralpha ( ) ) AA4 . 1 ( Lo ) , CD 27 ( ) , Flk 2 ( Lo ) , c Kit ( ) , DX 5 ( ) , and CD11b ( ) , while CD 4 and CD8alpha were variable . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
In the thymus , 2 types of Lin Sca 1+ ( lineage negative stem cell antigen 1 positive ) progenitors can generate T lineage cells : c Kit ( hi ) interleukin 7 receptor alpha negative ( c Kit ( hi ) IL 7Ralpha ) and c Kit ( lo ) IL 7Ralpha+ . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
It has been demonstrated that murine memory CD8+ T cell precursors specific for acute lymphocytic choriomeningitis virus express interleukin 7 receptor alpha ( IL 7Ralpha ) , and IL 7 is involved in maintaining memory populations after the clearance of antigen . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
One interleukin 7 receptor ( IL7R ) promoter single nucleotide polymorphism ( SNP ) , 504 C , was undertransmitted in PPMS trios ( P = 0 . 05 , TDT ) , and carriers of this allele were under represented in PPMS cases from two independent patient cohorts ( combined P = 0 . 006 , FE ) . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
As the course of the infection progressed , many activated CD 8 T cells down regulated expression of CD45RB and upregulated expression of the interleukin 7 receptor alpha chain , indicating a transition of these cells to a state of memory . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Interleukin 7 ( IL 7 ) and its receptor ( IL 7R alpha ) are known to mediate lymphopoiesis , and IL 7 is also known to be essential for the generation of DCs from lymphoid committed precursors in vitro . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
OBJECTIVES : To further understand differentiation and homeostasis of CD 8 T cells specific for HIV , Epstein Barr Virus ( EBV ) and cytomegalovirus ( CMV ) during HIV infection , we investigated interleukin 7 receptor alpha ( IL 7Ralpha ) expression on those virus specific T cells . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Loss of IL 7Ralpha is associated with CD 4 T cell depletion , high interleukin 7 levels and CD 28 down regulation in HIV infected patients . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Increased plasma interleukin 7 level correlates with decreased CD 127 and Increased CD 132 extracellular expression on T cell subsets in patients with HIV 1 infection . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Expression of the interleukin 7 receptor alpha chain ( CD 127 ) on virus specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection . ^^^ Indeed , a population of effector cells that express high levels of the interleukin 7 receptor alpha chain ( CD 127 ) as the precursors of memory CD8+ T cells has recently been identified in mice . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin 7 receptor alpha ( IL 7Ralpha ) expression , differing from the development of memory CD8+ T cells against viruses , which is associated with enhanced IL 7Ralpha expression . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Co culture with either autologous or allogeneic TEC results in similar thymocyte subset distribution as well as interleukin 7 receptor alpha ( CD 127 ) expression on these subsets . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
RECENT FINDINGS : Molecular studies have shown that besides the well known hypomorphic recombination activating gene defects , mutations in the nonhomologous end joining factor Artemis and in the interleukin 7 receptor alpha chain can contribute to the development of Omenn syndrome . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Quantitative reverse transcription PCR revealed reduced interleukin 7 receptor alpha ( IL 7Ralpha ) and Bcl 10 expression and elevated IL 2Ralpha mRNA expression of the CD8alphaalpha ( +high ) gammadelta T cells . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Here , we show that expression of CD 127 , the alpha chain of the interleukin 7 receptor , allows an unambiguous flow cytometry based distinction to be made between CD 127 ( lo ) T reg cells and CD 127 ( hi ) conventional T cells within the CD 25 ( + ) CD45RO ( + ) RA ( ) effector / memory and CD45RA ( + ) RO ( ) naive compartments in peripheral blood and lymph node . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
The different virus specific effector and memory sets are compared by phenotypic [ CD62L , interleukin 7 receptor alpha ( IL 7Ralpha ) , and IL 15Rbeta expression ] and functional [ interferon gamma ( IFN gamma ) , tumor necrosis factor alpha ( TNF alpha ) , and IL 2 production ] analyses . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Whereas the latter can respond to the homeostatic cytokine interleukin 7 ( IL 7 ) , many persistent virus specific T cells , recognizing latent herpesviruses such as Epstein Barr virus and cytomegalovirus ( CMV ) , lack IL 7 receptor alpha ( IL 7Ralpha ) and depend on viral antigens to persist . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
BACKGROUND : The interleukin 7 ( IL 7 ) / IL 7 receptor alpha ( IL 7Ralpha ) system is an important regulator of T cell homeostasis . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
Furthermore , expression of the interleukin 7 receptor alpha chain , which has been proposed to distinguish antigen specific T cells that differentiate into long lived memory T cells , did not differ among groups , suggesting that dilution of the vaccine does not affect the quantity of 10 specific memory T cells . ^^^ |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|
Interacting proteins: P13232 and P16871 |
Pubmed |
SVM Score :0.0 |
NA |
|