Pubmed abstracts for Protein-Protein Interaction search result :


Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
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Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
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Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
This study investigated the potential association of structural genes encoding for extracellular matrix components of FBN 1 , elastin , and one of the polypeptides of type 1 collagen ( COL1A2 ) with familial adolescent idiopathic scoliosis . ^^^ Genomic DNA was analyzed by genetic linkage utilizing four intragenic markers for the structural genes of FBN 1 , elastin , and COL1A2 . ^^^ Collectively , our results exclude the structural genes of FBN 1 , elastin , and COL1A2 as candidate genes within these families . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The first of them ( FBN 1 ) codes for the main constitutive protein of the elastic tissue : fibrillin 1 , present mainly in structures which must resist load and stress ( aortic adventitia , the suspending ligament of the lens , skin ) ; the second ( FBN 2 ) codes for fibrillin 2 : responsible for the orientation of the elastin and mainly present in cartilage , the aortic media , the bronchi , and all tissues rich in elastin . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
We investigated the expression of major elastic fiber components such as tropoelastin ( TE ) and fibrillin 1 ( FBN 1 ) and elastin related enzyme , lysyl oxidase ( LO ) , in a calcification model using beta glycerophosphate ( beta GP ) in cultured bovine aortic smooth muscle cells ( BASMCs ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
It sets in context the roles of specific genes and their protein products , such as polycystin ( PKD 1 ) , fibrillin ( FBN 1 ) , collagen 3 ( COL3A1 ) , elastin ( ELN ) , collagen 4 , protease inhibitor or alpha 1 antitrypsin ( PI ) and proteases . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The genetic basis of the mutation has been identified as a genomic duplication within the fibrillin 1 ( Fbn 1 ) gene that results in a larger than normal Fbn 1 transcript , but the mechanism that leads to dermal fibrosis is unclear Fibrillin molecules associate into a polymer that is coated with elastin molecules to form elastic fibers . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Analysis of the neonatal Fbn 1 / aorta documented a disorganized and poorly developed medial layer but normal levels of elastin cross links . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Starting from the fact that the ratio systolic work / myocardial mass ( WS / VM ) is a stable one in normal subjects ( 0 . 81 + / 0 . 03 ) , we were able to divide up the 70 patients with congenital and acquired aortic stenosis into three groups as follows : Group 1 . ^^^ WS / VM greater than 0 . 87 ; this group is called hyperfunctional , and characterised by an increase in WS , and a myocardial mass which is ostensibly normal . ^^^ Group 2 : 0 . 87 larger than or equal to WS / VM larger than or equal to 0 . 75 ; this isofunctional group is characterised by parallel increases in mass and systolic work . ^^^ Group 3 : WS / VM less than 0 . 75 ; this group is called hypofunctional , and is characterised by an increase in mass unrelated to an increase in work . ^^^ A comparison of the sensitivity of other parameters with that of WS / VM gives rise to optimism that the precision of determination of the prognosis will increase , as will that of the choice of the time to operative , but only those patients in groups 1 and 2 can expect a return to normal function and ventricular mass . . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
We describe a patient with WS who presented with an enlarging , painful mass of the right knee that proved to be a juxtaarticular osteosarcoma of the distal femur . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The method is sensitive enough to measure both substances in tissue fragments of 30 mg of wet mass , which means that it can be used to study elastin in small human biopsies . . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Conditioned media from cultures of human mononuclear phagocytes containing the 92 kDa enzyme produced a distinct zone of lysis in the kappa elastin zymograms at this molecular mass . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
At birth this infant boy had the diagnostic findings of WBS with macroglossia , ear lobule creases and pits , nevus flammeus , and omphalocele , and an abdominal mass . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Muscle mass loss of approximately 30 % was observed in soleus after 7 and 14 days of WBS . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
These parameters were compared with those relating to cardiac function , such as age , interventricular septal thickness ( IVST ) , LV mass index ( LVMI ) , % fractional shortening ( % FS ) , LV end systolic wall stress ( WS ) , blood pressure , and heart rate . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
This change exceeded the concurrent accumulation of elastin ( 77 % ) and smooth muscle cell mass ( 34 % ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Neither the absolute amounts and concentrations ( relative to tissue mass ) of elastin in mesenteric and cerebral arteries , nor the absolute amounts and concentrations of collagen in the mesenteric artery , were changed in the SHR . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Closely similar but nonidentical NH 2 terminal amino acid sequences have been reported for a protein or proteins in human neutrophils whose bioactivities is / are diverse ( as a serine protease , antibiotic , and Wegener ' s granulomatosis autoantigen ) but that share ( s ) several features : localization in the azurophil granules , a molecular mass of approximately 29 kD , reactivity with diisopropylfluorophosphate , and the ability to degrade elastin . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Three tropoelastin polypeptides with molecular mass 2 3 kDa higher than their corresponding tissue forms were also evident in cell free translation products of ligamentum nuchae RNA , suggesting that each tropoelastin species is encoded by a unique mRNA . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
