| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| In contrast , at least 10 fold lower factors of activation were achieved with ITF 1 , ITF 2 , and MTF 1 . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| There are three E protein genes in mammals , HEB ( TCF 12 ) , E2A ( TCF 3 ) , and E 2 2 ( TCF 4 ) . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| In zebrafish , four members have been identified : Lef 1 , Tcf 3 , Tcf3b , and Tcf 4 . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| The example identifies TCF 3 and TCF 4 as paralogs of the TCF12 / HTF4 gene . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| HEB , a helix loop helix protein related to E2A and ITF 2 that can modulate the DNA binding ability of myogenic regulatory factors . ^^^ We have isolated a cDNA for a human B HLH factor , denoted HEB , that shares nearly complete identity in the B HLH domain with the immunoglobulin enhancer binding proteins encoded by the E2A and ITF 2 genes ( E proteins ) . ^^^ HEB , ITF 2 , and the E 12 product of the E2A gene all bound to a similar spectrum of E box sequences as homo oligomers . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| We have identified at least two distinct functional classes of transcriptional activation domains . ' Proximal ' activation domains , exemplified by glutamine rich domains of Oct 1 , Oct 2A and Sp 1 , stimulate transcription only from a position close to the TATA box , usually in response to a remote enhancer . ' General ' activation domains , derived from VP 16 , GAL 4 , p 65 ( NF chi B ) , TFE 3 , ITF 1 and ITF 2 , can activate transcription from remote as well as proximal positions . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| Two complementary DNAs were isolated that encode proteins , denoted ITF 1 and ITF 2 , that are expressed in a variety of cell types and bind the microE5 / kappa 2 motif found in both heavy and kappa light chain enhancers . ^^^ The complementary DNAs are the products of distinct genes , yet both ITF 1 and ITF 2 are structurally and functionally similar . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| The Yae antibody recognized in vitro synthesized ITF 1 , a third E2A ( Pan ) gene product also produced by the mechanism of alternative RNA splicing , but did not recognize the related HLH proteins , ITF 2 , REB alpha , or REB beta . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| Three further clones represent the helix loop factors ITF 1 and ITF 2 , another one the nucleolar protein nucleophosmin , or B 23 . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| Recent studies have shown that melanocyte specific transcription factors , such as MITF , play important roles in these responses , but ubiquitous transcription factors , such as ITF 2 and E2A , are also involved . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| To gain further insight into the role of Tcf 4 in development and carcinogenesis we have generated several mouse monoclonal antibodies , one of which is specific for Tcf 4 and another of which recognizes both Tcf 3 and Tcf 4 . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| In addition , we cloned two tcf 3 genes and a homolog of tcf 4 , neither of which were strongly expressed in premigratory neural crest . . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| Activation of this pathway is caused by genetic mutations that stabilize the beta catenin protein , allowing it to accumulate in the nucleus and form complexes with any member of the lymphoid enhancer factor ( LEF 1 ) and T cell factor ( TCF 1 , TCF 3 , TCF 4 ) family of transcription factors ( referred to collectively as LEF / TCFs ) to activate transcription of target genes . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| A fragment of beta catenin and a peptide encoding the NH 2 terminus of Tcf 4 that block the interaction between beta catenin and Tcf 3 stimulate beta catenin degradation , indicating this interaction normally plays an important role in regulating beta catenin turnover . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| Tcf 1 , Lef 1 , Tcf 3 , Tcf 4 , sFrp 1 , sFrp 2 and sFrp 4 were also expressed in the PE , AE , and adjacent mesenchyme in specific spatio temporal patterns . . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| Primary HBEC and H 292 bronchial epithelial cells were found to express TCF 4 , TCF 3 and isoforms of LEF 1 , transcription factors that are regulated by Wnt signalling . ^^^ |
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| Interacting proteins: P15884 and P15923 |
Pubmed |
SVM Score :0.0 |
| Because nuclear complex consisting of TCF / LEF ( TCF 1 , TCF 3 , TCF 4 or LEF 1 ) , beta catenin , PYGO ( PYGO 1 or PYGO 2 ) and Legless ( BCL 9 or BCL9L ) binds to the TCF / LEF binding site to up regulate WNT / beta catenin target genes , FGF 16 gene was characterized as the evolutionarily conserved target of the WNT / beta catenin signaling pathway , just like FGF 18 and FGF 20 genes . ^^^ |
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