| Interacting proteins: P22105 and P15692 |
Pubmed |
SVM Score :1.0404033 |
| Previously , we demonstrated that TNX binds to vascular endothelial growth factors A and B ( VEGF A and B ) and that VEGF B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR 1 receptor . 1.0404033^^^ |
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| Interacting proteins: P22105 and P15692 |
Pubmed |
SVM Score :0.0 |
| The minimal region of TNX that interacts with VEGF B was mapped to the FNIII repeats ( FNIII 13 25 ) but not to the other characteristic domains of TNX . ^^^ The TNX binding site of VEGF B was located in the N terminal 115 amino acid region . mTNX / FNIII13 25 did not prevent the interaction of VEGF B with VEGFR 1 ( VEGF receptor 1 ) , and VEGF B could simultaneously bind to both mTNX / FNIII13 25 and VEGFR 1 . ^^^ A conditioned medium from transfected 293T cells coexpressing full length TNX and VEGF B could promote DNA synthesis in bovine endothelial cells in which VEGFR 1 were expressed . ^^^ CONCLUSION : TNX interacts with VEGF B and enhances the ability of VEGF B to stimulate cell proliferation . ^^^ |
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