From these experiments three distinct tropoelastin isoform patterns were detected at different developmental periods . 1 ) The fetal period was characterized by three polypeptides of about 67 , 65 , and 63 kDa produced in a ratio of 1 : 3 : 2 . 2 ) In neonatal tissue , the same molecular mass forms were detected ; however , the relative isoform ratio changed to 2 : 3 : 1 . 3 ) From adult ligament RNA , only the 67 and 65 kDa forms of tropoelastin were detected , and these were produced in equal amounts . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Western blot analysis of tropoelastin from progeroid fibroblasts confirmed increased production of elastin but revealed no gross changes in the molecular mass . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The patterns were compatible with an origin from the cross linking regions of collagen and elastin respectively . ( 5 ) Quantitative ( molar ) comparisons of the azo EC group content with amino acid , amino end group and sugar contents , and azo EC peptide molecular mass , suggest that a structure is present in the collagen azo EC peptides containing two EC groups shared between four peptide chains . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Several laboratories , including our own have reported the synthesis and activity of certain low relative molecular mass inhibitors of mammalian serine proteases , especially human leukocyte elastase ( HLE , EC 3 . 4 . 21 . 37 ) , an enzyme whose degradative activity on lung elastin has been implicated as a major causative factor in the induction of pulmonary emphysema , and which is present in the azurophil granules of human polymorphonuclear leukocytes ( PMN ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Medial thickening with hypertension is attributable primarily to increased smooth muscle cell mass , although enhanced deposition of collagen and elastin plays a contributory role . ^^^
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Authors succeeded in proving an insecticide Lannate 90 WS in coffee grounds by mass spectrometry and thin layer chromatography . ^^^
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The translated products showed two elastin related proteins ( a and b ; relative mass approximately 70 000 ) . ^^^
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The low molecular mass inhibitors inactivated elastase nearly completely , regardless of whether or not the enzyme was adsorbed to its substrate elastin prior to the addition of the inhibitors . ^^^
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Lung mass and body mass were recorded and lungs were prepared for frozen section examination and stained with hematoxylin and eosin , elastin , anti Factor 8 , and nitro blue tetrazolium to identify nicotinamide adenine dinucleotide phosphate ( NADPH ) diaphorase . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Systematic studies on weight gain and body mass index in WBS do not exist . ^^^
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A prominent metalloproteinase activity with an apparent molecular mass of 80 kD and additional activities at 67 through 70 , 50 , and 32 kD have been observed on casein , gelatin , and elastin gel zymography in extracts from abdominal aortic aneurysms ( AAAs ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
When compared with controls , content of CS and HS increased over the whole length of dissected aortas , whereas increased HA and DS were localised to dissected areas of affected aortas as were increased tissue mass and collagen and elastin content . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
By in situ hybridization , the transcripts for elastin nd biglycan were primarily localized to smooth muscle cells in the intima and were diminished by heparin in proportion to the decrease in intimal mass . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
In hypertension , the thickening of the arterial wall by an increase in the cellular mass and collagen and elastin content may be considered to be an adaptive response to the high blood pressure . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Analysis of canine PPP , WBS , platelet lysates , and primary canine endothelial cell ( EC ) cultures by sodium dodecyl sulfate polyacrylamide gel electrophoresis and fibrin autography revealed a plasminogen dependent lytic zone at 45 kd relative molecular mass that was shown to be related to urokinase type PA ( u PA ) by its selective inhibition through amiloride . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Following the nomenclature of Sandberg , the W 4 sequence of human elastin , [ sequence : see text ] , has been synthesized by solid phase methods and characterized by carbon 13 nuclear magnetic resonance , amino acid analysis , mass spectra and elemental analysis . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Elastin derived peptides ( kappa elastin : kappa E , mean molecular mass : 75 kDa ) , either coated onto plastic dishes or added to culture media ( 0 . 26 to 1 . 33 nM ) stimulated the growth of human skin fibroblasts ( HSF ) strains obtained from different donors and tested at different cell passages ( 4 to 12 ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
REE / kg body cell mass ( BCM ) was higher in WL and WS than in controls ( both p < 0 . 01 ) due to lower BCM in both patient groups ( p < 0 . 001 ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
V posterior wall ( PWi ) , with calculations of the LV mass index ( massi ) , ejection fraction ( EF ) , fractional shortening ( FS ) , the velocity of circumferential fiber shortening ( VCF ) and wall stress ( WS ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Involvement of intracellular cyclic GMP and cyclic GMP dependent protein kinase in alpha elastin induced macrophage chemotaxis . alpha Elastin with an average molecular mass of 70 kDa , an oxalic acid fragmentation product of highly purified insoluble elastin , induced the migration of macrophages , with maximum activity at 10 ( 1 ) microg / ml . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Five patients with WS ( mean age , 41 . 2 yr ; body mass index , 17 . 0 kg / m2 ) were treated with TRO ( 400 mg / day ) for 4 weeks . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The results indicated that creatine supplementation in comparison with placebo treatment during rapid body mass reduction may help to maintain muscle PT and W ( PT ) 1 at high angular velocities , not influencing Wmax and the rate of fatigue development during Wmax , but affecting adversely Ws max . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The relationship between abdominal aortic aneurysms ( AAA ) and chronical obstructive pulmonary disease ( COPD ) , and in particular the suggested common elastin degradation caused by elastase and smoking was analysed by a cross sectional population mass screening study for AAA , and a prospective cohort study of small AAA . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Tendons consist of collagen ( mostly type 1 collagen ) and elastin embedded in a proteoglycan water matrix with collagen accounting for 65 80 % and elastin approximately 1 2 % of the dry mass of the tendon . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
