| RESULTS : The results of cDNA arrays showed that 13 cancer related genes were up regulated > or =2 fold ( CDC25B , cyclin D 1 , PCNA , MET , Jagged 2 , Integrin alpha 3 , Integrin alpha 6 , Integrin beta 4 , Caveolin 2 , Caveolin 1 , MMP 13 , MMP 14 , and BIGH 3 ) and 5 genes were down regulated > or =2 fold ( CK 4 , Bad , IGFBP 2 , CSPCP , and IL 1RA ) in both ESCC cell lines at the mRNA level . ^^^ |