| Interacting proteins: P15941 and P49841 |
Pubmed |
SVM Score :0.76147876 |
| Here we show that MUC 1 associates with glycogen synthase kinase 3beta ( GSK3beta ) . 0.76147876^^^ |
|
| Interacting proteins: P15941 and P49841 |
Pubmed |
SVM Score :0.76402625 |
| The present studies demonstrate that MUC 1 associates with the c Src tyrosine kinase . c Src phosphorylates the MUC 1 cytoplasmic domain at a YEKV motif located between sites involved in interactions with GSK 3 beta and beta catenin . 0.76402625^^^ The findings support a novel role for c Src in regulating interactions of MUC 1 with GSK 3 beta and beta catenin . . 0.6808413^^^ |
|
| Interacting proteins: P15941 and P49841 |
Pubmed |
SVM Score :0.0 |
| Recently , studies have shown that MUC 1 interacts with beta catenin , erbB receptors , src , GSK 3beta and protein kinase Cdelta , possibly in a complex that promotes the disassembly of adherens junctions and the invasion of cells . ^^^ |
|
| Interacting proteins: P15941 and P49841 |
Pubmed |
SVM Score :0.0 |
| Consistent with the up regulation of beta catenin levels , our results show that MUC 1 blocks GSK3beta mediated phosphorylation and degradation of beta catenin . ^^^ These findings indicate that MUC 1 promotes transformation , at least in part , by blocking GSK3beta mediated phosphorylation and thereby degradation of beta catenin . . ^^^ |
|
| Interacting proteins: P15941 and P49841 |
Pubmed |
SVM Score :0.0 |
| NA |
|