| Interacting proteins: P16591 and P40763 |
Pubmed |
SVM Score :0.57453527 |
| The up regulation of Fer and its dissociation from Jak 1 were accompanied by an augmented association of activated Fer with Stat 3 and by a concomitant increase in the tyrosine phosphorylation of Stat 3 . 0.57453527^^^ |
|
| Interacting proteins: P16591 and P40763 |
Pubmed |
SVM Score :0.0 |
| FER kinase activation of Stat 3 is determined by the N terminal sequence . p 94 ( fer ) and p 51 ( ferT ) are two tyrosine kinases that share identical SH 2 and kinase domains but differ in their N terminal regions . ^^^ When combined with immunoprecipitation analysis , this assay showed that p 94 ( fer ) can lead to the tyrosine phosphorylation and activation of Stat 3 but not of Stat 1 or Stat 2 . ^^^ However , modified forms of p 94 ( fer ) , which are constitutively nuclear , could also lead to the phosphorylation of Stat 3 . ^^^ Endogenous Stat 3 and p 94 ( fer ) co immunoprecipitated with each other , thus proving the interaction of these two proteins in vivo . ^^^ Unlike p 94 ( fer ) , p 51 ( ferT ) did not induce the phosphorylation of Stat 3 but led to the phosphorylation of other nuclear proteins . ^^^ |
|
| Interacting proteins: P16591 and P40763 |
Pubmed |
SVM Score :0.0 |
| However , Fer kinase activity was not required for PDGF induced Stat 3 , p 120 ( ctn ) , or epidermal growth factor ( EGF ) induced beta catenin phosphorylation . ^^^ |
|
| Interacting proteins: P16591 and P40763 |
Pubmed |
SVM Score :0.0 |
| Gamma interferon down regulates Fer and induces its association with inactive Stat 3 in colon carcinoma cells . ^^^ Up and down regulation of Fer was paralleled by the activation and subsequent deactivation of Stat 3 , which is a potent oncogene and a putative substrate of the tyrosine kinase Fer . ^^^ Moreover , IFN gamma induced the association of Fer and Stat 3 and the newly formed complex was most stable at the down regulated states of the two proteins . ^^^ Thus , Fer and Stat 3 are two proliferation promoting factors whose down regulation could contribute to the cytostatic activity of IFN gamma in colon carcinoma cells . . ^^^ |
|
| Interacting proteins: P16591 and P40763 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic distribution of TMF / ARA160 was accompanied by its transient association with the tyrosine kinase Fer and with Stat 3 , which underwent proteasomal degradation under those conditions . ^^^ |
|
| Interacting proteins: P16591 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16591 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|