| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.76592201 |
| VEGF binds and activates two tyrosine kinase receptors called VEGFR 1 and VEGFR 2 and neuropilin 1 . 0.76592201^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.73979397 |
| It was concluded that the exon 7 encoded domain of VEGF 165 enhances its mitogenic activity for HUVEC by interacting with VEGF165R and modulating KDR / Flk 1 mediated mitogenicity indirectly and that exon 7 derived peptides may be useful VEGF antagonists in angiogenesis associated diseases . . 0.73979397^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.64090833 |
| Crosslinking experiments showed that ( 125 ) 1 VEGF ( 165 ) binds to both NRP 1 and VEGFR 2 present in decidual endothelial cells . 0.64090833^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Higher thrombin concentrations also up regulated mRNA for VEGF A and neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NP 1 ) is a receptor for vascular endothelial growth factor A 165 ( VEGF A 165 ) in endothelial cells . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , we evaluated the expression of VEGF A , VEGF R 2 and NRP 1 at the protein level . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , the VEGF ( 165 ) isoform binds to neuropilin 1 ( NP 1 ) , a receptor for collapsins / semaphorins . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( np 1 ) and neuropilin 2 ( np 2 ) are receptors for class 3 semaphorins and for several isoforms of VEGF . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Later , NRP was shown to bind semaphorins and vascular endothelial growth factor ( VEGF ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , the VEGF receptors neuropilin 1 and flt 1 were also upregulated . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Prostate cancer cells expressed the mRNA for VEGF receptor ( VEGFR ) neuropilin 1 but not the VEGFRs Flt 1 or KDR . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| One receptor for L 1 is Neuropilin 1 ( NRP 1 ) that is also known as a receptor for VEGF ( 165 ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| These transcripts included neuropilin 1 , vascular endothelial growth factor A , placental growth factor , elastin , and matrix metalloproteinases implicated in blood vessel growth and maintenance of vessel wall integrity . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Relative effects of VEGF A and VEGF C on endothelial cell proliferation , migration and PAF synthesis : Role of neuropilin 1 . ^^^ Recently , neuropilin 1 ( NRP 1 ) has been described as a coreceptor of KDR which potentiates VEGF A activity . ^^^ However , the role of NRP 1 in numerous VEGF A activities remains unclear . ^^^ To assess the contribution of NRP 1 to VEGF A mediated EC proliferation , migration , and PAF synthesis , we used porcine aortic EC ( PAEC ) recombinantly expressing Flt 1 , NRP 1 , KDR or KDR and NRP 1 . ^^^ Cells were stimulated with VEGF A , which binds to Flt 1 , KDR and NRP 1 , and VEGF C , which binds to KDR only . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| While more than 95 % of nonsmall cell lung carcinoma ( NSCLC ) expresses cell retained VEGF A isoform , the clinicopathologic implications of neuropilin ( NRP ) , considered the specific receptor for limited types of VEGF A isoform , are not well understood . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| BDCA 4 is shown here to be identical to neuropilin 1 ( NP 1 ) , a neuronal receptor for the axon guidance factors belonging to the class 3 semaphorin subfamily , and a receptor on endothelial and tumor cells for vascular endothelial growth factor ( VEGF A ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Microarray analysis detected maximal mRNA expression for a wide variety of angiogenic factors including angiopoietin 1 and 2 , both Tie receptors , VEGF A and D , VEGFR 2 , and neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| This can be explained by our finding that binding of hbVEGF E but not of parental OV VEGF E to the VEGFR 2 is strongly increased by the addition of neuropilin 1 ( NP 1 ) , a cognate co receptor for VEGF A . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Presence of GMP was associated with increased expression in tumour endothelium of the VEGF A receptors KDR , FLT 1 and neuropilin 1 , as well as VEGF D protein . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Nrp 1 also binds the VEGF A splice isoform VEGF 165 , stimulates angiogenesis , and is necessary for vascular development in the mouse . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| However , it is unknown whether VEGF A ( 165 ) is mediating PGI ( 2 ) synthesis through VEGF receptor 1 ( VEGFR 1 ) and / or VEGF receptor 2 ( VEGFR 2 ) activation and whether the coreceptor NRP 1 potentiates VEGF A ( 165 ) activity . ^^^ Treatment of BAEC with VEGF analogs , VEGF A ( 165 ) ( VEGFR 1 , VEGFR 2 and NRP 1 agonist ) and VEGF A ( 121 ) ( VEGFR 1 and VEGFR 2 agonist ) ( up to 10 ( 9 ) m ) , increased PGI ( 2 ) synthesis by 70 and 40 fold within 15 min . ^^^ In addition , the binding of VEGF A ( 165 ) to NRP 1 potentiates its capacity to promote PGI ( 2 ) synthesis . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Expression ( mRNA ) of the VEGF A splice variants and related receptors [ VEGF receptor ( VEGFR ) 1 , VEGFR 2 , and neuropilin 1 ] was determined by using qPCR . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The levels of VEGF A , VEGF R 1 , VEGF R 2 , neuropilin 1 , angiopoietin 1 , angiopoietin 2 , Tie 2 , and hypoxanthine phosphoribosyltransferase mRNAs were determined by real time reverse transcriptase polymerase chain reaction . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Expression of VEGF receptor 2 , the principal signaling receptor for VEGF A in endothelial cells , and coreceptor neuropilin 1 was significantly decreased in Dll 4 transduced endothelial cells . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin ( NRP ) is considered to be the specific receptor for limited types of VEGF A isoform , VEGF 165 . ^^^ The clinicopathological implications of NRP are not well understood in colon cancer , while almost all colon cancers overexpressed VEGF A . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| For example , levels of proangiogenic VEGF A , VEGF B , neuropilin 1 , VEGFR 1 , and VEGFR 2 were reduced and the levels of antiangiogenic thrombospondin 1 and retinoblastoma like 2 were increased . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| A VEGF A splice variant defective for heparan sulfate and neuropilin 1 binding shows attenuated signaling through VEGFR 2 . ^^^ VEGF A ( 165 ) b weakly binds to heparan sulfate and does not interact with neuropilin 1 , a coreceptor for VEGF receptor 2 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| This isoform specific VEGF receptor ( VEGF165R ) is identical to human neuropilin 1 , a receptor for the collapsin / semaphorin family that mediates neuronal cell guidance . ^^^ When coexpressed in cells with KDR , neuropilin 1 enhances the binding of VEGF 165 to KDR and VEGF 165 mediated chemotaxis . ^^^ Conversely , inhibition of VEGF 165 binding to neuropilin 1 inhibits its binding to KDR and its mitogenic activity for endothelial cells . ^^^ We propose that neuropilin 1 is a novel VEGF receptor that modulates VEGF binding to KDR and subsequent bioactivity and therefore may regulate VEGF induced angiogenesis . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The apparent molecular weight and the binding characteristics of these receptors correspond to those of the recently identified VEGF 165 specific receptor neuropilin 1 , and we therefore conclude that neuropilin 1 is a receptor for PlGF 2 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Endothelial cells express in addition the neuropilin 1 and neuropilin 2 coreceptors , which bind selectively to the 165 amino acid form of VEGF ( VEGF 165 ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) like protein from orf virus NZ 2 binds to VEGFR 2 and neuropilin 1 . ^^^ ORFV 2 VEGF was found to bind and induce autophosphorylation of VEGFR 2 and was unable to bind or activate VEGFR 1 and VEGFR 3 , but bound the newly identified VEGF 165 receptor neuropilin 1 . ^^^ These results indicate that , from a functional viewpoint , ORFV 2 VEGF is indeed a member of the VEGF family of molecules , but is unique , however , in that it utilizes only VEGFR 2 and neuropilin 1 . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that both splice isoforms of VEGF B bind specifically to Neuropilin 1 ( NRP 1 ) , a receptor for collapsins / semaphorins and for the VEGF ( 165 ) isoform . ^^^ The NRP 1 binding of VEGF B could be competed by an excess of VEGF ( 165 ) . ^^^ The binding of VEGF B ( 167 ) was mediated by the heparin binding domain , whereas the binding of VEGF B ( 186 ) to NRP 1 was regulated by exposure of a short COOH terminal proline rich peptide upon its proteolytic processing . ^^^ In immunohistochemistry , NRP 1 distribution was found to be overlapping or adjacent to known sites of VEGF B expression in several tissues , in particular in the developing heart , suggesting the involvement of VEGF B in NRP 1 mediated signaling . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Two neuropilin 1 ligands , semaphorin 3 and VEGF 165 , can bind to these cells , and the addition of VEGF 165 to MS 5 cells increases expression of 2 cytokines known to regulate early hematopoiesis , Tpo and Flt 3 L . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 is also expressed in endothelial cells and shown to bind vascular endothelial growth factor ( VEGF ) , a potent regulator for vasculogenesis and angiogenesis . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| To better understand the specific functions of these growth factors , we have here analyzed their binding to sections of mouse embryonic and adult tissues and compared the distribution of the bound growth factors with the expression patterns of the 3 known members of the VEGF receptor family as well as with neuropilin 1 , a coreceptor for VEGF ( 165 ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , VEGF 165 binds with a newly identified co receptor , neuropilin 1 , which is expressed in human endothelial cells and several types of non endothelial cells including tumor cells . ^^^ These studies demonstrate that normal rat pituitaries , estrogen induced rat pituitary tumors and GH 3 pituitary tumor cells expressed VEGF 164 and co receptor , neuropilin 1 . ^^^ The VEGF 164 and neuropilin 1 mRNA and protein levels were significantly higher in the estrogen induced pituitary tumors and GH 3 tumor cell line , as compared to normal pituitary . ^^^ The data suggest that both VEGF 164 and neuropilin 1 may actively participate in modulation of tumor angiogenesis and the development of pituitary tumors in Fisher 344 rats . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In a screen for genes whose expression was dependent upon dHAND ( using subtractive hybridization comparing wild type and dHAND null hearts ) , the VEGF ( 165 ) receptor , neuropilin 1 , was found to be downregulated in dHAND mutants . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a 130 kDa transmembrane receptor for semaphorins , mediators of neuronal guidance , and for vascular endothelial growth factor 165 ( VEGF ( 165 ) ) , an angiogenesis factor . ^^^ Neuropilin 1 ( NRP 1 ) is a 130 kDa transmembrane receptor for semaphorins , mediators of neuronal guidance , and for vascular endothelial growth factor 165 ( VEGF ( 165 ) ) , an angiogenesis factor . ^^^ A 2 . 2 kb truncated NRP 1 cDNA was cloned that encodes a 644 aa soluble NRP 1 ( sNRP 1 ) isoform containing just the a / CUB and b / coagulation factor homology extracellular domains of NRP 1 . sNRP 1 is secreted by cells as a 90 kDa protein that binds VEGF ( 165 ) , but not VEGF ( 121 ) . ^^^ These results demonstrate the existence of a naturally occurring , soluble NRP 1 that is expressed differently from intact NRP 1 and that appears to be a VEGF ( 165 ) antagonist . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Third , in endothelial cells , neuropilin 1 binds a potent endothelial cell mitogen , vascular endothelial growth factor ( VEGF ) ( 165 ) , and regulates vessel formation . ^^^ Though the binding sites in neuropilin 1 for the class 3 semaphorins and VEGF ( 165 ) have been analyzed , the sites involved in cell adhesion activity of the molecule have not been identified . ^^^ In addition , we demonstrated that the cell adhesion ligands for neuropilin 1 were proteins and distributed in embryonic mesenchymal cells but distinct from the class 3 semaphorins , VEGF , or plexins . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( np 1 ) and neuropilin 2 ( np 2 ) are receptors for axon guidance factors belonging to the class 3 semaphorins . np 1 also binds to the 165 amino acid heparin binding form of VEGF ( VEGF ( 165 ) ) but not to the shorter VEGF ( 121 ) form , which lacks a heparin binding ability . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| VEGF overexpression in clinically localized prostate tumors and neuropilin 1 overexpression in metastatic forms . ^^^ We have examined 42 primary sporadic prostate tumors at different clinical stages , together with 3 prostate cancer cell lines ( DU 145 , PC 3 and LNCaP ) , for expression of VEGF and the gene encoding the recently identified VEGF 165 isoform specific receptor neuropilin 1 , by using a quantitative reverse transcription ( RT ) PCR method . ^^^ Upregulation of VEGF and neuropilin 1 was observed in 12 and 14 tumors , respectively . ^^^ VEGF overexpression correlated with stage 2 disease ( p < 0 . 05 ) ; neuropilin 1 overexpression correlated with advanced disease ( p < 0 . 01 ) and a high Gleason grade ( p < 0 . 02 ) . ^^^ Our observations suggest that VEGF expression could be used as a prognostic marker in early stage prostate tumors , whereas neuropilin 1 overexpression might be a marker of aggressiveness . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| It mediates its activity mainly via two tyrosine kinase receptors , VEGFR 1 ( flt 1 ) and VEGFR 2 ( flk 1 / KDR ) , although other receptors , such as neuropilin 1 and 2 , can also bind VEGF . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Furthermore , wild type and P 4 treated PRLR / mice had similar expression of the implantation specific genes , LIF , amphiregulin , HB EGF , COX 1 , COX 2 , PPARdelta , Hoxa 10 , cyclin D 3 , VEGF , and its receptors , Flk 1 and neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| These receptors are encoded by the neuropilin 1 gene , and we have recently found that the related neuropilin 2 gene also encodes a VEGF 165 receptor . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Coexpression of VEGF receptors VEGF R 2 and neuropilin 1 in proliferative diabetic retinopathy . ^^^ RESULTS : RT PCR analysis demonstrated the expression of VEGF receptors VEGF R 1 , VEGF R 2 , and neuropilin 1 in 12 , 14 , and 14 of 22 cases , respectively . ^^^ Notably , VEGF R 2 and neuropilin 1 were simultaneously expressed in the identical 14 tissues . ^^^ The isoform VEGF 121 was constitutively expressed in all the tissues examined , whereas the expression of VEGF 165 was confined to the 7 tissues that also expressed VEGF R 2 and neuropilin 1 . ^^^ The vascular density of fibrovascular tissues evaluated by immunohistochemistry for CD 34 was significantly higher in the cases with the expression of VEGF R 2 and neuropilin 1 than in those without their expression ( P < 0 . 01 ) , whereas VEGF R 1 expression had no such relationship with the vascular density . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) , a potent mitogen , is expressed in podocytes in the glomerulus , and VEGF receptors ( flt 1 , KDR , and neuropilin 1 ) are present on endothelial cells and other cell types . ^^^ In conclusion , flt 1 , KDR , and neuropilin 1 are present on cultured HMC , and VEGF ( 165 ) induces HMC proliferation . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| These results suggest that NRP acts as a VEGF amplifier in a paracrine or autocrine manner in the osteosarcoma . ^^^ NRP 2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| This study examined the expression of vascular endothelial growth factor ( VEGF ) isoforms and VEGF receptors , Flt 1 , KDR and neuropilin 1 , in RA and osteoarthritis ( OA ) synovia , and studied the relationship between their expression and the synovial angiogenesis . ^^^ The expression of neuropilin 1 , an isoform specific receptor for VEGF ( 165 ) which enhances the binding of VEGF ( 165 ) to KDR , was also up regulated in the same RA synovia that expressed KDR . ^^^ Furthermore , there was a close correlation between the expression of isoform VEGF ( 165 ) and that of its receptors KDR and neuropilin 1 . ^^^ Morphometric analysis demonstrated that the vascular density is significantly higher in the RA synovial tissues with expression of VEGF ( 165 ) , KDR , and neuropilin 1 than in those without their expression ( p < 0 . 01 ) . ^^^ These results suggest that the selective up regulation of the isoform VEGF ( 165 ) and its signalling via KDR and neuropilin 1 play an important role in the synovial angiogenesis which occurs in RA . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Coexpression of neuropilin 1 , Flk 1 , and VEGF ( 164 ) in developing and mature mouse kidney glomeruli . ^^^ Neuropilin 1 , a neuronal cell surface semaphorin 3 receptor protein important for axonal guidance in developing peripheral nervous system efferents , has also been identified as a vascular endothelial growth factor ( VEGF ) receptor on endothelial cells . ^^^ However , the VEGF hybridization signal was markedly less in adult glomeruli than those for neuropilin 1 and Flk 1 . ^^^ Because neuropilin 1 specifically binds VEGF ( 165 ) in humans , we carried out RT PCR on mouse kidney RNA with primers that amplified the three alternatively spliced isoforms of VEGF mRNA . ^^^ We conclude that the expression of neuropilin 1 , in conjunction with Flk 1 and VEGF ( 164 ) , jointly contributes to the development and maintenance of glomerular capillaries . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| To investigate the mechanism of neuroprotection by VEGF , the expression of known target receptors for VEGF was measured by Western blotting , which showed that HN 33 cells expressed VEGFR 2 receptors and neuropilin 1 , but not VEGFR 1 receptors . ^^^ The neuropilin 1 ligand placenta growth factor 2 failed to reproduce the protective effect of VEGF , pointing to VEGFR 2 as the site of VEGF ' s neuroprotective action . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| However , recent evidence suggests that VEGF can also bind in an isoform specific fashion to a newly identified neuropilin 1 ( NP 1 ) receptor . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Using immunohistochemical and in situ hybridization methods we have here demonstrated that VEGF and its receptors Flk 1 , Flt 1 and Neuropilin 1 mRNAs and proteins are induced after incisions in the rat spinal cord . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrate that the viral VEGF , while recognizing a unique profile of the known VEGF receptors ( receptor 2 and neuropilin 1 ) , is able to stimulate a striking proliferation of blood vessels in the dermis underlying the site of infection . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a VEGF ( 165 ) and semaphorin receptor expressed by vascular endothelial cells ( EC ) and tumor cells . ^^^ Neuropilin 1 ( NRP 1 ) is a VEGF ( 165 ) and semaphorin receptor expressed by vascular endothelial cells ( EC ) and tumor cells . ^^^ Concomitant with increased NRP 1 expression in response to a tetracycline homologue , doxycycline ( Dox ) , basal cell motility , and VEGF ( 165 ) binding were increased three to fourfold in vitro . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are both receptors for semaphorins , which regulate neuronal guidance , and vascular endothelial growth factor ( VEGF ) , an angiogenic factor . ^^^ Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are both receptors for semaphorins , which regulate neuronal guidance , and vascular endothelial growth factor ( VEGF ) , an angiogenic factor . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The expression of neuropilin 1 ( NRP 1 ) , a recently described VEGF and semaphorin receptor expressed by endothelial cells ( EC ) but some non EC types as well , was analyzed in osteoblasts in vitro and in vivo . ^^^ Cultured MC3T3 E 1 osteoblasts expressed NRP 1 mRNA and bound VEGF ( 165 ) but not VEGF ( 121 ) , characteristic of the VEGF isoform specific binding of NRP 1 . ^^^ These cells did not express VEGFR 1 or VEGFR 2 so that VEGF binding to osteoblasts was strictly NRP 1 dependent . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The expression of the signalling VEGF receptors R 1 ( flt 1 ) and R 2 ( flk 1 ) was restricted to the endothelial cells of the cortex whereas neuropilin 1 was expressed by both endothelial and steroidogenic cells . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NP 1 ) is a receptor for vascular endothelial growth factor ( VEGF ) 165 ( VEGF 165 ) and acts as a coreceptor that enhances VEGF 165 function through tyrosine kinase VEGF receptor 2 ( VEGFR 2 ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| About 10 years after its isolation , NRP was identified as a receptor for semaphorin , a family of axonal chemorepellent proteins and for vascular endothelial growth factor ( VEGF ) , a family of potent angiogenic factors . ^^^ On the endothelium , NRP is expressed together with KDR , a VEGF receptor tyrosine kinase . ^^^ Some tumor cells can express high levels of NRP , which is typically their only VEGF receptor , but do not seem to respond to VEGF directly . ^^^ Possible use of NRP as a target for VEGF antagonists , in the context of antiangiogenic therapy , are described . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , Vegf 165 promoted survival of motor neurons during hypoxia through binding to Vegf receptor 2 and neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We also found coinduction of several groups of related genes that might represent functional modules within the ischemic neuronal transcriptome , including VEGF and its receptor , NRP 1 ; the IGF 1 receptor and the IGF 1 binding protein IGFBP 2 ; Rb , the Rb binding protein E2F1 , and the E2F related transcription factor , TFDP 1 ; the CACNB 3 and CACNB 4 beta subunits of the voltage gated calcium channel ; and caspase 3 and its substrates , ACINUS , FEM 1 , and GSN . