| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| The lysyl oxidase like ( LOXL ) gene is a new member of the lysyl oxidase family , a copper dependent enzyme that is implicated in the crosslinking of collagen and elastin fibers . ^^^ |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| The ultrastructural localization of LOXL was indicative of its association with elastin positive materials within the SE and human skin , though interaction with collagen could not be discarded . ^^^ |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| Lysyl oxidase like ( LOXL ) protein is a novel copper containing amine oxidase that is required for the cross linking of elastin and collagen in vitro . ^^^ |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| Lysyl oxidase ( LOX ) and lysyl oxidase like ( LOXL ) are extracellular enzymes that deaminate peptidyl lysyl residues involved in the cross linking of fibrillar collagens and elastin . ^^^ |
|
| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| Ligand blot and mammalian two hybrid assays confirmed an interaction between tropoelastin and the pro regions of both LOX and LOXL . ^^^ Our results showed that the pro regions of LOX and LOXL play a significant role in directing the deposition of both enzymes onto elastic fibers by mediating interactions with tropoelastin . ^^^ |
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| Interacting proteins: Q08397 and P15502 |
Pubmed |
SVM Score :0.0 |
| Thus elastin polymer deposition is a crucial aspect of elastic fiber maintenance and is dependent on LOXL 1 , which serves both as a cross linking enzyme and an element of the scaffold to ensure spatially defined deposition of elastin . . ^^^ Here we show that mice lacking the protein lysyl oxidase like 1 ( LOXL 1 ) do not deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse , enlarged airspaces of the lung , loose skin and vascular abnormalities with concomitant tropoelastin accumulation . ^^^ |
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