| Interacting proteins: P16591 and P35568 |
Pubmed |
SVM Score :0.78407097 |
| Insulin treatment of 3T3 L 1 adipocytes stimulated association of Fer with complexes containing tyrosine phosphorylated IRS 1 and PI 3 kinase but did not stimulate tyrosine phosphorylation of Fer . 0.78407097^^^ |
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| Interacting proteins: P16591 and P35568 |
Pubmed |
SVM Score :0.0 |
| We found that although IL 4 stimulation of 10 SCID B cells did not result in Janus tyrosine kinase 3 ( JAK 3 ) phosphorylation , other IL 4 substrates including JAK 1 and IRS 1 were phosphorylated . ^^^ |
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| Interacting proteins: P16591 and P35568 |
Pubmed |
SVM Score :0.0 |
| We have reported that the protein tyrosine kinase Fer is associated with signaling complexes containing insulin receptor substrate 1 ( IRS 1 ) and phosphatidylinositol 3 kinase ( PI 3 kinase ) in insulin stimulated 3T3 L 1 adipocytes [ J . ^^^ Overexpression of Fer increases the association of tyrosine phosphorylated IRS 1 with P 85 phosphatidylinositol kinase via SH 2 domain of Fer in transfected cells . ^^^ Based on transfection study , we have demonstrated that overexpression of both Fer and IRS 1 can induce Fer / IRS 1 / P85 complexes without insulin stimulation and SH 2 domain of Fer is essential for this complex . ^^^ Taken together , these data suggested that Fer may play a critically important role to form Fer / IRS 1 / P85 complex in LDM of insulin stimulated adipocytes and elicit biological effect through PI 3 kinase activity in LDM . . ^^^ |
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