| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.559434 |
| In contrast , MUC 1 has a highly conserved cytoplasmic tail , which binds beta catenin , a key component of adherens junctions and a regulator of transcription , in a process that is tightly regulated by MUC 1 phosphorylation . 0.559434^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.64810327 |
| Addition of MUC 1 cytoplasmic domain peptides to the invasive MDA MB 468 and MDA MB 231 cell lines increases their invasive capability , and these peptides colocalize with both beta catenin and the focal adhesion protein vinculin , primarily at sites of membrane invasion into a collagen matrix . 0.64810327^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.50913499 |
| Numerous studies have demonstrated an interaction between MUC 1 and other oncogenic proteins such as beta catenin , erbB receptors and c Src , but a functional role for MUC 1 in transformation has not been identified . 0.50913499^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Aberrant localization of the molecules , when present , can provide important insight into disease processes and aid in their diagnosis , such as loss of membranous E cadherin expression in lobular breast carcinoma , aberrant nuclear localization of beta catenin in colorectal adenocarcinoma , pattern of ALK staining in anaplastic large cell lymphoma correlating with the different types of chromosomal translocations , presence of additional cytoplasmic CD 10 staining in the enterocytes indicative of microvillous inclusion disease , and `` reversed ' ' staining for EMA in micropapillary mammary carcinoma . . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Recent studies have demonstrated that the cytoplasmic domain of MUC 1 interacts with beta catenin . ^^^ Phosphorylation of MUC 1 by GSK3beta decreases binding of MUC 1 to beta catenin in vitro and in vivo . ^^^ GSK3beta mediated phosphorylation of MUC 1 had no apparent effect on beta catenin levels or the transcriptional coactivation function of beta catenin . ^^^ The results , however , demonstrate that MUC 1 expression decreases binding of beta catenin to the E cadherin cell adhesion molecule . ^^^ Negative regulation of the beta catenin MUC 1 interaction by GSK3beta is associated with restoration of the complex between beta catenin and E cadherin . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| And in these cells , expression of E cadherin and beta catenin mRNA obviously began to increase , while expression of MUC 1 mRNA decreased , as demonstrated by Northern blot analysis . ^^^ Such change in mRNA levels were followed by increases in E cadherin and beta catenin protein levels and a decrease in MUC 1 protein level . ^^^ These findings show for the first time that adriamycin can induce E cadherin mediated cell cell adhesion by increasing expression of E cadherin and beta catenin and decreasing expression of MUC 1 during breast cancer cell apoptosis induced by this drug . . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| The MUC 1 cytoplasmic domain interacts with the c Src tyrosine kinase and thereby increases binding of MUC 1 and beta catenin . ^^^ Moreover , in vitro and in vivo studies demonstrate that EGF R increases binding of MUC 1 and beta catenin . ^^^ These findings support a novel role for EGF R in regulating interactions of MUC 1 with c Src and beta catenin . . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Pro oncogenic factors that also release beta catenin from the adherens complex and / or encourage translocation to the nucleus include ras , epidermal growth factor ( EGF ) , c erbB 2 , PKC betaII , MUC 1 , and PPAR gamma , whereas anti oncogenic factors that also inhibit nuclear beta catenin signaling include transforming growth factor ( TGF ) beta , retinoic acid , and vitamin D . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| To clarify the clinical significance of TSG expression in gastric carcinoma , the expression of various TSG candidates ( p 53 , E cadherin , FHIT , smad 4 , rb , VHL , PTEN , MGMT , p 16 , and KAI 1 ) , as well as other proteins ( bcl 2 , MUC 1 , MUC 2 , MUC5AC , MUC 6 , CEA , CD 44 , beta catenin , C erbB 2 , and cyclin B 2 ) , was evaluated immunohistochemically in 329 consecutive gastric carcinomas using the tissue array method . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| The functional significance of the MUC 1 Lyn interaction is supported by the demonstration that Lyn mediated phosphorylation of MUC 1 on YEKV induces binding of MUC 1 and the beta catenin signaling protein . ^^^ In concert with these results , IL 7 treatment is associated with binding of MUC 1 to beta catenin and targeting of the MUC 1 beta catenin complex to the nucleus . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Nuclear association of the cytoplasmic tail of MUC 1 and beta catenin . ^^^ The MUC 1 cytoplasmic tail ( CT ) is postulated to function in morphogenetic signal transduction via interactions with Grb2 / Sos , c Src , and beta catenin . ^^^ Fragments of the MUC 1 CT were associated with beta catenin in both cytoplasm and nuclei . ^^^ Overexpression of MUC 1 increased steady state levels of nuclear beta catenin but decreased nuclear levels of plakoglobin ( gamma catenin ) . ^^^ Coimmunoprecipitation experiments revealed that the cytoplasmic and nuclear association of MUC 1 CT and beta catenin was not affected by disruption of Ca2+ dependent intercellular cadherin interactions . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| The results demonstrate that , as found in human carcinomas , MUC 1 is expressed on the cell surface and as a complex with beta catenin in the nucleus of the transfectants . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| The protein products of 14 genes encompassing a variety of functional classes , such as tumor suppressor genes ( p 53 , Smad4 / Dpc4 ) , oncogenes ( beta catenin ) , cell cycle antigens ( p 16 , cyclin D 1 ) , proliferation antigens ( Ki 67 , topoisomerase 2 alpha ) , and epithelial apomucins ( MUC 1 , MUC 2 , MUC 5 ) , as well as `` novel ' ' genes described as differentially up regulated in invasive pancreas cancer by global microarray expression analysis ( mesothelin , prostate stem cell antigen , fascin , and 14 3 3varsigma ) , were analyzed by immunohistochemistry on the PanIN tissue microarray . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| The MUC 1 cytoplasmic domain ( CD ) binds directly to the Wnt effector , beta catenin , and colocalizes with beta catenin in the nucleus ; however , the nuclear function of MUC 1 is unknown . ^^^ The present results demonstrate that MUC 1 coactivates transcription of beta catenin Tcf binding sites in the pTOPFLASH reporter . ^^^ Activation of transcription was abrogated by expression of MUC 1 with a Y 46 > F mutation in the CD that attenuates binding of MUC 1 and beta catenin . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Moreover , a series of recent studies has shown that the highly conserved cytoplasmic tail of MUC 1 interacts specifically with a series of important signal transducing molecules including beta catenin , Grb 2 and erbB family members . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Histopathologic factors including tumor thickness , mode of invasion , Broders grade , total score of three different malignancy grading systems , eight other clinicopathologic parameters , and immunohistochemical expression of p 53 , cyclin D 1 , Ki 67 , epidermal growth factor receptor , microvessel density , cyclooxygenase 2 , MUC 1 , laminin 5 gamma 2 , E cadherin , and beta catenin were examined . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Interaction of human MUC 1 and beta catenin is regulated by Lck and ZAP 70 in activated Jurkat T cells . ^^^ The MUC 1 cytoplasmic domain ( CD ) interacts with beta catenin ; however , the role of MUC 1 in T cells is not known . ^^^ Lck phosphorylates MUC 1 CD on Y 46 and , in turn , stimulates the binding of MUC 1 to beta catenin . ^^^ However , like Lck , ZAP 70 mediated phosphorylation of MUC 1 Y 20 stimulates binding of MUC 1 and beta catenin . ^^^ These findings indicate that MUC 1 functions as a substrate for Lck and ZAP 70 in activated Jurkat T cells and that MUC 1 integrates T cell receptor signaling with the beta catenin pathway . . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Moreover , an emphasis is placed on the importance of critical signaling pathways and postulated interactions , including those of ErbB 2 , hepatocyte growth factor / Met , interleukin 6 / glycoprotein130 , cyclooxygenase 2 , vascular endothelial growth factor , transforming growth factor beta , MUC 1 and MUC 4 , beta catenin , telomerase , and Fas pathways as potential molecular therapeutic targets in cholangiocarcinoma . . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Examination of MMTV PyV MT glands on a wild type or Muc 1 null background demonstrates that Muc 1 expression promotes c Src signaling by influencing its association with known substrates such as the p 85 subunit of phosphatidylinositol 3 kinase and beta catenin . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| MUC 1 oncoprotein blocks glycogen synthase kinase 3beta mediated phosphorylation and degradation of beta catenin . ^^^ The MUC 1 oncoprotein is aberrantly overexpressed by most human carcinomas and associates with beta catenin . ^^^ However , the functional significance of the MUC 1 beta catenin interaction is not known . ^^^ Here , we show that MUC 1 increases beta catenin levels in the cytoplasm and nucleus of carcinoma cells . ^^^ Consistent with the up regulation of beta catenin levels , our results show that MUC 1 blocks GSK3beta mediated phosphorylation and degradation of beta catenin . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Two hundred and two paraffin embedded specimens of gastric carcinoma were examined by immunohistochemical staining using monoclonal antibodies against MUC 1 mucin , E cadherin and beta catenin . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| We also determined the immunophenotype of the tumors on the basis of their mucin ( MUC 1 , MUC 2 , MUC5AC , and MUC 6 ) and adhesion molecule ( E cadherin , alpha catenin , beta catenin ) expression patterns . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| In the current study , we examined the expression and interaction of cell surface adhesion molecules ( E cadherin , ICAM 1 , and MUC 1 ) and their intracellular binding partners ( alpha catenin , beta catenin , gamma catenin , and ezrin ) in 16HBE14o , HBE 1 , 1HAEo , BEAS 2B , A 549 , and NCI H 292 human airway epithelial cells . ^^^ E cadherin formed coimmunoprecipitation complexes with beta and gamma catenin , whereas MUC 1 only associated with beta catenin . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic tail of MUC 1 ( MUC1CT ) , the best characterized of the transmembrane mucins , is involved in several signaling pathways , including those involving Ras , beta catenin , p 120 catenin , p 53 and estrogen receptor alpha . ^^^ |
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| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| Regulation of the trunk tail patterning in the ascidian embryo : a possible interaction of cascades between lithium / beta catenin and localized maternal factor pem . ^^^ |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P35222 |
Pubmed |
SVM Score :0.0 |
| NA |
|