| Tropoelastin binding to fibulins , nidogen 2 and other extracellular matrix proteins . ^^^ These studies demonstrated a particularly high affinity ( K ( d ) about 1 nM ) of tropoelastin for microfibrillar fibulin 2 and the recently described nidogen 2 isoform . ^^^ In immunogold staining of mouse aortic media , elastic fibers were heavily decorated with tropoelastin , fibulin 2 and nidogen 2 , while the reaction with fibulin 1 was lower . ^^^ |