| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| Induction of Fer expression coincided with increased complex formation between Fer and the cadherin / src associated substrate p 120 ( cas ) and elevated tyrosine phosphorylation of p 120 ( cas ) . beta Catenin also exhibited clearly increased phosphotyrosine levels , and Fer and beta catenin were found to be in complex . ^^^ |
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| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| Using a polyclonal Fer antibody directed against a C terminal peptide , we studied its associations with cortactin , beta catenin and p120Cas in human prostate carcinoma PC 3 cells . ^^^ |
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| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| As reported for Fer , Fyn kinase is constitutively bound to p 120 catenin ; expression of K ras induces the phosphorylation of p 120 catenin on tyrosine residues increasing its affinity for E cadherin and , consequently , promotes the association of Fyn with the adherens junction complex . ^^^ Yes tyrosine kinase also binds to p 120 catenin but only upon activation , and stimulates Fer and Fyn tyrosine kinases . ^^^ These results indicate that p 120 catenin acts as a docking protein facilitating the activation of Fer / Fyn tyrosine kinases by Yes and demonstrate the role of these p 120 catenin associated kinases in the regulation of beta catenin alpha catenin interaction . . ^^^ |
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| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| Studies by immunoprecipitation revealed that Fer kinase associated with N cadherin , gamma catenin , p120ctn , c Src ( a putative PTK and the product of the transforming , sarcoma inducing gene of Rous sarcoma virus ) , Rab 8 ( a GTPase ) , actin , vimentin , but not E cadherin , afadin , nectin 3 , and integrin beta 1 , suggesting Fer kinase associates not only with the actin based cell cell AJ structures , such as the N cadherin / catenin complex ( but not the alpha6beta1 integrin / laminin and the afadin / nectin complex ) , but also with intermediate filament based cell cell desmosomes . ^^^ Yet this AF 2364 induced Fer kinase plummeting associated with an induction in N cadherin , beta catenin , and p120ctn , particularly at the base of the seminiferous epithelium . ^^^ |
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| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| Fer interacts with cadherin indirectly , through p120ctn . ^^^ We have mapped the interaction domains of Fer and p120ctn and peptides corresponding to these sequences release Fer from p120ctn in vitro and in live cells , resulting in loss of cadherin associated PTP1B , an increase in the pool of tyrosine phosphorylated beta catenin and loss of cadherin adhesion function . ^^^ |
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| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| Interaction of nonreceptor tyrosine kinase Fer and p 120 catenin is involved in neuronal polarization . ^^^ Furthermore , Fer binds p 120 catenin and has been shown to regulate cadherin function by modulating cadherin beta catenin interaction . ^^^ Inhibition of Fer p 120 catenin interaction with a cell permeable inhibitory peptide ( FerP ) increases neurite branching . ^^^ |
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| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16591 and O60716 |
Pubmed |
SVM Score :0.0 |
| NA |
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