To analyze the equipment performance , the rate of increase of the tablets mass , K 1 , and the adhesion coefficient eta were determined as a function of the feed flow rate of coating suspension Ws ; of the Reynolds number Rep ; of the flow rate of atomizing gas Wat , and of the cone base angle gamma . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Possible fluoride ingestion per Kg body mass ws estimated . ^^^
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Elastin zymography showed that the elastase activity was associated predominantly with a molecular mass of 25 kDa . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
In summary , the reduction in fiber cross sectional areas and increase in fiber and capillary densities support the hypothesis that in both forms of disuse , i . e . , W and WBS , there is a loss in soleus muscle cell mass and not in fiber numbers . . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
However , neither overall molecular mass , number of hydrophobic domains nor general hydropathy of the polypeptides provided a complete explanation for differences in coacervation temperature , suggesting that the specific nature of the sequences of these hydrophobic domains are an important determinant of the ability of elastin polypeptides to self assemble . . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The relatively low levels of urinary desmosine observed in patients with severe emphysema may be accounted for a decrease in elastin catabolism due to reduced lung elastin mass . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
RESULTS : SDS PAGE analysis showed that TCA solubilized polypeptides having a molecular mass of < 10 kDa from both WS and WI protein fractions of normal and cataractous lenses . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Quantification of elastin cross linking amino acids , desmosine and isodesmosine , in hydrolysates of rat lung by ion pair liquid chromatography mass spectrometry . ^^^ The elastin cross linking amino acids , desmosine ( DES ) and isodesmosine ( IDE ) , in hydrolysates of rat lungs were quantified by ion pair liquid chromatography electrospray mass spectrometry . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Biochemical and mechanical analysis revealed a continuous increase of cell mass , collagen and elastin contents and strength under pulsatile culture conditions compared to significantly lower values in the static controls . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
The optimum blend ratio for pyrolysis of coal / WS was 50 : 50 with a high degradation rate in all the thermal events and a higher mass loss over the course of the co pyrolysis compared to coal / WW blends examined . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
A novel transglutaminase cross link between tropoelastin and fibrillin 1 fragment ( encoded by exons 9 17 ) was localized by mass spectrometry to a sequence encoded by exon 17 . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Twenty women similar in body mass index , age , physical activity , and use of hormonal contraception were pairwise randomized either to the WBC group or the WS group . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
In addition , 540 mg silicon / kg diet resulted in higher aortic dry mass and aortic elastin content in both copper deficient and copper adequate rats . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Structural changes reported in the airways of asthmatics include epithelial fragility , goblet cell hyperplasia , enlarged submucosal mucus glands , angiogenesis , increased matrix deposition in the airway wall , increased airway smooth muscle mass , wall thickening and abnormalities in elastin . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Body mass shrinkage , foot atrophy , elevated mortality , and decreased foot and digestive gland glycogen were observed in both WS affected and starved , unexposed abalone , with the WS RLP exposed , starved group held at elevated temperature faring worst . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Precise contact residues between domain 4 of tropoelastin and domain 16 of fibrillin 1 were discovered through a novel combination of transglutaminase cross linking and mass spectroscopy , with contact sites at residues K 38 of tropoelastin and Q 669 of fibrillin 1 . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Mass spectrometric characterization of human skin elastin peptides produced by proteolytic digestion with pepsin and thermitase . ^^^ Characterization of the peptides was performed using two complementary mass spectrometric techniques ; LC / ESI ion trap and nano ESI qTOF MS . 155 different peptides were identified using a combined database based and de novo sequencing approach resulting in a total sequence coverage of 65 . 4 % calculated on the basis of the precursor tropoelastin ( accession number A 32707 ) . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Complementary mass spectrometric techniques to achieve complete sequence coverage of recombinant human tropoelastin . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
Three individuals with Williams Syndrome ( WMS ) , a genetic disorder due to the deletion of the elastin gene , were examined under these experimental conditions . ^^^
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
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Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
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Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA
Interacting proteins: P35555 and P15502 Pubmed SVM Score :0.0
NA