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The level of neuropilin 1 , an accessory receptor of VEGF to main receptor corresponds with that of VEGF and ang 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Next , we validated the motif PQPRPL as a novel chimeric ligand mimic that binds specifically to VEGF receptor 1 and to neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Selective induction of neuropilin 1 by vascular endothelial growth factor ( VEGF ) : a mechanism contributing to VEGF induced angiogenesis . ^^^ Neuropilin ( NRP ) 1 , previously identified as a neuronal receptor that mediates repulsive growth cone guidance , has been shown recently to function also in endothelial cells as an isoform specific receptor for vascular endothelial growth factor ( VEGF ) ( 165 ) and as a coreceptor in vitro of VEGF receptor 2 . ^^^ In the present study , we first show that VEGF selectively up regulates NRP 1 but not NRP 2 via the VEGF receptor 2 dependent pathway . ^^^ By NRP 1 binding analysis , we showed that its induction by VEGF accompanies functional receptor expression . ^^^ Endothelial proliferation stimulated by VEGF ( 165 ) was inhibited significantly by antibody perturbation of NRP 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although much is known about the biology of VEGF and its cognate receptors , VEGFR 1 and VEGFR 2 , the role of a recently identified co receptor for VEGF , neuropilin 1 , is not well understood . ^^^ In in vitro assays , VEGF induced formation of endothelial cord like structures on collagen gel and endothelial cell migration toward VEGF was inhibited by antibodies directed against neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and 2 ( NRP ) are novel specific receptors of VEGF ( 165 ) , whose role is unknown in human neuroblastoma . ^^^ Neuropilin 1 and 2 ( NRP ) are novel specific receptors of VEGF ( 165 ) , whose role is unknown in human neuroblastoma . ^^^ The mRNA expression of VEGF ( 165 ) and its receptors Flt 1 , KDR , NRP 1 , and NRP 2 was evaluated by real time reverse transcription polymerase chain reaction . ^^^ RESULTS : VEGF ( 165 ) mRNA was upregulated in Stage 3 and 4 and Flt 1 and KDR gene expression was increased in Stage 3 , while NRP 1 and 2 mRNA and protein levels were higher in Stages 1 4 vs . controls ( P < 0 . 05 ) . ^^^ CONCLUSIONS : These results show for the first time that human neuroblastoma expresses NRP , and that NRP co regulates VEGF angiogenic effect in human neuroblastoma . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| TSA inhibited in a dose dependent and reversible fashion the VEGF induced expression of VEGF receptors , VEGFR 1 , VEGFR 2 , and neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The murine VEGF gene is alternatively transcribed to yield the VEGF ( 120 ) , VEGF ( 164 ) , and VEGF ( 188 ) isoforms , which differ in their potential to bind to heparan sulfate and neuropilin 1 and to stimulate endothelial growth . ^^^ It is noteworthy that neuropilin 1 , a receptor for VEGF ( 164 ) , was predominantly expressed in retinal arterioles . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 , which enhances the binding of VEGF ( 165 ) to KDR , was also studied . ^^^ Compared with controls , coronary vessels of acute KD had upregulation of VEGF and flt 1 but not KDR or neuropilin 1 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Reverse transcription polymerase chain reaction ( RT PCR ) analysis revealed the expression of VEGF receptors VEGFR 1 ( Flt 1 ) , VEGFR 2 ( Kdr ) , and VEGFR 3 ( Flt 4 ) , as well as neuropilin 1 and 2 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and 2 ( NP 1 / NP 2 ) are transmembrane receptors that play a role in axonal guidance by binding of class 3 semaphorins , and in angiogenesis by binding of the vascular endothelial growth factor isoform VEGF 165 and placenta growth factor ( PLGF ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuroplin 1 ( NRP 1 ) , a receptor for vascular endothelial growth factor ( VEGF ) family members , has three distinct extracellular domains , a1a2 , b1b2 , and c . ^^^ To determine the VEGF ( 165 ) and placenta growth factor 2 ( PlGF 2 ) binding sites of NRP 1 , recombinant NRP 1 domains were expressed in mammalian cells as Myc tagged , soluble proteins , and used in co precipitation experiments with 125I VEGF 165 and 125I PlGF 2 . ^^^ In competition experiments , VEGF 165 competed PlGF 2 binding to the NRP 1 b1b2 domain , suggesting that the binding sites of VEGF 165 and PlGF 2 overlap . ^^^ It was concluded that an intact b1b2 domain serves as the VEGF 165 , PlGF 2 , and heparin binding sites in NRP 1 , and that heparin is a critical component for regulating VEGF 165 and PlGF 2 interactions with NRP 1 by physically interacting with both receptor and ligands . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 is required for vascular development and is a mediator of VEGF dependent angiogenesis in zebrafish . ^^^ Neuropilin 1 ( NRP 1 ) is a cell surface receptor for both vascular endothelial growth factor ( 165 ) ( VEGF ( 165 ) ) and class 3 semaphorins that is expressed by neurons and endothelial cells . ^^^ Neuropilin 1 ( NRP 1 ) is a cell surface receptor for both vascular endothelial growth factor ( 165 ) ( VEGF ( 165 ) ) and class 3 semaphorins that is expressed by neurons and endothelial cells . ^^^ The zebrafish NRP 1 gene ( znrp 1 ) was isolated and when overexpressed in cells , zNRP 1 protein was a functional receptor for human VEGF ( 165 ) . ^^^ To determine whether NRP 1 and VEGF activities were interdependent in vivo , zNRP 1 and VEGF morpholinos were coinjected into embryos at concentrations that individually did not significantly inhibit blood vessel development . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Members of this family bind differentially to three receptor tyrosine kinases , namely VEGF R 1 , R 2 and R 3 , and to the semaphorin receptors neuropilin 1 and 2 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Recently , a specific VEGF 165 receptor , neuropilin 1 ( NP 1 ) , was also identified in endothelial cells and upon VEGF binding , NP 1 , synergistically with VEGFR 2 , enhances VEGF induced cell proliferation and migration . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NP 1 ) is a receptor for vascular endothelial growth factor 165 ( VEGF 165 ) and acts as a coreceptor that enhances the function of VEGF 165 through VEGF receptor 2 ( VEGFR 2 ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In vivo administration of vascular endothelial growth factor ( VEGF ) and its antagonist , soluble neuropilin 1 , predicts a role of VEGF in the progression of acute myeloid leukemia in vivo . ^^^ The expression of VEGF and VEGF receptors KDR and neuropilin 1 ( NRP 1 ) was detected in these cells . ^^^ In a murine chloroma model , delivery of VEGF ( 165 ) using microencapsulation technology resulted in enhanced tumor growth and vascularization , whereas treatment with a VEGF antagonist soluble NRP 1 ( sNRP 1 ) inhibited tumor angiogenesis and growth . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We report that vascular endothelial growth factor ( VEGF ) , a major angiogenic factor , is also arequisite autocrine factor for breast carcinoma invasion in vitro and that the VEGF receptor Neuropilin 1 but not Flt 1 is essential for this function . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a receptor for the vascular endothelial growth factor ( VEGF ) family of angiogenesis factors and for the semaphorin family of secreted neuronal guidance polypeptides . ^^^ Neuropilin 1 ( NRP 1 ) is a receptor for the vascular endothelial growth factor ( VEGF ) family of angiogenesis factors and for the semaphorin family of secreted neuronal guidance polypeptides . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| To our surprise , HEX completely abrogated the response of HUVECs to vascular endothelial growth factor ( VEGF ) with regard to proliferation , migration , and invasion and abolished network formation by HUVECs on Matrigel . cDNA microarray analysis and quantitative real time reverse transcription polymerase chain reaction combined with Western blotting revealed that HEX significantly repressed the expression of VEGF receptor 1 , VEGF receptor 2 , neuropilin 1 , tyrosine kinase with Ig and EGF homology domains ( TIE ) 1 , TIE 2 , and the integrin alpha ( 5 ) subunit , whereas it augmented the expression of endoglin in HUVECs . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NRP 1 is a co receptor for VEGF receptor 2 ( VEGFR 2 ) that enhances the binding of VEGF 165 to VEGFR 2 and VEGF 165 mediated chemotaxis . ^^^ VEGF 165 and Sema3A are competitive inhibitors for NRP 1 mediated functions in EC and neurons . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) receptors can bind the class 3 semaphorin subfamily and the heparin binding forms of vascular endothelial growth factor ( VEGF ) and placenta growth factor ( PlGF ) . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The interaction of Neuropilin 1 and Neuropilin 2 with tyrosine kinase receptors for VEGF . ^^^ VEGF 165 binds to both NRP 1 and to NRP 2 but VEGF 121 , does not bind to either of these receptors . ^^^ VEGF 145 on the other hand , binds to NRP 2 but not to NRP 1 . ^^^ Additional VEGF family members such as the heparin binding form of placenta growth factor ( PlGF 2 ) and VEGF B bind to NRP 1 , and it was also shown that both PlGF 2 and VEGF C bind to NRP 2 . ^^^ The VEGF 165 induced proliferation and migration of cells that express the VEGF tyrosine kinase receptor VEGFR 2 is enhanced in the presence of NRP 1 , suggesting that Neuropilins may also form complexes with VEGF tyrosine kinase receptors such as VEGFR 2 . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Interestingly , class 3 Semaphorins and VEGF compete for common NRP binding . ^^^ During lung tumorigenesis , both NRP and VEGF expression increase on dysplastic lung epithelial cells ; SEMA3F expression is reduced and SEMA3F protein is delocalized from the membrane to the cytoplasm . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) acts as a coreceptor for VEGF 165 and increases its affinity for VEGF receptor 2 ( VEGFR 2 ) in endothelial cells . ^^^ Neuropilin 1 ( NRP 1 ) acts as a coreceptor for VEGF 165 and increases its affinity for VEGF receptor 2 ( VEGFR 2 ) in endothelial cells . ^^^ Moreover , in EGF R positive NCI N 87 and ST 2 cells , EGF induced both NRP 1 and VEGF mRNA expression . ^^^ C 225 , a monoclonal antibody to EGF R , blocked EGF induced NRP 1 and VEGF expression in NCI N 87 cells in a dose dependent manner . ^^^ Blockade of the Erk , phosphatidylinositol 3 kinase / Akt , or P 38 pathways in this cell line prevented EGF induction of NRP 1 and VEGF . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| VEGF has been shown to be an autocrine survival factor in neuropilin 1 positive , VEGF receptor negative breast carcinoma cells . ^^^ Normal human podocytes are also known to express neuropilin 1 , VEGF , and are VEGF R 2 negative . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Reverse transcriptase polymerase chain reaction ( RT PCR ) is utilized to measure the VEGF receptors flt 1 , KDR / flk 1 , flt 4 , neuropilin 1 ( NRP 1 ) , and neuropilin 2 ( NRP 2 ) . ^^^ Flt 4 , NRP 1 , and NRP 2 are present in the IMR 32 cells , and their expression is significantly increased by the administration of VEGF . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 , which mainly binds VEGF 165 , was detected at all stages during early osteoblastogenesis , but VEGF receptor 1 and 2 were not detected on RT PCR analyses . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Stimulation by either 50 ng / ml VEGF A 165 or by 24 h of anoxia resulted in an altered pattern of receptor expression for VEGF R 2 ( Flk 1 ) , VEGF R 3 ( Flt 4 ) , neuropilin 1 , and neuropilin 2 , whereas VEGF R 1 ( Flt 1 ) remained unexpressed . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 conveys semaphorin and VEGF signaling during neural and cardiovascular development . ^^^ Neuropilin 1 ( Npn 1 ) is a receptor that binds multiple ligands from structurally distinct families , including secreted semaphorins ( Sema ) and vascular endothelial growth factors ( VEGF ) . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : It was recently shown that neuropilin 1 ( NRP 1 ) , which was described originally as a receptor for the semaphorins / collapsins ( ligands involved in neuronal guidance ) , is a coreceptor for vascular endothelial growth factor ( VEGF ) and increases the affinity of specific isoforms of VEGF to its receptor , VEGF R 2 . ^^^ NRP 1 may act as a coreceptor for VEGF in pancreatic carcinoma , as it does in other tumor systems , thereby enhancing angiogenesis and the effect of VEGF on the growth of pancreatic adenocarcinoma . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors ( VEGFR 1 , its soluble form sVEGFR 1 , VEGFR 2 and neuropilin 1 ) are expressed predominantly by endothelial cells . ^^^ We used quantitative RT PCR , Western blot , gelatin zymography and immunohistochemistry to study the expression of VEGF , VEGFR 1 , VEGFR 2 , sVEGFR 1 , neuropilin 1 , MT 1 MMP , MMP 2 , MMP 9 and TIMP 2 in 20 human GBMs and 5 normal brains . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization demonstrated presence of mRNA for VEGF receptors Flt 1 , fetal liver kinase 1 , neuropilin 1 and 2 in several important cellular compartments of the spinal cord . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The roles of several growth factor receptor / ligand systems are also discussed , with an emphasis on the VEGF receptors , Flk 1 and neuropilin 1 . . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) has been found to be expressed by endothelial cells and tumor cells as an isoform specific receptor for vascular permeability factor / vascular endothelial growth factor ( VEGF ) . ^^^ Neuropilin 1 ( NRP 1 ) has been found to be expressed by endothelial cells and tumor cells as an isoform specific receptor for vascular permeability factor / vascular endothelial growth factor ( VEGF ) . ^^^ Previous studies were mainly focused on the extracellular domain of NRP 1 that can bind to VEGF 165 and , thus , enables NRP 1 to act as a co receptor for VEGF 165 , which enhances its binding to VEGFR 2 and its bioactivity . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NP 1 ) and neuropilin 2 ( NP 2 ) are receptors for semaphorins , which act as axonal chemorepellents , and for members of the vascular endothelial growth factor ( VEGF ) family of angiogenic growth factors . ^^^ After cellular expression of NRP 1 ( Delta exon 16 ) , we found ( unlike the two previously identified alternatively spliced NRP 1 isoforms ) no evidence that the extracellular domain of NRP 1 ( Delta exon 16 ) is secreted from cells as a soluble protein . ( 125 ) 1 VEGF bound with high affinity to NRP 1 and NRP 1 ( Delta exon 16 ) expressing cells , and VEGF treatment led to the formation of complexes between VEGFR 2 and either NRP 1 or NRP 1 ( Delta exon 16 ) . ^^^ It is concluded that NRP 1 and NRP 1 ( Delta exon 16 ) mediate VEGF induced signaling in a similar manner . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| METHODS : Normal and arterialized vein graft segments were evaluated by reverse transcription polymerase chain reaction ( RT PCR ) for expression of VEGF R 1 ( flt ) , VEGF R 2 ( KDR ) , and neuropilin 1 . ^^^ The cells expressing VEGF , VEGF R 1 , VEGF R 2 , and neuropilin 1 were identified in normal , stenotic , and arterialized vein graft segments by immunohistochemistry . ^^^ CONCLUSIONS : The differential expression of VEGF and its receptors in normal , arterialized , and stenotic vein grafts suggests that alterations in VEGF / VEGF R2 / neuropilin 1 interactions may be important determinants of the adaptive response of vein grafts to arterialization . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| A receptor binding assay revealed that snake venom VEGFs bound to KDR IgG with high affinity ( Kd = approximately 0 . 1 nm ) as well as to VEGF 165 but did not interact with Flt 1 , Flt 4 , or neuropilin 1 at all . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , receptors for the secreted semaphorins , neuropilin 1 and neuropilin 2 , have been shown to function as coreceptors for a subset of vascular endothelial growth factor ( VEGF ) isoforms and related growth factors . