| Interacting proteins: Q96AY3 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q96AY3 and P15502 |
Pubmed |
SVM Score :1.3344847 |
| In an earlier study , we identified that FKBP 65 associates with the extracellular matrix protein tropoelastin during its transport through the cell . 1.3344847^^^ |
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| Interacting proteins: Q96AY3 and P15502 |
Pubmed |
SVM Score :0.0 |
| Identification of tropoelastin as a ligand for the 65 kD FK 506 binding protein , FKBP 65 , in the secretory pathway . ^^^ The use of BFA and other secretion disrupting agents suggests that the association of tropoelastin with FKBP 65 occurs in the ER . ^^^ Results from this study provide the first identification of a ligand for an FKBP in the secretory pathway and suggest that the prolyl cis trans isomerase activity of FKBP 65 may be important for the proper folding of the proline rich tropoelastin molecule before secretion . . ^^^ |
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| Interacting proteins: Q96AY3 and P15502 |
Pubmed |
SVM Score :0.0 |
| Of the many eukaryotic FKBPs that have been identified , FKBP 65 is an endoplasmic reticulum localized protein that associates with tropoelastin in the secretory pathway . ^^^ |
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| Interacting proteins: Q96AY3 and P15502 |
Pubmed |
SVM Score :0.0 |
| In previous studies , we have shown that FKBP 65 is developmentally regulated and associates with the extracellular matrix protein , tropoelastin , during its maturation and transport through the ER . ^^^ In this study , we show that FKBP 65 is expressed in the lung with the same developmental pattern as tropoelastin and other matrix proteins . ^^^ After bleomycin instillation , FKBP 65 expression was reactivated in the lung with a pattern similar to that observed for tropoelastin and type 1 collagen . ^^^ |
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