| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| A novel activity producing gamma aminobutyric acid ( GABA ) from L ornithine in the presence of NAD ( P ) + was found in the crude extract of L ornithine induced Hafnia alvei , in addition to L ornithine decarboxylase ( ODC ) activity . ^^^ |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| Gene expression of human ovarian carcinoma cell lines and epithelial ovarian tumors was examined by oligonucleotide microarray for about 6000 human cDNAs . ( 1 ) Comparison of gene expression between CDDP sensitive human ovarian serous adenocarcinoma cell lines and CDDP resistant cell lines revealed that gamma glutamylcysteine synthetase , glutathione peroxidase like protein , dehydrogenase ( UGDH ) , NAD ( P ) H : quinoneoxireductase , glucose 6 phosphatase , ornithine decarboxylase and dihydrodiol dehydrogenase were associated with a mechanism of CDDP resistance . ^^^ |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| These systems include modulation of drug metabolism ( inhibition of Cyp1A activity , induction of NAD ( P ) H : quinone reductase ( QR ) activity in Hepa1c1c7 murine hepatoma cell culture ) , determination of radical scavenging ( DPPH scavenging ) and antioxidant effects ( scavenging of superoxide anion , hydroxyl and peroxyl radicals ) , anti inflammatory mechanisms ( inhibition of lipopolysaccharide ( LPS ) mediated nitric oxide ( NO ) generation by inducible NO synthase ( iNOS ) in Raw 264 . 7 murine macrophages , cyclooxygenase 1 ( Cox 1 ) inhibition ) , and anti tumor promoting activities ( inhibition of phorbol ester induced ornithine decarboxylase ( ODC ) activity in 308 murine keratinocytes ) . ^^^ |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| We describe here an alternative pathway for ODC degradation that is regulated by NAD ( P ) H quinone oxidoreductase 1 ( NQO 1 ) . ^^^ We show that NQO 1 binds and stabilizes ODC . ^^^ Dicoumarol , an inhibitor of NQO 1 , dissociates ODC NQO 1 interaction and enhances ubiquitin independent ODC proteasomal degradation . ^^^ This process of NQO 1 regulated ODC degradation was recapitulated in vitro by using purified 20S proteasomes . ^^^ Finally , we show that the regulation of ODC stability by NQO 1 is especially prominent under oxidative stress . ^^^ |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| NQO 1 binds and stabilizes several short lived proteins including the tumor suppressors p 53 and p 73 and the enzyme ornithine decarboxylase ( ODC ) . ^^^ Dicoumarol also disrupts the binding of NQO 1 to p 53 , p 73 , and ODC and induces their ubiquitin independent proteasomal degradation . ^^^ |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P15559 and P11926 |
Pubmed |
SVM Score :0.0 |
| NA |
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