| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| CD 36 , active Lyn , along with inactive Src and PLCgamma 2 co localize in small raft complexes in resting platelets . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| We report here that PPARgamma , SRC 1 , and PBP are differentially expressed in the brown fat , transitional epithelium of the urinary bladder , colonic mucosa , and mammary epithelium of the adult mouse . ^^^ PPARgamma and PBP expression overlapped in the brown fat and urogenital sinus at stage E15 . 5 of embryogenesis , whereas SRC 1 expression occurred mostly in neuroepithelium and cartilage between stages E9 . 5 and E13 . 5 of embryogenesis . . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Insulin signaling [ tyrosine phosphorylation of insulin receptor ( IR ) , insulin receptor substrate 1 ( IRS 1 ) , Src homology and collagen protein ( Shc ) and phosphatidyl inositol 3 ' kinase activity ( PI 3 ' kinase ) ] was studied in the liver and thigh muscles of fat ( FL ) and lean ( LL ) chickens . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| RESULTS : BMI was linearly associated with birth weight ( standardized regression coefficient , [ SRC ] =+0 . 27 ; P=0 . 0004 ) , as was the thigh muscle+bone area ( SRC=+0 . 22 ; P=0 . 0029 ) , but not the thigh subcutaneous fat area ( SRC=+0 . 13 ; P=0 . 086 ) . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Women randomized to NEP ( n = 50 ) experienced a large reduction in fat consumption ( 5 . 8 % of energy as fat ) at 4 months and much of this reduction was preserved at 1 year ( 4 . 1 % of energy ) ( both P < . 0002 ) vs no change in either SRC ( n = 51 ) or UC ( n = 56 ) . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| We found that fusion of FAT to Src , the p 85 subunit of phosphatidylinositol 3 kinase , Grb 7 and Grb 2 resulted in the efficient focal adhesion targeting of these signaling molecules . ^^^ We showed that expression of Src FAT , p 85 FAT , or Grb 7 FAT , but not Grb 2 FAT , each stimulated cell migration . ^^^ Interestingly , tyrosine phosphorylation of paxillin , but not p130cas , was induced by expression of Src FAT , suggesting a potential role of paxillin in mediating stimulation of cell migration by the chimeric molecule . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Stretch induced activation of p 38 MAPK was abolished by overexpression of FAT and CSK , which are inhibitors of the FAK and Src families , respectively , and was suppressed by overexpression of a dominant negative mutant of Ras . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis showed that the amounts of leukocyte antigen related PTPase ( LAR ) , PTPase 1B ( PTP1B ) , and src homology 2 containing PTPase ( SH PTP 2 ) were increased in particulate fractions of visceral and epididymal fat of OLETF rats . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| We report here that a developmental arrest in interscapular brown fat and defective adaptive thermogenesis occur in mice lacking both the p 160 family transcriptional coactivators SRC 1 and p / CIP due to a failure in induction of selective PPARgamma target genes involved in adipogenesis and mitochondrial uncoupling . ^^^ In the absence of p / CIP and SRC 1 , mice eat more food on both regular chow and a high fat diet because of decreased blood leptin levels . ^^^ However , the p / CIP ( / ) / SRC 1 ( / ) mice are lean and resistant to high fat diet induced obesity . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recent evidence suggests the cytosolic regulatory protein , calmodulin , plays a central role in regulating GPVI or GPIb 9 5 : first , calmodulin directly binds to conserved , juxtamembrane motifs within cytoplasmic domains of both GPVI and GPIb 9 5 ( GPIbbeta and GPV subunits ) on resting platelets , interactions that dissociate upon platelet activation ; second , an intact calmodulin binding site within GPVI in transfected cells is required for CaCa2+ signaling , but not for GPVI dependent pathways involving Src family kinases or co associated FcRgamma chain ; and third , calmodulin regulates metalloproteinase dependent ectodomain shedding of GPVI and GPV from human platelets . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this paper we report the identification of src related proteins p59fyn , pp60c src and p62yes in human microvascular endothelial cells cultured from normal human skin and their physical association with the thrombospondin receptor CD 36 . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Biochemical characterization of the Triton 10 100 insoluble fraction showed it to be cholesterol rich , greatly and specifically enriched in the plasma membrane glycoprotein CD 36 , and also to contain Src and the Src related kinase , Lyn . ^^^ CD 36 can form associations with certain Src related kinases and can signal to activate platelets . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Two new scavenger receptor receptors have been cloned ( SR BI and SR CI ) and a previously isolated integral membrane protein ( CD 36 ) has been found to possess lipoprotein binding properties that entitle it to be included in the family . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Chk and Lyn , but not Csk and c Src , co fractionated in the higher density lysate fractions of resting platelets , with Chk being found to localize close to CD 36 ( membrane glycoprotein 4 ) anchored Lyn . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| We show that Src induced tyrosine phosphorylation of caveolin 1 can be inhibited or uncoupled by targeting dually acylated proteins ( namely carcinoembryonic antigen ( CEA ) , CD 36 , and the NH ( 2 ) terminal domain of Galpha ( i 1 ) ) to the exoplasmic , transmembrane , and cytoplasmic regions of the caveolae membrane , respectively . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that in microglia and other tissue macrophages , beta amyloid initiates a CD 36 dependent signaling cascade involving the Src kinase family members , Lyn and Fyn , and the mitogen activated protein kinase , p44 / 42 . ^^^ Interruption of this signaling cascade , through targeted disruption of Src kinases downstream of CD 36 , inhibits macrophage inflammatory responses to beta amyloid , including reactive oxygen and chemokine production , and results in decreased recruitment of microglia to sites of amyloid deposition in vivo . ^^^ The finding that engagement of CD 36 by beta amyloid initiates a Src kinase dependent production of inflammatory mediators in cells of the macrophage lineage reveals a novel receptor mediated pro inflammatory signaling pathway of potential therapeutic importance . . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| CD 36 expression was necessary and sufficient to mediate PTEC apoptosis induced by glycated albumins ( AGE BSA and CML BSA ) and free fatty acid palmitate through sequential activation of src kinase , and proapoptotic p 38 MAPK and caspase 3 . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| Microglial activation might involve beta amyloid binding and activation of cell surface immune and adhesion molecules such as CD 45 , CD 40 , CD 36 and integrins , with the subsequent recruitment of Src family tyrosine kinases such as Fyn , Lyn and Syk kinases . ^^^ |
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| Interacting proteins: P16671 and P12931 |
Pubmed |
SVM Score :0.0 |
| However , while the Src family kinase inhibitors PP 1 and PP 2 and the specific AP inhibitor levamisole significantly reduced IRBC adhesion to wild type CD 36 transfectants as with HDMECs , the inhibitors had no effect on IRBC adhesion to the mutant cells . ^^^ Collectively , these results are consistent with a critical role for CD 36 dephosphorylation through Src family kinase activation in regulating IRBC adhesion to vascular endothelium . . ^^^ |
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