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : The Neuropilin ( NRP ) family is a novel receptor family that has been found to bind to a key molecule in angiogenesis , vascular endothelial growth factor ( VEGF ) . ^^^ In vascular endothelial cells , NRP 1 functions as an isoform specific receptor for VEGF 165 and has predominant expression compared to NRP 2 . ^^^ RESULTS : In cultured bovine retinal endothelial cells ( BREC ) , VEGF selectively up regulates NRP 1 expression . ^^^ NRP 1 functional blocking antibody inhibited VEGF induced mitogenesis of BRECs in vitro . ^^^ CONCLUSION : Our results suggest that NRP 1 plays a critical role in VEGF induced retinal angiogenesis and thus could be a viable therapeutic target for inhibition of retinal neovascularization . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We also observed upregulation of genes implicated in cell survival and growth , such as vascular endothelial growth factor ( VEGF ) , neuropilin 1 , adrenomedullin , and IGF 2 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Message for VEGF and the VEGF receptors KDR , flt 1 , flt 4 , neuropilin 1 ( NRP 1 ) , and neuropilin 2 ( NRP 2 ) are measured with RT PCR . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We examined the gene expression of vascular endothelial growth factor ( VEGF ) A , Flt 1 , KDR , NRP 1 and NRP 2 in 37 gliomas by real time reverse transcriptase PCR ( real time RT PCR ) as well as immunohistochemical analysis . ^^^ VEGF A and VEGFR overexpression did not show any correlation with the clinicopathological features , including NRP expression . ^^^ These results suggest that NRP 1 overexpression , rather than VEGF A or VEGFR , contributes to tumor progression and has clinical significance for glioma . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a coreceptor to a tyrosine kinase receptor for both the vascular endothelial growth factor ( VEGF ) family and semaphorin ( Sema ) family members . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilins ( NRP ) are receptors of angiogenic vascular endothelial growth factor ( VEGF ) . ^^^ Here , we observed in vitro that new ( 99m ) Tc labeled derivative of anti VEGF heptapeptide , ATWLPPR , binds to NRP 1 but not to NRP 2 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Glomerular upregulation of the VEGF ( 164 ) co receptor neuropilin 1 mRNA in nephritic rats was reduced by L NIL treatment only on day 7 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| A monoclonal antibody against human NRP 1 significantly blocked VEGF induced cell proliferation in Panc 1 cells . ^^^ CONCLUSIONS : The pancreatic carcinoma cell line Panc 1 and adenocarcinoma tissue specimens expressed high levels of NRP 1 and VEGF , but not VEGFRs , and exogenous VEGF significantly increased NRP 1 mediated , but not VEGFR mediated , Panc 1 cell proliferation . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The results showed that a large number of hematopoietic growth factor and receptor genes ( Epo / R , GM CSF / R , G CSF / R , LIF , IL 3 , TPO , Flt 3 , SCF ) were expressed in both groups , while many other growth factors ( VEGF , IGF 2 , PDGFA , PDGFB , TGFbeta 1 ) and receptors ( neuropilin 1 , neuropilin 2 , TGFbeta R 1 ) were expressed . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| VEGF acts through several receptors , including VEGF receptor 1 , VEGF receptor 2 , neuropilin 1 ( Npn 1 ) , and Npn 2 , but the exact role of these receptors in the development of retinal NV is unknown . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In endothelial cells , NRP 1 serves as a co receptor for vascular endothelial growth factor ( VEGF ) and regulates VEGF receptor 2 ( VEGFR 2 ) dependent angiogenesis . ^^^ Using RNA interference mediated silencing of NRP 1 or VEGFR 2 in primary human endothelial cells , we confirm that NRP 1 modulates VEGFR 2 signaling dependent mitogenic functions of VEGF . ^^^ Based on its dual role as an enhancer of VEGF activity and a mediator of endothelial cell adhesiveness described here , NRP 1 emerges as a promising molecular target for the development of antiangiogenic drugs . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Taking advantage of a collection of genetically engineered mouse mutants , we now demonstrate that the behavior of somata and axons of the facial nerve is regulated independently by two secreted ligands for the transmembrane receptor neuropilin 1 ( Nrp 1 ) , the semaphorin Sema3A and the VEGF 164 isoform of Vascular Endothelial Growth Factor . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These data demonstrate that HUVECs express higher mRNA levels of NRP 1 and NRP 2 than those of VEGFRs , and TNF alpha treatment significantly decreases the expression of VEGFR 2 , VEGFR 3 , and NRP 1 , which may be responsible for TNF alpha induced reduction of EC proliferation in response to VEGF ( 165 ) . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| ES cells were found to produce VEGF and to express VEGF receptor 2 and neuropilin 1 ( Nrp 1 ) , a VEGF 165 isoform specific receptor . ^^^ Neuropilin 1 was involved in the VEGF survival activity since overexpression of Nrp 1 decreased hypoxia induced apoptosis about 3 fold . ^^^ During hypoxia , expression levels of VEGF , Flk 1 , and Nrp 1 were elevated . ^^^ Neuropilin 1 was involved in the VEGF survival activity since overexpression of Nrp 1 decreased hypoxia induced apoptosis about 3 fold . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| To evaluate a possible contribution of the VEGF receptors , we performed immunohistochemical stainings of VEGF R 1 ( flt ) , R 2 ( KDR , flk ) , and Neuropilin 1 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Such genes included those for the glucose transporter , vascular endothelial growth factor ( VEGF ) , placental growth factor , angiopoietin 2 , tie 1 , VEGF receptor 2 and its coreceptor , neuropilin 1 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| A peptide corresponding to the neuropilin 1 binding site on VEGF ( 165 ) induces apoptosis of neuropilin 1 expressing breast tumour cells . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Arteriogenesis also requires endothelial expression of NRP 1 , an artery specific coreceptor for VEGF ( 164 ) that is itself induced by VEGF . ^^^ They also suggest a model in which a ' winner takes all ' competition for VEGF may control arterial differentiation , with the outcome biased by a VEGF ( 164 ) NRP 1 positive feedback loop . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor ( VEGF ) for angiogenesis . ^^^ Neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) are transmembrane glycoproteins that have been characterized as receptors for both semaphorins for neuronal guidance and vascular endothelial growth factor ( VEGF ) for angiogenesis . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin 1 : a computational model . ^^^ Neuropilin 1 ( NRP 1 ) and the signaling VEGF receptor , VEGFR 2 , do not interact directly but are bridged by one VEGF isoform , VEGF ( 165 ) . ^^^ Neuropilin 1 ( NRP 1 ) and the signaling VEGF receptor , VEGFR 2 , do not interact directly but are bridged by one VEGF isoform , VEGF ( 165 ) . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The neuropilin 1 ( np 1 ) and the neuropilin 2 ( np 2 ) receptors bind vascular endothelial growth factor ( VEGF ) and class 3 semaphorins . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Thalidomide induces the defect of major blood vessels , which is demonstrated by their morphologic loss and confirmed by the depletion of vascular endothelial growth factor ( VEGF ) receptors such as neuropilin 1 and Flk 1 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Vascular endothelial growth factor ( VEGF ) , its receptors ( VEGFR 1 , VEGFR 2 ) and neuropillin 1 ( NRP 1 ) are expressed at variable levels in bone marrow . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| A longer unique antisense oligo against a different region of pICln mRNA was found to also enhance EC growth and tube formation and to decrease mRNAs for soluble Flt 1 and neuropilin 1 vascular endothelial growth factor ( VEGF ) receptors , the angiostatic factors that are generated by alternative RNA splicing . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NRP 1 is also expressed in endothelial cells and is believed to promote angiogenesis by acting as a coreceptor with vascular endothelial growth factor ( VEGF ) receptor 2 . ^^^ Recent studies suggest that NRP 1 can function through both a VEGF dependent and VEGF independent fashion . ^^^ The exact role of NRP 1 in tumor cells is unknown , particularly in cells that lack the NRP 1 coreceptors VEGF receptor 2 and Plexin A 1 . ^^^ To discern the regulatory role ( s ) of NRP 1 in pancreatic adenocarcinoma that lack these coreceptors , we overexpressed both full length NRP 1 and a deletion form of NRP 1 that does not interact with semaphorin or VEGF . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although mRNA for VEGF 121 , VEGF 165 , VEGFR 1 and NRP 2 was widely expressed , mRNA expression for VEGF 189 , VEGFR 2 and NRP 1 was linked to a malignant phenotype such as local invasion . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( Npn 1 ) is a cell surface receptor that binds vascular endothelial growth factor ( VEGF ) , a potent mediator of endothelial permeability , chemotaxis , and proliferation . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| After induction of follicular growth by the eCG treatment , each mRNA expression of VEGF 120 , VEGF 164 , Neuropilin 1 and Flt 1 significantly increased . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a novel co receptor for vascular endothelial growth factor ( VEGF ) . ^^^ Neuropilin 1 ( NRP 1 ) is a novel co receptor for vascular endothelial growth factor ( VEGF ) . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although both antagonize VEGF binding / response to neuropilin ( NRP ) receptors , in lung cancer lines , SEMA3F is predominantly expressed and preferentially utilizes NRP 2 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| OTR 4120 showed high affinity binding to VEGF 165 ( Kd = 2 . 2 nm ) , as compared with heparin ( Kd = 15 nm ) , and potentiated the affinity of VEGF 165 for VEGF receptor 1 and 2 and for neuropilin 1 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Placental growth factor and Ang 2 expression were increased in SC adipose tissue of ob / ob mice , and thrombospondin 2 was increased in both their SC and GON fat pads . mRNA levels of vascular endothelial growth factor ( VEGF ) A isoforms VEGF B , VEGF C , VEGF receptor 1 , 2 , and 3 , and neuropilin 1 were not markedly modulated by obesity . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We now report that normal human melanocytes ( Mc ) maintained in serum free , hormone , and growth factor supplemented medium lacking phorbol ester and choleragen constitutively express VEGF receptor 1 ( VEGFR 1 ) , VEGFR 2 , and neuropilin 1 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| However , transcripts for VEGF 189 , VEGF 165 , and VEGF receptors ( Fms like tyrosine kinase 1 [ Flt 1 ] , kinase insert domain receptor [ KDR ] / fetal liver kinase 1 [ Flk 1 ] , and neuropilin 1 ) were suppressed in the BPD models . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| These morphogenic effects of VEGF 165 require activation of both VEGF receptor 2 ( VEGFR 2 ) and neuropilin 1 ( Nrp 1 ) , since neutralizing antibodies to either of these receptors or the addition of semaphorin 3A ( which blocks VEGF 165 binding to Nrp 1 ) prevents the morphogenic response and the phosphorylation of VEGFR 2 along with the downstream signaling . ^^^ We thus conclude that in addition to endothelial vasculogenesis , VEGF can induce renal epithelial cell morphogenesis in a Nrp 1 dependent fashion . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 , a receptor for axon repellent semaphorins and vascular endothelial growth factor ( VEGF ) , functions both in angiogenesis and axon growth . ^^^ |
|
| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| ECM genes profiled included the angiopoietin 1 and related genes ( angiopoietin 2 , tyrosine kinase with immunoglobulin like and EGF like domains 1 ( TIE 1 ) and 2 ( TIE 2 ) , vascular endothelial growth factor ( VEGF ) and related receptors ( VEGF receptor 1 , VEGF receptor 2 and neuropilin 1 ) , thrombospondin 4 , alpha 2 macroglobulin and transforming growth factor beta 2 . ^^^ RESULTS : neuropilin 1 ( 800 % ; p < 0 . 001 ) and VEGF receptor 2 ( 300 % ; p < 0 . 01 ) transcript abundance increased only in the HRG , whereas levels of VEGF receptor 1 mRNA actually declined in the LRG ( p < 0 . 05 ) . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In parallel , human NBL specimens were analyzed for expression of VEGF and neuropilin 1 ( NRP 1 ) . ^^^ NRP 1 was the only VEGF receptor produced in AS and DZ cells in vitro and in vivo . ^^^ VEGF and NRP 1 expression was also demonstrated in human NBL specimens . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours . ^^^ Neuropilin 1 , which can act as a VEGF receptor has been shown to be associated with tumour angiogenesis in some cancer systems . ^^^ We used immunohistochemistry to demonstrate expression of Neuropilin 1 in 63 malignant and 35 benign ovarian tumours and compared it to VEGF , Flt , Flk , SST expression and tumour microvessel density ( MVD ) . ^^^ These results show that Neuropilin 1 is expressed in ovarian tumours and also show that VEGF and SST are co expressed in the same tissue compartments raising the intriguing possibility that SST may be important in angiogenesis in ovarian cancer . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Exogenous human recombinant CypA reduced the mRNA levels of NRP 1 and VEGF , but not endogenous CypA , CypB , and CD 147 , in Panc 1 , MIA PaCa 2 , and BxPC 3 cells . ^^^ CONCLUSIONS : These data show that exogenous CypA downregulates NRP 1 and VEGF expression in pancreatic cancer cells . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We then validated a cyclic peptide , CPQPRPLC , as a VEGF mimic that binds specifically to neuropilin 1 and VEGF receptor 1 . ^^^ We show that : ( 1 ) CPQPRPLC has multiple interactive conformations ; ( 2 ) receptor binding is mediated by the motif Arg Pro Leu ; and ( 3 ) the Pro residue within Arg Pro Leu participates in binding to neuropilin 1 but not to VEGF receptor 1 , perhaps representing an evolutionary gain of function . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Real time RT PCR analysis showed that ( 1 ) the level of mRNA for VEGF was lower in old animals than young animals ; ( 2 ) the mRNA levels of Flt 1 and neuropilin 1 are lower in old animals than young animals , while that of KDR / Flk 1 remained unchanged with advancing age ; and ( 3 ) the levels of mRNA for angiopoietin 1 and 2 remained unchanged , while the mRNA for Tie 2 was lower in old animals than young animals . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Upregulation of neuropilin 1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF . ^^^ Neuropilin 1 ( NRP 1 ) is a co receptor for vascular endothelial growth factor ( VEGF ) . ^^^ Neuropilin 1 ( NRP 1 ) is a co receptor for vascular endothelial growth factor ( VEGF ) . ^^^ Further , the increase in NRP 1 expression by b FGF enhanced hVSMCs migration in response to VEGF ( 165 ) . ^^^ In conclusion , b FGF increased NRP 1 expression in hVSMCs that in turn enhance the effect of VEGF ( 165 ) on cell migration . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| TFt seems to be a trimolecular complex of chondroitin C sulfate proteoglycan , neuropilin 1 , and VEGF receptor 2 , overexpressed together only in highly angiogenic sites of the tumor microenvironment . