| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| The tyrosine kinase Fer , which modifies beta catenin Tyr 142 , lessening its association with alpha catenin , phosphorylates plakoglobin Tyr 549 and exerts the contrary effect : it raises the binding of plakoglobin to alpha catenin . ^^^ |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Fer binds p 120 catenin and has been shown to regulate cadherin function by modulating cadherin beta catenin interaction . ^^^ Fer is concentrated in growth cones together with cadherin , beta catenin , and cortactin in stage 2 hippocampal neurons . ^^^ |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| Induction of Fer expression coincided with increased complex formation between Fer and the cadherin / src associated substrate p 120 ( cas ) and elevated tyrosine phosphorylation of p 120 ( cas ) . beta Catenin also exhibited clearly increased phosphotyrosine levels , and Fer and beta catenin were found to be in complex . ^^^ Significantly , although the levels of alpha catenin , beta catenin , and E cadherin were unaffected by Fer overexpression , decreased amounts of alpha catenin and beta catenin were coimmunoprecipitated with E cadherin , demonstrating a dissolution of adherens junction complexes . ^^^ |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| Using a polyclonal Fer antibody directed against a C terminal peptide , we studied its associations with cortactin , beta catenin and p120Cas in human prostate carcinoma PC 3 cells . ^^^ |
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| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| However , Fer kinase activity was not required for PDGF induced Stat 3 , p 120 ( ctn ) , or epidermal growth factor ( EGF ) induced beta catenin phosphorylation . ^^^ |
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| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| Catenin associated Fer and Fyn tyrosine kinases regulate beta catenin Tyr 142 phosphorylation and beta catenin alpha catenin Interaction . beta Catenin has a key role in the formation of adherens junction through its interactions with E cadherin and alpha catenin . ^^^ Stable transfectants of the K ras oncogene in intestinal epithelial IEC 18 cells were generated which show little alpha catenin beta catenin association with respect to control clones ; this effect is accompanied by increased Tyr 142 phosphorylation and activation of Fer and Fyn kinases . ^^^ These results indicate that p 120 catenin acts as a docking protein facilitating the activation of Fer / Fyn tyrosine kinases by Yes and demonstrate the role of these p 120 catenin associated kinases in the regulation of beta catenin alpha catenin interaction . . ^^^ |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| Yet this AF 2364 induced Fer kinase plummeting associated with an induction in N cadherin , beta catenin , and p120ctn , particularly at the base of the seminiferous epithelium . ^^^ |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16591 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|