| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.71221743 |
| Immunoprecipitation experiments revealed that full length transgenic MUC 1 physically associates with all four erbB receptors , and co localizes with erbB 1 in the lactating gland . 0.71221743^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :1.2278609 |
| In the present work , coimmunoprecipitation studies demonstrate that MUC 1 associates constitutively with the epidermal growth factor receptor ( EGF R ) in human ZR 75 1 breast carcinoma cells . 1.2278609^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of epithelial membrane antigen ( EMA ) , Leu 7 antigen , epidermal growth factor receptor ( EGFr ) , and deoxyribonucleic acid ( DNA ) content in 40 thyroid nodules was investigated to identify those factors that might differentiate these lesions or correlate to their prognosis . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate the immunohistochemical expression of cytokeratin , epithelial membrane antigen ( EMA ) , CEA and EGFR in transitional cell bladder carcinomas ( TCC ) and to define any correlation of their expression with tumor grade , stage and patient survival . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| To ascertain the localization of EGFr immunoreactivity , neurofilament proteins ( NFP ) , S 100 protein ( S100P ) , and epithelial membrane antigen ( EMA ) were studied in parallel to label axons , Schwann cells , and perineurial cells , respectively , as well as their corpuscular derivatives . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| For immunostaining , antibodies reacting with epithelial membrane antigen ( EMA ) , pankeratin , vimentin , CA 125 , CA 19 9 , carcinoembryonic antigen ( CEA ) , alpha fetoprotein ( AFP ) , alpha 1 antitrypsin ( AT ) , epidermal growth factor receptor ( EGFR ) , c erbB 2 , bcl 2 and p 53 proteins were used . ^^^ All the cases examined were positive for EMA and pankeratin , specific markers for epithelial tumors , negative for the non epithelial tumor marker , vimentin , and also positive for EGFR . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The cells were simultaneously immunolabelled with antibodies recognising EMA ( luminal epithelial cells ) , CALLA / CD10 ( basal cells ) and the epidermal growth factor receptor ( EGFR ) . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The growth fraction ( MIB 1 ) , oestrogen receptor ( ER ) , progesterone receptor ( PR ) , p 53 mutant protein , c erbB 2 , epidermal growth factor receptor ( EGFR ) , NCRC11 / epithelial membrane antigen ( EMA ) and DNA plopidy were examined . ^^^ Significant EGFR and EMA , respectively . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Our results favor the possibility that the Drosophila EGF receptor DER / Egfr expressed by the EMA cells functions as a receptor for Vein . ^^^ We show that Vein / Egfr binding activates the Ras pathway in the EMA cells leading to the transcription of the tendon specific genes , stripe , delilah , and beta 1 tubulin . ^^^ These results suggest that inductive interactions between myotubes and their epidermal muscle attachment cells are initiated by the binding of Vein , to the Egfr on the surface of EMA cells . . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical co expression of c erbb 2 / Neu oncoprotein , altered tumour suppressor ( p 53 ) protein , EGF R and EMA in histological subtypes of infiltrating duct carcinoma of the breast . ^^^ Immunohistochemical staining of c erbB 2 ( Neu ) oncoprotein and mutant p 53 protein on 45 cases of infiltrating duct carcinoma ( IDC ) of the breast revealed 33 % membrane positivity of c erbB 2 oncoprotein , 46 % nuclear positivity of mutated p 53 protein , 33 % and 84 % membrane positivity of EGF R and EMA respectively . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| RESULTS : SCRC 1 cells were reactive with antibodies to NSE , chromogranin A , bombesin , Bcl 2 , CD44s , CD44v6 , CD44v7 to 8 , vimentin and S 100 protein ( predominantly beta subunit ) , and were unreactive with antibodies to EMA , CD 54 , EGFR ( R 1 ) , URO 5 , URO 7 , URO 8 and URO 10 . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| A lot of different epithelial markers were targeted with these techniques e . g . cytokeratins , EGFR , CEA , and EMA . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemistry and FISH were performed to determine NF 2 ( merlin ) , protein 4 . 1B , EMA , progesterone receptor ( PR ) , EGFR , survivin , VEGF , PDGF BB , PDGFR beta , E cadherin , and cathepsin D status . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Antibodies utilized were progesterone receptor ( PR ) , epithelial membrane antigen ( EMA ) , cathepsin D , E cadherin , platelet derived growth factor ( PDGF ) receptor beta , PDGF BB ligand , survivin , epithelial growth factor receptor ( EGFR ) , and vascular endothelial growth factor ( VEGF ) . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| MUC 1 ( episialin ) expression in non small cell lung cancer is independent of EGFR and c erbB 2 expression and correlates with poor survival in node positive patients . ^^^ AIM : To examine tumour samples immunohistochemically for MUC 1 ( episialin ) , epidermal growth factor receptor ( EGFR ) , and c erbB 2 , since the disruption of the cell cell adhesion system by MUC 1 and the c erbB oncoprotein family is known to be important in the development of metastasis in human cancers . ^^^ METHODS : 93 tumour samples from patients with early stage non small cell lung cancer treated with surgery alone were examined for episialin , EGFR , and c erbB 2 . ^^^ No correlation was observed between episialin and EGFR or c erbB 2 expression . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Twenty eight patients with intracranial neoplasms were injected intravenously with an average dose of 2 . 2 mCi 111In labeled anti EGFr 425 . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| METHODS : Four patients ( 3 men , 1 woman ; mean age 54 . 8 + / 9 . 2 yr ; range 42 64 yr ) were administered 3 mg of anti human epidermal growth factor receptor ( anti hEGF r ) antibody ( ior egf / r3 ) , radiolabeled with 99mTc activity of 39 . 5 + / 1 . 1 mCi ( range 38 . 5 mCi 40 . 7 mCi ) by intravenous bolus infusion . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| In breast cancer , these molecular targets have included principally tumor associated antigens , such as carcinoembryonic antigen ( CEA ) and the polymorphic epithelial mucin antigen , MUC 1 , and more recently the growth factor receptors , EGF R and HER 2 / neu . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Cell surface expression of the following was examined : EGP 2 ; MUC 1 ; EGFr ; E and N cadherin ; the alpha 2 , alpha 3 , alpha 5 , beta 1 and beta 4 integrins ; c erb B 2 ; and N CAM . c erb B 2 was expressed in a higher percentage of the bone metastasizing MT 1 cells than the MA 11 cells , whereas E cadherin was expressed in MA 11 but not MT 1 cells . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Archival gastric body samples from non ulcer dyspepsia biopsies and gastrectomies performed for peptic ulcer disease were stained with antibodies to the trefoil peptides TFF1 / pS2 and TFF2 / SP , pancreatic secretory trypsin inhibitor ( PSTI ) , epidermal growth factor ( EGF ) and its receptor ( EGFR ) , and to the MUC 1 gene product HMFG 2 . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate the immunohistochemical expression of epidermal growth factor receptor ( EGFR ) , mucin 1 ( MUC 1 ) and mucin 2 ( MUC 2 ) proteins in primary bladder carcinomas and to compare EGFR and MUC staining patterns with the histological findings , grade and stage of bladder carcinoma . ^^^ Of the 56 bladder tumors 42 ( 75 % ) expressed EGFR , 34 ( 60 . 71 % ) MUC 1 and 15 ( 26 . 78 % ) MUC 2 ; while 7 tumors ( 12 . 5 % ) coexpressed MUC 1 and MUC 2 proteins . ^^^ Immunohistochemical scores showed higher levels of EGFR than of MUC 1 ( P < 0 . 05 ) and MUC 2 ( P = 0 . 000 ) and higher levels of MUC 1 than MUC 2 ( P = 0 . 0010 ) . ^^^ EGFR and MUC 1 expression was stronger in high grade tumors ( grade 2 / 3 ) than in low grade ( grade 1 / 2 ) ones ( P < 0 . 05 ) and stronger in muscle invasive tumors ( T 2 T4 ) than in superficial ( Ta T 1 ) ones . ^^^ Linear regression showed a significant ( P < 0 . 05 ) correlation between EGFR and MUC 1 proteins , but no correlation between EGFR and MUC 2 or between MUC 1 and MUC 2 . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The monoclonal antibodies MOC 31 , BM 7 and 425 . 3 , which recognize epithelial glycoprotein 2 , MUC 1 mucin and the epidermal growth factor receptor , chemically conjugated to Pseudomonas exotoxin A ( PE ) , inhibited protein synthesis of the 2 breast cancer cell lines at concentrations of 0 . 3 0 . 4 ng / ml , except for BM 7 PE , which was less efficacious ( 65 ng / ml ) . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Thirty two patients received an average dose of 160 mCi of 1 125 EGFr concomitantly . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical evaluation for expression of antigen was performed using the following antibodies : CA 125 , CEA , cytokeratin , EGFR , erbB 2 , Ki 67 , Lewis Y , p 27 , PCNA , Tag 72 , TGF alpha , Muc 1 , and Muc 2 . