| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| This complex includes the proteins RAG 1 , RAG 2 , HMG 1 or the closely related HMG 2 protein , and the components of the DNA dependent protein kinase . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| In addition , HMG box containing proteins HMG 1 and HMG 2 enhance RAG 1 and RAG 2 mediated cleavage of substrates containing 23 RSS but not of substrates containing only 12 RSS . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| Hence , it became obvious that the initial steps of the reaction are carried out by the lymphocyte specific proteins RAG 1 and RAG 2 ( recombination activating genes ) , with the help of members of the high mobility group protein family of DNA binding proteins , HMG 1 or HMG 2 . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| A dimer of the lymphoid protein RAG 1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG 2 . ^^^ The high mobility group protein HMG 2 is stably incorporated into the recombinant RAG1 / RSS complex and can increase the affinity of RAG 1 for the RSS in the absence of RAG2 . . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| The RAG 1 homeodomain recruits HMG 1 and HMG 2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA bending activity of RAG 1 RAG2 . 5 ( D ) J recombination is initiated by the specific binding of the RAG 1 RAG2 ( RAG1 / 2 ) complex to the heptamer nonamer recombination signal sequences ( RSS ) . ^^^ Here we show that the RAG 1 homeodomain directly interacts with both HMG boxes of HMG 1 and HMG 2 ( HMG 1 , 2 ) . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| In contrast , 23 RSS complexes containing both RAG proteins and either HMG 1 or HMG 2 exhibited enhanced cleavage activity and displayed an altered distribution of cleavage products compared to 23 RSS complexes containing only RAG 1 and RAG 2 . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| Finally , purified core RAG 1 and RAG 2 proteins ( together with HMG 2 ) also reproduce B12 / 23 restriction in a cell free system . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| Synapsis of recombination signal sequences located in cis and DNA underwinding in 5 ( D ) J recombination . 5 ( D ) J recombination requires binding and synapsis of a complementary ( 12 / 23 ) pair of recombination signal sequences ( RSSs ) by the RAG 1 and RAG 2 proteins , aided by a high mobility group protein , HMG 1 or HMG 2 . ^^^ |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15918 and P26583 |
Pubmed |
SVM Score :0.0 |
| NA |
|