| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Immunoreactivity analyses showed that MMP 8 species in normal human plasma exists as a precursor but not as a complex form with tissue inhibitor of metalloproteinases ( TIMP ) 1 or TIMP 2 . . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Localization of MMP 1 , MMP 2 , MMP 8 , MMP 9 , MT 1 MMP , TIMP 1 , and TIMP 2 was verified by immunohistochemical analysis . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| To analyze the inhibition of the `` activated ' ' and `` superactivated ' ' variants of human neutrophil collagenase ( MMP 8 ) by TIMP 2 , we determined complex dissociation constants using biomolecular interaction analysis ( BIA ) . ^^^ These data reveal that TIMP 2 ( the recombinant inhibitory domain of human TIMP 2 and bovine TIMP 2 isolated from seminal plama ) is a better inhibitor of the activated neutrophil collagenase than of the superactivated variant ( the recombinant catalytic domain of human MMP 8 ) . ^^^ Therefore superactivation of MMP 8 correlates with weaker inhibition by TIMP 2 . . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| METHODS : Levels of MMP 1 , MMP 2 , MMP 3 , MMP 7 , MMP 8 , MMP 9 , MMP 13 , TIMP 1 , and TIMP 2 in SF aspirated from knee joints of 97 patients with RA and 103 patients with OA were measured by the corresponding one step sandwich enzyme immunoassays . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| To evaluate the spectrum and regulation of matrix metalloproteinases ( MMPs ) in bacterial meningitis ( BM ) , concentrations of MMP 2 , MMP 3 , MMP 8 , and MMP 9 and endogenous inhibitors of metalloproteinases ( TIMP 1 and TIMP 2 ) were measured in the cerebrospinal fluid ( CSF ) of 27 children with BM . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Patients were evaluated for toxicity and tumor response , and blood and urine samples were taken for pharmacokinetics , bone resorption markers , direct targets of the inhibitor [ matrix metalloproteinase 2 ( MMP 2 ) , MMP 8 , and MMP 9 ] , indirect targets [ tissue inhibitor of metalloproteinase 1 ( TIMP 1 ) , TIMP 2 , basic fibroblast growth factor , vascular endothelial growth factor , vascular cell adhesion molecule 1 , soluble urokinase plasminogen activator receptor , and cathepsins B and H ] and for a tumor necrosis factor alpha cytokine release assay . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| DESIGN : Pleural effusion fluid and plasma concentrations of MMP 1 , MMP 2 , MMP 3 , MMP 8 , MMP 9 , TIMP 1 and TIMP 2 were determined by ELISA in 21 patients with TB pleuritis . ^^^ CONCLUSION : Compartmentalized MMP 1 , MMP 2 , TIMP 1 , and TIMP 2 and , compared to CHF , a surplus of MMP 1 , MMP 2 , MMP 8 , and MMP 9 in the pleural space obviously contribute to the fibrotic reactions in TB pleuritis . . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : In preterm infants , an imbalance between pulmonary MMP 8 and TIMP 2 participates in the acute inflammatory process in respiratory distress syndrome and may contribute to the development of chronic lung injury . . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Antibodies used in this study were monoclonal antibodies to MMP 1 , MMP 2 , MMP 7 , MMP 8 , MMP 9 , TIMP 1 , TIMP 2 and polyclonal antibody to MMP 3 . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| The concentrations of MMP 1 , MMP 2 ( pro ) , MMP 2 ( active ) , MMP 8 , MMP 9 and TIMP 2 were measured in detergent extracts of the biopsy homogenates using ELISAs and gelatin zymography . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : A novel study has been carried out to characterize the amount and activity levels of metalloproteinases ( i . e . , MMP 1 , MMP 2 , MMP 3 , MMP 8 , MMP 9 and MMP 13 ) and of their inhibitors ( i . e . , TIMP 1 and TIMP 2 ) in synovial fluid from patients ( n = 56 ) with different degrees of either chondral lesions or knee arthritis identified and classified by arthroscopy . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Significant negative ( MMP 9 , MMP 3 , MMP 8 , TIMP 2 , total MMP activity ) and positive ( MMP 2 , TIMP 1 ) correlations were observed with the postoperative day , e . g . , total MMP 9 : day 1 , median , 121 ( range , 12 189 ) ng / ml ; day 3 , 46 ( 8 179 ) ; day 5 , 31 ( 0 155 ) , day 7 , 20 ( 6 58 ) . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| MMP 2 , MMP 9 , MMP 8 , TIMP 1 and TIMP 2 were detected by immunohistochemistry and the Western blot technique . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| MMP 7 ( 81 % ) , MMP 8 ( 95 % ) , MT 3 MMP ( 100 % ) , TIMP 2 ( 100 % ) , and TIMP 3 ( 96 % ) were expressed in all the OVCAs , but the staining intensities varied . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| In this study we examined the expression by gingival mast cells of matrix metalloproteinases , MMP 1 , MMP 2 , MMP 8 and the tissue inhibitors of metalloproteinases , TIMP 1 and TIMP 2 . ^^^ METHODS : Gingival specimens from 12 human immunodeficiency virus negative ( HIV ) and 15 HIV positive ( HIV+ ) patients with chronic marginal periodontitis ( CMP ) , and from 10 HIV and four HIV+ controls with clinically healthy gingiva ( HG ) were examined after double immunofluorescence staining for mast cell tryptase , combined with antibodies for MMP 1 , MMP 2 , MMP 8 or their inhibitors TIMP 1 and TIMP 2 . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Prompted by our recent observations of increased MMP 8 and MMP 9 with simultaneous downregulation of tissue inhibitor of metalloproteinase 2 ( TIMP 2 ) and TIMP 3 mRNA levels in the central nervous system ( CNS ) of mice with severe experimental autoimmune encephalomyelitis ( EAE ) , we used Semliki Forest virus ( SFV ) to transfer and express recombinant murine TIMP 1 3 genes in the CNS . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Inflammatory markers ( tumour necrosis factor alpha , interleukin 8 , polymorphonuclear elastase ) , fibrinolytic system variables ( tissue plasminogen activator ( PA ) , urokinase PA ( u PA ) , plasminogen activation inhibitor ( PAI ) 1 , PAI 2 ) , and several MMPs ( MMP 1 , MMP 2 , MMP 8 , MMP 9 ) and TIMPs ( TIMP 1 , TIMP 2 ) were determined by ELISA in plasma and pleural fluid . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| The goal of the study was to evaluate the plasma blood concentration of VEGF , bFGF , MMP 1 , MMP 2 , MMP 3 , MMP 8 , MMP 9 , TIMP 1 , and TIMP 2 in patients with cancer and in normal subjects . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Plasma levels of MMP 2 , MMP 9 , MMP 8 , TIMP 1 , TIMP 2 , TNF alpha , TNFR 1 , and TNFR 2 were measured by enzyme linked immunosorbent assay kits . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Human PMN pro MMP 8 was converted to the active form by MT 1 MMP , and TIMP 2 prevented this activation . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| The serum MMP 2 , MMP 8 , MMP 9 and TIMP 2 levels were not different in all groups . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| The concentrations of MMP 8 protein and its inhibitors , tissue inhibitor of metalloproteinase ( TIMP ) 1 and TIMP 2 , were quantified by enzyme linked immunosorbent assay . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Blood samples were drawn before tissue plasminogen activator treatment and an MMP array ( multiplex enzyme linked immunosorbent assay [ ELISA ] ) was performed including gelatinases ( MMP 2 and MMP 9 ) , collagenases ( MMP 1 , MMP 8 , and MMP 13 ) , stromelysines ( MMP 3 and MMP 10 ) , and MMP endogen inhibitors ( TIMP 1 and TIMP 2 ) . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry staining of CD 45 , CD 68 , MMP 8 , MMP 9 , TIMP 1 and TIMP 2 were assessed in cervical biopsies obtained directly prior to mechanical cervical dilatation and vacuum aspiration . ^^^ The immunostaining of MMP 8 and MMP 9 was greater in the treatment group , while the expression of TIMP 1 and TIMP 2 did not differ between control and treatment groups . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE AND DESIGN : To clarify the role of ovarian steroids in the differential regulation of MMP 1 , MMP 3 , MMP 7 , MMP 8 , MMP 10 , TIMP 1 , TIMP 2 , and TIMP 3 mRNAs , we compared their variations in the cycling endometrium in vivo with their response to hormone addition or withdrawal in corresponding explants . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| This was associated with reduced expression ( P < 0 . 01 ) and activity of MMP 8 , and 9 and increased localization of TIMP 1 ( P < 0 . 01 ) , whereas TIMP 2 was not affected . ^^^ This may be caused by reduced expression and activity of MMP 8 and 9 , increased expression of TIMP 1 , and sustained expression of TIMP 2 . . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| In this study , we report on the complex formation of the recombinant catalytic domain of the PMNL collagenase with TIMP 1 , nonglycosylated recombinant TIMP 1 , and recombinant TIMP 2 . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : Significant correlations between the severity of the periodontal disease and the actual MMP activity , the active form of MMP 8 and the low level of both TIMP 1 and TIMP 2 were found . . ^^^ |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P22894 and P16035 |
Pubmed |
SVM Score :0.0 |
| NA |
|