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| A direct association of CA 9 expression with epidermal growth factor receptor , c erbB 2 , and MUC 1 expression was also noted ( P < 0 . 04 ) . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The following markers have been analysed : carcinoembryonic antigen ( CEA ) , cytokeratins ( CK 19 and CK 20 ) , polymorphic epithelial mucin ( MUC 1 ) , epidermal growth factor receptor ( EGFR ) , maspin , and mammaglobin . ^^^ EGFR , MUC 1 , and CEA were sometimes expressed in normal blood cells and / or hematological tumors . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The previously studied markers epidermal growth factor receptor ( EGFR ) , mammaglobin 1 ( MGB 1 ) , epithelial cell adhesion molecule ( EpCAM / TACSTD1 ) , mucin 1 ( MUC 1 ) , carcinoembryonic antigen ( CEA ) were tested . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Recently , studies have shown that MUC 1 interacts with beta catenin , erbB receptors , src , GSK 3beta and protein kinase Cdelta , possibly in a complex that promotes the disassembly of adherens junctions and the invasion of cells . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Moreover , a series of recent studies has shown that the highly conserved cytoplasmic tail of MUC 1 interacts specifically with a series of important signal transducing molecules including beta catenin , Grb 2 and erbB family members . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Histopathologic factors including tumor thickness , mode of invasion , Broders grade , total score of three different malignancy grading systems , eight other clinicopathologic parameters , and immunohistochemical expression of p 53 , cyclin D 1 , Ki 67 , epidermal growth factor receptor , microvessel density , cyclooxygenase 2 , MUC 1 , laminin 5 gamma 2 , E cadherin , and beta catenin were examined . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Tissue microarrays ( TMAs ) were used to determine the immunohistochemical profile of eight proteins including E cadherin , EGFR , oestrogen and progesterone receptor ( ER and PR ) , MIB 1 , ERBB 2 , MUC 1 , and P 53 . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Expression of epidermal growth factor receptor ( EGFR ) , MUC 1 , MUC 2 , MUC5AC , MMP 2 , MMP 9 , and p 53 in both human and experimental rat cholangiocarcinoma was examined using immunohistochemistry . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Numerous studies have demonstrated an interaction between MUC 1 and other oncogenic proteins such as beta catenin , erbB receptors and c Src , but a functional role for MUC 1 in transformation has not been identified . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The expression of 13 different proteins was analyzed using immunohistochemistry ( Bcl 2 , p 53 , ILK , Syndecan 1 , MUC 1 , EGFR , HER2 / neu , HSP 90 , Ep CAM , MMP 2 , CD 10 , CD 117 and Ki 67 ) . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemically , pT1a RCCs were characterized by strong expression of p 27 ( 79 % ) , bcl 2 ( 67 % ) , MUC 1 ( 87 % ) , insulin like growth factor ( IGF ) 1 ( 71 % ) and CD 10 ( 88 % ) , as well as moderate expression of IGF 1 receptor ( 43 % ) and low expression of epidermal growth factor receptor ( EGFR , 20 % ) . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| The epidermal growth factor receptor ( EGFR ) is also overexpressed in many cancers and both it and MUC 1 constitute important therapeutic targets . ^^^ Surprisingly , suppression of MUC 1 also inhibited expression of EGFR at both the mRNA and protein levels whereas the reciprocal effect was not observed . ^^^ These results demonstrate a role for MUC 1 in the regulation of EGFR expression and suggest that MUC 1 gene silencing may represent a novel therapeutic approach in the treatment of a variety of human cancers . . ^^^ Suppression of MUC 1 synthesis downregulates expression of the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| Expression of CDX 2 , TFF 1 , MUC 1 , MUC 2 , MUC5AC , EGFR , and p 53 was determined by using immunohistochemistry . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| In concert with these results , we show that heregulin ( HRG ) , a ligand for ErbB receptors , activates c Src and , in turn , stimulates binding of MUC 1 to HSP 90 . ^^^ These findings indicate that MUC 1 is delivered to mitochondria by a mechanism involving activation of the ErbB receptor > c Src pathway and transport by the molecular chaperone HSP70 / HSP90 complex . . ^^^ |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15941 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|