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a co receptor for vascular endothelial growth factor ( VEGF ( 165 ) ) , an inducer of vascular permeability and angiogenesis . ^^^ Neuropilin 1 ( NRP 1 ) is a co receptor for vascular endothelial growth factor ( VEGF ( 165 ) ) , an inducer of vascular permeability and angiogenesis . ^^^ Previously , we have shown that the naturally occurring soluble form of NRP 1 ( sNRP 1 ) inhibits binding of VEGF ( 165 ) to endothelial cells in vitro and impairs tumor growth in vivo . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is expressed by endothelial cells and neurons and serves as a receptor for both vascular endothelial growth factor ( VEGF ) , an angiogenesis factor , and semaphorin 3A ( Sema3A ) , a mediator of axonal guidance . ^^^ Neuropilin 1 ( NRP 1 ) is expressed by endothelial cells and neurons and serves as a receptor for both vascular endothelial growth factor ( VEGF ) , an angiogenesis factor , and semaphorin 3A ( Sema3A ) , a mediator of axonal guidance . ^^^ To address function , HaCaT cells were exposed to two NRP 1 ligands , VEGF 165 and Sema3A . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| The three major VEGF isoforms are known to differ in their solubility ( VEGF 120 is freely soluble and VEGF 188 is completely matrix bound , while VEGF 164 has intermediate properties ) and receptor binding properties ( VEGF 164 does and VEGF 120 does not bind to neuropilin 1 ( Nrp 1 ) ) , but the specific biological function of these VEGF isoforms is largely unknown . ^^^ Predominant arterial expression of Nrp 1 implies that VEGF 164 may mediate arterial outgrowth via Nrp 1 . ^^^ VEGF 164 expression consistently colocalized with its receptor , Nrp 1 at DGS predilection sites , suggesting that both provide critical guidance or differentiation cues for vascular remodeling . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| VEGF ( 165 ) signaling through VEGF receptor ( VEGFR ) 2 / kinase insert domain receptor ( KDR ) is a highly regulated process involving the formation of a tertiary complex with glypican ( GYP ) 1 and neuropilin ( NRP ) 1 . ^^^ We show that cigarette smoke exposure reduces NRP 1 and GYP 1 as well as VEGF and VEGFR 2 levels in rat lungs and that VEGF , VEGFR 2 , GYP 1 , and NRP 1 expression in the lungs of both smokers and patients with COPD are also reduced compared with nonsmokers . ^^^ As both VEGF ( 165 ) and VEGFR 2 expression are reduced in emphysematous lungs , decreased GYP 1 and NRP 1 expression may yet further disrupt VEGF ( 165 ) VEGFR 2 signaling . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We unexpectedly found that tuftsin and a higher affinity antagonist , TKPPR , bind selectively to neuropilin 1 and block vascular endothelial growth factor ( VEGF ) binding to that receptor . ^^^ Homology between exon 8 of VEGF and TKPPR suggests that the sequence coded for by exon 8 may stabilize VEGF binding to neuropilin 1 to facilitate signaling through VEGFR 2 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To determine if vascular endothelial growth factor ( VEGF ) coreceptor neuropilin 1 ( NP 1 ) is expressed in choroidal neovascularization ( CNV ) and to localize the expression . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We studied the mRNA expression of the two most important isoforms of VEGF ( VEGF 120 and VEGF 164 ) as well as one type of VEGF receptors , neuropilins ( NRP ) , during maturation in the rat brain using real time PCR . 3 . ^^^ Both types of NRP , NRP 1 and NRP 2 , which only bind VEGF 164 , increased their expression about 2 folds only at P 30 , at levels similar to those observed for VEGF164 . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| A peptide competing with VEGF 165 binding on neuropilin 1 mediates targeting of a chlorin type photosensitizer and potentiates its photodynamic activity in human endothelial cells . ^^^ ATWLPPR and TPC Ahx ATWLPPR bound exclusively to neuropilin 1 ( NRP 1 ) recombinant chimeric protein ( IC50=19 and 171 microM , respectively ) but were devoid of affinity for VEGF receptor type 2 ( VEGFR 2 , KDR ) , to which ATWLPPR was initially thought to bind . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Ligand induced internalization selects use of common receptor neuropilin 1 by VEGF 165 and semaphorin3A . ^^^ Neuropilin 1 ( Npn 1 ) is a receptor shared by class 3 semaphorins and heparin binding forms of vascular endothelial growth factor ( VEGF ) , protein families that regulate endothelial and neuronal cell function . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilins ( NRP ) are membranous receptors capable of binding two disparate ligands , class 3 semaphorins ( SEMA ) and vascular endothelial growth factors ( VEGF ) , and regulating two diverse systems , neuronal guidance and angiogenesis . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| SCC 9 cells express the VEGF receptors Flk 1 and neuropilin 1 , with VEGF treatment increasing VEGF promoter activity and VEGF secretion that was attenuated by the Flk 1 tyrosine kinase inhibitor , ZM 323881 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although much is known about the biology of vascular endothelial growth factor ( VEGF ) and its receptors , little is known about the role of the VEGF receptors neuropilin ( NRP ) 1 and NRP 2 in the process of bovine follicle development . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemistry confirmed that proliferating and differentiated PC 12 cells express VEGF receptors 1 , 2 and neuropilin 1 . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a co receptor for vascular endothelial growth factor ( VEGF ) that enhances the angiogenic signals cooperatively with VEGFR 2 . ^^^ Neuropilin 1 ( NRP 1 ) is a co receptor for vascular endothelial growth factor ( VEGF ) that enhances the angiogenic signals cooperatively with VEGFR 2 . ^^^ Glycosylation increased VEGF binding in both cell types , but the differential GAG composition of NRP 1 mediates opposite responsiveness to VEGF in ECs and SMCs . ^^^ These findings indicate that GAG modification of NRP 1 plays a critical role in modulating VEGF signaling , and may provide new insights into physiological and pathological angiogenesis . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| A series of small molecule compounds interfering with the binding process of VEGF and NRP 1 has been identified and further optimized . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Finally , we show that a major NRP 1 ligand , vascular endothelial growth factor ( VEGF ) ( 165 ) , is secreted by mature human DCs and binds to NRP 1 captured by T lymphocytes . ^^^ These results show that NRP 1 transfer to T lymphocytes during the immune synapse can convert T lymphocytes into VEGF ( 165 ) carrying cells . ^^^ Together with the enhanced signaling of VEGF R 2 on endothelial cells in the presence , in trans , of the NRP 1 VEGF ( 165 ) complex , our results suggest that the intercellular transfer of NRP 1 might participate in the Ag independent remodelling of the endothelial vessels in secondary lymphoid organs during inflammation . . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| In addition , the expression of VEGF , hypoxia inducible factor 1alpha ( HIF 1alpha ) and neuropilin 1 ( NP 1 ) was significantly lower in CT 2A / TNG tumor cells than in control CT 2A tumor cells . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| We have recently showed that keratinocytes from human normal skin expressed all five known VEGF receptors and co receptors ( neuropilin 1 and 2 ) . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neoangiogenesis is connected with the expression of many markers of this process , among them vascular endothelial growth factor ( VEGF ) , endoglin ( CD 105 ) , a transmembranous glycoprotein which is a component of the receptor for transforming growth factor beta ( TGFbeta ) , as well as neuropilin ( NRP ) , the co receptor for VEGF . ^^^ |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15692 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
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