| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 6 is a differentiation antigen of human granulosa cells . ^^^ Partial amino acid sequencing of the 120 kDa protein purified from placenta revealed that the 16 amino acids from the N terminus were identical to those of the heavy chain of human integrin alpha 6 , the molecular mass of which is reportedly 118 126 kDa . ^^^ We examined the tissue distribution of integrins alpha 6 , beta 1 , and beta 4 , because integrin alpha 6 forms heterodimers with integrins beta 1 or beta 4 . ^^^ Indirect immunofluorescence staining of various follicles and corpora lutea using two known antiintegrin alpha 6 monoclonal antibodies ( 450 30A1 and GoH 3 ) showed that integrin alpha 6 was expressed on granulosa and large luteal cells in a profile similar to that of the OG 1 antigen . ^^^ These results indicate that the mAb OG 1 recognizes integrin alpha 6 , and that integrin alpha 6 is a differentiation related antigen of human GC , suggesting the involvement of integrins in human folliculogenesis and luteal formation . . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 6 beta 4 , a putative laminin receptor , is expressed in normal squamous epithelium and in squamous cell carcinomas . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitates by 3A1 and 8A12 antibodies were composed of two bands : 180kD and 140kD [ 205kD and 125kD by reduction ] , and were similar to integrin alpha 6 beta 4 precipitated by monoclonal anti alpha 6 subunit antibody . ^^^ These data indicated that 3A1 and 8A12 recognized integrin beta 4 subunit and that integrin alpha 6 beta 4 functioned as a laminin receptor on these cells . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 6 beta 4 is expressed on squamous epithelia , on subsets of endothelial cells , immature thymocytes and on Schwann cells and fibroblasts in the peripheral nervous system . ^^^ To study the contribution of the integrin alpha 6 beta 4 in hemidesmosome formation and their anchoring properties , we inactivated the beta 4 gene in mice by targeted gene disruption . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice . ^^^ Integrin alpha 6 can associate with either beta 1 or beta 4 ( refs 2 , 3 ) . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Abnormal expression of integrin alpha 6 beta 4 in cervical intraepithelial neoplasia . ^^^ We have used subunit specific monoclonal antibodies ( MAbs ) and immunohistochemistry to examine the distribution of integrin alpha 6 beta 4 in normal ectocervical epithelium and various grades of cervical intraepithelial neoplasia ( CIN ) . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Defective integrin alpha 6 beta 4 expression in the skin of patients with junctional epidermolysis bullosa and pyloric atresia . ^^^ In contrast , all three JEB / PA cases showed abnormalities in integrin alpha 6 beta 4 , but not in laminin 5 , expression in their basal epidermal cells . ^^^ Epidermal expression of the integrin alpha 6 subunit was variable in the JEB / PA patients . ^^^ Abnormal integrin alpha 6 beta 4 expression may define the subset of JEB cases with pyloric atresia . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The few hemidesmosome like structures found in cultured keratinocytes from the PA JEB patient contained the hemidesmosomal components BP 230 , BP 180 and HD 1 , but not the integrin alpha 6 subunit . ^^^ Our observations indicate that the integrin alpha 6 beta 4 plays a crucial role in the proper assembly of hemidesmosomes and in the stabilization of the dermal epidermal junction . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The presence of integrin alpha 6 subunit in all epithelia of embryonic kidney was demonstrated by immunofluorescence and by in situ hybridization . ^^^ Another possibility is that the antibodies against integrin alpha 6 and beta 1 subunit cause abnormal signalling by the integrin . . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 6 beta4 is a major component of hemidesmosomes , in which it mediates firm adhesion to laminin 5 . ^^^ Now , we have further defined sequences within beta 4 that are critical for its localization in hemidesmosomes and we demonstrate that these sequences also induce the redistribution of HD1 / plectin into junctional complexes containing the integrin alpha 6 beta4 in COS 7 cells , transfected with cDNAs encoding alpha6A and beta 4 . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Our results show that the mutated beta 4 subunit associates with integrin alpha 6 , but the resulting heterodimer does not induce nucleation of the bullous pemphigoid antigens BP 180 and BP 230 , and that of the inner plaque component plectin / HD1 , into hemidesmosomal structures . ^^^ Because in the transfected keratinocytes the distribution of BP 230 remains diffuse in the cytoplasm , we suggest that the interaction between plectin / HD1 and integrin alpha 6 beta 4 , followed by the association with BP 180 , constitutes the first step in the nucleation of the HD . . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| RESULTS : The results of cDNA arrays showed that 13 cancer related genes were up regulated > or =2 fold ( CDC25B , cyclin D 1 , PCNA , MET , Jagged 2 , Integrin alpha 3 , Integrin alpha 6 , Integrin beta 4 , Caveolin 2 , Caveolin 1 , MMP 13 , MMP 14 , and BIGH 3 ) and 5 genes were down regulated > or =2 fold ( CK 4 , Bad , IGFBP 2 , CSPCP , and IL 1RA ) in both ESCC cell lines at the mRNA level . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The integrin alpha 6 beta 4 plays a crucial role in the assembly and maintenance of hemidesmosomes . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Integrin alpha 6 beta4 and experimental allergic neuritis ] . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Pyloric atresia junctional epidermolysis bullosa syndrome ( PA JEB ) is an autosomal recessive inherited rare blistering disorder caused by mutations in ITGA 6 or ITGB 4 , genes encoding integrin alpha 6 or beta 4 , respectively . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The 230 kD bullous pemphigoid antigen ( BPAG 1 ) gene expression was also reduced by RA , whereas transcript levels of integrin alpha 6 , integrin beta 4 , the 180 kD bullous pemphigoid antigen ( BPAG 2 ) , and laminin 5 were not affected . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that sera of patients with MMP bind to human integrin beta 4 , while sera of patients with oral pemphigoid bind to the integrin alpha 6 component of the heterodimer . ^^^ In this study we compare the binding of sera from patients with OP from Boston , MA , USA to Naples , Italy , and attempt to identify an epitope to which the anti integrin alpha 6 human autoantibody binds . ^^^ They recognize a fragment 1 ( AA 23 462 ) and its subfragment IB ( AA 217 462 ) only , in the human integrin alpha 6 molecule . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined a family with two affected individuals with JEB PA for mutations in the ITGA 6 and ITGB 4 genes which encode the alpha 6 and beta 4 integrin polypeptides , respectively . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Mutations in the genes encoding the subunit polypeptides of the alpha6beta4 integrin ( ITGA 6 and ITGB 4 , respectively ) have been previously demonstrated in patients with a lethal form of epidermolysis bullosa with congenital pyloric atresia ( OMIM # 226730 ) . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Expression of the alpha 6 beta4 integrin is altered at the dermal epidermal basement membrane zone ; recently , mutations in the corresponding genes ( ITGA 6 and ITGB 4 ) have been disclosed in a limited number of patients , premature termination codons in both alleles being characteristic of lethal variants . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Recently , mutations in the genes encoding the epithelial integrin alpha6beta4 ( ITGA 6 and ITGB 4 ) have been identified in several patients with EB PA . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Junctional epidermolysis bullosa with pyloric atresia ( JEB PA ) ( MIM 226730 ) is an autosomal recessive disorder resulting from mutations in the genes encoding alpha 6 beta 4 integrin ( ITGA 6 and ITGB 4 ) . ^^^ We review all previously published ITGA 6 and ITGB 4 mutation reports to help define genotype phenotype correlation in this rare genodermatosis . . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Mutations in the genes encoding subunit polypeptides of the alpha 6 beta 4 integrin ( ITGA 6 and ITGB 4 ) have been demonstrated in EB PA patients . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The disease , which is caused by mutations in the alpha6beta4 integrin genes ( ITGA 6 , ITGB 4 ) , is usually lethal . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Epidermolysis bullosa with pyloric atresia ( EB PA ) , manifesting with neonatal blistering and gastric anomalies , is known to be caused by mutations in the hemidesmosomal genes ITGA 6 and ITGB 4 , which encode the alpha 6 and beta 4 integrin polypeptides , respectively . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Presence of CD 44 , CD49b , CD49f , and CD 104 and absence of CD 57 suggests that cultured cells were derived from basal cells of prostatic tissues . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Basal projection cells had a partial myoepithelial like phenotype : they reacted with CD 29 , CD49f , CD 104 , keratin 14 , vimentin , S100beta protein , and p 63 ; furthermore , many became positive for keratin 17 , alpha smooth muscle actin , and CD 10 ( but not for keratin 19 ) between wk 21 and 25 . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| Prostate basal epithelial cells do not express the CD antigens characteristic of prostate secretory cells ; and the basal cell CD markers , CD 29 , CD 44 , CD49b , CD49f , CD 104 , and nerve growth factor receptor ( NGFR ) are not expressed by cancer cells . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The present study aimed to investigate distribution patterns , staining intensity and sex steroid mediated regulation of integrin alpha 5 ( CD49e ) , integrin beta 4 ( CD49f ) expression and their ligands fibronectin and laminin during decidualization . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| The CDSCs were consistently negative for CD 14 , CD 34 , CD 38 , CD 45 , CD49f , CD 104 , CD 105 , CD 106 , CD 117 , HLA DR , and ABCG 2 , and positive for CD 10 , CD 44 , CD 71 , CD 73 , CD 90 , CD 147 , and HLA A , B , and C by FACS analysis . ^^^ |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23229 and P16144 |
Pubmed |
SVM Score :0.0 |
| NA |
|