| Interacting proteins: P16591 and P23458 |
Pubmed |
SVM Score :0.0 |
| We found that although IL 4 stimulation of 10 SCID B cells did not result in Janus tyrosine kinase 3 ( JAK 3 ) phosphorylation , other IL 4 substrates including JAK 1 and IRS 1 were phosphorylated . ^^^ |
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| Interacting proteins: P16591 and P23458 |
Pubmed |
SVM Score :0.0 |
| Collectively , we identified seven clones corresponding to previously characterized protein kinases ( JAK 1 , TYK 02 , AXL / UFO , IGF 1 R , KDR and FER ) as well as the recently identified MLK 3 / PTK1 protein kinase . ^^^ |
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| Interacting proteins: P16591 and P23458 |
Pubmed |
SVM Score :0.0 |
| Sixteen cDNAs were identical to the known kinase genes ( PKC beta , JAK 1 , JAK 2 , TYK 2 , HCK , FGR , FYN , BLK , c FES , FER , c ABL , c KIT , FLK 1 , FLK 2 , IGF1R , and ECK ) . ^^^ |
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| Interacting proteins: P16591 and P23458 |
Pubmed |
SVM Score :0.0 |
| Although in untreated cells Fer binds Jak 1 and its tyrosine phosphorylation level is low , insulin treatment induced the phosphorylation of Fer and its dissociation from Jak1 . ^^^ The up regulation of Fer and its dissociation from Jak 1 were accompanied by an augmented association of activated Fer with Stat 3 and by a concomitant increase in the tyrosine phosphorylation of Stat 3 . ^^^ Dissociation of Fer and Jak 1 , as well as elevation in the level of Fer and in the tyrosine phosphorylation of Stat 3 , depended on the activity of phosphatidylinositol 3 kinase ( PI3K ) and was abolished by a PI3K inhibitor . ^^^ |
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| Interacting proteins: P16591 and P23458 |
Pubmed |
SVM Score :0.0 |
| NA |
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